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Select item 109217401.

Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma

Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng

Respir Res. 2024; 25: 119. Published online 2024 Mar 8. doi: 10.1186/s12931-024-02743-z

PMCID:: PMC10921740

Abstract Article PDF–13M

Select item 108074052.

Structural insights into cytokine cleavage by inflammatory caspase-4

Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P. Gygi, Hao Wu, Jonathan C. Kagan

Nature. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Nature. 2023 Dec; 624(7991): 451–459. Published online 2023 Nov 22. doi: 10.1038/s41586-023-06751-9

Correction in:: Nature. 2024 Jan 3

PMCID:: PMC10807405

Abstract Article PDF–6.9M

Select item 107435093.

Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4

Christof Ulrich, Zeynep Canim, Eva Herberger, Matthias Girndt, Roman Fiedler

Int J Mol Sci. 2023 Dec; 24(24): 17550. Published online 2023 Dec 16. doi: 10.3390/ijms242417550

PMCID:: PMC10743509

Abstract Article PDF–1.6M

Select item 105974074.

Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

Abby R. Kroken, Keith A. Klein, Patrick S. Mitchell, Vincent Nieto, Eric J. Jedel, David J. Evans, Suzanne M. J. Fleiszig

mSphere. 2023 Sep-Oct; 8(5): e00351-23. Published online 2023 Aug 17. doi: 10.1128/msphere.00351-23

PMCID:: PMC10597407

Abstract Article PDF–11M

Select item 102508615.

Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis

Wantao Liu, Xinan Li, Qiang Ma, Yongtong Zhu, Wenzhong Zhao, Yisheng Yang, Weiqiang Xiao, Daxiong Huang, Fengbo Cai, David Yiu Leung Chan, Shanchao Zhao, Qingjun Chu

Reprod Biol Endocrinol. 2023; 21: 53. Published online 2023 Jun 9. doi: 10.1186/s12958-023-01101-w

PMCID:: PMC10250861

Abstract Article PDF–6.4M

Select item 93021796.

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin

Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21

PMCID:: PMC9302179

Abstract Article PDF–2.0M

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91775568.

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos, Juan Carlos Acosta

Cell Death Differ. 2022 Jun; 29(6): 1267–1282. Published online 2021 Dec 16. doi: 10.1038/s41418-021-00917-6

PMCID:: PMC9177556

Abstract Article PDF–7.9M

Select item 91738189.

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

Mostafa M. Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous, Eunsoo Kim, Asmaa Badr, Cierra Carafice, Kylene Daily, Owen Whitham, Maciej Pietrzak, Amy Webb, Jeffrey Kawahara, Adrian C. Eddy, Parker Denz, Mijia Lu, KC Mahesh, Mark E. Peeples, Jianrong Li, Jian Zhu, Jianwen Que, Richard Robinson, Oscar Rosas Mejia, Rachael E. Rayner, Luanne Hall-Stoodley, Stephanie Seveau, Mikhail A. Gavrilin, Xiaoli Zhang, Jeronay Thomas, Jacob E. Kohlmeier, Mehul S. Suthar, Eugene Oltz, Andrea Tedeschi, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Emily A. Hemann, Eman Abdelrazik, Adriana Forero, Shahid M. Nimjee, Prosper N. Boyaka, Estelle Cormet-Boyaka, Jacob S. Yount, Amal O. Amer

Proc Natl Acad Sci U S A. 2022 May 24; 119(21): e2202012119. Published online 2022 May 19. doi: 10.1073/pnas.2202012119

PMCID:: PMC9173818

Abstract Article PDF–3.5M

Select item 896702010.

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion

Shanshan Wang, France Moreau, Kris Chadee

PLoS Pathog. 2022 Mar; 18(3): e1010415. Published online 2022 Mar 18. doi: 10.1371/journal.ppat.1010415

PMCID:: PMC8967020

Abstract Article PDF–4.7M

Select item 882170111.

The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli

Anna Lindblad, Charlotte Johansson, Katarina Persson, Isak Demirel

Sci Rep. 2022; 12: 2005. Published online 2022 Feb 7. doi: 10.1038/s41598-022-06052-7

PMCID:: PMC8821701

Abstract Article PDF–4.6M

Select item 880645112.

Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4

Jing Meng, Xiaoying Song, Guoliang Yan, Haihui Wang, Haitao Li, Danfei Lou

Bioengineered. 2021; 12(1): 4452–4463. Published online 2021 Jul 24. doi: 10.1080/21655979.2021.1956672

PMCID:: PMC8806451

Abstract Article PDF–3.6M

Select item 855977813.

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme

Pascal Devant, Anh Cao, Jonathan C. Kagan

Sci Immunol. Author manuscript; available in PMC 2022 Feb 10.

Published in final edited form as: Sci Immunol. 2021 Aug 10; 6(62): eabh3567. doi: 10.1126/sciimmunol.abh3567

PMCID:: PMC8559778

Abstract Article PDF–2.3M

Select item 816503014.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 791425415.

Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis

Chuang Yuan, Ming Wu, Qicai Xiao, Wang Zhao, Hongli Li, Yanjun Zhong, Minyi Zhao, Cheng Li, Yang Li, Xinyu Yang

Signal Transduct Target Ther. 2021; 6: 92. Published online 2021 Feb 28. doi: 10.1038/s41392-021-00483-w

PMCID:: PMC7914254

Article PDF–1.4M

Select item 732748516.

Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions

Miriam Kutsch, Linda Sistemich, Cammie F Lesser, Marcia B Goldberg, Christian Herrmann, Jörn Coers

EMBO J. 2020 Jul 1; 39(13): e104926. Published online 2020 Jun 8. doi: 10.15252/embj.2020104926

PMCID:: PMC7327485

Abstract Article PDF–5.6M

Select item 732417317.

Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility

Lan Ye, Ge Li, Anna Goebel, Abhinav V. Raju, Feng Kong, Yanfei Lv, Kailin Li, Yuanjun Zhu, Shreya Raja, Peijian He, Fang Li, Simon Musyoka Mwangi, Wenhui Hu, Shanthi Srinivasan

J Clin Invest. 2020 Jul 1; 130(7): 3621–3636. Published online 2020 Jun 2. doi: 10.1172/JCI130176

PMCID:: PMC7324173

Abstract Article PDF–11M

Select item 731479818.

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz

Nat Commun. 2020; 11: 3276. Published online 2020 Jun 24. doi: 10.1038/s41467-020-16889-z

PMCID:: PMC7314798

Abstract Article PDF–3.7M

Select item 673449119.

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

Qin Chen, Peiliang Shi, Yufang Wang, Dayuan Zou, Xiuwen Wu, Dingyu Wang, Qiongyuan Hu, Yujie Zou, Zan Huang, Jianan Ren, Zhaoyu Lin, Xiang Gao

J Mol Cell Biol. 2019 Jun; 11(6): 496–508. Published online 2018 Oct 15. doi: 10.1093/jmcb/mjy056

PMCID:: PMC6734491

Abstract Article PDF–1.2M

Select item 673123220.

Caspase-11 signaling enhances graft-versus-host disease

Yanyan Lu, Ran Meng, Xiangyu Wang, Yajing Xu, Yiting Tang, Jianfeng Wu, Qianqian Xue, Songlin Yu, Mingwu Duan, Dongyong Shan, Qingde Wang, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Fangping Chen, Ben Lu

Nat Commun. 2019; 10: 4044. Published online 2019 Sep 6. doi: 10.1038/s41467-019-11895-2

Correction in:: Nat Commun. 2020; 11: 1349.

PMCID:: PMC6731232

Abstract Article PDF–2.1M

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