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Select item 106856071.

RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma

Yang Su, Hechun Lin, Junming Yu, Lin Mao, Wenjiao Jin, Tengfei Liu, Shuqing Jiang, Yunyu Wu, Saihua Zhang, Qin Geng, Chao Ge, Fangyu Zhao, Taoyang Chen, Ying Cui, Jinjun Li, Helei Hou, Xinli Zhou, Hong Li

J Exp Clin Cancer Res. 2023; 42: 326. Published online 2023 Nov 29. doi: 10.1186/s13046-023-02892-x

PMCID:: PMC10685607

Abstract Article PDF–14M

Select item 88488602.

Multiomics characterization of oncogenic signaling mediated by wild-type and mutant RIT1

April Lo, Kristin Holmes, Shriya Kamlapurkar, Filip Mundt, Sitapriya Moorthi, Iris Fung, Shaunt Fereshetian, Jacqueline Watson, Steven A. Carr, Philipp Mertins, Alice H. Berger

Sci Signal. Author manuscript; available in PMC 2022 May 30.

Published in final edited form as: Sci Signal. 2021 Nov 30; 14(711): eabc4520. Published online 2021 Nov 30. doi: 10.1126/scisignal.abc4520

PMCID:: PMC8848860

Abstract Article PDF–1.7M

Select item 87111273.

Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies

I Gómez-Seguí, H Makishima, A Jerez, K Yoshida, B Przychodzen, S Miyano, Y Shiraishi, HD Husseinzadeh, K Guinta, M Clemente, N Hosono, MA McDevitt, AR Moliterno, MA Sekeres, S Ogawa, JP Maciejewski

Leukemia. Author manuscript; available in PMC 2021 Dec 27.

Published in final edited form as: Leukemia. 2013 Sep; 27(9): 1943–1946. Published online 2013 Jun 14. doi: 10.1038/leu.2013.179

PMCID:: PMC8711127

Article PDF–639K

Select item 83529644.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 77870546.

The molecular functions of RIT1 and its contribution to human disease

Richard Van, Antonio Cuevas-Navarro, Pau Castel, Frank McCormick

Biochem J. Author manuscript; available in PMC 2021 Aug 14.

Published in final edited form as: Biochem J. 2020 Aug 14; 477(15): 2755–2770. doi: 10.1042/BCJ20200442

PMCID:: PMC7787054

Abstract Article PDF–1.5M

Select item 71699837.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69866828.

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Pau Castel, Alice Cheng, Antonio Cuevas-Navarro, David B. Everman, Alex G. Papageorge, Dhirendra K. Simanshu, Alexandra Tankka, Jacqueline Galeas, Anatoly Urisman, Frank McCormick

Science. Author manuscript; available in PMC 2020 Jan 28.

Published in final edited form as: Science. 2019 Mar 15; 363(6432): 1226–1230. doi: 10.1126/science.aav1444

PMCID:: PMC6986682

Abstract Article PDF–1.1M

Select item 65792599.

Rin, a Neuron-Specific and Calmodulin-Binding Small G-Protein, and Rit Define a Novel Subfamily of Ras Proteins

Ching-Hsien J. Lee, Neil G. Della, Christina E. Chew, Donald J. Zack

J Neurosci. 1996 Nov 1; 16(21): 6784–6794. doi: 10.1523/JNEUROSCI.16-21-06784.1996

PMCID:: PMC6579259

Abstract Article

Select item 619727910.

RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis

Yan-Fen Feng, Yi-Yan Lei, Jia-Bin Lu, Shao-Yan Xi, Yu Zhang, Qi-Tao Huang, Qiu-Liang Wu, Fang Wang

Cell Death Dis. 2018 Nov; 9(11): 1085. Published online 2018 Oct 22. doi: 10.1038/s41419-018-0979-x

PMCID:: PMC6197279

Abstract Article PDF–2.8M

Select item 616668211.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 599210412.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 593773713.

RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1

Uta Meyer zum Büschenfelde, Laura Isabel Brandenstein, Leonie von Elsner, Kristina Flato, Tess Holling, Martin Zenker, Georg Rosenberger, Kerstin Kutsche

PLoS Genet. 2018 May; 14(5): e1007370. Published online 2018 May 7. doi: 10.1371/journal.pgen.1007370

PMCID:: PMC5937737

Abstract Article PDF–29M

Select item 579923614.

Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies

Gordon K. C. Leung, H. M. Luk, Vincent H. M. Tang, W. W. Gao, Christopher C. Y. Mak, Mullin H. C. Yu, W. L. Wong, Yoyo W. Y. Chu, W. L. Yang, Wilfred H. S. Wong, Alvin C. H. Ma, Anskar Y. H. Leung, D. Y. Jin, Kelvin Y. K. Chan, Judith Allanson, Ivan F. M. Lo, Brian H. Y. Chung

Sci Rep. 2018; 8: 2421. Published online 2018 Feb 5. doi: 10.1038/s41598-018-20894-0

PMCID:: PMC5799236

Abstract Article PDF–2.9M

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 497068716.

Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia

Hélène Cavé, Aurélie Caye, Nehla Ghedira, Yline Capri, Nathalie Pouvreau, Natacha Fillot, Aurélien Trimouille, Cédric Vignal, Odile Fenneteau, Yves Alembik, Jean-Luc Alessandri, Patricia Blanchet, Odile Boute, Patrice Bouvagnet, Albert David, Anne Dieux Coeslier, Bérénice Doray, Olivier Dulac, Valérie Drouin-Garraud, Marion Gérard, Delphine Héron, Bertrand Isidor, Didier Lacombe, Stanislas Lyonnet, Laurence Perrin, Marlène Rio, Joëlle Roume, Sylvie Sauvion, Annick Toutain, Catherine Vincent-Delorme, Marjorie Willems, Clarisse Baumann, Alain Verloes

Eur J Hum Genet. 2016 Aug; 24(8): 1124–1131. Published online 2016 Jan 13. doi: 10.1038/ejhg.2015.273

PMCID:: PMC4970687

Abstract Article PDF–1.4M

Select item 495704817.

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1)

Zhenhao Fang, Christopher B. Marshall, Jiani C. Yin, Mohammad T. Mazhab-Jafari, Geneviève M. C. Gasmi-Seabrook, Matthew J. Smith, Tadateru Nishikawa, Yang Xu, Benjamin G. Neel, Mitsuhiko Ikura

J Biol Chem. 2016 Jul 22; 291(30): 15641–15652. Published online 2016 May 18. doi: 10.1074/jbc.M116.714196

PMCID:: PMC4957048

Abstract Article PDF–1.3M

Select item 476068918.

Mutations in RIT1 cause Noonan syndrome – additional functional evidence and expanding the clinical phenotype

Martin Koenighofer, Christina Y. Hung, Jacob L. McCauley, Julia Dallman, Emma J. Back, Ivana Mihalek, Karen W. Gripp, Katia Sol-Church, Paolo Rusconi, Zhaiyi Zhang, Geng-Xian Shi, Douglas A. Andres, Olaf A. Bodamer

Clin Genet. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Clin Genet. 2016 Mar; 89(3): 359–366. Published online 2015 Jun 4. doi: 10.1111/cge.12608

PMCID:: PMC4760689

Abstract Article PDF–1000K

Select item 463755419.

Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer

Fengjuan Xu, Su’an Sun, Shilan Yan, Hongling Guo, Miao Dai, Yincheng Teng

Int J Clin Exp Pathol. 2015; 8(9): 10315–10324. Published online 2015 Sep 1.

PMCID:: PMC4637554

Abstract Article PDF–1.5M

Select item 415098820.

Oncogenic RIT1 mutations in lung adenocarcinoma

A H Berger, M Imielinski, F Duke, J Wala, N Kaplan, G-X Shi, D A Andres, M Meyerson

Oncogene. 2014; 33(35): 4418–4423. Published online 2014 Jan 27. doi: 10.1038/onc.2013.581

Correction in:: Oncogene. 2022; 41(19): 2788.

PMCID:: PMC4150988

Abstract Article PDF–1.8M

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