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Select item 105658761.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102820492.

DIS3L2 knockdown impairs key oncogenic properties of colorectal cancer cells via the mTOR signaling pathway

Juan F. García-Moreno, Rafaela Lacerda, Paulo J. da Costa, Marcelo Pereira, Margarida Gama-Carvalho, Paulo Matos, Luísa Romão

Cell Mol Life Sci. 2023 Jul; 80(7): 185. Published online 2023 Jun 20. doi: 10.1007/s00018-023-04833-5

PMCID:: PMC10282049

Abstract Article PDF–3.4M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92792854.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 87489585.

EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation

Liyuan Wang, Chan Chen, Zemin Song, Honghong Wang, Minghui Ye, Donghai Wang, Wenqian Kang, Hudan Liu, Guoliang Qing

Nat Commun. 2022; 13: 12. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27609-6

PMCID:: PMC8748958

Abstract Article PDF–3.0M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75668817.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 73607748.

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90

Wenwen Chen, Wei Wang, Xiaoxia Sun, Shanshan Xie, Xiaoyang Xu, Min Liu, Chunxia Yang, Min Li, Wen Zhang, Wei Liu, Liangjing Wang, Tianhua Zhou, Yuehong Yang

Cell Death Dis. 2020 Jul; 11(7): 534. Published online 2020 Jul 14. doi: 10.1038/s41419-020-02739-9

PMCID:: PMC7360774

Abstract Article PDF–3.3M

Select item 72930079.

DIS3L2 and LSm proteins are involved in the surveillance of Sm ring-deficient snRNAs

Adriana Roithová, Zuzana Feketová, Štěpánka Vaňáčová, David Staněk

Nucleic Acids Res. 2020 Jun 19; 48(11): 6184–6197. Published online 2020 May 6. doi: 10.1093/nar/gkaa301

Correction in:: Nucleic Acids Res. 2022 Nov 28; 50(21): 12597.

PMCID:: PMC7293007

Abstract Article PDF–2.3M

Select item 726549010.

AGO-bound mature miRNAs are oligouridylated by TUTs and subsequently degraded by DIS3L2

Acong Yang, Tie-Juan Shao, Xavier Bofill-De Ros, Chuanjiang Lian, Patricia Villanueva, Lisheng Dai, Shuo Gu

Nat Commun. 2020; 11: 2765. Published online 2020 Jun 2. doi: 10.1038/s41467-020-16533-w

PMCID:: PMC7265490

Abstract Article PDF–3.4M

Select item 725086411.

The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis

Mehdi Pirouz, Chih-Hao Wang, Qi Liu, Aref G. Ebrahimi, Farnaz Shamsi, Yu-Hua Tseng, Richard I. Gregory

Nat Commun. 2020; 11: 2619. Published online 2020 May 26. doi: 10.1038/s41467-020-16418-y

PMCID:: PMC7250864

Abstract Article PDF–2.1M

Select item 711512812.

Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan

Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam

Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525

PMCID:: PMC7115128

Abstract Article PDF–1.6M

Select item 616668213.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 589141714.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 582692615.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 547112516.

Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

D. Williams Parsons, Angshumoy Roy, Yaping Yang, Tao Wang, Sarah Scollon, Katie Bergstrom, Robin A. Kerstein, Stephanie Gutierrez, Andrea K. Petersen, Abhishek Bavle, Frank Y. Lin, Dolores H. López-Terrada, Federico A. Monzon, M. John Hicks, Karen W. Eldin, Norma M. Quintanilla, Adekunle M. Adesina, Carrie A. Mohila, William Whitehead, Andrew Jea, Sanjeev A. Vasudevan, Jed G. Nuchtern, Uma Ramamurthy, Amy L. McGuire, Susan G. Hilsenbeck, Jeffrey G. Reid, Donna M. Muzny, David A. Wheeler, Stacey L. Berg, Murali M. Chintagumpala, Christine M. Eng, Richard A. Gibbs, Sharon E. Plon

JAMA Oncol. Author manuscript; available in PMC 2017 Jul 28.

Published in final edited form as: JAMA Oncol. 2016 May 1; 2(5): 616–624. doi: 10.1001/jamaoncol.2015.5699

PMCID:: PMC5471125

Abstract Article PDF–394K

Select item 531149017.

Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

Jakub Stanislaw Nowak, Fruzsina Hobor, Angela Downie Ruiz Velasco, Nila Roy Choudhury, Gregory Heikel, Alastair Kerr, Andres Ramos, Gracjan Michlewski

RNA. 2017 Mar; 23(3): 317–332. doi: 10.1261/rna.059196.116

PMCID:: PMC5311490

Abstract Article PDF–1.8M

Select item 513741918.

Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs

Anna Łabno, Zbigniew Warkocki, Tomasz Kuliński, Paweł Szczepan Krawczyk, Krystian Bijata, Rafał Tomecki, Andrzej Dziembowski

Nucleic Acids Res. 2016 Dec 1; 44(21): 10437–10453. Published online 2016 Jul 18. doi: 10.1093/nar/gkw649

PMCID:: PMC5137419

Abstract Article PDF–6.4M

Select item 506955519.

TUT‐DIS3L2 is a mammalian surveillance pathway for aberrant structured non‐coding RNAs

Dmytro Ustianenko, Josef Pasulka, Zuzana Feketova, Lukas Bednarik, Dagmar Zigackova, Andrea Fortova, Mihaela Zavolan, Stepanka Vanacova

EMBO J. 2016 Oct 17; 35(20): 2179–2191. Published online 2016 Sep 19. doi: 10.15252/embj.201694857

PMCID:: PMC5069555

Abstract Article PDF–899K

Select item 503652720.

Panorama of ancient metazoan macromolecular complexes

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Nature. Author manuscript; available in PMC 2016 Sep 26.

Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877

PMCID:: PMC5036527

Abstract Article PDF–4.7M

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