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Select item 109316871.

Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia

David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins

Int J Mol Sci. 2024 Mar; 25(5): 2852. Published online 2024 Mar 1. doi: 10.3390/ijms25052852

PMCID:: PMC10931687

Abstract Article PDF–3.1M

Select item 108753652.

RP11-495P10.1 promotes HCC cell proliferation by regulating reprogramming of glucose metabolism and acetylation of the NR4A3 promoter via the PDK1/PDH axis: RP11-495P10.1 promotes HCC cell proliferation

Chi Liu, Jie Shi, Zhengyuan Jiang, Shan Jiang, Yuan Wu, Dongqian Peng, Jiebing Tang, Linchi Guo

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 44–53. Published online 2023 Oct 30. doi: 10.3724/abbs.2023242

PMCID:: PMC10875365

Abstract Article PDF–1.8M

Select item 103287213.

NR4A3 Expression is Consistently Absent in Acinic Cell Carcinomas of the Breast: A Potential Nosologic Shift

Edward T. Richardson, Pier Selenica, Fresia Pareja, Paola Dal Cin, Etta Hanlon, Britta Weigelt, Jorge S. Reis-Filho, Jason L. Hornick, Vickie Y. Jo, Stuart J. Schnitt

Mod Pathol. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Mod Pathol. 2023 Jun; 36(6): 100144. Published online 2023 Feb 22. doi: 10.1016/j.modpat.2023.100144

PMCID:: PMC10328721

Abstract Article PDF–1.1M

Select item 102571434.

BLIMP1 and NR4A3 Transcription Factors Reciprocally Regulate Antitumor CAR T-cell Stemness and Exhaustion

In-Young Jung, Vivek Narayan, Sierra McDonald, Andrew J. Rech, Robert Bartoszek, Gwanui Hong, Megan M. Davis, Jun Xu, Alina C. Boesteanu, Julie S. Barber-Rotenberg, Gabriela Plesa, Simon F. Lacey, Julie K. Jadlowsky, Donald L. Siegel, Dana M. Hammill, Park F. Cho-Park, Shelley L. Berger, Naomi B. Haas, Joseph A. Fraietta

Sci Transl Med. Author manuscript; available in PMC 2023 Jun 10.

Published in final edited form as: Sci Transl Med. 2022 Nov 9; 14(670): eabn7336. Published online 2022 Nov 9. doi: 10.1126/scitranslmed.abn7336

PMCID:: PMC10257143

Abstract Article PDF–1.8M

Select item 101080545.

Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

Nila H. Servaas, Sanne Hiddingh, Eleni Chouri, Catharina G. K. Wichers, Alsya J. Affandi, Andrea Ottria, Cornelis P. J. Bekker, Marta Cossu, Sandra C. Silva‐Cardoso, Maarten van der Kroef, Anneline C. Hinrichs, Tiago Carvalheiro, Nadia Vazirpanah, Lorenzo Beretta, Marzia Rossato, Femke Bonte‐Mineur, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Marianne Boes, Aridaman Pandit

Arthritis Rheumatol. 2023 Feb; 75(2): 279–292. Published online 2022 Dec 8. doi: 10.1002/art.42319

PMCID:: PMC10108054

Abstract Article PDF–3.0M

Select item 94633476.

Functional association of NR4A3 downregulation with impaired differentiation in myeloid leukemogenesis

Shih-Chiang Lin, Chi-Yuan Yao, Cheng-An Hsu, Chien-Ting Lin, Marcus J. Calkins, Yuan-Yeh Kuo, Jih-Luh Tang, Hwei-Fang Tien, Shang-Ju Wu

Ann Hematol. 2022; 101(10): 2209–2218. Published online 2022 Aug 30. doi: 10.1007/s00277-022-04961-1

PMCID:: PMC9463347

Abstract Article PDF–1.3M

Select item 90374437.

MiR-501-5p alleviates cardiac dysfunction in septic patients through targeting NR4A3 to prevent its binding with Bcl-2

Lan Gao, Zhongjie Zhai, Qindong Shi, Jinqi Yan, Linjing Zhou, Yongxin Wu, Qinjing Zeng, Gang Tian, Hao Li

Cell Cycle. 2022; 21(9): 961–971. Published online 2022 Mar 1. doi: 10.1080/15384101.2022.2035618

PMCID:: PMC9037443

Abstract Article PDF–2.8M

Select item 85837008.

NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond

José Martínez-González, Laia Cañes, Judith Alonso, Carme Ballester-Servera, Antonio Rodríguez-Sinovas, Irene Corrales, Cristina Rodríguez

Int J Mol Sci. 2021 Nov; 22(21): 11371. Published online 2021 Oct 21. doi: 10.3390/ijms222111371

PMCID:: PMC8583700

Abstract Article PDF–2.1M

Select item 84747879.

NR4A3 and CCL20 clusters dominate the genetic networks in CD146⁺ blood cells during acute myocardial infarction in humans

Yan-hui Wang, Chen-xin Li, Jessica M. Stephenson, Sean P. Marrelli, Yan-ming Kou, Da-zhi Meng, Ting Wu

Eur J Med Res. 2021; 26: 113. Published online 2021 Sep 26. doi: 10.1186/s40001-021-00586-8

PMCID:: PMC8474787

Abstract Article PDF–4.9M

Select item 826790610.

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Eoin P. Cummins

Front Immunol. 2021; 12: 676644. Published online 2021 Jun 25. doi: 10.3389/fimmu.2021.676644

PMCID:: PMC8267906

Abstract Article PDF–3.4M

Select item 760460311.

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury

Bingzheng Lu, Zhu Zhu, Longxiang Sheng, Yuan Li, Yang Yang, Yupin Chen, Dongdong Xue, Yuwei Zhou, Wei Cai, Chen Chen, Cailv Wei, Dong Xu, Min Yan, Suizhen Lin, Guangmei Yan, Wei Yin

Oxid Med Cell Longev. 2020; 2020: 2048210. Published online 2020 Oct 23. doi: 10.1155/2020/2048210

PMCID:: PMC7604603

Abstract Article PDF–3.0M

Select item 746955412.

miR-106b-5p induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura through NR4A3/Foxp3 pathway

Jian-Qin Li, Jian-Mei Tian, Xiao-Ru Fan, Zhao-Yue Wang, Jing Ling, Xiao-Fang Wu, Fei-Yun Yang, Ya-Lin Xia

Cell Cycle. 2020; 19(11): 1265–1274. Published online 2020 Apr 23. doi: 10.1080/15384101.2020.1746485

Correction in:: Cell Cycle. 2020; 19(15): 1994–1995.

PMCID:: PMC7469554

Abstract Article PDF–2.9M

Select item 717140813.

Long non‐coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3

Haihao Wang, Qiannan Guo, Kan‐Paatib Barnabo Nampoukime, Peiwen Yang, Ke Ma

J Cell Mol Med. 2020 Apr; 24(7): 3822–3836. Published online 2020 Mar 3. doi: 10.1111/jcmm.14942

PMCID:: PMC7171408

Abstract Article PDF–2.3M

Select item 716998314.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 701737215.

Disruption of Beta-Cell Mitochondrial Networks by the Orphan Nuclear Receptor Nor1/Nr4a3

Anne-Françoise Close, Nidheesh Dadheech, Hélène Lemieux, Qian Wang, Jean Buteau

Cells. 2020 Jan; 9(1): 168. Published online 2020 Jan 9. doi: 10.3390/cells9010168

PMCID:: PMC7017372

Abstract Article PDF–4.6M

Select item 693332616.

The pro‐inflammatory effect of NR4A3 in osteoarthritis

Chiyuan Ma, Lingyun Wu, Lu Song, Yuzhe He, Safwat Adel Abdo Moqbel, Shigui Yan, Kunkun Sheng, Haobo Wu, Jisheng Ran, Lidong Wu

J Cell Mol Med. 2020 Jan; 24(1): 930–940. Published online 2019 Nov 7. doi: 10.1111/jcmm.14804

PMCID:: PMC6933326

Abstract Article PDF–1.4M

Select item 676696917.

NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas

Monica Brenca, Silvia Stacchiotti, Kelly Fassetta, Marta Sbaraglia, Milijana Janjusevic, Dominga Racanelli, Maurizio Polano, Sabrina Rossi, Silvia Brich, Gian P Dagrada, Paola Collini, Chiara Colombo, Alessandro Gronchi, Annalisa Astolfi, Valentina Indio, Maria A Pantaleo, Piero Picci, Paolo G Casali, Angelo P Dei Tos, Silvana Pilotti, Roberta Maestro

J Pathol. 2019 Sep; 249(1): 90–101. Published online 2019 May 14. doi: 10.1002/path.5284

Correction in:: J Pathol. 2021 Aug; 254(5): 606.

PMCID:: PMC6766969

Abstract Article PDF–7.4M

Select item 660091518.

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, Jolien Souffriau, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Rudi Beyaert, Karolien De Bosscher, Jorma J. Palvimo, Marc Van Montagu, Claude Libert

Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12942–12951. Published online 2019 Jun 10. doi: 10.1073/pnas.1821565116

Correction in:: Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15745.

PMCID:: PMC6600915

Abstract Article PDF–1.7M

Select item 657976319.

miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer

Xin-Ge Zhao, Jing-Ye Hu, Jun Tang, Wei Yi, Mei-Yin Zhang, Rong Deng, Shi-Juan Mai, Nuo-Qing Weng, Rui-Qi Wang, Ji Liu, Hui-Zhong Zhang, Jie-Hua He, Hui-Yun Wang

Cell Death Dis. 2019 Jul; 10(7): 479. Published online 2019 Jun 17. doi: 10.1038/s41419-019-1705-z

PMCID:: PMC6579763

Abstract Article PDF–2.9M

Select item 644203020.

The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass

Anne-Françoise Close, Nidheesh Dadheech, Bárbara Scoralick Villela, Claude Rouillard, Jean Buteau

J Biol Chem. 2019 Mar 29; 294(13): 4889–4897. Published online 2019 Jan 29. doi: 10.1074/jbc.RA118.005135

PMCID:: PMC6442030

Abstract Article PDF–1.9M

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