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Select item 110723271.

Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells

Nikhil Ponnoor Anto, Awadhesh Kumar Arya, Amitha Muraleedharan, Jakeer Shaik, Pulak Ranjan Nath, Etta Livneh, Zuoming Sun, Alex Braiman, Noah Isakov

Cell Mol Life Sci. 2023 Jan; 80(1): 7. Published online 2022 Dec 10. doi: 10.1007/s00018-022-04657-9

PMCID:: PMC11072327

Abstract Article PDF–3.1M

Select item 102583072.

Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain

Cédric Mongellaz, Rita Vicente, Lenora M. Noroski, Nelly Noraz, Valérie Courgnaud, Javier Chinen, Emilia Faria, Valérie S. Zimmermann, Naomi Taylor

Front Immunol. 2023; 14: 1155883. Published online 2023 May 29. doi: 10.3389/fimmu.2023.1155883

PMCID:: PMC10258307

Abstract Article PDF–12M

Select item 94550823.

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling

Annika Schultz, Marvin Schnurra, Ali El-Bizri, Nadine M. Woessner, Sara Hartmann, Roland Hartig, Susana Minguet, Burkhart Schraven, Luca Simeoni

Cells. 2022 Sep; 11(17): 2723. Published online 2022 Sep 1. doi: 10.3390/cells11172723

PMCID:: PMC9455082

Abstract Article PDF–1.7M

Select item 90473004.

AQP9 and ZAP70 as immune-related prognostic biomarkers suppress proliferation, migration and invasion of laryngeal cancer cells

Li Ren, Ping Li, Zhouping Li, Quan Chen

BMC Cancer. 2022; 22: 465. Published online 2022 Apr 28. doi: 10.1186/s12885-022-09458-8

PMCID:: PMC9047300

Abstract Article PDF–12M

Select item 88923395.

Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor

Jesse Goyette, David Depoil, Zhengmin Yang, Samuel A. Isaacson, Jun Allard, P. Anton van der Merwe, Katharina Gaus, Michael L. Dustin, Omer Dushek

Proc Natl Acad Sci U S A. 2022 Mar 1; 119(9): e2116815119. Published online 2022 Feb 23. doi: 10.1073/pnas.2116815119

PMCID:: PMC8892339

Abstract Article PDF–2.3M

Select item 87890986.

T and NK cell lymphoma cell lines do not rely on ZAP-70 for survival

Sanjay de Mel, Nurulhuda Mustafa, Viknesvaran Selvarajan, Muhammad Irfan Azaman, Patrick William Jaynes, Shruthi Venguidessane, Hoang Mai Phuong, Zubaida Talal Alnaseri, The Phyu, Louis-Pierre Girard, Wee Joo Chng, Joanna Wardyn, Ying Li, Omer An, Henry Yang, Siok Bian Ng, Anand D. Jeyasekharan

PLoS One. 2022; 17(1): e0261469. Published online 2022 Jan 25. doi: 10.1371/journal.pone.0261469

PMCID:: PMC8789098

Abstract Article PDF–1.8M

Select item 86371467.

The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling

Mobashar Hussain Urf Turabe Fazil, Chandra Sekhar Chirumamilla, Claudina Perez-Novo, Brandon Han Siang Wong, Sunil Kumar, Siu Kwan Sze, Wim Vanden Berghe, Navin Kumar Verma

J Biol Chem. 2021 Dec; 297(6): 101377. Published online 2021 Nov 3. doi: 10.1016/j.jbc.2021.101377

PMCID:: PMC8637146

Abstract Article PDF–4.8M

Select item 86053738.

Differences in the dynamics of the tandem‐SH2 modules of the Syk and ZAP‐70 tyrosine kinases

Helen T. Hobbs, Neel H. Shah, Jean M. Badroos, Christine L. Gee, Susan Marqusee, John Kuriyan

Protein Sci. 2021 Dec; 30(12): 2373–2384. Published online 2021 Oct 23. doi: 10.1002/pro.4199

PMCID:: PMC8605373

Abstract Article PDF–5.8M

Select item 84095849.

TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection

Yongjian Wu, Minhao Wu, Siqi Ming, Xiaoxia Zhan, Shengfeng Hu, Xingyu Li, Huan Yin, Can Cao, Jiao Liu, Jinai Li, Zhilong Wu, Jie Zhou, Lei Liu, Sitang Gong, Duanman He, Xi Huang

J Clin Invest. 2021 Sep 1; 131(17): e137407. Published online 2021 Sep 1. doi: 10.1172/JCI137407

PMCID:: PMC8409584

Abstract Article PDF–12M

Select item 835867810.

Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological Synapse

Bonah Kim, Hee Young Kim, Won-Woo Lee

Front Immunol. 2021; 12: 687367. Published online 2021 Jul 29. doi: 10.3389/fimmu.2021.687367

PMCID:: PMC8358678

Abstract Article PDF–8.7M

Select item 835296411.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 831978912.

Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling

Kelsey Kaman, Monique Abrams, Kerry Dobbs, Luigi D. Notarangelo, Ottavia M. Delmonte, Boaz Palterer, Sung-Yun Pai, Alicia Johnston

J Clin Immunol. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: J Clin Immunol. 2021 Feb; 41(2): 470–472. Published online 2020 Nov 13. doi: 10.1007/s10875-020-00913-4

PMCID:: PMC8319789

Article PDF–403K

Select item 823933613.

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

Teresa Sadras, Mickaël Martin, Kohei Kume, Mark E. Robinson, Supraja Saravanakumar, Gal Lenz, Zhengshan Chen, Joo Y. Song, Tanya Siddiqi, Laura Oksa, Anne Marie Knapp, Jevon Cutler, Kadriye Nehir Cosgun, Lars Klemm, Veronika Ecker, Janet Winchester, Dana Ghergus, Pauline Soulas-Sprauel, Friedemann Kiefer, Nora Heisterkamp, Akhilesh Pandey, Vu Ngo, Lili Wang, Hassan Jumaa, Maike Buchner, Jürgen Ruland, Wing-Chung Chan, Eric Meffre, Thierry Martin, Markus Müschen

Mol Cell. Author manuscript; available in PMC 2022 May 20.

Published in final edited form as: Mol Cell. 2021 May 20; 81(10): 2094–2111.e9. Published online 2021 Apr 19. doi: 10.1016/j.molcel.2021.03.043

PMCID:: PMC8239336

Abstract Article PDF–3.6M

Select item 800913414.

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self ligands

Lin Shen, Mehrdad Matloubian, Theresa A. Kadlecek, Arthur Weiss

Sci Signal. Author manuscript; available in PMC 2021 Aug 2.

Published in final edited form as: Sci Signal. 2021 Feb 2; 14(668): eabc4479. Published online 2021 Feb 2. doi: 10.1126/scisignal.abc4479

PMCID:: PMC8009134

Abstract Article PDF–2.0M

Select item 794905815.

T cell receptor–dependent S-acylation of ZAP-70 controls activation of T cells

Ritika Tewari, Bieerkehazhi Shayahati, Ying Fan, Askar M. Akimzhanov

J Biol Chem. 2021 Jan-Jun; 296: 100311. Published online 2021 Jan 19. doi: 10.1016/j.jbc.2021.100311

PMCID:: PMC7949058

Abstract Article PDF–1.2M

Select item 790504016.

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer

Hantao Wang, Junjie Xing, Wei Wang, Guifen Lv, Haiyan He, Yeqing Lu, Mei Sun, Haiyan Chen, Xu Li

Front Cell Dev Biol. 2020; 8: 601502. Published online 2021 Feb 11. doi: 10.3389/fcell.2020.601502

PMCID:: PMC7905040

Abstract Article PDF–3.2M

Select item 734034317.

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Jesse E. Jun, Kayla R. Kulhanek, Hang Chen, Arup Chakraborty, Jeroen P. Roose

Sci Signal. Author manuscript; available in PMC 2020 Jul 7.

Published in final edited form as: Sci Signal. 2019 Jul 23; 12(591): eaao0736. Published online 2019 Jul 23. doi: 10.1126/scisignal.aao0736

PMCID:: PMC7340343

Abstract Article PDF–2.4M

Select item 721480018.

Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review

Niusha Sharifinejad, Mahnaz Jamee, Majid Zaki-Dizaji, Bernice Lo, Mohammadreza Shaghaghi, Hamed Mohammadi, Farhad Jadidi-Niaragh, Shiva Shaghaghi, Reza Yazdani, Hassan Abolhassani, Asghar Aghamohammadi, Gholamreza Azizi

Front Immunol. 2020; 11: 831. Published online 2020 May 5. doi: 10.3389/fimmu.2020.00831

PMCID:: PMC7214800

Abstract Article PDF–704K

Select item 719584919.

Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling

Jiji Xie, Xuemei Han, Chensi Zhao, Ann J. Canonigo-Balancio, John R. Yates, III, Yingqiu Li, Björn F. Lillemeier, Amnon Altman

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2019 Apr 16; 12(577): eaar3349. Published online 2019 Apr 16. doi: 10.1126/scisignal.aar3349

PMCID:: PMC7195849

Abstract Article PDF–2.0M

Select item 698120620.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

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