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Select item 91197361.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 84042412.

The association between sarcopenia susceptibility and polymorphisms of FTO, ACVR2B, and IRS1 in Tibetans

Xianpeng Zhang, Liping Ye, Xin Li, Ying Chen, Yaqiong Jiang, Wenhui Li, Youfeng Wen

Mol Genet Genomic Med. 2021 Aug; 9(8): e1747. Published online 2021 Jul 24. doi: 10.1002/mgg3.1747

PMCID:: PMC8404241

Abstract Article PDF–1.2M

Select item 82063713.

Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury

Christoph Wallner, Marius Drysch, Mustafa Becerikli, Sonja Verena Schmidt, Stephan Hahn, Johannes Maximilian Wagner, Felix Reinkemeier, Mehran Dadras, Alexander Sogorski, Maxi von Glinski, Marcus Lehnhardt, Björn Behr

Sci Rep. 2021; 11: 12572. Published online 2021 Jun 15. doi: 10.1038/s41598-021-92159-2

PMCID:: PMC8206371

Abstract Article PDF–5.5M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71131875.

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway

Dongyeob Seo, Su Myung Jung, Jin Seok Park, Jaewon Lee, Jihoon Ha, Minbeom Kim, Seok Hee Park

EBioMedicine. 2019 Nov; 49: 55–71. Published online 2019 Nov 1. doi: 10.1016/j.ebiom.2019.10.039

PMCID:: PMC7113187

Abstract Article PDF–3.5M

Select item 61118266.

MicroRNA‐194 protects against chronic hepatitis B‐related liver damage by promoting hepatocyte growth via ACVR2B

Xue Gao, Pan Zhao, Jie Hu, Hongguang Zhu, Jiming Zhang, Zhongwen Zhou, Jingmin Zhao, Feng Tang

J Cell Mol Med. 2018 Sep; 22(9): 4534–4544. Published online 2018 Jul 25. doi: 10.1111/jcmm.13714

PMCID:: PMC6111826

Abstract Article PDF–3.6M

Select item 58269267.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 54952259.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 535451410.

Biochemical and Cellular Analysis Reveals Ligand Binding Specificities, a Molecular Basis for Ligand Recognition, and Membrane Association-dependent Activities of Cripto-1 and Cryptic

Senem Aykul, Anthony Parenti, Kit Yee Chu, Jake Reske, Monique Floer, Amy Ralston, Erik Martinez-Hackert

J Biol Chem. 2017 Mar 10; 292(10): 4138–4151. Published online 2017 Jan 26. doi: 10.1074/jbc.M116.747501

PMCID:: PMC5354514

Abstract Article PDF–3.1M

Select item 526093911.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 523361012.

TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

Lucy Cassar, Craig Nicholls, Alex R. Pinto, Ruping Chen, Lihui Wang, He Li, Jun-Ping Liu

Protein Cell. 2017 Jan; 8(1): 39–54. Published online 2016 Sep 30. doi: 10.1007/s13238-016-0322-1

PMCID:: PMC5233610

Abstract Article PDF–3.2M

Select item 491128113.

Genetic Variant in ACVR2B Is Associated with Lean Mass

Yann C. Klimentidis, Jennifer W. Bea, Patricia Thompson, Walter T. Klimecki, Chengcheng Hu, Guanglin Wu, Skye Nicholas, Kelli K. Ryckman, Zhao Chen

Med Sci Sports Exerc. Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: Med Sci Sports Exerc. 2016 Jul; 48(7): 1270–1275. doi: 10.1249/MSS.0000000000000889

PMCID:: PMC4911281

Abstract Article PDF–132K

Select item 481495814.

NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients

Ru-Hui Tian, Shi Yang, Zi-Jue Zhu, Jun-Long Wang, Yun Liu, Chencheng Yao, Meng Ma, Ying Guo, Qingqing Yuan, Yanan Hai, Yi-Ran Huang, Zuping He, Zheng Li

Asian J Androl. 2015 Nov-Dec; 17(6): 996–1005. Published online 2015 Aug 19. doi: 10.4103/1008-682X.159722

PMCID:: PMC4814958

Abstract Article PDF–3.8M

Select item 461721115.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 446768116.

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B

Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan, Toril Holien

Cell Commun Signal. 2015; 13: 27. Published online 2015 Jun 6. doi: 10.1186/s12964-015-0104-z

PMCID:: PMC4467681

Abstract Article PDF–1.3M

Select item 430301517.

microRNA-21 Mediates Stretch-Induced Osteogenic Differentiation in Human Periodontal Ligament Stem Cells

Fulan Wei, Dongxu Liu, Cheng Feng, Fan Zhang, Shuangyan Yang, Yijun Hu, Gang Ding, Songlin Wang

Stem Cells Dev. 2015 Feb 1; 24(3): 312–319. Published online 2014 Sep 9. doi: 10.1089/scd.2014.0191

PMCID:: PMC4303015

Abstract Article PDF–533K

Select item 414102418.

Genetic Determinants of P Wave Duration and PR Segment

Niek Verweij, Irene Mateo Leach, Malou van den Boogaard, Dirk J. van Veldhuisen, Vincent M. Christoffels, LifeLines Cohort Study, Hans L. Hillege, Wiek H. van Gilst, Phil Barnett, Rudolf A. de Boer, Pim van der Harst

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Aug; 7(4): 475–481. Published online 2014 May 21. doi: 10.1161/CIRCGENETICS.113.000373

PMCID:: PMC4141024

Abstract Article PDF–410K

Select item 405841019.

N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding

Jonathan W. Lowery, Jose M. Amich, Alex Andonian, Vicki Rosen

Cell Mol Life Sci. 2014 Aug; 71(16): 3165–3172. Published online 2013 Dec 15. doi: 10.1007/s00018-013-1541-8

PMCID:: PMC4058410

Abstract Article PDF–2.0M

Select item 390683020.

Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2

György Szláma, Mária Trexler, László Patthy

FEBS J. 2013 Aug; 280(16): 3822–3839. Published online 2013 Jul 5. doi: 10.1111/febs.12377

PMCID:: PMC3906830

Abstract Article PDF–684K

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