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Select item 109208961.

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck

Nat Commun. 2024; 15: 2071. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46235-6

PMCID:: PMC10920896

Abstract Article PDF–5.8M

Select item 109168662.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 107466203.

The Human GP130 Cytokine Receptor and Its Expression—an Atlas and Functional Taxonomy of Genetic Variants

Yin-Huai Chen, Sarah van Zon, Alex Adams, Dirk Schmidt-Arras, Arian D. J. Laurence, Holm H. Uhlig

J Clin Immunol. 2024; 44(1): 30. Published online 2023 Dec 22. doi: 10.1007/s10875-023-01603-7

PMCID:: PMC10746620

Abstract Article PDF–1.5M

Select item 106033394.

Mononuclear cells from patients with rhupus are influenced by TNF in their production of gp130/sIL-6Rb and APRIL

Luis M Amezcua-Guerra, Fausto Sánchez-Muñoz, Santiago Guzmán-García, Ricardo Márquez-Velasco, Enrique Becerril-Villanueva, Yadira Vázquez-Panchos, Yaneli Juárez-Vicuña

Lupus Sci Med. 2023; 10(2): e000970. Published online 2023 Oct 25. doi: 10.1136/lupus-2023-000970

PMCID:: PMC10603339

Abstract Article PDF–415K

Select item 105688285.

Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder

Ting Sun, Qian Chen, Junchi Mei, Yan Li

BMC Psychiatry. 2023; 23: 742. Published online 2023 Oct 12. doi: 10.1186/s12888-023-05248-z

PMCID:: PMC10568828

Abstract Article PDF–1.2M

Select item 103232526.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 102634357.

Diminuição dos Níveis Séricos do Receptor Solúvel da Oncostatina M (sOSMR) e Glicoproteína 130 (sgp130) em Pacientes com Doença Arterial Coronariana

Vanessa Mylenna Florêncio de Carvalho, Priscilla Stela Santana de Oliveira, Amanda Pinheiro Barros de Albuquerque, Moacyr Jesus Barreto de Melo Rêgo, Michelle Melgarejo da Rosa, Dinaldo Cavalcanti de Oliveira, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta

Arq Bras Cardiol. 2023 Apr; 120(4): e20220326. Portuguese. Published online 2023 Apr 4. doi: 10.36660/abc.20220326

PMCID:: PMC10263435

Abstract Article PDF–986K

Select item 102207398.

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Fabíola Brasil Barbosa Rodrigues, Rosilene da Silva, Erika Ferreira dos Santos, Mioni Thieli Figueiredo Magalhães de Brito, Andréa Luciana Soares da Silva, Mauro de Meira Leite, Flávia Póvoa da Costa, Maria de Nazaré do Socorro de Almeida Viana, Kevin Matheus Lima de Sarges, Marcos Henrique Damasceno Cantanhede, Adriana de Oliveira Lameira Veríssimo, Mayara da Silva Carvalho, Daniele Freitas Henriques, Carla Pinheiro da Silva, Igor Brasil Costa, Juliana Abreu Lima Nunes, Iran Barros Costa, Giselle Maria Rachid Viana, Maria Alice Freitas Queiroz, Sandra Souza Lima, Jeferson da Costa Lopes, Maria Karoliny da Silva Torres, Izaura Maria Vieira Cayres Vallinoto, Carlos David Araújo Bichara, Antonio Carlos Rosário Vallinoto, Eduardo José Melo dos Santos

Viruses. 2023 May; 15(5): 1197. Published online 2023 May 19. doi: 10.3390/v15051197

PMCID:: PMC10220739

Abstract Article PDF–280K

Select item 98099329.

Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

Enrico Desideri, Serena Castelli, Coralie Dorard, Stefanie Toifl, Gian Luca Grazi, Maria Rosa Ciriolo, Manuela Baccarini

Autophagy. 2023; 19(1): 152–162. Published online 2022 Apr 18. doi: 10.1080/15548627.2022.2063004

PMCID:: PMC9809932

Abstract Article PDF–2.1M

Select item 976109210.

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai

Cancer Med. 2022 Dec; 11(24): 5001–5012. Published online 2022 May 16. doi: 10.1002/cam4.4823

PMCID:: PMC9761092

Abstract Article PDF–3.5M

Select item 953576611.

Structural insights into the assembly and activation of the IL‐27 signaling complex

Yibo Jin, Paul K Fyfe, Scott Gardner, Stephan Wilmes, Doryen Bubeck, Ignacio Moraga

EMBO Rep. 2022 Oct; 23(10): e55450. Published online 2022 Aug 3. doi: 10.15252/embr.202255450

PMCID:: PMC9535766

Abstract Article PDF–5.6M

Select item 923162312.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 917141113.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 882868714.

gp130 cytokines activate novel signaling pathways and alter bone dissemination in ER+ breast cancer cells

Tolu Omokehinde, Alec Jotte, Rachelle W. Johnson

J Bone Miner Res. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: J Bone Miner Res. 2022 Feb; 37(2): 185–201. Published online 2021 Sep 17. doi: 10.1002/jbmr.4430

PMCID:: PMC8828687

Abstract Article PDF–3.0M

Select item 880152315.

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

Jorge Mena, Iraide Alloza, Raquel Tulloch Navarro, Ane Aldekoa, Javier Díez García, Ane Villanueva Etxebarria, Cecilia Lindskog, Alfredo Antigüedad, Sabas Boyero, María del Mar Mendibe-Bilbao, Amaya Álvarez de Arcaya, José Luis Sánchez Menoyo, Luciana Midaglia, Noelia Villarrubia, Sunny Malhotra, Xavier Montalban, Luisa María Villar, Manuel Comabella, Koen Vandenbroeck

Front Immunol. 2021; 12: 816930. Published online 2022 Jan 17. doi: 10.3389/fimmu.2021.816930

PMCID:: PMC8801523

Abstract Article PDF–8.0M

Select item 850277516.

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

Pim P. van Krieken, Timothy S. Odermatt, Marcela Borsigova, Matthias Blüher, Stephan Wueest, Daniel Konrad

Mol Metab. 2021 Dec; 54: 101341. Published online 2021 Sep 20. doi: 10.1016/j.molmet.2021.101341

PMCID:: PMC8502775

Abstract Article PDF–1.0M

Select item 844351917.

The two facets of gp130 signalling in liver tumorigenesis

Dirk Schmidt-Arras, Eithan Galun, Stefan Rose-John

Semin Immunopathol. 2021; 43(4): 609–624. Published online 2021 May 28. doi: 10.1007/s00281-021-00861-0

PMCID:: PMC8443519

Abstract Article PDF–2.7M

Select item 829810218.

The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR

Kilian Trillet, Kathryn A. Jacobs, Gwennan André-Grégoire, An Thys, Clément Maghe, Jonathan Cruard, Stéphane Minvielle, Sara Gonzalez Diest, Guillaume Montagnac, Nicolas Bidère, Julie Gavard

J Cell Biol. 2021 Sep 6; 220(9): e202004114. Published online 2021 Jul 21. doi: 10.1083/jcb.202004114

PMCID:: PMC8298102

Abstract Article PDF–5.7M

Select item 828487019.

A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

Shikha Nayar, Joshua K. Morrison, Mamta Giri, Kyle Gettler, Ling-shiang Chuang, Laura A. Walker, Huaibin M. Ko, Ephraim Kenigsberg, Subra Kugathasan, Miriam Merad, Jaime Chu, Judy H. Cho

Nature. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Nature. 2021 May; 593(7858): 275–281. Published online 2021 Mar 31. doi: 10.1038/s41586-021-03484-5

PMCID:: PMC8284870

Article PDF–5.4M

Select item 826234220.

CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity

Pauliina Filppu, Jayendrakishore Tanjore Ramanathan, Kirsi J. Granberg, Erika Gucciardo, Hannu Haapasalo, Kaisa Lehti, Matti Nykter, Vadim Le Joncour, Pirjo Laakkonen

JCI Insight. 2021 May 10; 6(9): e141486. Published online 2021 May 10. doi: 10.1172/jci.insight.141486

PMCID:: PMC8262342

Abstract Article PDF–16M

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