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Select item 114609701.

Association of IRS1 gene Pro512Ala polymorphism with nonalcoholic fatty liver disease

Asadollah Asadi, Mitra Rostami, Radmehr Shafiee, Abbas Ardalani, Atefeh Dehghanitafti, Zakieh Golshadi, Kiarash Kohansal, Fatemeh Ghasemi, Maryam Najafi, Touraj Mahmoudi, Gholamreza Rezamand, Reza Dabiri, Hossein Nobakht, Hamid Farahani, Seidamir Pasha Tabaeian

Arch Endocrinol Metab. 2024; 68: e230216. Published online 2024 Aug 26. doi: 10.20945/2359-4292-2023-0216

PMCID:: PMC11460970

Abstract Article PDF–219K

Select item 112170002.

Sex differences in adipose insulin resistance are linked to obesity, lipolysis and insulin receptor substrate 1

Peter Arner, Nathalie Viguerie, Lucas Massier, Mikael Rydén, Arne Astrup, Ellen Blaak, Dominique Langin, Daniel Peter Andersson

Int J Obes (Lond) 2024; 48(7): 934–940. Published online 2024 Mar 15. doi: 10.1038/s41366-024-01501-x

PMCID:: PMC11217000

Abstract Article PDF–975K

Select item 107949923.

An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling

Hua-Lin Zhou, Zachary W. Grimmett, Nicholas M. Venetos, Colin T. Stomberski, Zhaoxia Qian, Precious McLaughlin, Puneet K. Bansal, Rongli Zhang, James D. Reynolds, Richard T. Premont, Jonathan S. Stamler

Cell. Author manuscript; available in PMC 2024 Dec 21.

Published in final edited form as: Cell. 2023 Dec 21; 186(26): 5812–5825.e21. Published online 2023 Dec 5. doi: 10.1016/j.cell.2023.11.009

PMCID:: PMC10794992

Abstract Article PDF–2.6M

Select item 105658764.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 100914995.

Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice

Xihong Zhang, Sidhant Varma, Douglas Yee

Endocrinology. 2023 Mar; 164(3): bqac214. Published online 2023 Jan 4. doi: 10.1210/endocr/bqac214

PMCID:: PMC10091499

Abstract Article

Select item 99169656.

Overexpression of Insulin Receptor Substrate 1 (IRS1) Relates to Poor Prognosis and Promotes Proliferation, Stemness, Migration, and Oxidative Stress Resistance in Cholangiocarcinoma

Waleeporn Kaewlert, Chadamas Sakonsinsiri, Worachart Lert-itthiporn, Piti Ungarreevittaya, Chawalit Pairojkul, Somchai Pinlaor, Mariko Murata, Raynoo Thanan

Int J Mol Sci. 2023 Feb; 24(3): 2428. Published online 2023 Jan 26. doi: 10.3390/ijms24032428

PMCID:: PMC9916965

Abstract Article PDF–6.4M

Select item 97701507.

Blocking MG53^S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury

Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao

Circ Res. 2022 Dec 2; 131(12): 962–976. Published online 2022 Nov 7. doi: 10.1161/CIRCRESAHA.122.321055

PMCID:: PMC9770150

Abstract Article PDF–7.3M

Select item 94081348.

Insulin Receptor Substrate 1 Gly972Arg (rs1801278) Polymorphism Is Associated with Obesity and Insulin Resistance in Kashmiri Women with Polycystic Ovary Syndrome

Shayaq Ul Abeer Rasool, Mudasar Nabi, Sairish Ashraf, Shajrul Amin

Genes (Basel) 2022 Aug; 13(8): 1463. Published online 2022 Aug 17. doi: 10.3390/genes13081463

PMCID:: PMC9408134

Abstract Article PDF–765K

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 926261410.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 904055611.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 900533212.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

Danielle L. Swaney, Dana J. Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael McGregor, Kari A. Herrington, Rachel O’Keefe, Nan Jin, Nathan K. VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F. Kreisberg, Minkyu Kim, Daniel E. Johnson, Natalia Jura, Jennifer R. Grandis, J. Silvio Gutkind, Trey Ideker, Nevan J. Krogan

Science. Author manuscript; available in PMC 2022 Apr 13.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf2911. Published online 2021 Oct 1. doi: 10.1126/science.abf2911

PMCID:: PMC9005332

Abstract Article PDF–2.0M

Select item 897367613.

Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761

Lingling Xu, Yinling Tan, Fengxia Xu, Yong Zhang

Bioengineered. 2022; 13(2): 2028–2043. Published online 2022 Jan 14. doi: 10.1080/21655979.2021.2019872

PMCID:: PMC8973676

Abstract Article PDF–4.6M

Select item 887529714.

CRL4^AMBRA1 is a master regulator of D-type cyclins

Daniele Simoneschi, Gergely Rona, Nan Zhou, Yeon-Tae Jeong, Shaowen Jiang, Giacomo Milletti, Arnaldo A. Arbini, Alfie O’Sullivan, Andrew A. Wang, Sorasicha Nithikasem, Sarah Keegan, Yik Siu, Valentina Cianfanelli, Emiliano Maiani, Francesca Nazio, Francesco Cecconi, Francesco Boccalatte, David Fenyö, Drew R. Jones, Luca Busino, Michele Pagano

Nature. Author manuscript; available in PMC 2022 Apr 14.

Published in final edited form as: Nature. 2021 Apr; 592(7856): 789–793. Published online 2021 Apr 14. doi: 10.1038/s41586-021-03445-y

PMCID:: PMC8875297

Abstract Article PDF–6.0M

Select item 884313815.

Insulin Receptor Substrate 1 Gene and Glucose Metabolism Characteristics in Type 2 Diabetes Mellitus with Comorbidities

Mariya Marushchak, Inna Krynytska

Ethiop J Health Sci. 2021 Sep; 31(5): 1001–1010. doi: 10.4314/ejhs.v31i5.12

PMCID:: PMC8843138

Abstract Article PDF–408K

Select item 870036916.

TGF-β Induction of miR-143/145 Is Associated to Exercise Response by Influencing Differentiation and Insulin Signaling Molecules in Human Skeletal Muscle

Simon I. Dreher, Selina Höckele, Peter Huypens, Martin Irmler, Christoph Hoffmann, Tim Jeske, Maximilian Hastreiter, Anja Moller, Andreas L. Birkenfeld, Hans-Ulrich Häring, Andreas Peter, Johannes Beckers, Martin Hrabě de Angelis, Cora Weigert

Cells. 2021 Dec; 10(12): 3443. Published online 2021 Dec 7. doi: 10.3390/cells10123443