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Select item 92768031.

Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study

Kristin Köhler-Forsberg, Brice Ozenne, Søren V. Larsen, Asbjørn S. Poulsen, Elizabeth B. Landman, Vibeke H. Dam, Cheng-Teng Ip, Anders Jørgensen, Claus Svarer, Gitte M. Knudsen, Vibe G. Frokjaer, Martin B. Jørgensen

Transl Psychiatry. 2022; 12: 273. Published online 2022 Jul 11. doi: 10.1038/s41398-022-02034-5

PMCID:: PMC9276803

Abstract Article PDF–1.2M

Select item 78576002.

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Barbora Waclawiková, Amber Bullock, Markus Schwalbe, Carmen Aranzamendi, Sieger A. Nelemans, Gertjan van Dijk, Sahar El Aidy

PLoS Biol. 2021 Jan; 19(1): e3001070. Published online 2021 Jan 22. doi: 10.1371/journal.pbio.3001070

PMCID:: PMC7857600

Abstract Article PDF–2.0M

Select item 70046863.

Association of human serotonin receptor 4 promoter methylation with autism spectrum disorder

Zhenyu Hu, Xiuru Ying, Ling Huang, Yuanzhi Zhao, Dongsheng Zhou, Jing Liu, Jie Zhong, Tianyi Huang, Wenwu Zhang, Fang Cheng, Shiwei Duan

Medicine (Baltimore) 2020 Jan; 99(4): e18838. Published online 2020 Jan 24. doi: 10.1097/MD.0000000000018838

PMCID:: PMC7004686

Abstract Article PDF–683K

Select item 56658674.

miR-16 and miR-103 impact 5-HT₄ receptor signalling and correlate with symptom profile in irritable bowel syndrome

Carolin Wohlfarth, Stefanie Schmitteckert, Janina D. Härtle, Lesley A. Houghton, Harsh Dweep, Marina Fortea, Ghazaleh Assadi, Alexander Braun, Tanja Mederer, Sarina Pöhner, Philip P. Becker, Christine Fischer, Martin Granzow, Hubert Mönnikes, Emeran A. Mayer, Gregory Sayuk, Guy Boeckxstaens, Mira M. Wouters, Magnus Simrén, Greger Lindberg, Bodil Ohlsson, Peter Thelin Schmidt, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Mauro D’Amato, Barbara Burwinkel, Justo Lorenzo Bermejo, Ralph Röth, Felix Lasitschka, Maria Vicario, Marco Metzger, Javier Santos, Gudrun A. Rappold, Cristina Martinez, Beate Niesler

Sci Rep. 2017; 7: 14680. Published online 2017 Oct 31. doi: 10.1038/s41598-017-13982-0

PMCID:: PMC5665867

Abstract Article PDF–3.4M

Select item 53908475.

Brain serotonin 4 receptor binding is inversely associated with verbal memory recall

Dea S. Stenbæk, Patrick M. Fisher, Brice Ozenne, Emil Andersen, Liv V. Hjordt, Brenda McMahon, Steen G. Hasselbalch, Vibe G. Frokjaer, Gitte M. Knudsen

Brain Behav. 2017 Apr; 7(4): e00674. Published online 2017 Mar 17. doi: 10.1002/brb3.674

PMCID:: PMC5390847

Abstract Article PDF–478K

Select item 53717306.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 49546517.

Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT₄ Receptor versus the TRPV1 Receptor

Chih-Hsun Yi, Wei-Yi Lei, Jui-Sheng Hung, Tso-Tsai Liu, William C. Orr, Pace Fabio, Chien-Lin Chen

PLoS One. 2016; 11(7): e0159452. Published online 2016 Jul 20. doi: 10.1371/journal.pone.0159452

PMCID:: PMC4954651

Abstract Article PDF–430K

Select item 43688728.

Familial Risk for Major Depression is Associated with Lower Striatal 5-HT₄ Receptor Binding

Karine Madsen, Eva Torstensen, Klaus K. Holst, Mette E. Haahr, Ulla Knorr, Vibe G. Frokjaer, Malene Brandt-Larsen, Pernille Iversen, Patrick M. Fisher, Gitte M. Knudsen

Int J Neuropsychopharmacol. 2015 Jan; 18(1): pyu034. Published online 2014 Dec 19. doi: 10.1093/ijnp/pyu034

Correction in:: Int J Neuropsychopharmacol. 2016 Oct; 19(10): pyw031.

PMCID:: PMC4368872

Abstract Article PDF–678K

Select item 43407609.

Astrocytic adenosine receptor A_2A and G_s-coupled signaling regulate memory

Anna G. Orr, Edward C. Hsiao, Max M. Wang, Kaitlyn Ho, Daniel H. Kim, Xin Wang, Weikun Guo, Jing Kang, Gui-Qiu Yu, Anthony Adame, Nino Devidze, Dena B. Dubal, Eliezer Masliah, Bruce R. Conklin, Lennart Mucke

Nat Neurosci. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Nat Neurosci. 2015 Mar; 18(3): 423–434. Published online 2015 Jan 26. doi: 10.1038/nn.3930

PMCID:: PMC4340760

Abstract Article PDF–1.9M

Select item 428554710.

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse

John S. House, Huiling Li, Laura M. DeGraff, Gordon Flake, Darryl C. Zeldin, Stephanie J. London

FASEB J. 2015 Jan; 29(1): 323–335. Published online 2014 Oct 23. doi: 10.1096/fj.14-253898

PMCID:: PMC4285547

Abstract Article

Select item 413650211.

ADAM19 and HTR4 Variants and Pulmonary Function: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study

Stephanie J. London, Wei Gao, Sina A. Gharib, Dana B. Hancock, Jemma B. Wilk, John S. House, Richard A. Gibbs, Donna M. Muzny, Thomas Lumley, Nora Franceschini, Kari E. North, Bruce M. Psaty, Christie L. Kovar, Josef Coresh, Yanhua Zhou, Susan R. Heckbert, Jennifer A. Brody, Alanna C. Morrison, Josée Dupuis

Circ Cardiovasc Genet. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Jun; 7(3): 350–358. doi: 10.1161/CIRCGENETICS.113.000066

PMCID:: PMC4136502

Abstract Article PDF–572K

Select item 375031712.

HTR4 gene structure and altered expression in the developing lung

Emily Hodge, Carl P Nelson, Suzanne Miller, Charlotte K Billington, Ceri E Stewart, Caroline Swan, Anders Malarstig, Amanda P Henry, Catherine Gowland, Erik Melén, Ian P Hall, Ian Sayers

Respir Res. 2013; 14(1): 77. Published online 2013 Jul 26. doi: 10.1186/1465-9921-14-77

PMCID:: PMC3750317

Abstract Article PDF–2.6M

Select item 365666213.

A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor

Jasmina Profirovic, Elena Strekalova, Norifumi Urao, Aleksandar Krbanjevic, Alexandra Andreeva, Sudhahar Varadarajan, Tohru Fukai, René Hen, Masuko Ushio-Fukai, Tatyana A. Voyno-Yasenetskaya

Angiogenesis. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Angiogenesis. 2013 Jan; 16(1): 15–28. Published online 2012 Aug 18. doi: 10.1007/s10456-012-9296-7

PMCID:: PMC3656662

Abstract Article PDF–4.5M

Select item 352721314.

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

Dana B. Hancock, María Soler Artigas, Sina A. Gharib, Amanda Henry, Ani Manichaikul, Adaikalavan Ramasamy, Daan W. Loth, Medea Imboden, Beate Koch, Wendy L. McArdle, Albert V. Smith, Joanna Smolonska, Akshay Sood, Wenbo Tang, Jemma B. Wilk, Guangju Zhai, Jing Hua Zhao, Hugues Aschard, Kristin M. Burkart, Ivan Curjuric, Mark Eijgelsheim, Paul Elliott, Xiangjun Gu, Tamara B. Harris, Christer Janson, Georg Homuth, Pirro G. Hysi, Jason Z. Liu, Laura R. Loehr, Kurt Lohman, Ruth J. F. Loos, Alisa K. Manning, Kristin D. Marciante, Ma'en Obeidat, Dirkje S. Postma, Melinda C. Aldrich, Guy G. Brusselle, Ting-hsu Chen, Gudny Eiriksdottir, Nora Franceschini, Joachim Heinrich, Jerome I. Rotter, Cisca Wijmenga, O. Dale Williams, Amy R. Bentley, Albert Hofman, Cathy C. Laurie, Thomas Lumley, Alanna C. Morrison, Bonnie R. Joubert, Fernando Rivadeneira, David J. Couper, Stephen B. Kritchevsky, Yongmei Liu, Matthias Wjst, Louise V. Wain, Judith M. Vonk, André G. Uitterlinden, Thierry Rochat, Stephen S. Rich, Bruce M. Psaty, George T. O'Connor, Kari E. North, Daniel B. Mirel, Bernd Meibohm, Lenore J. Launer, Kay-Tee Khaw, Anna-Liisa Hartikainen, Christopher J. Hammond, Sven Gläser, Jonathan Marchini, Peter Kraft, Nicholas J. Wareham, Henry Völzke, Bruno H. C. Stricker, Timothy D. Spector, Nicole M. Probst-Hensch, Deborah Jarvis, Marjo-Riitta Jarvelin, Susan R. Heckbert, Vilmundur Gudnason, H. Marike Boezen, R. Graham Barr, Patricia A. Cassano, David P. Strachan, Myriam Fornage, Ian P. Hall, Josée Dupuis, Martin D. Tobin, Stephanie J. London

PLoS Genet. 2012 Dec; 8(12): e1003098. Published online 2012 Dec 20. doi: 10.1371/journal.pgen.1003098

PMCID:: PMC3527213

Abstract Article PDF–417K

Select item 348051715.

Genome-Wide Association Studies Identify CHRNA5/3 and HTR4 in the Development of Airflow Obstruction

Jemma B. Wilk, Nick R. G. Shrine, Laura R. Loehr, Jing Hua Zhao, Ani Manichaikul, Lorna M. Lopez, Albert Vernon Smith, Susan R. Heckbert, Joanna Smolonska, Wenbo Tang, Daan W. Loth, Ivan Curjuric, Jennie Hui, Michael H. Cho, Jeanne C. Latourelle, Amanda P. Henry, Melinda Aldrich, Per Bakke, Terri H. Beaty, Amy R. Bentley, Ingrid B. Borecki, Guy G. Brusselle, Kristin M. Burkart, Ting-hsu Chen, David Couper, James D. Crapo, Gail Davies, Josée Dupuis, Nora Franceschini, Amund Gulsvik, Dana B. Hancock, Tamara B. Harris, Albert Hofman, Medea Imboden, Alan L. James, Kay-Tee Khaw, Lies Lahousse, Lenore J. Launer, Augusto Litonjua, Yongmei Liu, Kurt K. Lohman, David A. Lomas, Thomas Lumley, Kristin D. Marciante, Wendy L. McArdle, Bernd Meibohm, Alanna C. Morrison, Arthur W. Musk, Richard H. Myers, Kari E. North, Dirkje S. Postma, Bruce M. Psaty, Stephen S. Rich, Fernando Rivadeneira, Thierry Rochat, Jerome I. Rotter, María Soler Artigas, John M. Starr, André G. Uitterlinden, Nicholas J. Wareham, Cisca Wijmenga, Pieter Zanen, Michael A. Province, Edwin K. Silverman, Ian J. Deary, Lyle J. Palmer, Patricia A. Cassano, Vilmundur Gudnason, R. Graham Barr, Ruth J. F. Loos, David P. Strachan, Stephanie J. London, H. Marike Boezen, Nicole Probst-Hensch, Sina A. Gharib, Ian P. Hall, George T. O’Connor, Martin D. Tobin, Bruno H. Stricker

Am J Respir Crit Care Med. 2012 Oct 1; 186(7): 622–632. Published online 2012 Oct 1. doi: 10.1164/rccm.201202-0366OC

PMCID:: PMC3480517

Abstract Article PDF–770K

Select item 347754516.

Activation of Colonic Mucosal 5-HT₄ Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity

JILL M. HOFFMAN, KARL TYLER, SARAH J. MACEACHERN, ONESMO B. BALEMBA, ANTHONY C. JOHNSON, ELICE M. BROOKS, HONG ZHAO, GREG M. SWAIN, PETER L. MOSES, JAMES J. GALLIGAN, KEITH A. SHARKEY, BEVERLEY GREENWOOD–VAN MEERVELD, GARY M. MAWE

Gastroenterology. Author manuscript; available in PMC 2013 Apr 1.

Published in final edited form as: Gastroenterology. 2012 Apr; 142(4): 844–854.e4. Published online 2012 Jan 4. doi: 10.1053/j.gastro.2011.12.041

PMCID:: PMC3477545

Abstract Article PDF–1.9M

Select item 339841617.

Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function

María Soler Artigas, Louise V. Wain, Emmanouela Repapi, Ma'en Obeidat, Ian Sayers, Paul R. Burton, Toby Johnson, Jing Hua Zhao, Eva Albrecht, Anna F. Dominiczak, Shona M. Kerr, Blair H. Smith, Gemma Cadby, Jennie Hui, Lyle J. Palmer, Aroon D. Hingorani, S. Goya Wannamethee, Peter H. Whincup, Shah Ebrahim, George Davey Smith, Inês Barroso, Ruth J. F. Loos, Nicholas J. Wareham, Cyrus Cooper, Elaine Dennison, Seif O. Shaheen, Jason Z. Liu, Jonathan Marchini, Santosh Dahgam, Åsa Torinsson Naluai, Anna-Carin Olin, Stefan Karrasch, Joachim Heinrich, Holger Schulz, Tricia M. McKeever, Ian D. Pavord, Markku Heliövaara, Samuli Ripatti, Ida Surakka, John D. Blakey, Mika Kähönen, John R. Britton, Fredrik Nyberg, John W. Holloway, Debbie A. Lawlor, Richard W. Morris, Alan L. James, Cathy M. Jackson, Ian P. Hall, Martin D. Tobin, Medical Research Council National Survey of Health and Development (NSHD) Respiratory Study Team, the SpiroMeta Consortium

Am J Respir Crit Care Med. 2011 Oct 1; 184(7): 786–795. Published online 2011 Oct 1. doi: 10.1164/rccm.201102-0192OC