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Items: 1 to 20 of 40

1.
MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression
Yanjin WANG, Yifei CHEN, Fuji YANG, Xiaolong YU, Ying CHU, Jing ZHOU, Yongmin YAN, Jianbo XI
J Zhejiang Univ Sci B. 2024 Jul 16; 25(7): 594–604. Published online 2024 May 17. doi: 10.1631/jzus.B2300305
PMCID:
PMC11254680
AbstractArticlePDF–3.1M
2.
Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway
Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu, Liang Dong
Respir Res. 2024; 25: 230. Published online 2024 Jun 1. doi: 10.1186/s12931-024-02811-4
PMCID:
PMC11144323
AbstractArticlePDF–8.7M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
Yun Sun Lee, Hyung Sun Kim, Hyo Jung Kim, Hyeon Woong Kang, Da Eun Lee, Myeong Jin Kim, Woosol Chris Hong, Ju Hyun Kim, Minsoo Kim, Jae-Ho Cheong, Joon Seong Park
J Mol Med (Berl) 2023; 101(11): 1449–1464. Published online 2023 Sep 22. doi: 10.1007/s00109-023-02369-6
PMCID:
PMC10663195
AbstractArticlePDF–2.0M
5.
Lysyl oxidase‐like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
Yi‐Jie Lu, Yi‐Ting Deng, Hui‐Hsin Ko, Hsin‐Hui Peng, Hsiang‐Chieh Lee, Mark Yen‐Ping Kuo, Shih‐Jung Cheng
Cancer Sci. 2023 Oct; 114(10): 3957–3971. Published online 2023 Jul 26. doi: 10.1111/cas.15912
PMCID:
PMC10551584
AbstractArticlePDF–48M
6.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities
Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji
Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888
PMCID:
PMC10191441
AbstractArticlePDF–2.4M
7.
Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development
Patricia G. Santamaría, Pierre Dubus, José Bustos-Tauler, Alfredo Floristán, Alberto Vázquez-Naharro, Saleta Morales, Amparo Cano, Francisco Portillo
Int J Mol Sci. 2022 May; 23(10): 5730. Published online 2022 May 20. doi: 10.3390/ijms23105730
PMCID:
PMC9144032
AbstractArticlePDF–2.1M
8.
An in situ activity assay for lysyl oxidases
Huilei Wang, Alan Poe, Lydia Pak, Kavitha Nandakumar, Sandeep Jandu, Jochen Steppan, Reik Löser, Lakshmi Santhanam
Commun Biol. 2021; 4: 840. Published online 2021 Jul 5. doi: 10.1038/s42003-021-02354-0
Correction in:
Commun Biol. 2021; 4: 1110.
PMCID:
PMC8257687
AbstractArticlePDF–3.4M
9.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
10.
LOXL2 promotes aggrecan and gender-specific anabolic differences to TMJ cartilage
Mustafa M. Tashkandi, Saqer F. Alsaqer, Thabet Alhousami, Faiza Ali, Yu-Chiao Wu, Jennifer Shin, Pushkar Mehra, Larry M. Wolford, Louis C. Gerstenfeld, Mary B. Goldring, Manish V. Bais
Sci Rep. 2020; 10: 20179. Published online 2020 Nov 19. doi: 10.1038/s41598-020-77178-9
PMCID:
PMC7678826
AbstractArticlePDF–3.6M
11.
Lysyl oxidase like-2 contributes to renal fibrosis in Col4a3/Alport Mice.
Dominic Cosgrove, Brianna Dufek, Daniel T. Meehan, Duane Delimont, Michael Hartnett, Gina Samuelson, Michael Anne Gratton, Grady Phillips, Deidre A. MacKenna, Gretchen Bain
Kidney Int. Author manuscript; available in PMC 2020 Sep 29.
Published in final edited form as: Kidney Int. 2018 Aug; 94(2): 303–314. Published online 2018 May 16. doi: 10.1016/j.kint.2018.02.024
PMCID:
PMC7523185
AbstractArticlePDF–1.6M
12.
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis
Mordehay Klepfish, Tamar Gross, Milena Vugman, Nikolaos A. Afratis, Sapir Havusha-Laufer, Eli Brazowski, Inna Solomonov, Chen Varol, Irit Sagi
Front Immunol. 2020; 11: 480. Published online 2020 Mar 31. doi: 10.3389/fimmu.2020.00480
PMCID:
PMC7136575
AbstractArticlePDF–2.5M
13.
miR-29a is repressed by MYC in pancreatic cancer and its restoration drives tumor suppressive effects via downregulation of LOXL2
Shatovisha Dey, Jason J. Kwon, Sheng Liu, Gabriel A. Hodge, Solaema Taleb, Teresa A. Zimmers, Jun Wan, Janaiah Kota
Mol Cancer Res. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: Mol Cancer Res. 2020 Feb; 18(2): 311–323. Published online 2019 Oct 29. doi: 10.1158/1541-7786.MCR-19-0594
PMCID:
PMC7002266
AbstractArticlePDF–2.1M
14.
Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice
Mustafa Tashkandi, Faiza Ali, Saqer Alsaqer, Thabet Alhousami, Amparo Cano, Alberto Martin, Fernando Salvador, Francisco Portillo, Louis C. Gerstenfeld, Mary B. Goldring, Manish V. Bais
Int J Mol Sci. 2019 Oct; 20(19): 4798. Published online 2019 Sep 27. doi: 10.3390/ijms20194798
PMCID:
PMC6801581
AbstractArticlePDF–3.7M
15.
Lysyl oxidase-like 2 depletion is protective in age-associated vascular stiffening
Jochen Steppan, Huilei Wang, Yehudit Bergman, Marcel J. Rauer, Siqi Tan, Sandeep Jandu, Kavitha Nandakumar, Sebastian Barreto-Ortiz, Robert N. Cole, Tatiana N. Boronina, Wanqu Zhu, Marc K. Halushka, Steven S. An, Dan E. Berkowitz, Lakshmi Santhanam
Am J Physiol Heart Circ Physiol. 2019 Jul 1; 317(1): H49–H59. Published online 2019 Apr 19. doi: 10.1152/ajpheart.00670.2018
PMCID:
PMC6692735
AbstractArticle
16.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
17.
Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation
Katharina Isabelle Kober, Amparo Cano, Cyrill Géraud, Kalle Sipilä, Seyedeh Atefeh Mobasseri, Christina Philippeos, Angela Oliveira Pisco, Andrew Stannard, Alberto Martin, Fernando Salvador, Vanesa Santos, Michael Boutros, Emanuel Rognoni, Fiona M. Watt
PLoS One. 2018; 13(6): e0199679. Published online 2018 Jun 28. doi: 10.1371/journal.pone.0199679
PMCID:
PMC6023175
AbstractArticlePDF–26M
18.
Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer
Fernando Salvador, Alberto Martin, Celia López-Menéndez, Gema Moreno-Bueno, Vanesa Santos, Alberto Vázquez-Naharro, Patricia G. Santamaria, Saleta Morales, Pierre R. Dubus, Laura Muinelo-Romay, Rafael López-López, Jason C. Tung, Valerie M. Weaver, Francisco Portillo, Amparo Cano
Cancer Res. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Cancer Res. 2017 Nov 1; 77(21): 5846–5859. Published online 2017 Jul 18. doi: 10.1158/0008-5472.CAN-16-3152
Correction in:
Cancer Res. 2023 Mar 15; 83(6): 974.
PMCID:
PMC5656180
AbstractArticlePDF–2.9M
19.
Lysyl oxidase-like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis
Sung-Eun Choi, Nara Jeon, Hoon Young Choi, Jae Il Shin, Hyeon Joo Jeong, Beom Jin Lim
Mol Med Rep. 2017 Sep; 16(3): 2477–2482. Published online 2017 Jul 4. doi: 10.3892/mmr.2017.6918
PMCID:
PMC5548064
AbstractArticlePDF–1.7M
20.
ZEB1 Induces LOXL2-Mediated Collagen Stabilization and Deposition in the Extracellular Matrix to Drive Lung Cancer Invasion and Metastasis
David H. Peng, Christin Ungewiss, Pan Tong, Lauren A. Byers, Jing Wang, Jaime Rodriguez Canales, Pamela A. Villalobos, Naohiro Uraoka, Barbara Mino, Carmen Behrens, Ignacio I. Wistuba, Richard I Han, Charles A. Wanna, Monica Fahrenholtz, Kathryn Jane Grande-Allen, Chad J. Creighton, Don L. Gibbons
Oncogene. Author manuscript; available in PMC 2017 Apr 7.
Published in final edited form as: Oncogene. 2017 Apr 6; 36(14): 1925–1938. Published online 2016 Oct 3. doi: 10.1038/onc.2016.358
PMCID:
PMC5378666
AbstractArticlePDF–1.8M

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