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Select item 103791571.

A Novel KCNN2 Variant in a Family with Essential Tremor Plus: Clinical Characteristics and In Silico Analysis

Maria d’Apolito, Caterina Ceccarini, Rosa Savino, Iolanda Adipietro, Ighli di Bari, Rosa Santacroce, Maria Curcetti, Giovanna D’Andrea, Anna-Irma Croce, Carla Cesarano, Anna Nunzia Polito, Maurizio Margaglione

Genes (Basel) 2023 Jul; 14(7): 1380. Published online 2023 Jun 29. doi: 10.3390/genes14071380

PMCID:: PMC10379157

Abstract Article PDF–1.1M

Select item 100699732.

Loss-of-function K_Ca2.2 mutations abolish channel activity

Young-Woo Nam, Mohammad Asikur Rahman, Grace Yang, Razan Orfali, Meng Cui, Miao Zhang

Am J Physiol Cell Physiol. 2023 Mar 1; 324(3): C658–C664. Published online 2023 Jan 30. doi: 10.1152/ajpcell.00584.2022

PMCID:: PMC10069973

Abstract Article

Select item 98410423.

Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function

Andrew S. Butler, Jules C. Hancox, Neil V. Marrion

J Biol Chem. 2023 Jan; 299(1): 102783. Published online 2022 Dec 9. doi: 10.1016/j.jbc.2022.102783

PMCID:: PMC9841042

Abstract Article PDF–1.9M

Select item 75417454.

SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases

Jiandong Sun, Yan Liu, Michel Baudry, Xiaoning Bi

Biochim Biophys Acta Mol Cell Res. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Dec; 1867(12): 118834. Published online 2020 Aug 27. doi: 10.1016/j.bbamcr.2020.118834

PMCID:: PMC7541745

Abstract Article PDF–724K

Select item 60842955.

Functional interaction of Junctophilin 2 with small‐ conductance Ca²⁺‐activated potassium channel subtype 2(SK2) in mouse cardiac myocytes

H. K. Fan, T. X. Luo, W. D. Zhao, Y. H. Mu, Y. Yang, W. J. Guo, H. Y. Tu, Q. Zhang

Acta Physiol (Oxf) 2018 Mar; 222(3): e12986. Published online 2017 Dec 7. doi: 10.1111/apha.12986

PMCID:: PMC6084295

Abstract Article PDF–2.2M

Select item 59633166.

Ca²⁺/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca²⁺-Activated K⁺ Current in Patients with Chronic Atrial Fibrillation

Xuehui Fan, Yiyan Yu, Huan Lan, Xianhong Ou, Lijie Yang, Tao Li, Jimin Cao, Xiaorong Zeng, Miaoling Li

Med Sci Monit. 2018; 24: 3011–3023. Published online 2018 May 8. doi: 10.12659/MSM.909684

PMCID:: PMC5963316

Abstract Article PDF–1.2M

Select item 54952257.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 53741148.

Distinct subcellular mechanisms for the enhancement of the surface membrane expression of SK2 channel by its interacting proteins, α‐actinin2 and filamin A

Zheng Zhang, Hannah A. Ledford, Seojin Park, Wenying Wang, Sassan Rafizadeh, Hyo Jeong Kim, Wilson Xu, Ling Lu, Victor C. Lau, Anne A. Knowlton, Xiao‐Dong Zhang, Ebenezer N. Yamoah, Nipavan Chiamvimonvat

J Physiol. 2017 Apr 1; 595(7): 2271–2284. Published online 2016 Dec 7. doi: 10.1113/JP272942

PMCID:: PMC5374114

Abstract Article PDF–1.2M

Select item 53343919.

Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain

Michael Willis, Maria Trieb, Irmgard Leitner, Georg Wietzorrek, Josef Marksteiner, Hans-Günther Knaus

Brain Struct Funct. 2017; 222(2): 973–979. Published online 2016 Jun 29. doi: 10.1007/s00429-016-1258-1

PMCID:: PMC5334391

Abstract Article PDF–1.1M

Select item 526579610.

KCNN2 polymorphisms and cardiac tachyarrhythmias

Chih-Chieh Yu, Tsai Chia-Ti, Pei-Lung Chen, Cho-Kai Wu, Fu-Chun Chiu, Fu-Tien Chiang, Peng-Sheng Chen, Chi-Ling Chen, Lian-Yu Lin, Jyh-Ming Juang, Li-Ting Ho, Ling-Ping Lai, Wei-Shiung Yang, Jiunn-Lee Lin

Medicine (Baltimore) 2016 Jul; 95(29): e4312. Published online 2016 Jul 22. doi: 10.1097/MD.0000000000004312

PMCID:: PMC5265796

Abstract Article PDF–351K

Select item 495851911.

Arrhythmogenic Calmodulin Mutations Impede Activation of Small-conductance Calcium-Activated Potassium Current

Chih-Chieh Yu, Jum-Suk Ko, Tomohiko Ai, Wen-Chin Tsai, Zhenhui Chen, Michael Rubart, Matteo Vatta, Thomas H. Everett, Alfred L. George, Jr., Peng-Sheng Chen

Heart Rhythm. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: Heart Rhythm. 2016 Aug; 13(8): 1716–1723. Published online 2016 May 7. doi: 10.1016/j.hrthm.2016.05.009

PMCID:: PMC4958519

Abstract Article PDF–951K

Select item 483210212.

Activation of SK2 channels preserves ER Ca²⁺ homeostasis and protects against ER stress-induced cell death

M Richter, N Vidovic, B Honrath, P Mahavadi, R Dodel, A M Dolga, C Culmsee

Cell Death Differ. 2016 May; 23(5): 814–827. Published online 2015 Nov 20. doi: 10.1038/cdd.2015.146

PMCID:: PMC4832102

Abstract Article PDF–4.6M

Select item 410334513.

Functional interaction with filamin A and intracellular Ca²⁺ enhance the surface membrane expression of a small-conductance Ca²⁺-activated K⁺ (SK2) channel

Sassan Rafizadeh, Zheng Zhang, Ryan L. Woltz, Hyo Jeong Kim, Richard E. Myers, Ling Lu, Dipika Tuteja, Anil Singapuri, Amir Ali Ziaei Bigdeli, Sana Ben Harchache, Anne A. Knowlton, Vladimir Yarov-Yarovoy, Ebenezer N. Yamoah, Nipavan Chiamvimonvat

Proc Natl Acad Sci U S A. 2014 Jul 8; 111(27): 9989–9994. Published online 2014 Jun 20. doi: 10.1073/pnas.1323541111

PMCID:: PMC4103345

Abstract Article PDF–1.2M

Select item 404069214.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons

A M Dolga, A de Andrade, L Meissner, H-G Knaus, M Höllerhage, P Christophersen, H Zischka, N Plesnila, G U Höglinger, C Culmsee

Cell Death Dis. 2014 Jan; 5(1): e999. Published online 2014 Jan 16. doi: 10.1038/cddis.2013.530

PMCID:: PMC4040692

Abstract Article PDF–4.9M

Select item 360323615.

Heterogeneous Upregulation of Apamin‐Sensitive Potassium Currents in Failing Human Ventricles

Po‐Cheng Chang, Isik Turker, John C. Lopshire, Saqib Masroor, Bich‐Lien Nguyen, Wen Tao, Michael Rubart, Peng‐Sheng Chen, Zhenhui Chen, Tomohiko Ai

J Am Heart Assoc. 2013 Feb; 2(1): e004713. Published online 2013 Feb 22. doi: 10.1161/JAHA.112.004713

PMCID:: PMC3603236

Abstract Article PDF–1.0M

Select item 352258716.

Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population

Anthony G. Comuzzie, Shelley A. Cole, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Richard A. Gibbs, Nancy F. Butte

PLoS One. 2012; 7(12): e51954. Published online 2012 Dec 14. doi: 10.1371/journal.pone.0051954

PMCID:: PMC3522587

Abstract Article PDF–130K

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 277529418.

α-Actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca²⁺-activated K⁺ channel (SK2 channel)

Ling Lu, Valeriy Timofeyev, Ning Li, Sassan Rafizadeh, Anil Singapuri, Todd R. Harris, Nipavan Chiamvimonvat

Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43): 18402–18407. Published online 2009 Oct 8. doi: 10.1073/pnas.0908207106

PMCID:: PMC2775294

Abstract Article PDF–1.9M

Select item 267377719.

Ablation of a Ca²⁺-activated K⁺ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation

Ning Li, Valeriy Timofeyev, Dipika Tuteja, Danyan Xu, Ling Lu, Qian Zhang, Zhao Zhang, Anil Singapuri, Trevine R Albert, Amutha V Rajagopal, Chris T Bond, Muthu Periasamy, John Adelman, Nipavan Chiamvimonvat

J Physiol. 2009 Mar 1; 587(Pt 5): 1087–1100. Published online 2009 Jan 12. doi: 10.1113/jphysiol.2008.167718