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Select item 100729061.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 100534032.

Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling

Tao Xu, Peng Gao, Yifan Huang, Mengyuan Wu, Jiang Yi, Zheng Zhou, Xuan Zhao, Tao Jiang, Hao Liu, Tao Qin, Zhenqi Yang, Xiaowei Wang, Tianyi Bao, Jian Chen, Shujie Zhao, Guoyong Yin

Redox Biol. 2023 Jun; 62: 102682. Published online 2023 Mar 20. doi: 10.1016/j.redox.2023.102682

PMCID:: PMC10053403

Abstract Article PDF–12M

Select item 91197363.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88570494.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, Michael E. Ward, Erica Stevenson, Ruth Hüttenhain, Grant Kauwe, Maria Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue-Ann Mok, Man Ying Wong, Maria Telpoukhovskaia, Sang-Won Min, Chao Wang, Peter Dongmin Sohn, Jordie Martin, Yungui Zhou, Wenjie Luo, John Q. Trojanowski, Virginia M.Y. Lee, Shiaoching Gong, Giovanni Manfredi, Giovanni Coppola, Nevan J. Krogan, Daniel H. Geschwind, Li Gan

Cell. Author manuscript; available in PMC 2022 Feb 19.

Published in final edited form as: Cell. 2022 Feb 17; 185(4): 712–728.e14. Published online 2022 Jan 20. doi: 10.1016/j.cell.2021.12.041

PMCID:: PMC8857049

Abstract Article PDF–3.6M

Select item 83641815.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 83578886.

Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation

Xiaohong Tan, Lu Tong, Lin Li, Jinjin Xu, Shaofang Xie, Lei Ji, Junjiang Fu, Qingwu Liu, Shihui Shen, Yun Liu, Yanhui Xiao, Feiran Gao, Robb E. Moses, Nabeel Bardeesy, Yanxiao Wang, Jishuai Zhang, Longying Tang, Lei Li, Kwok-kin Wong, Dianwen Song, Xiao Yang, Jian Liu, Xiaotao Li

Nat Commun. 2021; 12: 4853. Published online 2021 Aug 11. doi: 10.1038/s41467-021-24898-9

PMCID:: PMC8357888

Abstract Article PDF–8.9M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 71640049.

Arabidopsis HY5 protein functions as a DNA‐binding tag for purification and functional immobilization of proteins on agarose/DNA microplate

Tatsuya Sawasaki, Nami Kamura, Satoko Matsunaga, Mihoro Saeki, Masateru Tsuchimochi, Ryo Morishita, Yaeta Endo

FEBS Lett. 2008 Jan 23; 582(2): 221–228. Published online 2007 Dec 17. doi: 10.1016/j.febslet.2007.12.004

PMCID:: PMC7164004

Abstract Article PDF–2.1M

Select item 701753610.

Novel PAK3 gene missense variant associated with two Chinese siblings with intellectual disability: a case report

Yanyan Qian, Bingbing Wu, Yulan Lu, Wenhao Zhou, Sujuan Wang, Huijun Wang

BMC Med Genet. 2020; 21: 31. Published online 2020 Feb 12. doi: 10.1186/s12881-020-0957-x

PMCID:: PMC7017536

Abstract Article PDF–1.0M

Select item 701576411.

Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease

Julie C. Lauterborn, Conor D. Cox, See Wing Chan, Peter W. Vanderklish, Gary Lynch, Christine M. Gall

Brain Pathol. 2020 Mar; 30(2): 319–331. Published online 2019 Sep 8. doi: 10.1111/bpa.12779

PMCID:: PMC7015764

Abstract Article PDF–1.3M

Select item 674072912.

DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3

Donna L. McPhie, Robert Coopersmith, Andrew Hines-Peralta, Yuzhi Chen, Kathryn J. Ivins, Susan P. Manly, Michael R. Kozlowski, Kim A. Neve, Rachael L. Neve

J Neurosci. 2003 Jul 30; 23(17): 6914–6927. doi: 10.1523/JNEUROSCI.23-17-06914.2003

PMCID:: PMC6740729

Abstract Article PDF–598K

Select item 673020213.

The Mental Retardation Protein PAK3 Contributes to Synapse Formation and Plasticity in Hippocampus

Bernadett Boda, Stefano Alberi, Irina Nikonenko, Roxanne Node-Langlois, Pascal Jourdain, Marlyse Moosmayer, Lorena Parisi-Jourdain, Dominique Muller

J Neurosci. 2004 Dec 1; 24(48): 10816–10825. doi: 10.1523/JNEUROSCI.2931-04.2004

PMCID:: PMC6730202

Abstract Article PDF–563K

Select item 644813614.

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis

Fiona J. Sorrell, Lena Marie Kilian, Jonathan M. Elkins

Biochem J. 2019 Apr 15; 476(7): 1037–1051. Prepublished online 2019 Mar 11. Published online 2019 Apr 4. doi: 10.1042/BCJ20180867

PMCID:: PMC6448136

Abstract Article PDF–4.6M

Select item 558615815.

Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability

Babylakshmi Muthusamy, Lakshmi Dhevi N. Selvan, Thong T. Nguyen, Jesna Manoj, Eric W. Stawiski, Bijay S. Jaiswal, Weiru Wang, Remya Raja, Vedam Laxmi Ramprasad, Ravi Gupta, Sakthivel Murugan, Jayarama S. Kadandale, T.S. Keshava Prasad, Kavita Reddy, Andrew Peterson, Akhilesh Pandey, Somasekar Seshagiri, Satish Chandra Girimaji, Harsha Gowda

OMICS. 2017 May 1; 21(5): 295–303. Published online 2017 May 1. doi: 10.1089/omi.2017.0009

PMCID:: PMC5586158

Abstract Article PDF–486K

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549522517.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 499302518.

Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression

Beata Fuchsova, Anabel Alvarez Juliá, Hooriyah S. Rizavi, Alberto Carlos Frasch, Ghanshyam N. Pandey

Neuroscience. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Neuroscience. 2016 Oct 1; 333: 331–344. Published online 2016 Jul 27. doi: 10.1016/j.neuroscience.2016.07.037

PMCID:: PMC4993025

Abstract Article PDF–611K

Select item 460063719.

Altered expression of CDC42 signaling pathway components in cortical layer 3 pyramidal cells in schizophrenia

Dibyadeep Datta, Dominique Arion, John P. Corradi, David A. Lewis

Biol Psychiatry. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Biol Psychiatry. 2015 Dec 1; 78(11): 775–785. Published online 2015 Apr 11. doi: 10.1016/j.biopsych.2015.03.030

PMCID:: PMC4600637

Abstract Article PDF–1.3M

Select item 438583020.

Group I Paks as therapeutic targets in NF2-deficient meningioma

Hoi-Yee Chow, Biao Dong, Sergio G. Duron, David A. Campbell, Christy C. Ong, Klaus P. Hoeflich, Long-Sheng Chang, D. Bradley Welling, Zeng-jie Yang, Jonathan Chernoff

Oncotarget. 2015 Feb; 6(4): 1981–1994. Published online 2015 Jan 24. doi: 10.18632/oncotarget.2810

PMCID:: PMC4385830

Abstract Article PDF–7.1M

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