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Items: 1 to 20 of 52

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development
Xiangyan Wang, Yan Zhang, Jianjie Yu, Yabo Ma, Yaxiu Xu, Jiaqi Shi, Zhipeng Qi, Xinfeng Liu
BMC Genomics. 2024; 25: 139. Published online 2024 Feb 3. doi: 10.1186/s12864-024-10058-y
PMCID:
PMC10837906
AbstractArticlePDF–7.1M
3.
Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK
Natasha S. Clayton, Millie Fox, Jose J. Vicenté-Garcia, Courtney M. Schroeder, Trevor D. Littlewood, Jonathon I. Wilde, Kadalmani Krishnan, Murray J.B. Brown, Claire Crafter, Helen R. Mott, Darerca Owen
J Biol Chem. 2022 Jun; 298(6): 101916. Published online 2022 Apr 13. doi: 10.1016/j.jbc.2022.101916
PMCID:
PMC9127371
AbstractArticlePDF–2.6M
4.
Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling
Qian Wang, Chenqi Tao, Abdul Hannan, Sungtae Yoon, Xuanyu Min, John Peregrin, Xiuxia Qu, Hongge Li, Honglian Yu, Jean Zhao, Xin Zhang
Sci Adv. 2021 Jul; 7(27): eabf1068. Published online 2021 Jun 30. doi: 10.1126/sciadv.abf1068
PMCID:
PMC8245041
AbstractArticlePDF–1.8M
5.
PIK3R2/Pik3r2 activating mutations result in brain overgrowth and EEG changes
Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa, Tao Tao, Jeffrey A. Golden
Ann Neurol. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: Ann Neurol. 2020 Dec; 88(6): 1077–1094. Published online 2020 Sep 28. doi: 10.1002/ana.25890
PMCID:
PMC8176885
AbstractArticlePDF–1.8M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
8.
The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization
Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber
Oncogene. Author manuscript; available in PMC 2017 Feb 14.
Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331
PMCID:
PMC5308218
AbstractArticlePDF–3.8M
9.
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor
Grinu Mathew, Abdul Hannan, Kristina Hertzler-Schaefer, Fen Wang, Gen-Sheng Feng, Jian Zhong, Jean J. Zhao, Julian Downward, Xin Zhang
Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46): 13156–13161. Published online 2016 Oct 31. doi: 10.1073/pnas.1604450113
PMCID:
PMC5135310
AbstractArticlePDF–2.1M
10.
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Thati Madhusudhan, Hongjie Wang, Wei Dong, Sanchita Ghosh, Fabian Bock, Veera Raghavan Thangapandi, Satish Ranjan, Juliane Wolter, Shrey Kohli, Khurrum Shahzad, Florian Heidel, Martin Krueger, Vedat Schwenger, Marcus J. Moeller, Thomas Kalinski, Jochen Reiser, Triantafyllos Chavakis, Berend Isermann
Nat Commun. 2015 Mar 10; 6: 6496. Published online 2015 Mar 10. doi: 10.1038/ncomms7496
PMCID:
PMC4366504
AbstractArticlePDF–5.2M
11.
Phosphoinositide 3-kinase p85beta regulates invadopodium formation
Ariel E. Cariaga-Martínez, Isabel Cortés, Esther García, Vicente Pérez-García, María J. Pajares, Miguel A. Idoate, Javier Redondo-Muñóz, Inés M. Antón, Ana C. Carrera
Biol Open. 2014 Oct 15; 3(10): 924–936. Published online 2014 Sep 12. doi: 10.1242/bio.20148185
PMCID:
PMC4197441
AbstractArticlePDF–2.0M
12.
Optogenetic Control of PIP3: PIP3 Is Sufficient to Induce the Actin-Based Active Part of Growth Cones and Is Regulated via Endocytosis
Toshiyuki Kakumoto, Takao Nakata
PLoS One. 2013; 8(8): e70861. Published online 2013 Aug 7. doi: 10.1371/journal.pone.0070861
PMCID:
PMC3737352
AbstractArticlePDF–9.8M
13.
Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms
Kazuma Kaneko, Kohjiro Ueki, Noriko Takahashi, Shinji Hashimoto, Masayuki Okamoto, Motoharu Awazawa, Yukiko Okazaki, Mitsuru Ohsugi, Kazunori Inabe, Toshihiro Umehara, Masashi Yoshida, Masafumi Kakei, Tadahiro Kitamura, Ji Luo, Rohit N. Kulkarni, C. Ronald Kahn, Haruo Kasai, Lewis C. Cantley, Takashi Kadowaki
Cell Metab. Author manuscript; available in PMC 2013 Aug 7.
Published in final edited form as: Cell Metab. 2010 Dec 1; 12(6): 619–632. doi: 10.1016/j.cmet.2010.11.005
PMCID:
PMC3736578
AbstractArticlePDF–2.4M
14.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
15.
p38α senses environmental stress to control innate immune responses via mTOR
Karl Katholnig, Christopher C. Kaltenecker, Hiroko Hayakawa, Margit Rosner, Caroline Lassnig, Gerhard J. Zlabinger, Matthias Gaestel, Mathias Müller, Markus Hengstschläger, Walter H. Hörl, Jin Mo Park, Marcus D. Säemann, Thomas Weichhart
J Immunol. Author manuscript; available in PMC 2014 Feb 15.
Published in final edited form as: J Immunol. 2013 Feb 15; 190(4): 1519–1527. Published online 2013 Jan 11. doi: 10.4049/jimmunol.1202683
PMCID:
PMC3563859
AbstractArticlePDF–1.6M
16.
Acute Inhibition of PI3K-PDK1-Akt Pathway Potentiates Insulin Secretion through Upregulation of Newcomer Granule Fusions in Pancreatic β-Cells
Kyota Aoyagi, Mica Ohara-Imaizumi, Chiyono Nishiwaki, Yoko Nakamichi, Kohjiro Ueki, Takashi Kadowaki, Shinya Nagamatsu
PLoS One. 2012; 7(10): e47381. Published online 2012 Oct 15. doi: 10.1371/journal.pone.0047381
PMCID:
PMC3471824
AbstractArticlePDF–990K
17.
p85β phosphoinositide 3-kinase subunit regulates tumor progression
Isabel Cortés, Jesús Sánchez-Ruíz, Susana Zuluaga, Vincenzo Calvanese, Miriam Marqués, Carmen Hernández, Teresa Rivera, Leonor Kremer, Ana González-García, Ana C. Carrera
Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11318–11323. Published online 2012 Jun 25. doi: 10.1073/pnas.1118138109
PMCID:
PMC3396516
AbstractArticlePDF–1.3M
18.
PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation
Ekaterina Bobrovnikova-Marjon, Dariusz Pytel, Matthew J. Riese, Laura Pontano Vaites, Nickpreet Singh, Gary A. Koretzky, Eric S. Witze, J. Alan Diehl
Mol Cell Biol. 2012 Jun; 32(12): 2268–2278. doi: 10.1128/MCB.00063-12
PMCID:
PMC3372262
AbstractArticlePDF–2.0M
19.
p85β regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis
Subha Krishnan, Raghuveer Singh Mali, Baskar Ramdas, Emily Sims, Peilin Ma, Joydeep Ghosh, Veerendra Munugalavadla, Philip Hanneman, Joal D. Beane, Reuben Kapur
Blood. 2012 Apr 26; 119(17): 3951–3961. Prepublished online 2012 Feb 29. doi: 10.1182/blood-2011-05-355602
PMCID:
PMC3350362
AbstractArticle
20.
The hypersensitive sites of the murine β-globin locus control region act independently to affect nuclear localization and transcriptional elongation
M. A. Bender, Tobias Ragoczy, Jongjoo Lee, Rachel Byron, Agnes Telling, Ann Dean, Mark Groudine
Blood. 2012 Apr 19; 119(16): 3820–3827. Prepublished online 2012 Feb 29. doi: 10.1182/blood-2011-09-380485
PMCID:
PMC3335386
AbstractArticle

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