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Select item 70196511.

Envelope-Specific IgG3 and IgG1 Responses Are Associated with Clearance of Acute Hepatitis C Virus Infection

Melanie R. Walker, Auda A. Eltahla, Michael M. Mina, Hui Li, Andrew R. Lloyd, Rowena A. Bull

Viruses. 2020 Jan; 12(1): 75. Published online 2020 Jan 8. doi: 10.3390/v12010075

PMCID:: PMC7019651

Abstract Article PDF–3.5M

Select item 67467632.

Clearance of hepatitis C virus is associated with early and potent but narrowly-directed, Envelope-specific antibodies

Melanie R. Walker, Preston Leung, Auda A. Eltahla, Alexander Underwood, Arunasingam Abayasingam, Nicholas A. Brasher, Hui Li, Bing-Ru Wu, Lisa Maher, Fabio Luciani, Andrew R. Lloyd, Rowena A. Bull

Sci Rep. 2019; 9: 13300. Published online 2019 Sep 16. doi: 10.1038/s41598-019-49454-w

PMCID:: PMC6746763

Abstract Article PDF–2.5M

Select item 67415923.

Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry

Mohamed R. Hamed, Richard J.P. Brown, Carsten Zothner, Richard A. Urbanowicz, Christopher P. Mason, Anders Krarup, C. Patrick McClure, William L. Irving, Jonathan K. Ball, Mark Harris, Timothy P. Hickling, Alexander W. Tarr

J Innate Immun. 2014 Aug; 6(5): 676–684. Published online 2014 May 15. doi: 10.1159/000362209

PMCID:: PMC6741592

Abstract Article PDF–798K

Select item 67394844.

Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir

Peter A.C. Wing, Meleri Jones, Michelle Cheung, Sampath DaSilva, Connor Bamford, Wing-Yiu Jason Lee, Elihu Aranday-Cortes, Ana Da Silva Filipe, John McLauchlan, David Smith, William Irving, Morven Cunningham, Azim Ansari, Eleanor Barnes, Graham R. Foster

Gastroenterology. 2019 Sep; 157(3): 692–704.e9. doi: 10.1053/j.gastro.2019.05.007

PMCID:: PMC6739484

Abstract Article

Select item 67139295.

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

Hengxia Jia, Peng Gong

Front Microbiol. 2019; 10: 1945. Published online 2019 Aug 22. doi: 10.3389/fmicb.2019.01945

PMCID:: PMC6713929

Abstract Article PDF–10M

Select item 67040696.

Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR

Lorena Vigón, Sonia Vázquez-Morón, Juan Berenguer, Juan González-García, Ma Ángeles Jiménez-Sousa, Josep M. Guardiola, Manuel Crespo, Ignacio de Los Santos, Miguel A. Von Wichmann, Ana Carrero, María Belén Yélamos, Julián Gómez, Salvador Resino, Isidoro Martínez, The GESIDA 3603b Cohort Study Group

Sci Rep. 2019; 9: 12163. Published online 2019 Aug 21. doi: 10.1038/s41598-019-48592-5

PMCID:: PMC6704069

Abstract Article PDF–1.9M

Select item 66260207.

Circulating CXCR3⁺ Tfh cells positively correlate with neutralizing antibody responses in HCV-infected patients

Jian Zhang, Wenpei Liu, Bo Wen, Ting Xie, Ping Tang, Yabin Hu, Liyan Huang, Kun Jin, Ping Zhang, Ziyan Liu, Ling Niu, Xiaowang Qu

Sci Rep. 2019; 9: 10090. Published online 2019 Jul 12. doi: 10.1038/s41598-019-46533-w

PMCID:: PMC6626020

Abstract Article PDF–3.5M

Select item 65437108.

A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice

Makutiro Ghislain Masavuli, Danushka K. Wijesundara, Alexander Underwood, Dale Christiansen, Linda Earnest-Silveira, Rowena Bull, Joseph Torresi, Eric J. Gowans, Branka Grubor-Bauk

Front Immunol. 2019; 10: 1145. Published online 2019 May 24. doi: 10.3389/fimmu.2019.01145

PMCID:: PMC6543710

Abstract Article PDF–8.7M

Select item 65425419.

Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis C virus infections uncover molecular determinants for E2 targeting and vaccine design

Zhen-Yong Keck, Brian G. Pierce, Patrick Lau, Janine Lu, Yong Wang, Alexander Underwood, Rowena A. Bull, Jannick Prentoe, Rodrigo Velázquez-Moctezuma, Melanie R. Walker, Fabio Luciani, Johnathan D. Guest, Catherine Fauvelle, Thomas F. Baumert, Jens Bukh, Andrew R. Lloyd, Steven K. H. Foung

PLoS Pathog. 2019 May; 15(5): e1007772. Published online 2019 May 17. doi: 10.1371/journal.ppat.1007772

PMCID:: PMC6542541

Abstract Article PDF–2.6M

Select item 643054310.

Potent Anti-hepatitis C Virus (HCV) T Cell Immune Responses Induced in Mice Vaccinated with DNA-Launched RNA Replicons and Modified Vaccinia Virus Ankara-HCV

María Q. Marín, Patricia Pérez, Karl Ljungberg, Carlos Óscar S. Sorzano, Carmen E. Gómez, Peter Liljeström, Mariano Esteban, Juan García-Arriaza

J Virol. 2019 Apr 1; 93(7): e00055-19. Prepublished online 2019 Jan 23. Published online 2019 Mar 21. doi: 10.1128/JVI.00055-19

PMCID:: PMC6430543

Abstract Article PDF–2.8M

Select item 626647811.

Understanding the Determinants of BnAb Induction in Acute HCV Infection

Alexander P. Underwood, Melanie R. Walker, Nicholas A. Brasher, Auda A. Eltahla, Lisa Maher, Fabio Luciani, Andrew R. Lloyd, Rowena A. Bull

Viruses. 2018 Nov; 10(11): 659. Published online 2018 Nov 21. doi: 10.3390/v10110659

PMCID:: PMC6266478

Abstract Article PDF–1.5M

Select item 617905312.

Baseline dasabuvir resistance in Hepatitis C virus from the genotypes 1, 2 and 3 and modeling of the NS5B-dasabuvir complex by the in silico approach

Dario Akaberi, Assar Bergfors, Midori Kjellin, Nader Kameli, Louise Lidemalm, Bhavya Kolli, Robert W. Shafer, Navaneethan Palanisamy, Johan Lennerstrand

Infect Ecol Epidemiol. 2018; 8(1): 1528117. Published online 2018 Oct 5. doi: 10.1080/20008686.2018.1528117

PMCID:: PMC6179053

Abstract Article PDF–1.5M

Select item 599838013.

Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice

Vasil B. Krapchev, Malgorzata Rychłowska, Alicja Chmielewska, Karolina Zimmer, Arvind H. Patel, Krystyna Bieńkowska-Szewczyk

Virology. 2018 Jun; 519: 33–41. doi: 10.1016/j.virol.2018.03.026

PMCID:: PMC5998380

Abstract Article

Select item 578476114.

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1

Ahmed Atef Mesalam, Isabelle Desombere, Ali Farhoudi, Freya Van Houtte, Lieven Verhoye, Jonathan Ball, Jean Dubuisson, Steven K.H. Foung, Arvind H. Patel, Mats A.A. Persson, Geert Leroux-Roels, Philip Meuleman

Virology. Author manuscript; available in PMC 2018 Jan 25.

Published in final edited form as: Virology. 2018 Jan 15; 514: 30–41. Published online 2017 Nov 10. doi: 10.1016/j.virol.2017.10.019

PMCID:: PMC5784761

Abstract Article PDF–2.0M

Select item 551224915.

Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E

Zhihua Li, Yadong Li, Yanwei Bi, Hui Zhang, Yufeng Yao, Qihan Li, Wei Cun, Shaozhong Dong

J Virol. 2017 Aug 1; 91(15): e02227-16. Prepublished online 2017 May 24. Published online 2017 Jul 12. doi: 10.1128/JVI.02227-16

PMCID:: PMC5512249

Abstract Article PDF–4.2M

Select item 546467116.

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

Tiffany Benzine, Ryan Brandt, William C. Lovell, Daisuke Yamane, Petra Neddermann, Raffaele De Francesco, Stanley M. Lemon, Alan S. Perelson, Ruian Ke, David R. McGivern

PLoS Pathog. 2017 Jun; 13(6): e1006343. Published online 2017 Jun 8. doi: 10.1371/journal.ppat.1006343

PMCID:: PMC5464671

Abstract Article PDF–3.7M

Select item 544873417.

Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus

Amruta S. Naik, Ania Owsianka, Brendan A. Palmer, Ciaran J. O’Halloran, Nicole Walsh, Orla Crosbie, Elizabeth Kenny-Walsh, Arvind H. Patel, Liam J. Fanning

PLoS One. 2017; 12(5): e0175349. Published online 2017 May 30. doi: 10.1371/journal.pone.0175349

PMCID:: PMC5448734

Abstract Article PDF–4.3M

Select item 530995118.

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

Kathleen McCaffrey, Irene Boo, Catherine M. Owczarek, Matthew P. Hardy, Matthew A. Perugini, Louis Fabri, Pierre Scotney, Pantelis Poumbourios, Heidi E. Drummer

J Virol. 2017 Mar 1; 91(5): e01668-16. Prepublished online 2016 Dec 28. Published online 2017 Feb 14. doi: 10.1128/JVI.01668-16

PMCID:: PMC5309951

Abstract Article PDF–2.6M

Select item 524467819.

Anti‐envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection

R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K. H. Foung, J. McLauchlan, A. H. Patel, M. E. Cramp

J Viral Hepat. 2016 Nov; 23(11): 873–880. Published online 2016 Jul 13. doi: 10.1111/jvh.12568

PMCID:: PMC5244678

Abstract Article PDF–541K

Select item 504212920.

Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay

Richard A. Urbanowicz, C. Patrick McClure, Barnabas King, Christopher P. Mason, Jonathan K. Ball, Alexander W. Tarr

J Gen Virol. 2016 Sep; 97(9): 2265–2279. Published online 2016 Sep. doi: 10.1099/jgv.0.000537

PMCID:: PMC5042129

Abstract Article PDF–3.5M

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