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Select item 108497801.

Activation of S1P₂ is protective against cisplatin‐induced peripheral neuropathy

Brenda Wan Shing Lam, Ping Xiang, Boya Peng, Ling Jun Joshua Soon, Amelia Ting Yu Yam, Claudine Ming Hui Lim, Yu Zheng, Long N. Nguyen, Deron R. Herr, Minh T. N. Le

Cell Prolif. 2024 Feb; 57(2): e13549. Published online 2023 Sep 19. doi: 10.1111/cpr.13549

PMCID:: PMC10849780

Article PDF–3.8M

Select item 102263372.

Down-regulation of S1PR2 is correlated with poor prognosis and immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma

Yu Zhang, Haichuan Wang, Jie Lu, Qiang Lv, Bei Yun, Zhiru Ge, Li Yan

Int J Immunopathol Pharmacol. 2023 Jan-Dec; 37: 03946320231178131. Published online 2023 May 26. doi: 10.1177/03946320231178131

PMCID:: PMC10226337

Abstract Article PDF–2.5M

Select item 98012303.

Sphingosine 1-phosphate receptor 2 is central to maintaining epidermal barrier homeostasis

Satomi Igawa, Ayaka Ohzono, Phoebe Pham, Zhenping Wang, Teruaki Nakatsuji, Tatsuya Dokoshi, Anna Di Nardo

J Invest Dermatol. Author manuscript; available in PMC 2022 Dec 30.

Published in final edited form as: J Invest Dermatol. 2021 May; 141(5): 1188–1197.e5. Published online 2020 Nov 14. doi: 10.1016/j.jid.2020.09.026

PMCID:: PMC9801230

Abstract Article PDF–1.5M

Select item 87487754.

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Melissa R. Pitman, Alexander C. Lewis, Lorena T. Davies, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Jason A. Powell, Stuart M. Pitson

Sci Rep. 2022; 12: 454. Published online 2022 Jan 10. doi: 10.1038/s41598-021-04009-w

PMCID:: PMC8748775

Abstract Article PDF–1.4M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80274386.

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation

Yu-hang Zhang, Shu-xiang Cui, Sheng-biao Wan, Shu-hua Wu, Xian-jun Qu

Acta Pharmacol Sin. 2021 Mar; 42(3): 460–469. Published online 2020 Jul 9. doi: 10.1038/s41401-020-0460-0

PMCID:: PMC8027438

Abstract Article PDF–3.8M

Select item 76821017.

Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer

Luciana Petti, Giulia Rizzo, Federica Rubbino, Sudharshan Elangovan, Piergiuseppe Colombo, Silvia Restelli, Andrea Piontini, Vincenzo Arena, Michele Carvello, Barbara Romano, Tommaso Cavalleri, Achille Anselmo, Federica Ungaro, Silvia D’Alessio, Antonino Spinelli, Sanja Stifter, Fabio Grizzi, Alessandro Sgambato, Silvio Danese, Luigi Laghi, Alberto Malesci, Stefania Vetrano

J Exp Clin Cancer Res. 2020; 39: 253. Published online 2020 Nov 23. doi: 10.1186/s13046-020-01740-6

PMCID:: PMC7682101

Abstract Article PDF–5.0M

Select item 69491928.

β3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P₂ modulation

Gennaro Bruno, Francesca Cencetti, Alessandro Pini, Annalisa Tondo, Daniela Cuzzubbo, Filippo Fontani, Vanessa Strinna, Anna Maria Buccoliero, Gabriella Casazza, Chiara Donati, Luca Filippi, Paola Bruni, Claudio Favre, Maura Calvani

Oncogene. 2020; 39(2): 368–384. Published online 2019 Sep 2. doi: 10.1038/s41388-019-0993-1

PMCID:: PMC6949192

Abstract Article PDF–6.6M

Select item 68997119.

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF‐1

Lei Liu, Katrin Panzitt, Silvia Racedo, Martin Wagner, Wolfgang Platzer, Alex Zaufel, Verena Theiler‐Schwetz, Barbara Obermayer‐Pietsch, Helmut Müller, Gerald Höfler, Akos Heinemann, Gernot Zollner, Peter Fickert

Liver Int. 2019 Nov; 39(11): 2112–2123. Published online 2019 Feb 17. doi: 10.1111/liv.14052

Correction in:: Liver Int. 2021 May; 41(5): 1175.

PMCID:: PMC6899711

Abstract Article PDF–1.3M

Select item 674461410.

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Yanbao Xiong, Wenji Piao, C. Colin Brinkman, Lushen Li, Joseph M. Kulinski, Ana Olivera, Andreane Cartier, Timothy Hla, Keli L. Hippen, Bruce R. Blazar, Susan R. Schwab, Jonathan S. Bromberg

Sci Immunol. Author manuscript; available in PMC 2019 Sep 15.

Published in final edited form as: Sci Immunol. 2019 Mar 15; 4(33): eaav1263. doi: 10.1126/sciimmunol.aav1263

PMCID:: PMC6744614

Abstract Article PDF–3.6M

Select item 670215711.

S1P₂ contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

Arjun Sapkota, Bhakta Prasad Gaire, Min-Gu Kang, Ji Woong Choi

Sci Rep. 2019; 9: 12106. Published online 2019 Aug 20. doi: 10.1038/s41598-019-48609-z

PMCID:: PMC6702157

Abstract Article PDF–4.6M

Select item 644672112.

Endothelial Differentiation G Protein‐Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency

Irina Neganova, Lewis Cotts, Peter Banks, Katja Gassner, Anvar Shukurov, Lyle Armstrong, Graham Ladds, Majlinda Lako

Stem Cells. 2019 Mar; 37(3): 318–331. Published online 2019 Feb 7. doi: 10.1002/stem.2954

PMCID:: PMC6446721

Abstract Article PDF–1.4M

Select item 629825413.

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Emmy Van Quickelberghe, Delphine De Sutter, Geert van Loo, Sven Eyckerman, Kris Gevaert

Sci Data. 2018; 5: 180289. Published online 2018 Dec 18. doi: 10.1038/sdata.2018.289

PMCID:: PMC6298254

Abstract Article PDF–1.4M

Select item 610592314.

Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2–Mediated Yes-Associated Protein Activation

Runping Liu, Xiaojiaoyang Li, Phillip B. Hylemon, Huiping Zhou

Am J Pathol. 2018 Sep; 188(9): 2042–2058. doi: 10.1016/j.ajpath.2018.05.015

PMCID:: PMC6105923

Abstract Article

Select item 596014815.

The conserved p.Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family

Michaela A. H. Hofrichter, Majid Mojarad, Julia Doll, Clemens Grimm, Atiye Eslahi, Neda Sadat Hosseini, Mohsen Rajati, Tobias Müller, Marcus Dittrich, Reza Maroofian, Thomas Haaf, Barbara Vona

BMC Med Genet. 2018; 19: 81. Published online 2018 May 18. doi: 10.1186/s12881-018-0598-5

PMCID:: PMC5960148

Abstract Article PDF–3.2M

Select item 575432516.

Vitamin D attenuates sphingosine-1-phosphate (S1P)-mediated inhibition of extravillous trophoblast migration

Melissa Westwood, Khiria Al-Saghir, Sarah Finn-Sell, Cherlyn Tan, Elizabeth Cowley, Stéphane Berneau, Daman Adlam, Edward D. Johnstone

Placenta. 2017 Dec; 60: 1–8. doi: 10.1016/j.placenta.2017.09.009

PMCID:: PMC5754325

Abstract Article

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 499982518.

Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human

Masaya Sato, Hitoshi Ikeda, Baasanjav Uranbileg, Makoto Kurano, Daisuke Saigusa, Junken Aoki, Harufumi Maki, Hiroki Kudo, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi

Sci Rep. 2016; 6: 32119. Published online 2016 Aug 26. doi: 10.1038/srep32119

PMCID:: PMC4999825

Abstract Article PDF–493K

Select item 493595519.

S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse

Neil J. Ingham, Francesca Carlisle, Selina Pearson, Morag A. Lewis, Annalisa Buniello, Jing Chen, Rivka L. Isaacson, Johanna Pass, Jacqueline K. White, Sally J. Dawson, Karen P. Steel

Sci Rep. 2016; 6: 28964. Published online 2016 Jul 7. doi: 10.1038/srep28964

PMCID:: PMC4935955

Abstract Article PDF–3.1M

Select item 486198020.

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2

Sathya Narayanan Patmanathan, Steven P. Johnson, Sook Ling Lai, Suthashini Panja Bernam, Victor Lopes, Wenbin Wei, Maha Hafez Ibrahim, Federico Torta, Pradeep Narayanaswamy, Markus R. Wenk, Deron R. Herr, Paul G. Murray, Lee Fah Yap, Ian C. Paterson

Sci Rep. 2016; 6: 25650. Published online 2016 May 10. doi: 10.1038/srep25650

PMCID:: PMC4861980

Abstract Article PDF–1.5M

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