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Select item 109436461.

Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice

Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen

eBioMedicine. 2024 Apr; 102: 105045. Published online 2024 Mar 11. doi: 10.1016/j.ebiom.2024.105045

PMCID:: PMC10943646

Abstract Article PDF–2.1M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 99382163.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Abstract Article PDF–5.3M

Select item 95591744.

Validation of superior reference genes in mouse submandibular glands under developmental and functional regeneration states

Huikai Liu, Liwen He, Qianyu Cheng, Wenping Luo, Tianyu Zhao, Deqin Yang

Int J Mol Med. 2022 Nov; 50(5): 132. Published online 2022 Sep 5. doi: 10.3892/ijmm.2022.5188

PMCID:: PMC9559174

Abstract Article PDF–2.9M

Select item 91775995.

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB

Minho Won, Kyeong Ah Park, Sup Kim, Eunjin Ju, Youngbok Ko, Heonjong Yoo, Hyunju Ro, Jaeseob Lee, Junseo Oh, Eun Gyo Lee, Sang Yean Kim, Suk Woo Nam, Han-Ming Shen, Min-Kyung Yeo, Jin Man Kim, Gang Min Hur

Cell Death Differ. 2022 Jun; 29(6): 1152–1163. Published online 2021 Nov 27. doi: 10.1038/s41418-021-00906-9

PMCID:: PMC9177599

Abstract Article PDF–3.4M

Select item 91463846.

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development

Wenjing Xu, Nathan P. Nelson-Maney, László Bálint, Hyouk-Bum Kwon, Reema B. Davis, Danielle C. M. Dy, James M. Dunleavey, Brad St. Croix, Kathleen M. Caron

Int J Mol Sci. 2022 May; 23(10): 5712. Published online 2022 May 20. doi: 10.3390/ijms23105712

PMCID:: PMC9146384

Abstract Article PDF–3.9M

Select item 90626597.

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0

Fujun Hou, Zeyu Sun, Yue Deng, Siyu Chen, Xiyuan Yang, Feiyang Ji, Menghao Zhou, Keyi Ren, Dongli Pan

Front Microbiol. 2022; 13: 856471. Published online 2022 Apr 18. doi: 10.3389/fmicb.2022.856471

PMCID:: PMC9062659

Abstract Article PDF–3.5M

Select item 90107608.

Multiubiquitination of TRPV4 reduces channel activity independent of surface localization

William H. Aisenberg, Brett A. McCray, Jeremy M. Sullivan, Erika Diehl, Lauren R. DeVine, Jonathan Alevy, Anna M. Bagnell, Patrice Carr, Jack K. Donohue, Benedikt Goretzki, Robert N. Cole, Ute A. Hellmich, Charlotte J. Sumner

J Biol Chem. 2022 Apr; 298(4): 101826. Published online 2022 Mar 14. doi: 10.1016/j.jbc.2022.101826

PMCID:: PMC9010760

Abstract Article PDF–3.9M

Select item 89031959.

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum

Cell Rep. 2022 Mar 8; 38(10): 110434. Published online 2022 Mar 8. doi: 10.1016/j.celrep.2022.110434

PMCID:: PMC8903195

Abstract Article PDF–5.7M

Select item 869289610.

Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation

Rongqing Li, Xueqin Li, Jie Zhao, Fandong Meng, Chen Yao, Ensi Bao, Na Sun, Xin Chen, Wanpeng Cheng, Hui Hua, Xiangyang Li, Bo Wang, Hui Wang, Xiucheng Pan, Hongjuan You, Jing Yang, Takayuki Ikezoe

Theranostics. 2022; 12(2): 976–998. Published online 2022 Jan 1. doi: 10.7150/thno.63751

PMCID:: PMC8692896

Abstract Article PDF–3.7M

Select item 755684711.

USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis

Jaehyun Kim, Junnosuke Nakamura, Chiharu Hamada, Takumi Taketomi, Sarasa Yano, Tomomi Okajima, Shin-ichi Kashiwabara, Tadashi Baba, Ban Sato, Tomoki Chiba, Fuminori Tsuruta

Mol Cell Biol. 2020 Nov; 40(21): e00098-20. Prepublished online 2020 Aug 24. Published online 2020 Oct 13. doi: 10.1128/MCB.00098-20

PMCID:: PMC7556847

Abstract Article PDF–3.9M

Select item 746949912.

PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies

Shinrye Lee, Yu-Mi Jeon, Sun Joo Cha, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim, Hyung-Jun Kim

Autophagy. 2020; 16(8): 1396–1412. Published online 2019 Nov 5. doi: 10.1080/15548627.2019.1686729

PMCID:: PMC7469499

Abstract Article PDF–6.9M

Select item 733750913.

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling

Paurav B. Desai, Michael W. Stuck, Bo Lv, Gregory J. Pazour

J Cell Biol. 2020 Jul 6; 219(7): e201912104. Published online 2020 May 20. doi: 10.1083/jcb.201912104

PMCID:: PMC7337509

Abstract Article PDF–4.2M

Select item 719587514.

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Sirish K. Ippagunta, Julie A. Pollock, Naina Sharma, Wenwei Lin, Taosheng Chen, Kazuki Tawaratsumida, Anthony A. High, Jaeki Min, Yizhe Chen, R. Kiplin Guy, Vanessa Redecke, John A. Katzenellenbogen, Hans Häcker

Sci Signal. Author manuscript; available in PMC 2020 May 2.

Published in final edited form as: Sci Signal. 2018 Aug 14; 11(543): eaaq1077. Published online 2018 Aug 14. doi: 10.1126/scisignal.aaq1077

PMCID:: PMC7195875

Abstract Article PDF–1.7M

Select item 714484015.

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen, Zhenyu Yue

Autophagy. 2020; 16(5): 917–931. Published online 2019 Jul 30. doi: 10.1080/15548627.2019.1644076

PMCID:: PMC7144840

Abstract Article PDF–5.3M

Select item 663562416.

Topologically correct central projections of tetrapod inner ear afferents require Fzd3

Jeremy S. Duncan, Bernd Fritzsch, Douglas W. Houston, Elizabeth M. Ketchum, Jennifer Kersigo, Michael R. Deans, Karen L. Elliott

Sci Rep. 2019; 9: 10298. Published online 2019 Jul 16. doi: 10.1038/s41598-019-46553-6

PMCID:: PMC6635624

Abstract Article PDF–7.9M

Select item 661898217.

p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model

Hideki Doi, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Shinjiro Matsumoto, Naohide Kondo, Yu Miyazaki, Madoka Iida, Genki Tohnai, Qiang Qiang, Fumiaki Tanaka, Toru Yanagawa, Eiji Warabi, Tetsuro Ishii, Gen Sobue

J Neurosci. 2013 May 1; 33(18): 7710–7727. doi: 10.1523/JNEUROSCI.3021-12.2013

PMCID:: PMC6618982

Abstract Article PDF–7.6M

Select item 652743918.

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

M. Di Rienzo, M. Antonioli, C. Fusco, Y. Liu, M. Mari, I. Orhon, G. Refolo, F. Germani, M. Corazzari, A. Romagnoli, F. Ciccosanti, B. Mandriani, M. T. Pellico, R. De La Torre, H. Ding, M. Dentice, M. Neri, A. Ferlini, F. Reggiori, M. Kulesz-Martin, M. Piacentini, G. Merla, G. M. Fimia

Sci Adv. 2019 May; 5(5): eaau8857. Published online 2019 May 8. doi: 10.1126/sciadv.aau8857

PMCID:: PMC6527439

Abstract Article PDF–4.3M

Select item 634668519.

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells

Farzad Asadi, Savita Dhanvantari

Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792

PMCID:: PMC6346685

Abstract Article PDF–3.6M

Select item 624418320.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

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