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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 94276892.

IL-13Rα1-Mediated Signaling Regulates Age-Associated/Autoimmune B-Cell Expansion and Lupus Pathogenesis

Zhu Chen, Danny Flores Castro, Sanjay Gupta, Swati Phalke, Michela Manni, Juan Rivera-Correa, Rolf Jessberger, Habib Zaghouani, Evgenia Giannopoulou, Tania Pannellini, Alessandra B. Pernis

Arthritis Rheumatol. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2022 Sep; 74(9): 1544–1555. Published online 2022 Aug 22. doi: 10.1002/art.42146

PMCID:: PMC9427689

Abstract Article PDF–1.2M

Select item 83551593.

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice

Edd Ricker, Michela Manni, Danny Flores-Castro, Daniel Jenkins, Sanjay Gupta, Juan Rivera-Correa, Wenzhao Meng, Aaron M. Rosenfeld, Tania Pannellini, Mahesh Bachu, Yurii Chinenov, Peter K. Sculco, Rolf Jessberger, Eline T. Luning Prak, Alessandra B. Pernis

Nat Commun. 2021; 12: 4813. Published online 2021 Aug 10. doi: 10.1038/s41467-021-25102-8

PMCID:: PMC8355159

Abstract Article PDF–7.5M

Select item 77719614.

Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

Zhonghao Deng, Courtney Ng, Kazuki Inoue, Ziyu Chen, Yuhan Xia, Xiaoyu Hu, Matthew Greenblatt, Alessandra Pernis, Baohong Zhao

eLife. 2020; 9: e59659. Published online 2020 Dec 29. doi: 10.7554/eLife.59659

PMCID:: PMC7771961

Abstract Article PDF–1.2M

Select item 64595105.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194

PMCID:: PMC6459510

Abstract Article PDF–5.1M

Select item 63334606.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 60951397.

Regulation of Age-associated B cells by IRF5 in systemic autoimmunity

Michela Manni, Sanjay Gupta, Edd Ricker, Yurii Chinenov, Sung Ho Park, Man Shi, Tania Pannellini, Rolf Jessberger, Lionel Ivashkiv, Alessandra B. Pernis

Nat Immunol. Author manuscript; available in PMC 2018 Aug 26.

Published in final edited form as: Nat Immunol. 2018 Apr; 19(4): 407–419. Published online 2018 Feb 26. doi: 10.1038/s41590-018-0056-8

PMCID:: PMC6095139

Abstract Article PDF–1.1M

Select item 58774698.

Regulation of systemic autoimmunity and CD11c⁺ Tbet⁺ B cells by SWEF proteins

Michela Manni, Edd Ricker, Alessandra B. Pernis

Cell Immunol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Cell Immunol. 2017 Nov; 321: 46–51. Published online 2017 Jul 11. doi: 10.1016/j.cellimm.2017.05.010

PMCID:: PMC5877469

Abstract Article PDF–519K

Select item 57071899.

Def-6, a Novel Regulator of Small GTPases in Podocytes, Acts Downstream of Atypical Protein Kinase C (aPKC) λ/ι

Kirstin Worthmann, Michael Leitges, Beina Teng, Marcello Sestu, Irini Tossidou, Thomas Samson, Hermann Haller, Tobias B. Huber, Mario Schiffer

Am J Pathol. 2013 Dec; 183(6): 1945–1959. doi: 10.1016/j.ajpath.2013.08.026

PMCID:: PMC5707189

Abstract Article PDF–2.4M

Select item 555798210.

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity

Woelsung Yi, Sanjay Gupta, Edd Ricker, Michela Manni, Rolf Jessberger, Yurii Chinenov, Henrik Molina, Alessandra B. Pernis

Nat Commun. 2017; 8: 254. Published online 2017 Aug 15. doi: 10.1038/s41467-017-00348-3

PMCID:: PMC5557982

Abstract Article PDF–3.5M

Select item 542515611.

Def6 restrains osteoclastogenesis and inflammatory bone resorption¹

Nikolaus Binder, Christine Miller, Masaki Yoshida, Kazuki Inoue, Shinichi Nakano, Xiaoyu Hu, Lionel B. Ivashkiv, Georg Schett, Alessandra Pernis, Steven R. Goldring, F. Patrick Ross, Baohong Zhao

J Immunol. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: J Immunol. 2017 May 1; 198(9): 3436–3447. Published online 2017 Mar 17. doi: 10.4049/jimmunol.1601716

PMCID:: PMC5425156

Abstract Article PDF–2.3M

Select item 499919712.

SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells

Tatsiana Ripich, Carlos Andrés Chacón-Martínez, Luise Fischer, Alessandra Pernis, Nadine Kiessling, Annette I. Garbe, Rolf Jessberger

PLoS One. 2016; 11(8): e0161060. Published online 2016 Aug 25. doi: 10.1371/journal.pone.0161060

PMCID:: PMC4999197

Abstract Article PDF–2.6M

Select item 471281313.

SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1

Marjorie Côte, Camille Fos, Ann J. Canonigo-Balancio, Klaus Ley, Stéphane Bécart, Amnon Altman

J Cell Sci. 2015 Dec 1; 128(23): 4341–4352. doi: 10.1242/jcs.172742

PMCID:: PMC4712813

Abstract Article

Select item 463628514.

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus

Michela Manni, Sanjay Gupta, Briana G. Nixon, Casey T. Weaver, Rolf Jessberger, Alessandra B. Pernis

PLoS One. 2015; 10(11): e0141927. Published online 2015 Nov 6. doi: 10.1371/journal.pone.0141927

PMCID:: PMC4636285

Abstract Article PDF–3.3M

Select item 430011415.

Association of the EF-hand and PH domains of the guanine nucleotide exchange factor SLAT with IP₃ receptor 1 promotes Ca²⁺ signaling in T cells

Camille Fos, Stephane Becart, Ann J. Canonigo Balancio, Darren Boehning, Amnon Altman

Sci Signal. Author manuscript; available in PMC 2015 Jan 20.

Published in final edited form as: Sci Signal. 2014 Sep 30; 7(345): ra93. Published online 2014 Sep 30. doi: 10.1126/scisignal.2005565

PMCID:: PMC4300114

Abstract Article PDF–1.3M

Select item 388797816.

SLAT Negatively Regulates RANKL-Induced Osteoclast Differentiation

Bang Ung Youn, Kabsun Kim, Jung Ha Kim, Jongwon Lee, Jang Bae Moon, Inyoung Kim, Yong-Wook Park, Nacksung Kim

Mol Cells. 2013 Sep 30; 36(3): 252–257. Published online 2013 Aug 29. doi: 10.1007/s10059-013-0159-x

PMCID:: PMC3887978

Abstract Article PDF–9.1M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 352979218.

SLAT regulates CD8⁺ T cell clonal expansion in a Cdc42 and NFAT1 dependent manner

Sonia Feau, Stephen P. Schoenberger, Amnon Altman, Stéphane Bécart

J Immunol. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: J Immunol. 2013 Jan 1; 190(1): 174–183. Published online 2012 Nov 28. doi: 10.4049/jimmunol.1201685

PMCID:: PMC3529792

Abstract Article PDF–3.3M

Select item 339849519.

SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU)

Barbara P. Vistica, Guangpu Shi, Lindsey Nugent, Cuiyan Tan, Amnon Altman, Igal Gery

Mol Vis. 2012; 18: 1858–1864. Published online 2012 Jul 7.

PMCID:: PMC3398495

Abstract Article PDF–950K

Select item 330223720.

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity

Partha S. Biswas, Sanjay Gupta, Roslynn A. Stirzaker, Varsha Kumar, Rolf Jessberger, Theresa T. Lu, Govind Bhagat, Alessandra B. Pernis

J Exp Med. 2012 Mar 12; 209(3): 581–596. doi: 10.1084/jem.20111195

PMCID:: PMC3302237

Abstract Article PDF–2.9M

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