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Select item 110801231.

IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p

Ehsan Gharib, Leili Rejali, Moein Piroozkhah, Elham Zonoobi, Parinaz Nasri Nasrabadi, Zahra Arabsorkhi, Kaveh Baghdar, Elahe Shams, Amir Sadeghi, Peter J. K. Kuppen, Zahra Salehi, Ehsan Nazemalhosseini-Mojarad

J Transl Med. 2024; 22: 439. Published online 2024 May 8. doi: 10.1186/s12967-024-05251-2

PMCID:: PMC11080123

Abstract Article PDF–4.5M

Select item 107094542.

PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity

Rui Liu, Lin-Wen Zeng, Hui-Fang Li, Jun-Ge Shi, Bo Zhong, Hong-Bing Shu, Shu Li

Cell Res. 2023 Dec; 33(12): 923–939. Published online 2023 Nov 6. doi: 10.1038/s41422-023-00890-4

PMCID:: PMC10709454

Abstract Article PDF–4.4M

Select item 106171973.

NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells

Ju A Shim, So Min Lee, Jin Woo Jeong, Hyori Kim, Woo Jae Son, Jun Hong Park, Parkyong Song, Sin-Hyeog Im, Sangsu Bae, Jung-Hyun Park, Yuna Jo, Changwan Hong

Cell Commun Signal. 2023; 21: 309. Published online 2023 Oct 30. doi: 10.1186/s12964-023-01326-7

PMCID:: PMC10617197

Abstract Article PDF–5.1M

Select item 102921214.

In vivo availability of the cytokine IL-7 constrains the survival and homeostasis of peripheral iNKT cells

Joo-Young Park, Hee Yeun Won, Devon T. DiPalma, Hye Kyung Kim, Tae-Hyoun Kim, Can Li, Noriko Sato, Changwan Hong, Ninan Abraham, Ronald E. Gress, Jung-Hyun Park

Cell Rep. Author manuscript; available in PMC 2023 Jun 26.

Published in final edited form as: Cell Rep. 2022 Jan 11; 38(2): 110219. doi: 10.1016/j.celrep.2021.110219

PMCID:: PMC10292121

Abstract Article PDF–2.8M

Select item 87745915.

Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined Immunodeficiency

Yujuan Hou, Hans Peter Gratz, Guillermo Ureña-Bailén, Paul G. Gratz, Karin Schilbach-Stückle, Tina Renno, Derya Güngör, Daniel A. Mader, Elke Malenke, Justin S. Antony, Rupert Handgretinger, Markus Mezger

Genes (Basel) 2022 Jan; 13(1): 35. Published online 2021 Dec 23. doi: 10.3390/genes13010035

PMCID:: PMC8774591

Abstract Article PDF–3.2M

Select item 84988966.

Survival‐Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah^–/–Rag2^–/–IL2rg^–/– Rats

Ludi Zhang, Jian‐Yun Ge, Yun‐Wen Zheng, Zhen Sun, Chenhua Wang, Zhaoliang Peng, Baihua Wu, Mei Fang, Kinji Furuya, Xiaolong Ma, Yanjiao Shao, Nobuhiro Ohkohchi, Tatsuya Oda, Jianglin Fan, Guoyu Pan, Dali Li, Lijian Hui

Adv Sci (Weinh) 2021 Oct; 8(19): 2101188. Published online 2021 Aug 11. doi: 10.1002/advs.202101188

PMCID:: PMC8498896

Abstract Article PDF–16M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80937678.

Case Report: A Novel IL2RG Frame-Restoring Rescue Mutation Mimics Early T Cell Engraftment Following Haploidentical Hematopoietic Stem Cell Transplantation in a Patient With X-SCID

Jolanda Steininger, Alexander Leiss-Piller, Christoph B. Geier, Raphael Rossmanith, Reem Elfeky, David Bra, Herbert Pichler, Anita Lawitschka, Natascha Zubarovskaya, Gottfried Artacker, Susanne Matthes-Leodolter, Martha M. Eibl, Hermann M. Wolf

Front Immunol. 2021; 12: 644687. Published online 2021 Apr 20. doi: 10.3389/fimmu.2021.644687

PMCID:: PMC8093767

Abstract Article PDF–3.6M

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 714205210.

Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency

Elina A. Tuovinen, Juha Grönholm, Tiina Öhman, Sakari Pöysti, Raine Toivonen, Anna Kreutzman, Kaarina Heiskanen, Luca Trotta, Sanna Toiviainen-Salo, John M. Routes, James Verbsky, Satu Mustjoki, Janna Saarela, Juha Kere, Markku Varjosalo, Arno Hänninen, Mikko R. J. Seppänen

J Clin Immunol. 2020; 40(3): 503–514. Published online 2020 Feb 19. doi: 10.1007/s10875-020-00745-2

PMCID:: PMC7142052

Abstract Article PDF–1.7M

Select item 706638711.

The IL‐2RG R328X nonsense mutation allows partial STAT‐5 phosphorylation and defines a critical region involved in the leaky‐SCID phenotype

A. Arcas‐García, M. Garcia‐Prat, M. Magallón‐Lorenz, A. Martín‐Nalda, O. Drechsel, S. Ossowski, L. Alonso, J. G. Rivière, P. Soler‐Palacín, R. Colobran, J. Sayós, M. Martínez‐Gallo, C. Franco‐Jarava

Clin Exp Immunol. 2020 Apr; 200(1): 61–72. Published online 2020 Jan 19. doi: 10.1111/cei.13405

PMCID:: PMC7066387

Abstract Article PDF–730K

Select item 677618612.

Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T-cell lymphoma expressing the ITK-SYK fusion gene

Lei-Lei Zhang, Hua-Xiong Pan, Yi-Xuan Wang, Tao Guo, Lin Liu

Int J Oncol. 2019 Nov; 55(5): 1077–1089. Published online 2019 Sep 20. doi: 10.3892/ijo.2019.4882

PMCID:: PMC6776186

Abstract Article PDF–1.8M

Select item 674264613.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 641780914.

Implications for Gene Therapy-Limiting Expression of IL-2Rγ_c Delineate Differences in Signaling Thresholds Required for Lymphocyte Development and Maintenance

Selinda J. Orr, Stephen Roessler, Laura Quigley, Tim Chan, Jill W. Ford, Geraldine M. O’Connor, Daniel W. McVicar

J Immunol. Author manuscript; available in PMC 2019 Mar 14.

Published in final edited form as: J Immunol. 2010 Aug 1; 185(3): 1393–1403. Published online 2010 Jun 30. doi: 10.4049/jimmunol.0903528

PMCID:: PMC6417809

Abstract Article PDF–1.9M

Select item 637588515.

Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses

Byunghyuk Lee, Yuna Jo, Geona Kim, Laraib Amir Ali, Dong Hyun Sohn, Seung-Geun Lee, Kiseok Kim, Euisu Shin, Sung Ho Ryu, Changwan Hong

Front Immunol. 2019; 10: 209. Published online 2019 Feb 8. doi: 10.3389/fimmu.2019.00209

PMCID:: PMC6375885

Abstract Article PDF–6.4M

Select item 631529916.

The common γ-chain cytokine receptor: tricks-and-treats for T cells

Adam T. Waickman, Joo-Young Park, Jung-Hyun Park

Cell Mol Life Sci. 2016 Jan; 73(2): 253–269. Published online 2015 Oct 14. doi: 10.1007/s00018-015-2062-4

PMCID:: PMC6315299

Abstract Article PDF–767K

Select item 615842817.

Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency

Michael A. Rak, Jason Buehler, Sebastian Zeltzer, Justin Reitsma, Belen Molina, Scott Terhune, Felicia Goodrum

J Virol. 2018 Oct 15; 92(20): e00919-18. Prepublished online 2018 Aug 8. Published online 2018 Sep 26. doi: 10.1128/JVI.00919-18

Correction in:: J Virol. 2020 Apr; 94(7): e00748-19.

PMCID:: PMC6158428

Abstract Article PDF–759K

Select item 602464018.

B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation

Alexandra M. Miggelbrink, Brent R. Logan, Rebecca H. Buckley, Roberta E. Parrott, Christopher C. Dvorak, Neena Kapoor, Hisham Abdel-Azim, Susan E. Prockop, David Shyr, Hélène Decaluwe, Imelda C. Hanson, Alfred Gillio, Blachy J. Dávila Saldaña, Hermann Eibel, Gregory Hopkins, Jolan E. Walter, Jennifer S. Whangbo, Donald B. Kohn, Jennifer M. Puck, Morton J. Cowan, Linda M. Griffith, Elie Haddad, Richard J. O’Reilly, Luigi D. Notarangelo, Sung-Yun Pai

Blood. 2018 Jun 28; 131(26): 2967–2977. Prepublished online 2018 May 4. doi: 10.1182/blood-2017-10-809822

PMCID:: PMC6024640

Abstract Article

Select item 562206819.

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model

Jamal Alzubi, Celeste Pallant, Claudio Mussolino, Steven J. Howe, Adrian J. Thrasher, Toni Cathomen

Sci Rep. 2017; 7: 12475. Published online 2017 Sep 29. doi: 10.1038/s41598-017-12750-4

PMCID:: PMC5622068

Abstract Article PDF–3.4M

Select item 553161120.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

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