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Items: 1 to 20 of 105

1.
The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC
Huizi Li, Jin Liu, Jie Lai, Xinyao Su, Xiaofeng Wang, Jiaqing Cao, Shengxun Mao, Tong Zhang, Qiuping Gu
J Transl Med. 2024; 22: 537. Published online 2024 Jun 6. doi: 10.1186/s12967-024-05324-2
PMCID:
PMC11155165
AbstractArticlePDF–11M
2.
Expression analysis of loci associated with type 2 diabetes in human tissues
C. Cotsapas, L. Prokunina-Olsson, C. Welch, R. Saxena, C. Weaver, N. Usher, C. Guiducci, S. Bonakdar, N. Turner, B. LaCroix, J. L. Hall
Diabetologia. Author manuscript; available in PMC 2023 Jul 7.
Published in final edited form as: Diabetologia. 2010 Nov; 53(11): 2334–2339. Published online 2010 Aug 12. doi: 10.1007/s00125-010-1861-2
PMCID:
PMC10328108
AbstractArticlePDF–1.0M
3.
Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model
Ryo Ito, Azuma Kimura, Yurie Hirose, Yu Hatano, Atsushi Mima, Shin-Ichi Mae, Yamato Keidai, Toshihiro Nakamura, Junji Fujikura, Yohei Nishi, Akira Ohta, Taro Toyoda, Nobuya Inagaki, Kenji Osafune
Sci Rep. 2023; 13: 8659. Published online 2023 May 29. doi: 10.1038/s41598-023-35875-1
PMCID:
PMC10227077
AbstractArticlePDF–3.3M
4.
Assessment of community efforts to advance network-based prediction of protein–protein interactions
Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu
Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7
PMCID:
PMC10033937
AbstractArticlePDF–1.5M
5.
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
Yuegui Guo, Zhehui Zhu, Zhenyu Huang, Long Cui, Wei Yu, Wanjin Hong, Zhaocai Zhou, Peng Du, Chen-Ying Liu
Nat Commun. 2022; 13: 4995. Published online 2022 Aug 25. doi: 10.1038/s41467-022-32674-6
PMCID:
PMC9411202
AbstractArticlePDF–9.8M
6.
Unraveling the Influence of HHEX Risk Polymorphism rs7923837 on Multiple Sclerosis Pathogenesis
Adela González-Jiménez, Pilar López-Cotarelo, Teresa Agudo-Jiménez, Marisa Martínez-Ginés, Jose Manuel García-Domínguez, Elena Urcelay, Laura Espino-Paisán
Int J Mol Sci. 2022 Jul; 23(14): 7956. Published online 2022 Jul 19. doi: 10.3390/ijms23147956
PMCID:
PMC9321666
AbstractArticlePDF–1.1M
7.
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci
Hamish W King, Kristen L Wells, Zohar Shipony, Arwa S Kathiria, Lisa E Wagar, Caleb Lareau, Nara Orban, Robson Capasso, Mark M Davis, Lars M Steinmetz, Louisa K James, William J Greenleaf
Sci Immunol. Author manuscript; available in PMC 2022 Oct 15.
Published in final edited form as: Sci Immunol. 2021 Oct 15; 6(64): eabh3768. Published online 2021 Oct 8. doi: 10.1126/sciimmunol.abh3768
PMCID:
PMC8859880
AbstractArticlePDF–3.3M
8.
Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cells
Xiaopeng Li, Guilin Ma, Wenjie Guo, Ning Mu, Yingying Wang, Xiangguo Liu, Ling Su
Cell Commun Signal. 2021; 19: 80. Published online 2021 Jul 28. doi: 10.1186/s12964-021-00763-6
PMCID:
PMC8320060
AbstractArticlePDF–2.3M
9.
The association between HHEX single-nucleotide polymorphism rs5015480 and gestational diabetes mellitus: A meta-analysis
Xingjie Wang, Yuanlin Ding, Xinshan Zhang, Jiawei Rao, Haibin Yu, Haiyan Pan
Medicine (Baltimore) 2020 Mar; 99(12): e19478. Published online 2020 Mar 20. doi: 10.1097/MD.0000000000019478
PMCID:
PMC7220328
AbstractArticlePDF–771K
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
Effect of smoking on the association of HHEX (rs5015480) with diabetes among Korean women and heavy smoking men
Jae Woong Sull, Tae Yong Lee, Sun Ha Jee
BMC Med Genet. 2018; 19: 68. Published online 2018 May 2. doi: 10.1186/s12881-018-0582-0
PMCID:
PMC5930756
AbstractArticlePDF–563K
12.
Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism
K.S. Wadey, B.A. Brown, G.B. Sala-Newby, P.-S. Jayaraman, K. Gaston, S.J. George
Vascul Pharmacol. 2017 Dec; 99: 34–44. doi: 10.1016/j.vph.2017.09.004
PMCID:
PMC5718878
AbstractArticlePDF–3.0M
13.
HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs
Lingfang Li, Meitong Liu, Leitao Kang, Yifan Li, Ziyu Dai, Bing Wang, Shuiping Liu, Liyu Chen, Yurong Tan, Guojun Wu
Front Cell Infect Microbiol. 2016; 6: 169. Published online 2016 Nov 30. doi: 10.3389/fcimb.2016.00169
PMCID:
PMC5127840
AbstractArticlePDF–9.0M
14.
Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population
Rui Sun, Jian-Ping Liu, Chang Gao, Ying-Ying Xiong, Min Li, Ya-Ping Wang, Yan-Wei Su, Mei Lin, An-Li Jiang, Ling-Fan Xiong, Yan Xie, Jue-Ping Feng
Oncotarget. 2016 May 17; 7(20): 29770–29779. Published online 2016 Apr 20. doi: 10.18632/oncotarget.8865
PMCID:
PMC5045432
AbstractArticlePDF–1.4M
15.
NUP98 fusion oncoproteins interact with the APC/CCdc20 as a pseudosubstrate and prevent mitotic checkpoint complex binding
Valentina Salsi, Sebastian Fantini, Vincenzo Zappavigna
Cell Cycle. 2016; 15(17): 2275–2287. Published online 2016 Apr 20. doi: 10.1080/15384101.2016.1172156
PMCID:
PMC5004700
AbstractArticlePDF–956K
16.
Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression
Victoria Stepanova, Padma-Sheela Jayaraman, Sergei V. Zaitsev, Tatiana Lebedeva, Khalil Bdeir, Rachael Kershaw, Kelci R. Holman, Yelena V. Parfyonova, Ekaterina V. Semina, Irina B. Beloglazova, Vsevolod A. Tkachuk, Douglas B. Cines
J Biol Chem. 2016 Jul 15; 291(29): 15029–15045. Published online 2016 May 4. doi: 10.1074/jbc.M115.678490
PMCID:
PMC4946921
AbstractArticlePDF–3.0M
17.
Association of CDKAL1, CDKN2A/B & HHEX gene polymorphisms with type 2 diabetes mellitus in the population of Hyderabad, India
Uma Jyothi Kommoju, Subburaj Kadarkarai Samy, Jayaraj Maruda, Kumuda Irgam, Jaya Prasad Kotla, Lakshmi Velaga, Battini Mohan Reddy
Indian J Med Res. 2016 Apr; 143(4): 455–463. doi: 10.4103/0971-5916.184303
PMCID:
PMC4928552
AbstractArticlePDF–468K
18.
PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response
Ernestina Saulle, Alessia Petronelli, Elvira Pelosi, Elena Coppotelli, Luca Pasquini, Ramona Ilari, Francesco Lo-Coco, Ugo Testa
J Hematol Oncol. 2016; 9: 33. Published online 2016 Apr 7. doi: 10.1186/s13045-016-0262-5
PMCID:
PMC4823896
AbstractArticlePDF–1.5M
19.
Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis
Shiguo Liu, Jian Chai, Guohua Zheng, Huichao Li, Deguo Lu, Yinlin Ge
J Clin Res Pediatr Endocrinol. 2016 Mar; 8(1): 21–25. Published online 2016 Mar 1. doi: 10.4274/jcrpe.2456
PMCID:
PMC4805044
AbstractArticlePDF–104K
20.
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a
Benjamin J. Shields, Jacob T. Jackson, Donald Metcalf, Wei Shi, Qiutong Huang, Alexandra L. Garnham, Stefan P. Glaser, Dominik Beck, John E. Pimanda, Clifford W. Bogue, Gordon K. Smyth, Warren S. Alexander, Matthew P. McCormack
Genes Dev. 2016 Jan 1; 30(1): 78–91. doi: 10.1101/gad.268425.115
PMCID:
PMC4701980
AbstractArticlePDF–1.6M

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