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Select item 110932021.

Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer‐associated fibroblasts contributes to tumor progression: Role of IL8/AKT/p‐ACLY axis

Pan Liu, Yue Wang, Xiang Li, Zhenan Liu, Yunqing Sun, Hanzhe Liu, Zhe Shao, Erhui Jiang, Xiaocheng Zhou, Zhengjun Shang

Cancer Sci. 2024 May; 115(5): 1433–1445. Published online 2024 Mar 17. doi: 10.1111/cas.16111

PMCID:: PMC11093202

Abstract Article PDF–10M

Select item 110731442.

BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions

Yangzi Tian, Jingjing Ma, Hao Wang, Xiuli Yi, Huina Wang, Hengxiang Zhang, Sen Guo, Yuqi Yang, Baolu Zhang, Juan Du, Qiong Shi, Tianwen Gao, Weinan Guo, Chunying Li

Cell Mol Life Sci. 2023 Nov; 80(11): 315. Published online 2023 Oct 6. doi: 10.1007/s00018-023-04965-8

PMCID:: PMC11073144

Abstract Article PDF–11M

Select item 109424673.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 107999034.

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly

Emilie Murigneux, Laurent Softic, Corentin Aubé, Carmen Grandi, Delphine Judith, Johanna Bruce, Morgane Le Gall, François Guillonneau, Alain Schmitt, Vincent Parissi, Clarisse Berlioz-Torrent, Laurent Meertens, Maike M. K. Hansen, Sarah Gallois-Montbrun

Nat Commun. 2024; 15: 640. Published online 2024 Jan 20. doi: 10.1038/s41467-024-44958-0

PMCID:: PMC10799903

Abstract Article PDF–25M

Select item 104805355.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 104635456.

ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis

Paolo Convertini, Anna Santarsiero, Simona Todisco, Michele Gilio, Donatella Palazzo, Ilaria Pappalardo, Dominga Iacobazzi, Maria Frontuto, Vittoria Infantino

J Transl Med. 2023; 21: 568. Published online 2023 Aug 24. doi: 10.1186/s12967-023-04431-w

PMCID:: PMC10463545

Abstract Article PDF–4.7M

Select item 102818867.

ACLY-induced reprogramming of glycolytic metabolism plays an important role in the progression of breast cancer: Role of ACLY in breast cancer

Yu Lu, Liping Tian, Chengcheng Peng, Jienan Kong, Pengpeng Xiao, Nan Li

Acta Biochim Biophys Sin (Shanghai) 2023 May; 55(5): 878–881. Published online 2023 Apr 28. doi: 10.3724/abbs.2023084

PMCID:: PMC10281886

Article PDF–861K

Select item 102374228.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516159.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 1015053110.

Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress

Chenyu Hu, Zechang Xin, Xiaoyan Sun, Yang Hu, Chunfeng Zhang, Rui Yan, Yuying Wang, Min Lu, Jing Huang, Xiaojuan Du, Baocai Xing, Xiaofeng Liu

J Exp Clin Cancer Res. 2023; 42: 108. Published online 2023 May 1. doi: 10.1186/s13046-023-02656-7

PMCID:: PMC10150531

Abstract Article PDF–14M

Select item 1014884311.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 1011579512.

Allosteric role of the citrate synthase homology domain of ATP citrate lyase

Xuepeng Wei, Kollin Schultz, Hannah L. Pepper, Emily Megill, Austin Vogt, Nathaniel W. Snyder, Ronen Marmorstein

Nat Commun. 2023; 14: 2247. Published online 2023 Apr 19. doi: 10.1038/s41467-023-37986-9

PMCID:: PMC10115795

Abstract Article PDF–4.6M

Select item 997863513.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 995044714.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 980996715.

Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation

Hainan He, Junling Wang, Xingmei Mou, Xin Liu, Qiao Li, Mingyue Zhong, Bingbing Luo, Zhisheng Yu, Jingjing Zhang, Tian Xu, Chengli Dou, Danya Wu, Wei Qing, Linhui Wu, Kai Zhou, Zhengang Fan, Tingting Wang, Taotao Hu, Xia Zhang, Jilong Zhou, Yi-Liang Miao

Autophagy. 2023; 19(1): 163–179. Published online 2022 Apr 25. doi: 10.1080/15548627.2022.2063005

PMCID:: PMC9809967

Abstract Article PDF–4.4M

Select item 979798816.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255817.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969818.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 966343319.

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li, Wenqi Wang, Ruhong Zhou, Tianhua Zhou, Aifu Lin

Nat Commun. 2022; 13: 6951. Published online 2022 Nov 14. doi: 10.1038/s41467-022-34346-x

PMCID:: PMC9663433

Abstract Article PDF–4.4M

Select item 962668820.

Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis

Xi Ling, Jiayi Lu, Xiaoyun Wang, Lan Liu, Lu Liu, Yadi Wang, Yujun Sun, Chune Ren, Chao Lu, Zhenhai Yu

iScience. 2022 Nov 18; 25(11): 105363. Published online 2022 Oct 14. doi: 10.1016/j.isci.2022.105363

PMCID:: PMC9626688

Abstract Article PDF–6.0M

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