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Select item 104998211.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson

Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8

PMCID:: PMC10499821

Abstract Article PDF–2.6M

Select item 96330532.

RGS3 and IL1RAPL1 missense variants implicate defective neurotransmission in early-onset inherited schizophrenias

Ambreen Kanwal, José V. Pardo, Sadaf Naz

J Psychiatry Neurosci. 2022 Nov-Dec; 47(6): E379–E390. Published online 2022 Nov 1. doi: 10.1503/jpn.220070

PMCID:: PMC9633053

Abstract Article PDF–888K

Select item 95962093.

Pseudogene UBE2MP1 derived transcript enhances in vitro cell proliferation and apoptosis resistance of hepatocellular carcinoma cells through miR-145-5p/RGS3 axis

Fengjie Hao, Nan Wang, Honglian Gui, Yifan Zhang, Zhiyuan Wu, Junqing Wang

Aging (Albany NY) 2022 Oct 15; 14(19): 7906–7925. Published online 2022 Oct 7. doi: 10.18632/aging.204319

PMCID:: PMC9596209

Abstract Article PDF–2.1M

Select item 92950104.

The G-protein signaling regulator RGS3 enhances the GTPase activity of KRAS

Chuanchuan Li, Alberto Vides, Dongsung Kim, Jenny Xue, Yulei Zhao, Piro Lito

Science. Author manuscript; available in PMC 2022 Jul 19.

Published in final edited form as: Science. 2021 Oct 8; 374(6564): 197–201. Published online 2021 Oct 7. doi: 10.1126/science.abf1730

PMCID:: PMC9295010

Abstract Article PDF–1.3M

Select item 82501315.

Host PDZ‐containing proteins targeted by SARS‐CoV‐2

Célia Caillet‐Saguy, Fabien Durbesson, Veronica V. Rezelj, Gergö Gogl, Quang Dinh Tran, Jean‐Claude Twizere, Marco Vignuzzi, Renaud Vincentelli, Nicolas Wolff

FEBS J. 2021 Sep; 288(17): 5148–5162. Published online 2021 May 1. doi: 10.1111/febs.15881

PMCID:: PMC8250131

Abstract Article PDF–1.4M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75032227.

Pro- and anti-apoptotic dual functions of the C5a receptor: involvement of regulator of G protein signaling 3 and extracellular signal-regulated kinase

Hiroshi Nishiura, Hideo Nonaka, Ivette S Revollo, Umeko Semba, Ying Li, Yoshihiko Ota, Atsushi Irie, Kumiko Harada, John H Kehrl, Tetsuro Yamamoto

Lab Invest. Author manuscript; available in PMC 2020 Sep 21.

Published in final edited form as: Lab Invest. 2009 Jun; 89(6): 676–694. Published online 2009 Mar 30. doi: 10.1038/labinvest.2009.27

PMCID:: PMC7503222

Abstract Article PDF–8.1M

Select item 74273278.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 655243210.

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression

Jung-Sik Kim, Xiaoyuan He, Jie Liu, Zhijun Duan, Taeyeon Kim, Julia Gerard, Brian Kim, Manoj M. Pillai, William S. Lane, William S. Noble, Bogdan Budnik, Todd Waldman

J Biol Chem. 2019 May 31; 294(22): 8760–8772. Published online 2019 Apr 22. doi: 10.1074/jbc.RA119.007832

PMCID:: PMC6552432

Abstract Article PDF–3.5M

Select item 645814011.

A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function

Akram Yazdani, Azam Yazdani, Raúl Méndez Giráldez, David Aguilar, Luca Sartore

Sci Rep. 2019; 9: 5845. Published online 2019 Apr 10. doi: 10.1038/s41598-019-41362-3

PMCID:: PMC6458140

Abstract Article PDF–1.8M

Select item 616668212.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 604563113.

KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development

Anqi Geng, Runxiang Qiu, Kiyohito Murai, Jiancheng Liu, Xiwei Wu, Heying Zhang, Henry Farhoodi, Nam Duong, Meisheng Jiang, Jiing-kuan Yee, Walter Tsark, Qiang Lu

Nat Commun. 2018; 9: 2707. Published online 2018 Jul 13. doi: 10.1038/s41467-018-05152-1

PMCID:: PMC6045631

Abstract Article PDF–8.3M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 426658815.

A proteome-scale map of the human interactome network

Thomas Rolland, Murat Taşan, Benoit Charloteaux, Samuel J. Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, Irma Lemmens, Celia Fontanillo, Roberto Mosca, Atanas Kamburov, Susan D. Ghiassian, Xinping Yang, Lila Ghamsari, Dawit Balcha, Bridget E. Begg, Pascal Braun, Marc Brehme, Martin P. Broly, Anne-Ruxandra Carvunis, Dan Convery-Zupan, Roser Corominas, Jasmin Coulombe-Huntington, Elizabeth Dann, Matija Dreze, Amélie Dricot, Changyu Fan, Eric Franzosa, Fana Gebreab, Bryan J. Gutierrez, Madeleine F. Hardy, Mike Jin, Shuli Kang, Ruth Kiros, Guan Ning Lin, Katja Luck, Andrew MacWilliams, Jörg Menche, Ryan R. Murray, Alexandre Palagi, Matthew M. Poulin, Xavier Rambout, John Rasla, Patrick Reichert, Viviana Romero, Elien Ruyssinck, Julie M. Sahalie, Annemarie Scholz, Akash A. Shah, Amitabh Sharma, Yun Shen, Kerstin Spirohn, Stanley Tam, Alexander O. Tejeda, Shelly A. Wanamaker, Jean-Claude Twizere, Kerwin Vega, Jennifer Walsh, Michael E. Cusick, Yu Xia, Albert-László Barabási, Lilia M. Iakoucheva, Patrick Aloy, Javier De Las Rivas, Jan Tavernier, Michael A. Calderwood, David E. Hill, Tong Hao, Frederick P. Roth, Marc Vidal

Cell. Author manuscript; available in PMC 2015 Nov 20.

Published in final edited form as: Cell. 2014 Nov 20; 159(5): 1212–1226. doi: 10.1016/j.cell.2014.10.050

PMCID:: PMC4266588

Abstract Article PDF–3.1M

Select item 425026416.

DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis

Stefano Marchesi, Francesca Montani, Gianluca Deflorian, Rocco D’Antuono, Alessandro Cuomo, Serena Bologna, Carmela Mazzoccoli, Tiziana Bonaldi, Pier Paolo Di Fiore, Francesco Nicassio

Dev Cell. 2014 Nov 24; 31(4): 420–433. doi: 10.1016/j.devcel.2014.09.009

PMCID:: PMC4250264

Abstract Article

Select item 389433817.

Regulation of Protease-activated Receptor 1 Signaling by the Adaptor Protein Complex 2 and R4 Subfamily of Regulator of G Protein Signaling Proteins

Buxin Chen, David P. Siderovski, Richard R. Neubig, Mark A. Lawson, JoAnn Trejo

J Biol Chem. 2014 Jan 17; 289(3): 1580–1591. Published online 2013 Dec 2. doi: 10.1074/jbc.M113.528273

PMCID:: PMC3894338

Abstract Article PDF–2.4M

Select item 346044918.

Regulator of G-Protein Signaling 3 Isoform 1 (PDZ-RGS3) Enhances Canonical Wnt Signaling and Promotes Epithelial Mesenchymal Transition

Chong-Shan Shi, Ning-Na Huang, John H. Kehrl

J Biol Chem. 2012 Sep 28; 287(40): 33480–33487. Published online 2012 Aug 2. doi: 10.1074/jbc.M112.361873

PMCID:: PMC3460449

Abstract Article PDF–2.2M

Select item 332987119.

Regulation of Smad-Mediated Gene Transcription by RGS3

Douglas M. Yau, Nan Sethakorn, Sebastien Taurin, Steven Kregel, Nathan Sandbo, Blanca Camoretti-Mercado, Anne I. Sperling, Nickolai O. Dulin

Mol Pharmacol. Author manuscript; available in PMC 2012 Apr 19.

Published in final edited form as: Mol Pharmacol. 2008 May; 73(5): 1356–1361. Published online 2008 Feb 20. doi: 10.1124/mol.108.044990

PMCID:: PMC3329871

Abstract Article PDF–2.0M

Select item 332986920.

Gα_s-Biased β₂-Adrenergic Receptor Signaling from Restoring Synchronous Contraction in the Failing Heart

Khalid Chakir, Charlene Depry, Veronica L. Dimaano, Wei-Zhong Zhu, Marc Vanderheyden, Jozef Bartunek, Theodore P. Abraham, Gordon F. Tomaselli, Shu-bai Liu, Yang K. Xiang, Manling Zhang, Eiki Takimoto, Nickolai Dulin, Rui Ping Xiao, Jin Zhang, David A. Kass

Sci Transl Med. Author manuscript; available in PMC 2012 Sep 14.

Published in final edited form as: Sci Transl Med. 2011 Sep 14; 3(100): 100ra88. doi: 10.1126/scitranslmed.3001909

PMCID:: PMC3329869

Abstract Article PDF–2.2M

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