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Select item 108508181.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 103782752.

The Molecular Pathogenesis of Tumor-Suppressive miR-486-5p and miR-486-3p Target Genes: GINS4 Facilitates Aggressiveness in Lung Adenocarcinoma

Yuya Tomioka, Takayuki Suetsugu, Naohiko Seki, Kengo Tanigawa, Yoko Hagihara, Masahiro Shinmura, Shunichi Asai, Naoko Kikkawa, Hiromasa Inoue, Keiko Mizuno

Cells. 2023 Jul; 12(14): 1885. Published online 2023 Jul 18. doi: 10.3390/cells12141885

PMCID:: PMC10378275

Abstract Article PDF–7.8M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 96754564.

Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia

Matilde I. Conte, M. Cecilia Poli, Angelo Taglialatela, Giuseppe Leuzzi, Ivan K. Chinn, Sandra A. Salinas, Emma Rey-Jurado, Nixa Olivares, Liz Veramendi-Espinoza, Alberto Ciccia, James R. Lupski, Juan Carlos Aldave Becerra, Emily M. Mace, Jordan S. Orange

JCI Insight. 2022 Nov 8; 7(21): e154948. Published online 2022 Nov 8. doi: 10.1172/jci.insight.154948

PMCID:: PMC9675456

Abstract Article PDF–2.0M

Select item 93655675.

Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma

Kexin Zhang, Jian Zhou, Tong Wu, Qunyan Tian, Tang Liu, Wanchun Wang, Hua Zhong, Ziyuan Chen, Xungang Xiao, Gen Wu

Aging (Albany NY) 2022 Jul 31; 14(14): 5895–5907. Published online 2022 Jul 27. doi: 10.18632/aging.204191

PMCID:: PMC9365567

Abstract Article PDF–2.0M

Select item 89763716.

GINS4 might be a novel prognostic immune-related biomarker of not only esophageal squamous cell carcinoma and other cancers

Donghui Jin, Ligong Yuan, Feng Li, Shuaibo Wang, Yousheng Mao

BMC Med Genomics. 2022; 15: 75. Published online 2022 Apr 1. doi: 10.1186/s12920-022-01223-x

PMCID:: PMC8976371

Abstract Article PDF–7.7M

Select item 87442697.

Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle

Li Zhu, Xinyu Li, Henan Xu, Lifeng Fu, George Fu Gao, Wenjun Liu, Linqing Zhao, Xiaojun Wang, Wei Jiang, Min Fang

J Gen Virol. 2021; 102(12): 001697. Published online 2021 Dec 9. doi: 10.1099/jgv.0.001697

PMCID:: PMC8744269

Abstract Article PDF–10M

Select item 84619168.

Overexpression of GINS4 is associated with poor prognosis and survival in glioma patients

Binfeng Liu, Zhendong Liu, Yanbiao Wang, Xiaoyu Lian, Zhibin Han, Xingbo Cheng, Yongjie Zhu, Runze Liu, Yaoye Zhao, Yanzheng Gao

Mol Med. 2021; 27: 117. Published online 2021 Sep 23. doi: 10.1186/s10020-021-00378-0

PMCID:: PMC8461916

Abstract Article PDF–9.7M

Select item 83641819.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 835296410.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 833109211.

Reconstitution of human CMG helicase ubiquitylation by CUL2^LRR1 and multiple E2 enzymes

Thanh Thi Le, Johanna Ainsworth, Cristian Polo Rivera, Thomas Macartney, Karim P.M. Labib

Biochem J. 2021 Jul 30; 478(14): 2825–2842. Prepublished online 2021 Jun 29. Published online 2021 Jul 23. doi: 10.1042/BCJ20210315

PMCID:: PMC8331092

Abstract Article PDF–1.9M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 760600813.

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A

Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng

Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676

PMCID:: PMC7606008

Abstract Article PDF–2.5M

Select item 742732714.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 730600515.

Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer

Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanović, Katherine Murphy, Binbin Wang, Xintao Qiu, Jennifer E. Endress, Jaime Reyes, Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Tengfei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D’Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, X. Shirley Liu, Henry Long, Myles Brown, Jason S. Carroll, Joan S. Brugge, James Bradner, Franziska Michor, Kornelia Polyak

Mol Cell. Author manuscript; available in PMC 2021 Jun 18.

Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1096–1113.e8. Published online 2020 May 15. doi: 10.1016/j.molcel.2020.04.027

PMCID:: PMC7306005

Abstract Article PDF–3.2M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 715684017.

GINS complex subunit 4, a prognostic biomarker and reversely mediated by Krüppel‐like factor 4, promotes the growth of colorectal cancer

Zeyin Rong, Zai Luo, Jianming Zhang, Tengfei Li, Zhonglin Zhu, Zhilong Yu, Zhongmao Fu, Zhengjun Qiu, Chen Huang

Cancer Sci. 2020 Apr; 111(4): 1203–1217. Published online 2020 Mar 17. doi: 10.1111/cas.14341

PMCID:: PMC7156840

Abstract Article PDF–3.2M

Select item 685705018.

The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42

Zhonglin Zhu, Zhilong Yu, Zeyin Rong, Zai Luo, Jing Zhang, Zhengjun Qiu, Chen Huang

Theranostics. 2019; 9(26): 8294–8311. Published online 2019 Oct 21. doi: 10.7150/thno.36256

PMCID:: PMC6857050

Abstract Article PDF–4.1M

Select item 674264619.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 659924420.

LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer

Rui Yang, Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Fenglei Yu, Ya Cao, Qin Yan, Shuang Liu, Yongguang Tao

J Exp Clin Cancer Res. 2019; 38: 280. Published online 2019 Jun 28. doi: 10.1186/s13046-019-1276-y

PMCID:: PMC6599244

Abstract Article PDF–6.6M

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