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Select item 110350631.

Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA

Kanal Elamparithi Balu, Mitchell Gulkis, Danah Almohdar, Melike Çağlayan

J Biol Chem. 2024 May; 300(5): 107216. Published online 2024 Mar 24. doi: 10.1016/j.jbc.2024.107216

PMCID:: PMC11035063

Abstract Article PDF–3.4M

Select item 103479602.

The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese

SHANG-MIAO CHANG, YA-CHEN YANG, GUAN-LIANG CHEN, LI-HSIOU CHEN, TE-CHUN SHEN, YEN-FENG LIU, YUN-CHI WANG, CHIA-WEN TSAI, TE-CHUN HSIA, DA-TIAN BAU, WEN-SHIN CHANG

In Vivo. 2023 Jul-Aug; 37(4): 1504–1510. Published online 2023 Jul 3. doi: 10.21873/invivo.13235

PMCID:: PMC10347960

Abstract Article PDF–131K

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100205464.

Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1

Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Pierre-Antoine Defossez, Alan E. Tomkinson

Sci Rep. 2023; 13: 4363. Published online 2023 Mar 16. doi: 10.1038/s41598-023-31367-4

PMCID:: PMC10020546

Abstract Article PDF–3.7M

Select item 98811305.

Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity

Justin R McNally, Amanda M Ames, Suzanne J Admiraal, Patrick J O’Brien

Nucleic Acids Res. 2023 Jan 25; 51(2): 796–805. Published online 2023 Jan 10. doi: 10.1093/nar/gkac1263

PMCID:: PMC9881130

Abstract Article PDF–1.9M

Select item 97696986.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 94339387.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 92792858.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 889702210.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 875541911.

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation

Yuzheng Zhou, Rong Zheng, Sixu Liu, Cyrollah Disoma, Ashuai Du, Shiqin Li, Zongpeng Chen, Zijun Dong, Yongxing Zhang, Sijia Li, Pinjia Liu, Aroona Razzaq, Xuan Chen, Yujie Liao, Siyi Tao, Yuxin Liu, Lunan Xu, Qianjun Zhang, Jian Peng, Xu Deng, Shanni Li, Taijiao Jiang, Zanxian Xia

J Biol Chem. 2022 Feb; 298(2): 101584. Published online 2022 Jan 13. doi: 10.1016/j.jbc.2022.101584

PMCID:: PMC8755419

Abstract Article PDF–3.5M

Select item 872704712.

Human DNA ligases in replication and repair

Annahita Sallmyr, Ishtiaque Rashid, Seema Khattri Bhandari, Tasmin Naila, Alan E. Tomkinson

DNA Repair (Amst) Author manuscript; available in PMC 2022 Jan 4.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102908. doi: 10.1016/j.dnarep.2020.102908

PMCID:: PMC8727047

Abstract Article PDF–1.5M

Select item 872704313.

Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation

Yoshihiro Matsumoto, Rhys C. Brooks, Aleksandr Sverzhinsky, John M. Pascal, Alan E. Tomkinson

J Mol Biol. Author manuscript; available in PMC 2022 Jan 4.

Published in final edited form as: J Mol Biol. 2020 Dec 4; 432(24): 166698. Published online 2020 Nov 4. doi: 10.1016/j.jmb.2020.10.032

PMCID:: PMC8727043

Abstract Article PDF–2.5M

Select item 834401614.

Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers

Reem Ali, Muslim Alabdullah, Mashael Algethami, Adel Alblihy, Islam Miligy, Ahmed Shoqafi, Katia A. Mesquita, Tarek Abdel-Fatah, Stephen YT Chan, Pei Wen Chiang, Nigel P Mongan, Emad A Rakha, Alan E Tomkinson, Srinivasan Madhusudan

Theranostics. 2021; 11(17): 8350–8361. Published online 2021 Jul 25. doi: 10.7150/thno.51456

PMCID:: PMC8344016

Abstract Article PDF–2.5M

Select item 822039115.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 802470917.

DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized and mismatch nucleotide insertion products in base excision repair

Pradnya Kamble, Kalen Hall, Mahesh Chandak, Qun Tang, Melike Çağlayan

J Biol Chem. 2021 Jan-Jun; 296: 100427. Published online 2021 Feb 16. doi: 10.1016/j.jbc.2021.100427

PMCID:: PMC8024709

Abstract Article PDF–4.3M

Select item 789752018.

LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency

Thomas J Jurkiw, Percy P Tumbale, Matthew J Schellenberg, Charlotte Cunningham-Rundles, R Scott Williams, Patrick J O’Brien

Nucleic Acids Res. 2021 Feb 22; 49(3): 1619–1630. Published online 2021 Jan 14. doi: 10.1093/nar/gkaa1297

PMCID:: PMC7897520

Abstract Article PDF–11M

Select item 784618919.

DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage

Qun Tang, Pradnya Kamble, Melike Çağlayan

Mutagenesis. 2020 Sep; 35(5): 391–404. Published online 2020 Sep 11. doi: 10.1093/mutage/geaa023

PMCID:: PMC7846189

Abstract Article PDF–3.9M

Select item 758520320.

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells

Robert M. Vaughan, Ariana Kupai, Caroline A. Foley, Cari A. Sagum, Bailey M. Tibben, Hope E. Eden, Rochelle L. Tiedemann, Christine A. Berryhill, Varun Patel, Kevin M. Shaw, Krzysztof Krajewski, Brian D. Strahl, Mark T. Bedford, Stephen V. Frye, Bradley M. Dickson, Scott B. Rothbart

Epigenetics Chromatin. 2020; 13: 44. Published online 2020 Oct 23. doi: 10.1186/s13072-020-00366-4

PMCID:: PMC7585203

Abstract Article PDF–5.8M

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