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Select item 107642671.

Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions

Tong Zhang, Sheng Wang, Dongsheng Hua, Xuan Shi, Huimin Deng, Shuqing Jin, Xin Lv

Redox Biol. 2024 Feb; 69: 102985. Published online 2023 Dec 12. doi: 10.1016/j.redox.2023.102985

PMCID:: PMC10764267

Abstract Article PDF–8.8M

Select item 106176732.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 93525413.

Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular endothelial cells

Brittany L. Steimle, Danielle K. Bailey, Frances M. Smith, Shaina L. Rosenblum, Daniel J. Kosman

J Biol Chem. 2022 Aug; 298(8): 102211. Published online 2022 Jul 2. doi: 10.1016/j.jbc.2022.102211

PMCID:: PMC9352541

Abstract Article PDF–2.4M

Select item 91516854.

Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis

Paul S. Foster, Hock L. Tay, Brian G. Oliver

J Clin Invest. 2022 Jun 1; 132(11): e160595. Published online 2022 Jun 1. doi: 10.1172/JCI160595

PMCID:: PMC9151685

Abstract Article PDF–242K

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 85837996.

The Impact of ZIP8 Disease-Associated Variants G38R, C113S, G204C, and S335T on Selenium and Cadmium Accumulations: The First Characterization

Zhan-Ling Liang, Heng Wee Tan, Jia-Yi Wu, Xu-Li Chen, Xiu-Yun Wang, Yan-Ming Xu, Andy T. Y. Lau

Int J Mol Sci. 2021 Nov; 22(21): 11399. Published online 2021 Oct 22. doi: 10.3390/ijms222111399

PMCID:: PMC8583799

Abstract Article PDF–3.5M

Select item 82318637.

HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn²⁺ Accumulation in Inflammatory Synoviocytes

Noriyuki Hatano, Masaki Matsubara, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki

Int J Mol Sci. 2021 Jun; 22(12): 6349. Published online 2021 Jun 14. doi: 10.3390/ijms22126349

PMCID:: PMC8231863

Abstract Article PDF–3.1M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81025589.

ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses

Jung-Ah Kang, Ji-Sun Kwak, Sang-Heon Park, Kyu-Young Sim, Seul Ki Kim, Youngnim Shin, In Jung Jung, Jeong-In Yang, Jang-Soo Chun, Sung-Gyoo Park

Exp Mol Med. 2021 Apr; 53(4): 560–571. Published online 2021 Apr 1. doi: 10.1038/s12276-021-00591-1

PMCID:: PMC8102558

Abstract Article PDF–3.0M

Select item 808689410.

N-glycome analysis detects dysglycosylation missed by conventional methods in SLC39A8 deficiency

Julien H Park, Robert G Mealer, Abdallah F Elias, Susanne Hoffmann, Marianne Grüneberg, Saskia Biskup, Manfred Fobker, Jaclyn Haven, Ute Mangels, Janine Reunert, Stephan Rust, Jonathan Schoof, Corbin Schwanke, Jordan W Smoller, Richard D Cummings, Thorsten Marquardt

J Inherit Metab Dis. Author manuscript; available in PMC 2021 Apr 30.

Published in final edited form as: J Inherit Metab Dis. 2020 Nov; 43(6): 1370–1381. Published online 2020 Sep 14. doi: 10.1002/jimd.12306

PMCID:: PMC8086894

Abstract Article PDF–956K

Select item 789594811.

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl

Transl Psychiatry. 2021; 11: 136. Published online 2021 Feb 19. doi: 10.1038/s41398-021-01262-5

PMCID:: PMC7895948

Abstract Article PDF–2.5M

Select item 768232712.

A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity

Toru Nakata, Elizabeth A. Creasey, Motohiko Kadoki, Helen Lin, Martin K. Selig, Junmei Yao, Ariel Lefkovith, Mark J. Daly, Daniel B. Graham, Ramnik J. Xavier

Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46): 28930–28938. Published online 2020 Nov 2. doi: 10.1073/pnas.2014742117

PMCID:: PMC7682327

Abstract Article PDF–1.2M

Select item 760552313.

Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

Laxmi Sunuwar, Azra Frkatović, Sodbo Sharapov, Qinchuan Wang, Heather M. Neu, Xinqun Wu, Talin Haritunians, Fengyi Wan, Sarah Michel, Shaoguang Wu, Mark Donowitz, Dermot McGovern, Gordan Lauc, Cynthia Sears, Joanna Melia

JCI Insight. 2020 Oct 15; 5(20): e140978. Published online 2020 Oct 15. doi: 10.1172/jci.insight.140978

PMCID:: PMC7605523

Abstract Article PDF–10M

Select item 756688114.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 742392115.

Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS)

Omid Gharooi Ahangar, Niloufar Javanrouh, Maryam S. Daneshpour, Maryam Barzin, Majid Valizadeh, Fereidoun Azizi, Farhad Hosseinpanah

Sci Rep. 2020; 10: 13600. Published online 2020 Aug 12. doi: 10.1038/s41598-020-70627-5

PMCID:: PMC7423921

Abstract Article PDF–934K

Select item 740343216.

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

Robert G. Mealer, Bruce G. Jenkins, Chia-Yen Chen, Mark J. Daly, Tian Ge, Sylvain Lehoux, Thorsten Marquardt, Christopher D. Palmer, Julien H. Park, Patrick J. Parsons, Robert Sackstein, Sarah E. Williams, Richard D. Cummings, Edward M. Scolnick, Jordan W. Smoller

Sci Rep. 2020; 10: 13162. Published online 2020 Aug 4. doi: 10.1038/s41598-020-70108-9

PMCID:: PMC7403432

Abstract Article PDF–3.5M

Select item 737222217.

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

Constantinos A. Parisinos, Henry R. Wilman, E. Louise Thomas, Matt Kelly, Rowan C. Nicholls, John McGonigle, Stefan Neubauer, Aroon D. Hingorani, Riyaz S. Patel, Harry Hemingway, Jimmy D. Bell, Rajarshi Banerjee, Hanieh Yaghootkar

J Hepatol. 2020 Aug; 73(2): 241–251. doi: 10.1016/j.jhep.2020.03.032