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Select item 111595051.

Roles of a prostaglandin E‐type receptor, EP3, in upregulation of matrix metalloproteinase‐9 and vascular endothelial growth factor during enhancement of tumor metastasis

Hideki Amano, Yoshiya Ito, Tastunori Suzuki, Shintaro Kato, Yoshio Matsui, Fumihiro Ogawa, Takahiko Murata, Yukihiko Sugimoto, Robert Senior, Hidero Kitasato, Izumi Hayashi, Yukitoshi Satoh, Shuh Narumiya, Masataka Majima

Cancer Sci. 2009 Dec; 100(12): 2318–2324. Published online 2009 Aug 25. doi: 10.1111/j.1349-7006.2009.01322.x

PMCID:: PMC11159505

Abstract Article PDF–572K

Select item 111451282.

PTGER3 knockdown inhibits the vulnerability of triple‐negative breast cancer to ferroptosis

Song Wang, Yueyao Zhang, Dan Zhang, Jie Meng, Na Che, Xiulan Zhao, Tieju Liu

Cancer Sci. 2024 Jun; 115(6): 2067–2081. Published online 2024 Apr 2. doi: 10.1111/cas.16169

PMCID:: PMC11145128

Abstract Article PDF–49M

Select item 100531913.

E prostanoid receptor‐3 promotes oxidized low‐density lipoprotein‐induced human aortic smooth muscle cells inflammation

Chuang‐Jia Hu, Yan‐Wei Wang, Wei‐Xing Huang, Yu‐Bin Xia

ESC Heart Fail. 2023 Apr; 10(2): 1077–1089. Published online 2022 Dec 28. doi: 10.1002/ehf2.14264

PMCID:: PMC10053191

Abstract Article PDF–2.9M

Select item 93795454.

PGE₂‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase

Xixi Tao, Ronglu Du, Shumin Guo, Xiangling Feng, Tingting Yu, Qian OuYang, Qiaoli Chen, Xutong Fan, Xueqi Wang, Chen Guo, Xiaozhou Li, Fengxia Xue, Shuai Chen, Minghan Tong, Michael Lazarus, Shengkai Zuo, Ying Yu, Yujun Shen

EMBO J. 2022 Aug; 41(16): e110439. Published online 2022 Jul 4. doi: 10.15252/embj.2021110439

PMCID:: PMC9379545

Abstract Article PDF–20M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73826636.

Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR)

Yao Ye, Lin Peng, Aurelia Vattai, Eileen Deuster, Christina Kuhn, Christian Dannecker, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt, Helene H. Heidegger

J Cancer Res Clin Oncol. 2020; 146(9): 2189–2203. Published online 2020 Jun 1. doi: 10.1007/s00432-020-03272-0

PMCID:: PMC7382663

Abstract Article PDF–2.1M

Select item 73523547.

EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases

Alaleh Zati Zehni, Udo Jeschke, Anna Hester, Thomas Kolben, Nina Ditsch, Sven-Niclas Jacob, Jan-Niclas Mumm, Helene Hildegard Heidegger, Sven Mahner, Theresa Vilsmaier

Int J Mol Sci. 2020 Jun; 21(12): 4418. Published online 2020 Jun 22. doi: 10.3390/ijms21124418

PMCID:: PMC7352354

Abstract Article PDF–1.1M

Select item 65612468.

Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor

Rana N. Ozdeslik, Lauren E. Olinski, Melissa M. Trieu, Daniel D. Oprian, Elena Oancea

Proc Natl Acad Sci U S A. 2019 Jun 4; 116(23): 11508–11517. Published online 2019 May 16. doi: 10.1073/pnas.1902825116

PMCID:: PMC6561246

Abstract Article PDF–2.2M

Select item 64119659.

PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis

Cristian Rodriguez-Aguayo, Emine Bayraktar, Cristina Ivan, Burcu Aslan, Junhua Mai, Guangan He, Lingegowda S. Mangala, Dahai Jiang, Archana S. Nagaraja, Bulent Ozpolat, Arturo Chavez-Reyes, Mauro Ferrari, Rahul Mitra, Zahid H. Siddik, Haifa Shen, Xianbin Yang, Anil K. Sood, Gabriel Lopez-Berestein

EBioMedicine. 2019 Feb; 40: 290–304. Published online 2019 Jan 14. doi: 10.1016/j.ebiom.2018.11.045

Correction in:: eBioMedicine. 2022 Sep; 83: 104194.

PMCID:: PMC6411965

Abstract Article PDF–5.4M

Select item 631495710.

An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders

Siwei Chen, Robert Fragoza, Lambertus Klei, Yuan Liu, Jiebiao Wang, Kathryn Roeder, Bernie Devlin, Haiyuan Yu

Nat Genet. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Nat Genet. 2018 Jul; 50(7): 1032–1040. Published online 2018 Jun 11. doi: 10.1038/s41588-018-0130-z

PMCID:: PMC6314957

Abstract Article PDF–1.3M

Select item 628972111.

Crystal structure of misoprostol bound to the labor inducer prostaglandin E₂ receptor

Martin Audet, Kate L. White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez, David Manahan, Hao Hu, Uwe Weierstall, Wei Liu, Wenqing Shui, Vsevolod Katritch, Vadim Cherezov, Michael A. Hanson, Raymond C. Stevens

Nat Chem Biol. Author manuscript; available in PMC 2019 Jun 3.

Published in final edited form as: Nat Chem Biol. 2019 Jan; 15(1): 11–17. Published online 2018 Dec 3. doi: 10.1038/s41589-018-0160-y

Correction in:: Nat Chem Biol. 2018 Dec 20

PMCID:: PMC6289721

Abstract Article PDF–1.9M

Select item 623761312.

Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels

Yafei Tian, Tingting Yang, Shuntai Yu, Cuiyun Liu, Min He, Changlong Hu

J Cell Mol Med. 2018 Dec; 22(12): 6327–6337. Published online 2018 Oct 19. doi: 10.1111/jcmm.13931

PMCID:: PMC6237613

Abstract Article PDF–1.1M

Select item 595624613.

Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3

Yan Zhang, Yanfang Liu, Lehao Wu, Chao Fan, Zhiwei Wang, Xiuli Zhang, Amal Alachkar, Xinmiao Liang, Olivier Civelli

FASEB J. 2018 Jun; 32(6): 3184–3192. Published online 2018 Jan 22. doi: 10.1096/fj.201700337RR

PMCID:: PMC5956246

Abstract Article

Select item 590299614.

EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer

Anna Semmlinger, Viktoria von Schoenfeldt, Verena Wolf, Alexandra Meuter, Theresa Maria Kolben, Thomas Kolben, Christine Zeder-Goess, Florian Weis, Julia Gallwas, Rachel Wuerstlein, Kerstin Hermelink, Elisa Schmoeckel, Nadia Harbeck, Doris Mayr, Sven Mahner, Udo Jeschke, Nina Ditsch

BMC Cancer. 2018; 18: 431. Published online 2018 Apr 16. doi: 10.1186/s12885-018-4286-9

PMCID:: PMC5902996

Abstract Article PDF–906K

Select item 553605915.

The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients

Helene Heidegger, Sebastian Dietlmeier, Yao Ye, Christina Kuhn, Aurelia Vattai, Caroline Aberl, Udo Jeschke, Sven Mahner, Bernd Kost

Int J Mol Sci. 2017 Jul; 18(7): 1571. Published online 2017 Jul 19. doi: 10.3390/ijms18071571

PMCID:: PMC5536059

Abstract Article PDF–8.1M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 490861717.

Inhibition of prostaglandin E₂ receptor EP3 mitigates thrombin-induced brain injury

Xiaoning Han, Xi Lan, Qiang Li, Yufeng Gao, Wei Zhu, Tian Cheng, Takayuki Maruyama, Jian Wang

J Cereb Blood Flow Metab. 2016 Jun; 36(6): 1059–1074. Published online 2015 Oct 2. doi: 10.1177/0271678X15606462

PMCID:: PMC4908617

Abstract Article PDF–2.3M

Select item 482920318.

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants

Digna R. Velez, Stephen Fortunato, Poul Thorsen, Salvatore J. Lombardi, Scott M. Williams, Ramkumar Menon

Am J Obstet Gynecol. Author manuscript; available in PMC 2016 Apr 12.

Published in final edited form as: Am J Obstet Gynecol. 2009 Feb; 200(2): 209.e1–209.27. Published online 2008 Nov 18. doi: 10.1016/j.ajog.2008.08.051

PMCID:: PMC4829203

Abstract Article PDF–164K

Select item 464794119.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

Select item 461721120.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

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