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Select item 106378491.

A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker

Xiaoyun Zhang, Chaogui Tang, Jianchun Lian, Yuzhang Jiang

Can J Gastroenterol Hepatol. 2023; 2023: 5557546. Published online 2023 Nov 3. doi: 10.1155/2023/5557546

PMCID:: PMC10637849

Abstract Article PDF–1.5M

Select item 101122812.

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

François Le Guerroué, Eric N Bunker, William M Rosencrans, Jack T Nguyen, Mohammed A Basar, Achim Werner, Tsui-Fen Chou, Chunxin Wang, Richard J Youle

Mol Cell. Author manuscript; available in PMC 2024 Mar 16.

Published in final edited form as: Mol Cell. 2023 Mar 16; 83(6): 927–941.e8. Published online 2023 Mar 9. doi: 10.1016/j.molcel.2023.02.023

PMCID:: PMC10112281

Abstract Article PDF–2.4M

Select item 99020463.

Audiologic Measures in an Indigenous Community with A2ML1- and FUT2-Related Otitis Media

Regie Lyn P. Santos-Cortez, Kimberly Mae C. Ong, Angeli Carlos-Hiceta, Ma. Leah C. Tantoco, Talitha Karisse L. Yarza, Ma. Luz San Agustin, Melquiadesa Pedro, Teresa Luisa G. Cruz, Eva Maria Cutiongco-de la Paz, Generoso T. Abes, Erasmo Gonzalo d.V. Llanes, Abner L. Chan, Charlotte M. Chiong, Maria Rina T. Reyes-Quintos

Genet Test Mol Biomarkers. January 2023; 27(1): 12–17. Published online 2023 Jan 31. doi: 10.1089/gtmb.2022.0171

PMCID:: PMC9902046

Abstract Article PDF–218K

Select item 92902414.

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer

Annamaria Salvati, Viola Melone, Assunta Sellitto, Francesca Rizzo, Roberta Tarallo, Tuula A. Nyman, Giorgio Giurato, Giovanni Nassa, Alessandro Weisz

Breast Cancer Res. 2022; 24: 52. Published online 2022 Jul 18. doi: 10.1186/s13058-022-01547-7

PMCID:: PMC9290241

Abstract Article PDF–8.2M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92778536.

A functional reference map of the RNF8 interactome in cancer

Chuanyang Liu, Jingyu Kuang, Yuxuan Wang, Ting Duan, Lu Min, Chenyu Lu, Tianyi Zhang, Ruifen Chen, Ying Wu, Lingyun Zhu

Biol Direct. 2022; 17: 17. Published online 2022 Jul 13. doi: 10.1186/s13062-022-00331-z

PMCID:: PMC9277853

Abstract Article PDF–5.9M

Select item 91567587.

Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

Nadia Sukusu Nielsen, Alessandra Zarantonello, Seandean Lykke Harwood, Kathrine Tejlgård Jensen, Katarzyna Kjøge, Ida B. Thøgersen, Leif Schauser, Jesper Lykkegaard Karlsen, Gregers R. Andersen, Jan J. Enghild

Nat Commun. 2022; 13: 3033. Published online 2022 May 31. doi: 10.1038/s41467-022-30758-x

PMCID:: PMC9156758

Abstract Article PDF–2.9M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 85664739.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794061411.

The clinical significance of A2ML1 variants in Noonan syndrome has to be reconsidered

Julia Brinkmann, Christina Lissewski, Valentina Pinna, Yoann Vial, Francesca Pantaleoni, Francesca Lepri, Paola Daniele, Birute Burnyte, Goran Cuturilo, Christine Fauth, Alper Gezdirici, Dieter Kotzot, Elif Yılmaz Güleç, Violeta Iotova, Denny Schanze, Francis Ramond, Markéta Havlovicová, Gulen Eda Utine, Pelin Ozlem Simsek-Kiper, Milena Stoyanova, Alain Verloes, Alessandro De Luca, Marco Tartaglia, Hélène Cavé, Martin Zenker

Eur J Hum Genet. 2021 Mar; 29(3): 524–527. Published online 2020 Oct 20. doi: 10.1038/s41431-020-00743-3

PMCID:: PMC7940614

Abstract Article PDF–616K

Select item 742732712.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 739233413.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 678687314.

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection

Amy T. Y. Yeung, Yoon Ha Choi, Amy H. Y. Lee, Christine Hale, Hannes Ponstingl, Derek Pickard, David Goulding, Mark Thomas, Erin Gill, Jong Kyoung Kim, Allan Bradley, Robert E. W. Hancock, Gordon Dougan

mBio. 2019 Sep-Oct; 10(5): e02169-19. Published online 2019 Oct 8. doi: 10.1128/mBio.02169-19

PMCID:: PMC6786873

Abstract Article PDF–2.2M

Select item 671178415.

A2ML1 and otitis media: novel variants, differential expression and relevant pathways

Eric D. Larson, Jose Pedrito M. Magno, Matthew J. Steritz, Erasmo Gonzalo d.V. Llanes, Jonathan Cardwell, Melquiadesa Pedro, Tori Bootpetch Roberts, Elisabet Einarsdottir, Rose Anne Q. Rosanes, Christopher Greenlee, Rachel Ann P. Santos, Ayesha Yousaf, Sven-Olrik Streubel, Aileen Trinidad R. Santos, Amanda G. Ruiz, Sheryl Mae Lagrana-Villagracia, Dylan Ray, Talitha Karisse L. Yarza, Melissa A. Scholes, Catherine B. Anderson, Anushree Acharya, University of Washington Center for Mendelian Genomics, Samuel P. Gubbels, Michael J. Bamshad, Stephen P. Cass, Nanette R. Lee, Rehan S. Shaikh, Deborah A. Nickerson, Karen L. Mohlke, Jeremy D. Prager, Teresa Luisa G. Cruz, Patricia J. Yoon, Generoso T. Abes, David A. Schwartz, Abner L. Chan, Todd M. Wine, Eva Maria Cutiongco-de la Paz, Norman Friedman, Katerina Kechris, Juha Kere, Suzanne M. Leal, Ivana V. Yang, Janak A. Patel, Ma. Leah C. Tantoco, Saima Riazuddin, Kenny H. Chan, Petri S. Mattila, Maria Rina T. Reyes-Quintos, Zubair M. Ahmed, Herman A. Jenkins, Tasnee Chonmaitree, Lena Hafrén, Charlotte M. Chiong, Regie Lyn P. Santos-Cortez

Hum Mutat. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Hum Mutat. 2019 Aug; 40(8): 1156–1171. Published online 2019 May 21. doi: 10.1002/humu.23769

PMCID:: PMC6711784

Abstract Article PDF–640K

Select item 589141716.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 583915817.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 579923618.

Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies

Gordon K. C. Leung, H. M. Luk, Vincent H. M. Tang, W. W. Gao, Christopher C. Y. Mak, Mullin H. C. Yu, W. L. Wong, Yoyo W. Y. Chu, W. L. Yang, Wilfred H. S. Wong, Alvin C. H. Ma, Anskar Y. H. Leung, D. Y. Jin, Kelvin Y. K. Chan, Judith Allanson, Ivan F. M. Lo, Brian H. Y. Chung

Sci Rep. 2018; 8: 2421. Published online 2018 Feb 5. doi: 10.1038/s41598-018-20894-0

PMCID:: PMC5799236

Abstract Article PDF–2.9M

Select item 572973919.

Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline

Lei Yu, Robert J. Dawe, Patricia A. Boyle, Chris Gaiteri, Jingyun Yang, Aron S. Buchman, Julie A. Schneider, Konstantinos Arfanakis, Philip L. De Jager, David A. Bennett

JAMA Neurol. Author manuscript; available in PMC 2018 Dec 1.

Published in final edited form as: JAMA Neurol. 2017 Dec 1; 74(12): 1473–1480. doi: 10.1001/jamaneurol.2017.2807

PMCID:: PMC5729739

Abstract Article PDF–430K

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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