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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 103001222.

K235 acetylation couples with PSPC1 to regulate the m⁶A demethylation activity of ALKBH5 and tumorigenesis

Xiao-Lan Zhang, Xin-Hui Chen, Binwu Xu, Min Chen, Song Zhu, Nan Meng, Ji-Zhong Wang, Huifang Zhu, De Chen, Jin-Bao Liu, Guang-Rong Yan

Nat Commun. 2023; 14: 3815. Published online 2023 Jun 27. doi: 10.1038/s41467-023-39414-4

PMCID:: PMC10300122

Abstract Article PDF–3.0M

Select item 95403453.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 92792854.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91197365.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89737336.

Ropivacaine represses the proliferation, invasion, and migration of glioblastoma via modulating the microRNA-21-5p/KAT8 regulatory NSL complex subunit 2 axis

Zexiang Deng, Yanping Jian, Hongwei Cai

Bioengineered. 2022; 13(3): 5975–5986. Published online 2022 Feb 22. doi: 10.1080/21655979.2022.2037955

PMCID:: PMC8973733

Abstract Article PDF–3.6M

Select item 88288957.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 83529648.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 82923189.

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler

Nat Commun. 2021; 12: 4404. Published online 2021 Jul 20. doi: 10.1038/s41467-021-24601-y

PMCID:: PMC8292318

Abstract Article PDF–8.3M

Select item 822039110.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808891212.

MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma

Shan Wei, Wei Liu, Ning Sun, Yi Wu, Huijuan Song, Chunyu Wang, Shengli Wang, Renlong Zou, Lin Lin, Kai Zeng, Baosheng Zhou, Manlin Wang, Ruina Luan, Fan Yang, Yue Zhao

Cancer Sci. 2021 May; 112(5): 1865–1877. Published online 2021 Mar 30. doi: 10.1111/cas.14836

PMCID:: PMC8088912

Abstract Article PDF–2.9M

Select item 805618613.

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis

Aliaksandra Radzisheuskaya, Pavel V. Shliaha, Vasily V. Grinev, Daria Shlyueva, Helene Damhofer, Richard Koche, Vladimir Gorshkov, Sergey Kovalchuk, Yingqian Zhan, Keli L. Rodriguez, Andrea L. Johnstone, Michael-C Keogh, Ronald C. Hendrickson, Ole N. Jensen, Kristian Helin

Mol Cell. Author manuscript; available in PMC 2022 Apr 15.

Published in final edited form as: Mol Cell. 2021 Feb 23 : S1097-2765(21)00098-8. Published online 2021 Feb 23. doi: 10.1016/j.molcel.2021.02.012

PMCID:: PMC8056186

Abstract Article PDF–2.3M

Select item 794857214.

Dysregulation of intercellular signaling by MOF deletion leads to liver injury

Hongwei Lei, Aaron D. denDekker, Guobing Li, Zhiguo Zhang, Liang Sha, Matthew A. Schaller, Steven L. Kunkel, Liangyou Rui, Kaixiong Tao, Yali Dou

J Biol Chem. 2021 Jan-Jun; 296: 100235. Published online 2021 Jan 7. doi: 10.1074/jbc.RA120.016079

PMCID:: PMC7948572

Abstract Article PDF–4.4M

Select item 783057015.

Substrate Scope for Human Histone Lysine Acetyltransferase KAT8

Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinović

Int J Mol Sci. 2021 Jan; 22(2): 846. Published online 2021 Jan 15. doi: 10.3390/ijms22020846

PMCID:: PMC7830570

Abstract Article PDF–1.9M

Select item 773761016.

Receptor‐mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

EMBO J. 2020 Dec 15; 39(24): e104948. Published online 2020 Nov 23. doi: 10.15252/embj.2020104948

PMCID:: PMC7737610

Abstract Article PDF–3.7M

Select item 761059317.

Disruption of the MSL complex inhibits tumor maintenance by exacerbating chromosomal instability

Josep Monserrat, Cristina Morales Torres, Louise Richardson, Thomas S. Wilson, Harshil Patel, Marie-Charlotte Domart, Stuart Horswell, Ok-Ryul Song, Ming Jiang, Margaret Crawford, Minh Bui, Yamini Dalal, Paola Scaffidi

Nat Cell Biol. Author manuscript; available in PMC 2021 Oct 9.

Published in final edited form as: Nat Cell Biol. 2021 Apr 1; 23(4): 401–412. Published online 2021 Apr 9. doi: 10.1038/s41556-021-00657-2

PMCID:: PMC7610593

Abstract Article PDF–4.9M

Select item 745926318.

Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development

Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita

Mol Cell Biol. 2020 Sep; 40(18): e00232-20. Prepublished online 2020 Jul 13. Published online 2020 Aug 28. doi: 10.1128/MCB.00232-20

PMCID:: PMC7459263

Abstract Article PDF–961K

Select item 739871919.

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation

M. Felicia Basilicata, Ange-Line Bruel, Giuseppe Semplicio, Claudia Isabelle Keller Valsecchi, Tuğçe Aktaş, Yannis Duffourd, Tobias Rumpf, Jenny Morton, Iben Bache, Witold G. Szymanski, Christian Gilissen, Olivier Vanakker, Katrin Õunap, Gerhard Mittler, Ineke van der Burgt, Salima El Chehadeh-Djebbar, Megan T Cho, Rolph Pfundt, Tiong Yang Tan, Maria Kirchhoff, Björn Menten, Sarah Vergult, Kristin Lindstrom, André Reis, Diana S. Johnson, Alan Fryer, Victoria McKay, DDD Study, Richard B. Fisher, Christel Thauvin-Robinet, David Francis, Tony Roscioli, Sander Pajusalu, Kelly Radtke, Jaya Ganesh, Han G. Brunner, Meredith Wilson, Laurence Faivre, Vera M. Kalscheuer, Julien Thevenon, Asifa Akhtar

Nat Genet. Author manuscript; available in PMC 2020 Aug 3.

Published in final edited form as: Nat Genet. 2018 Oct; 50(10): 1442–1451. Published online 2018 Sep 17. doi: 10.1038/s41588-018-0220-y

PMCID:: PMC7398719

Abstract Article PDF–2.2M

Select item 738783020.

An NAD⁺-Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39

Ling Dong, Le Yu, Hui Li, Lei Shi, Zhong Luo, Huakan Zhao, Zhaojian Liu, Guobing Yin, Xiaohua Yan, Zhenghong Lin

iScience. 2020 Aug 21; 23(8): 101351. Published online 2020 Jul 9. doi: 10.1016/j.isci.2020.101351

PMCID:: PMC7387830

Abstract Article PDF–7.2M

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