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Select item 108508181.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 107775522.

Upregulation of CENPM promotes breast carcinogenesis by altering immune infiltration

Yanchu Tong, Tongzhou Zhou, Xiaokun Wang, Shun Deng, Lu Qin

BMC Cancer. 2024; 24: 54. Published online 2024 Jan 10. doi: 10.1186/s12885-023-11808-z

PMCID:: PMC10777552

Abstract Article PDF–8.2M

Select item 100809083.

The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia

Sadek Amhaz, Batiste Boëda, Mouna Chouchène, Sabrina Colasse, Florent Dingli, Damarys Loew, Julien Henri, Céline Prunier, Laurence Levy

BMC Biol. 2023; 21: 73. Published online 2023 Apr 7. doi: 10.1186/s12915-023-01576-4

PMCID:: PMC10080908

Abstract Article PDF–3.2M

Select item 99093024.

Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway: CENPM promotes lung adenocarcinoma progression

Chao Liu, Yun Wang, Yuyang Dao, Shuting Wang, Fei Hou, Zhixian Yang, Pengjie Liu, Juan Lv, Ling Lv, Gaofeng Li, Youjun Zhou, Zhiyong Deng

Acta Biochim Biophys Sin (Shanghai) 2022 Jan; 54(1): 99–112. Published online 2021 Dec 27. doi: 10.3724/abbs.2021013

PMCID:: PMC9909302

Abstract Article PDF–19M

Select item 98379035.

Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma

Zhi-Cheng Zhang, Yi-Fu Liu, Ping Xi, Ye-Chen Nie, Ting Sun, Bin-Bin Gong

Hereditas. 2023; 160: 1. Published online 2023 Jan 13. doi: 10.1186/s41065-023-00262-3

PMCID:: PMC9837903

Abstract Article PDF–10M

Select item 94634436.

Structural insights into human CCAN complex assembled onto DNA

Tian Tian, Lili Chen, Zhen Dou, Zhisen Yang, Xinjiao Gao, Xiao Yuan, Chengliang Wang, Ran Liu, Zuojun Shen, Ping Gui, Maikun Teng, Xianlei Meng, Donald L. Hill, Lin Li, Xuan Zhang, Xing Liu, Linfeng Sun, Jianye Zang, Xuebiao Yao

Cell Discov. 2022; 8: 90. Published online 2022 Sep 9. doi: 10.1038/s41421-022-00439-6

PMCID:: PMC9463443

Abstract Article PDF–5.7M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 83529648.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795026110.

TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma

Jicheng Duan, Youwen Qian, Xiaohui Fu, Meiling Chen, Kai Liu, Hu Liu, Jiahe Yang, Chen Liu, Yanxin Chang

Aging (Albany NY) 2021 Feb 28; 13(4): 5585–5606. Published online 2021 Feb 11. doi: 10.18632/aging.202487

PMCID:: PMC7950261

Abstract Article PDF–2.2M

Select item 756688111.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 753349012.

Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans

Ying Liu, Wenfeng Yu, Peng Ren, Ting Zhang

Mol Med Rep. 2020 Nov; 22(5): 3922–3934. Published online 2020 Aug 25. doi: 10.3892/mmr.2020.11461

Correction in:: Mol Med Rep. 2024 Apr; 29(4): 62.

PMCID:: PMC7533490

Abstract Article PDF–1.8M

Select item 738824313.

Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer

Chenlei Zheng, Tan Zhang, Ding Li, Chongchu Huang, Hengjie Tang, Xiao-Feng Ni, Bicheng Chen

Oncol Rep. 2020 Sep; 44(3): 1003–1012. Published online 2020 Jul 7. doi: 10.3892/or.2020.7673

PMCID:: PMC7388243

Abstract Article PDF–1.0M

Select item 683917814.

Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms

Yusha Xiao, Rahmathullah Mohamed Najeeb, Dong Ma, Kang Yang, Qiu Zhong, Quanyan Liu

J Exp Clin Cancer Res. 2019; 38: 458. Published online 2019 Nov 8. doi: 10.1186/s13046-019-1444-0

PMCID:: PMC6839178

Abstract Article PDF–6.2M

Select item 676324215.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 642645516.

Mapping the genetic landscape of human cells

Max A. Horlbeck, Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert

Cell. Author manuscript; available in PMC 2019 Aug 9.

Published in final edited form as: Cell. 2018 Aug 9; 174(4): 953–967.e22. Published online 2018 Jul 19. doi: 10.1016/j.cell.2018.06.010

PMCID:: PMC6426455

Abstract Article PDF–3.6M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 484178318.

The cell proliferation antigen Ki-67 organises heterochromatin

Michal Sobecki, Karim Mrouj, Alain Camasses, Nikolaos Parisis, Emilien Nicolas, David Llères, François Gerbe, Susana Prieto, Liliana Krasinska, Alexandre David, Manuel Eguren, Marie-Christine Birling, Serge Urbach, Sonia Hem, Jérôme Déjardin, Marcos Malumbres, Philippe Jay, Vjekoslav Dulic, Denis LJ Lafontaine, Robert Feil, Daniel Fisher

eLife. 2016; 5: e13722. Published online 2016 Mar 7. doi: 10.7554/eLife.13722

PMCID:: PMC4841783

Abstract Article PDF–5.1M

Select item 461721119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 439450920.

The CENP-T C-Terminus Is Exclusively Proximal to H3.1 and not to H3.2 or H3.3

Christian Abendroth, Antje Hofmeister, Sandra B. Hake, Paul K. Kamweru, Elke Miess, Carsten Dornblut, Isabell Küffner, Wen Deng, Heinrich Leonhardt, Sandra Orthaus, Christian Hoischen, Stephan Diekmann

Int J Mol Sci. 2015 Mar; 16(3): 5839–5863. Published online 2015 Mar 12. doi: 10.3390/ijms16035839

PMCID:: PMC4394509

Abstract Article PDF–2.2M

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