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Select item 110287811.

Anti-CD137 monoclonal antibodies and adoptive T cell therapy: a perfect marriage?

Bettina Weigelin, Elixabet Bolaños, Maria E. Rodriguez-Ruiz, Ivan Martinez-Forero, Peter Friedl, Ignacio Melero

Cancer Immunol Immunother. 2016 May; 65(5): 493–497. Published online 2016 Mar 12. doi: 10.1007/s00262-016-1818-5

PMCID:: PMC11028781

Abstract Article PDF–815K

Select item 109922392.

Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors

Mukul Prasad, Sashigala Ponnalagu, Qun Zeng, Khang Luu, Si Min Lang, Hiu Yi Wong, Man Si Cheng, Meihui Wu, Karthik Mallilankaraman, Radoslaw Mikolaj Sobota, Yan Ting Lim, Loo Chien Wang, Chuan Keng Goh, Kai Xun Joshua Tay, Kwok Seng Loh, Cheng-I. Wang, Wen-Hsien Lee, Boon Cher Goh, Chwee Ming Lim, Herbert Schwarz

Cancer Immunol Immunother. 2022 Nov; 71(11): 2583–2596. Published online 2022 Mar 17. doi: 10.1007/s00262-022-03183-8

PMCID:: PMC10992239

Abstract Article PDF–2.1M

Select item 107443193.

Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients

Ulrich Räth, Patricia Mester, Herbert Schwarz, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel

Int J Mol Sci. 2023 Dec; 24(24): 17518. Published online 2023 Dec 15. doi: 10.3390/ijms242417518

PMCID:: PMC10744319

Abstract Article PDF–1.9M

Select item 92633554.

Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB

Morten Aagaard Nielsen, Kristian Juul-Madsen, John Stegmayr, Chao Gao, Akul Y. Mehta, Stinne Ravn Greisen, Tue Wenzel Kragstrup, Malene Hvid, Thomas Vorup-Jensen, Richard D. Cummings, Hakon Leffler, Bent Winding Deleuran

Front Immunol. 2022; 13: 915890. Published online 2022 Jun 24. doi: 10.3389/fimmu.2022.915890

PMCID:: PMC9263355

Abstract Article PDF–4.1M

Select item 86326785.

CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity

A. Stoll, H. Bruns, M. Fuchs, S. Völkl, F. Nimmerjahn, M. Kunz, M. Peipp, A. Mackensen, D. Mougiakakos

Leukemia. 2021; 35(12): 3482–3496. Published online 2021 May 21. doi: 10.1038/s41375-021-01287-1

PMCID:: PMC8632678

Abstract Article PDF–4.7M

Select item 85758916.

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Baptiste Lamarthée, Armance Marchal, Soëli Charbonnier, Tifanie Blein, Juliette Leon, Emmanuel Martin, Lucas Rabaux, Katrin Vogt, Matthias Titeux, Marianne Delville, Hélène Vinçon, Emmanuelle Six, Nicolas Pallet, David Michonneau, Dany Anglicheau, Christophe Legendre, Jean-Luc Taupin, Ivan Nemazanyy, Birgit Sawitzki, Sylvain Latour, Marina Cavazzana, Isabelle André, Julien Zuber

Nat Commun. 2021; 12: 6446. Published online 2021 Nov 8. doi: 10.1038/s41467-021-26844-1

PMCID:: PMC8575891

Abstract Article PDF–5.0M

Select item 83415297.

Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis

Lotte Lindgreen Eriksen, Morten Aagaard Nielsen, Tea Lund Laursen, Bent Deleuran, Hendrik Vilstrup, Sidsel Støy

PLoS One. 2021; 16(8): e0255574. Published online 2021 Aug 5. doi: 10.1371/journal.pone.0255574

PMCID:: PMC8341529

Abstract Article PDF–1.3M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79629469.

Role of ADAM10 and ADAM17 in Regulating CD137 Function

Jana Seidel, Sinje Leitzke, Björn Ahrens, Maria Sperrhacke, Sucharit Bhakdi, Karina Reiss

Int J Mol Sci. 2021 Mar; 22(5): 2730. Published online 2021 Mar 8. doi: 10.3390/ijms22052730

PMCID:: PMC7962946

Abstract Article PDF–1.6M

Select item 791490310.

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis

Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz

Cells. 2021 Feb; 10(2): 353. Published online 2021 Feb 9. doi: 10.3390/cells10020353

PMCID:: PMC7914903

Abstract Article PDF–1.4M

Select item 788363311.

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

Benjamin I. Philipson, Roddy S. O’Connor, Michael J. May, Carl H. June, Steven M. Albelda, Michael C. Milone

Sci Signal. Author manuscript; available in PMC 2021 Feb 15.

Published in final edited form as: Sci Signal. 2020 Mar 31; 13(625): eaay8248. Published online 2020 Mar 31. doi: 10.1126/scisignal.aay8248

PMCID:: PMC7883633

Abstract Article PDF–1.3M

Select item 787202412.

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting

Kang Yi Lee, Hiu Yi Wong, Qun Zeng, Jia Le Lin, Man Si Cheng, Chik Hong Kuick, Kenneth Tou En Chang, Amos Hong Pheng Loh, Herbert Schwarz

Oncoimmunology. 2021; 10(1): 1877459. Published online 2021 Feb 4. doi: 10.1080/2162402X.2021.1877459

PMCID:: PMC7872024

Abstract Article PDF–3.4M

Select item 783373513.

T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production

Saskia D. van Asten, Rosa de Groot, Marleen M. van Loenen, Suzanne M. Castenmiller, Jeroen de Jong, Kim Monkhorst, John B.A.G. Haanen, Derk Amsen, Axel Bex, Robbert M. Spaapen, Monika C. Wolkers

Oncoimmunology. 2021; 10(1): 1860482. Published online 2021 Jan 21. doi: 10.1080/2162402X.2020.1860482

PMCID:: PMC7833735

Abstract Article PDF–1.9M

Select item 769137414.

4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2^nd Generation Chimeric Antigen Receptor-Modified T Cells

Qiang Dai, Ping Han, Xinyue Qi, Fanlin Li, Min Li, Lilv Fan, Huihui Zhang, Xiaoqing Zhang, Xuanming Yang

Front Immunol. 2020; 11: 539654. Published online 2020 Nov 13. doi: 10.3389/fimmu.2020.539654

PMCID:: PMC7691374

Abstract Article PDF–934K

Select item 760460415.

Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway

Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

Mediators Inflamm. 2020; 2020: 1649453. Published online 2020 Oct 24. doi: 10.1155/2020/1649453

PMCID:: PMC7604604

Abstract Article PDF–3.0M

Select item 744776816.

PD-1 abrogates the prolonged persistence of CD8⁺ CAR-T cells with 4-1BB co-stimulation

Feng Li, Zhen Zhang, Yujing Xuan, Daiqun Zhang, Jinyan Liu, Aitian Li, Shumin Wang, Ting Li, Xiaojuan Shi, Yi Zhang

Signal Transduct Target Ther. 2020; 5: 164. Published online 2020 Aug 25. doi: 10.1038/s41392-020-00277-6

PMCID:: PMC7447768

Article PDF–1.6M

Select item 726958517.

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

Zachary T. Freeman, Thomas R. Nirschl, Daniel H. Hovelson, Robert J. Johnston, John J. Engelhardt, Mark J. Selby, Christina M. Kochel, Ruth Y. Lan, Jingyi Zhai, Ali Ghasemzadeh, Anuj Gupta, Alyza M. Skaist, Sarah J. Wheelan, Hui Jiang, Alexander T. Pearson, Linda A. Snyder, Alan J. Korman, Scott A. Tomlins, Srinivasan Yegnasubramanian, Charles G. Drake

J Clin Invest. 2020 Mar 2; 130(3): 1405–1416. Published online 2020 Feb 4. doi: 10.1172/JCI128672

PMCID:: PMC7269585

Abstract Article PDF–6.4M

Select item 726681418.

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus

Yujun Pei, Kun Wen, Zheng Xiang, Chunyu Huang, Xiwei Wang, Xiaofeng Mu, Liyan Wen, Yinping Liu, Wenwei Tu

Signal Transduct Target Ther. 2020; 5: 74. Published online 2020 Jun 3. doi: 10.1038/s41392-020-0174-2

PMCID:: PMC7266814

Abstract Article PDF–3.5M

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 715475320.

4‐1BB Delineates Distinct Activation Status of Exhausted Tumor‐Infiltrating CD8⁺ T Cells in Hepatocellular Carcinoma

Hyung‐Don Kim, Seongyeol Park, Seongju Jeong, Yong Joon Lee, Hoyoung Lee, Chang Gon Kim, Kyung Hwan Kim, Seung‐Mo Hong, Jung‐Yun Lee, Sunghoon Kim, Hong Kwan Kim, Byung Soh Min, Jong Hee Chang, Young Seok Ju, Eui‐Cheol Shin, Gi‐Won Song, Shin Hwang, Su‐Hyung Park

Hepatology. 2020 Mar; 71(3): 955–971. Published online 2019 Oct 18. doi: 10.1002/hep.30881

PMCID:: PMC7154753

Abstract Article PDF–1.7M

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