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Select item 113919661.

Role of ACE2 and TMPRSS2 polymorphisms on COVID-19 outcome and disease severity in adult patients: A prospective cohort study in a tertiary hospital, Indonesia

Rina Yunita, Arlinda S. Wahyuni, Bintang YM. Sinaga, Zulham Yamamoto, Amin Soebandrio, R. Lia Kusumawati, Rosita J. Sembiring, Pandiaman Pandia

Narra J. 2024 Aug; 4(2): e919. Published online 2024 Aug 12. doi: 10.52225/narra.v4i2.919

PMCID:: PMC11391966

Abstract Article PDF–557K

Select item 113462792.

No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks

Nathaniel M. Pearson, John Novembre

BMC Med. 2024; 22: 337. Published online 2024 Aug 26. doi: 10.1186/s12916-024-03539-0

PMCID:: PMC11346279

Abstract Article PDF–1.1M

Select item 112947273.

Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

Dorothea Bestle, Linda Bittel, Anke-Dorothee Werner, Lennart Kämper, Olga Dolnik, Verena Krähling, Torsten Steinmetzer, Eva Böttcher-Friebertshäuser

Virus Res. 2024 Sep; 347: 199430. Published online 2024 Jul 8. doi: 10.1016/j.virusres.2024.199430

PMCID:: PMC11294727

Abstract Article PDF–6.2M

Select item 111574564.

Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients

Noha M. Elemam, Amal Bouzid, Habiba Alsafar, Samrein BM Ahmed, Shirin Hafezi, Thenmozhi Venkatachalam, Leen Eldohaji, Tasneem Al Hamidi, Peter Habib Gerges, Nour Halabi, Hassen Hadj-Kacem, Iman M. Talaat, Jalal Taneera, Nabil Sulaiman, Azzam A. Maghazachi, Qutayba Hamid, Rifat Hamoudi, Maha Saber-Ayad

Front Immunol. 2024; 15: 1348229. Published online 2024 May 24. doi: 10.3389/fimmu.2024.1348229

PMCID:: PMC11157456

Abstract Article PDF–5.9M

Select item 111572635.

Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina

Neven Meseldžić, Besim Prnjavorac, Tanja Dujić, Maja Malenica, Una Glamočlija, Lejla Prnjavorac, Omer Bedak, Selma Imamović Kadrić, Damir Marjanović, Tamer Bego

Croat Med J. 2024 Jun; 65(3): 220–232. doi: 10.3325/cmj.2024.65.220

PMCID:: PMC11157263

Abstract Article PDF–175K

Select item 110199506.

ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells

Miriam Ruth Heindl, Anna-Lena Rupp, Marie Schwerdtner, Dorothea Bestle, Anne Harbig, Amy De Rocher, Luna C. Schmacke, Bart Staker, Torsten Steinmetzer, David A. Stein, Hong M. Moulton, Eva Böttcher-Friebertshäuser

J Virol. 2024 Apr; 98(4): e00102-24. Published online 2024 Mar 12. doi: 10.1128/jvi.00102-24

PMCID:: PMC11019950

Abstract Article PDF–1.6M

Select item 108071547.

Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt

Marwa H. Elnagdy, Alshimaa Magdy, Waleed Eldars, Mohamed Elgamal, Ahmed Hazem El-Nagdy, Omnia Salem, Mohamed Magdy Elmowafy, Omar Ahmed Elborsh, Abdelrahman Walid Elshafey, Muhammad Magdy Kesba, Ahmed Elsaeed Abdulgalil, Ali Sobh

Virol J. 2024; 21: 27. Published online 2024 Jan 23. doi: 10.1186/s12985-024-02298-x

PMCID:: PMC10807154

Abstract Article PDF–1.5M

Select item 108020418.

Evaluation of relationship between TMPRSS2 p.(Val197Met) variant and COVID-19 susceptibility and severity

Nora Ahmed Saleh Bashar, Nadida Mohammed Abdel-Hamid Gohar, Ahmed A. Tantawy, Mai Hamed Mohamed Kamel

BMC Infect Dis. 2024; 24: 112. Published online 2024 Jan 22. doi: 10.1186/s12879-024-08987-w

PMCID:: PMC10802041

Abstract Article PDF–1.2M

Select item 106120369.

The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus Entry

Romano Strobelt, Julia Adler, Yosef Shaul

Viruses. 2023 Oct; 15(10): 2124. Published online 2023 Oct 19. doi: 10.3390/v15102124

PMCID:: PMC10612036

Abstract Article PDF–6.3M

Select item 1050647710.

SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models

Anna Z. Mykytyn, Tim I. Breugem, Maarten H. Geurts, Joep Beumer, Debby Schipper, Romy van Acker, Petra B. van den Doel, Martin E. van Royen, Jingshu Zhang, Hans Clevers, Bart L. Haagmans, Mart M. Lamers

J Virol. 2023 Aug; 97(8): e00851-23. Published online 2023 Aug 9. doi: 10.1128/jvi.00851-23

PMCID:: PMC10506477

Abstract Article PDF–3.9M

Select item 1039991711.

TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS

Danielle Cicka, Qiankun Niu, Min Qui, Kun Qian, Eric Miller, Dacheng Fan, Xiulei Mo, Andrey A Ivanov, Stefan G Sarafianos, Yuhong Du, Haian Fu

J Mol Cell Biol. 2023 Mar; 15(3): mjad017. Published online 2023 Mar 15. doi: 10.1093/jmcb/mjad017

PMCID:: PMC10399917

Abstract Article PDF–1015K

Select item 1035594512.

Micro-RNA-204 Participates in TMPRSS2/ERG Regulation and Androgen Receptor Reprogramming in Prostate Cancer

Krassimira Todorova, Metodi V. Metodiev, Gergana Metodieva, Milcho Mincheff, Nelson Fernández, Soren Hayrabedyan

Horm Cancer. 2017 Feb; 8(1): 28–48. Published online 2017 Jan 3. doi: 10.1007/s12672-016-0279-9

PMCID:: PMC10355945

Abstract Article PDF–3.4M

Select item 1022879713.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2

Yong Ma, Pengbin Li, Yunqi Hu, Tianyi Qiu, Lixiang Wang, Hongjie Lu, Kexin Lv, Mengxin Xu, Jiaxin Zhuang, Xue Liu, Suhua He, Bing He, Shuning Liu, Lin Liu, Yuanyuan Wang, Xinyu Yue, Yanmei Zhai, Wanyu Luo, Haoting Mai, Yu Kuang, Shifeng Chen, Feng Ye, Na Zhou, Wenjing Zhao, Jun Chen, Shoudeng Chen, Xiaoli Xiong, Mang Shi, Ji-An Pan, Yao-Qing Chen

PLoS Pathog. 2023 May; 19(5): e1011123. Published online 2023 May 17. doi: 10.1371/journal.ppat.1011123

PMCID:: PMC10228797

Abstract Article PDF–4.2M

Select item 1020081014.

Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells

Marie Schwerdtner, Annika Skalik, Hannah Limburg, Jeff Bierwagen, Anna Lena Jung, Jens Dorna, Andreas Kaufmann, Stefan Bauer, Bernd Schmeck, Eva Böttcher-Friebertshäuser

Life Sci Alliance. 2023 Aug; 6(8): e202201813. Published online 2023 May 19. doi: 10.26508/lsa.202201813

PMCID:: PMC10200810

Abstract Article PDF–1.6M

Select item 1015870215.

Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic

Kanae Ogawa, Khaleque N. Khan, Akemi Koshiba, Akira Fujishita, Go Horiguchi, Satoshi Teramukai, Kyoko Itoh, Sun-Wei Guo, Taisuke Mori

BMC Womens Health. 2023; 23: 229. Published online 2023 May 4. doi: 10.1186/s12905-023-02378-0

PMCID:: PMC10158702

Abstract Article PDF–2.5M

Select item 1013483316.

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase

Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso, Šárka Lehtonen, Johanna Kuusisto, Olli Pietiläinen, Saber H. Saber, Merja Joensuu, Olli P. Vapalahti, Jari Koistinaho, Taisia Rolova, Giuseppe Balistreri

J Virol. 2023 Apr; 97(4): e00144-23. Published online 2023 Apr 11. doi: 10.1128/jvi.00144-23

PMCID:: PMC10134833

Abstract Article PDF–4.2M

Select item 1010154217.

Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFα genes associated with susceptibility and severity of SARS-CoV-2 infection: a systematic review and meta-analysis

Valentina Pecoraro, Michela Cuccorese, Tommaso Trenti

Clin Exp Med. 2023 Apr 13 : 1–14. doi: 10.1007/s10238-023-01038-9 [Epub ahead of print]

PMCID:: PMC10101542

Abstract Article PDF–1.2M

Select item 1003393718.

Assessment of community efforts to advance network-based prediction of protein–protein interactions

Xu-Wen Wang, Lorenzo Madeddu, Kerstin Spirohn, Leonardo Martini, Adriano Fazzone, Luca Becchetti, Thomas P. Wytock, István A. Kovács, Olivér M. Balogh, Bettina Benczik, Mátyás Pétervári, Bence Ágg, Péter Ferdinandy, Loan Vulliard, Jörg Menche, Stefania Colonnese, Manuela Petti, Gaetano Scarano, Francesca Cuomo, Tong Hao, Florent Laval, Luc Willems, Jean-Claude Twizere, Marc Vidal, Michael A. Calderwood, Enrico Petrillo, Albert-László Barabási, Edwin K. Silverman, Joseph Loscalzo, Paola Velardi, Yang-Yu Liu

Nat Commun. 2023; 14: 1582. Published online 2023 Mar 22. doi: 10.1038/s41467-023-37079-7

PMCID:: PMC10033937

Abstract Article PDF–1.5M

Select item 1002667919.

Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia

JI EUN PARK, DAE HYUN SONG, YU-MIN KIM, HYEN CHUL JO, JONG CHUL BAEK, HYOEUN KIM, JUSEOK YANG, HYO JUNG AN

In Vivo. 2023 Mar-Apr; 37(2): 625–633. Published online 2023 Mar 3. doi: 10.21873/invivo.13121

PMCID:: PMC10026679

Abstract Article PDF–4.8M

Select item 998750320.

Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population

Olga Izmailova, Oksana Shlykova, Alina Kabaliei, Anastasia Vatsenko, Dmytro Ivashchenko, Maksym Dudchenko, Andrii Volianskyi, Gennadiy Zelinskyy, Tetiana Koval, Ulf Dittmer, Igor Kaidashev

Acta Biomed. 2023; 94(1): e2023030. Published online 2023 Feb 13. doi: 10.23750/abm.v94i1.13543

PMCID:: PMC9987503

Abstract Article PDF–257K

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