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Select item 111427461.

Human NLRC4 expression promotes cancer survival and associates with type I interferon signaling and immune infiltration

Charlotte Domblides, Steven Crampton, Hong Liu, Juliet M. Bartleson, Annie Nguyen, Claudia Champagne, Emily E. Landy, Lindsey Spiker, Christopher Proffitt, Sunil Bhattarai, Anissa P. Grawe, Matias Fuentealba Valenzuela, Lydia Lartigue, Isabelle Mahouche, Jeremy Dupaul-Chicoine, Kazuho Nishimura, Félix Lefort, Marie Decraecker, Valérie Velasco, Sonia Netzer, Vincent Pitard, Christian Roy, Isabelle Soubeyran, Victor Racine, Patrick Blanco, Julie Déchanet-Merville, Maya Saleh, Scott W. Canna, David Furman, Benjamin Faustin

J Clin Invest. 2024 Jun 3; 134(11): e166085. Published online 2024 Apr 23. doi: 10.1172/JCI166085

PMCID:: PMC11142746

Abstract Article PDF–12M

Select item 109208832.

NFκB and NLRP3/NLRC4 inflammasomes regulate differentiation, activation and functional properties of monocytes in response to distinct SARS-CoV-2 proteins

Ilya Tsukalov, Ildefonso Sánchez-Cerrillo, Olga Rajas, Elena Avalos, Gorane Iturricastillo, Laura Esparcia, María José Buzón, Meritxell Genescà, Camila Scagnetti, Olga Popova, Noa Martin-Cófreces, Marta Calvet-Mirabent, Ana Marcos-Jimenez, Pedro Martínez-Fleta, Cristina Delgado-Arévalo, Ignacio de los Santos, Cecilia Muñoz-Calleja, María José Calzada, Isidoro González Álvaro, José Palacios-Calvo, Arantzazu Alfranca, Julio Ancochea, Francisco Sánchez-Madrid, Enrique Martin-Gayo

Nat Commun. 2024; 15: 2100. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46322-8

PMCID:: PMC10920883

Abstract Article PDF–2.7M

Select item 105559503.

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis

Yaping An, Zihan Zhai, Xin Wang, Yiyun Ding, Linlin He, Lingfeng Li, Qi Mo, Chenlu Mu, Runxiang Xie, Tianyu Liu, Weilong Zhong, Bangmao Wang, Hailong Cao

J Adv Res. 2023 Oct; 52: 219–232. Published online 2023 Aug 15. doi: 10.1016/j.jare.2023.08.008

PMCID:: PMC10555950

Abstract Article PDF–6.3M

Select item 102032934.

LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection

Yunhuan Gao, Yazheng Yang, Jianmei Wei, Jianmei Yue, Ya Wang, Qianjing Zhang, Mengli Jin, Rong Wang, Xiaorong Yang, Junqi Zhang, Xinqi Liu, Lin Liu, Yuan Zhang, Rongcun Yang

Cell Mol Immunol. 2023 May; 20(5): 475–488. Published online 2023 Mar 20. doi: 10.1038/s41423-023-00995-1

PMCID:: PMC10203293

Abstract Article PDF–6.2M

Select item 97468185.

NLRC4-mediated activation of CD1c⁺ DC contributes to perpetuation of synovitis in rheumatoid arthritis

Cristina Delgado-Arévalo, Marta Calvet-Mirabent, Ana Triguero-Martínez, Enrique Vázquez de Luis, Alberto Benguría-Filippini, Raquel Largo, Diego Calzada-Fraile, Olga Popova, Ildefonso Sánchez-Cerrillo, Ilya Tsukalov, Roberto Moreno-Vellisca, Hortensia de la Fuente, Gabriel Herrero-Beaumont, Almudena Ramiro, Francisco Sánchez-Madrid, Santos Castañeda, Ana Dopazo, Isidoro González Álvaro, Enrique Martin-Gayo

JCI Insight. 2022 Nov 22; 7(22): e152886. Published online 2022 Nov 22. doi: 10.1172/jci.insight.152886

PMCID:: PMC9746818

Abstract Article PDF–3.0M

Select item 93021796.

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin

Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21

PMCID:: PMC9302179

Abstract Article PDF–2.0M

Select item 88787747.

Association of Tim-3/Gal-9 Axis with NLRC4 Inflammasome in Glioma Malignancy: Tim-3/Gal-9 Induce the NLRC4 Inflammasome

JeongMin Sim, JeongMan Park, Suwan Kim, Sojung Hwang, KyoungSu Sung, Jung-Eun Lee, SeungHo Yang, Kyunggi Cho, SungHwan Lee, Jong-Seok Moon, JuWon Ahn, Jaejoon Lim

Int J Mol Sci. 2022 Feb; 23(4): 2028. Published online 2022 Feb 12. doi: 10.3390/ijms23042028

PMCID:: PMC8878774

Abstract Article PDF–7.1M

Select item 84274308.

The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

Tiantian Tang, Ping Li, Xinhui Zhou, Rui Wang, Xiuqin Fan, Mengyi Yang, Kemin Qi

Front Immunol. 2021; 12: 741839. Published online 2021 Aug 26. doi: 10.3389/fimmu.2021.741839

PMCID:: PMC8427430

Abstract Article PDF–2.1M

Select item 83995769.

Inflammasome Genetic Variants, Macrophage Function, and Clinical Outcomes in Cystic Fibrosis

Andrew D. Graustein, William R. Berrington, Kati J. Buckingham, Felicia K. Nguyen, Lara L. Joudeh, Margaret Rosenfeld, Michael J. Bamshad, Ronald L. Gibson, Thomas R. Hawn, Mary J. Emond

Am J Respir Cell Mol Biol. 2021 Aug; 65(2): 157–166. Published online 2021 Mar 30. doi: 10.1165/rcmb.2020-0257OC

PMCID:: PMC8399576

Abstract Article PDF–993K

Select item 836418110.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 807222411.

Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16): e2013963118. Published online 2021 Apr 12. doi: 10.1073/pnas.2013963118

PMCID:: PMC8072224

Abstract Article PDF–4.7M

Select item 744679212.

A role for the NLRC4 inflammasome in premature rupture of membrane

Jinming Zhu, Chunling Ma, Lina Zhu, Juan Li, Fengyun Peng, Lei Huang, Xiaomei Luan

PLoS One. 2020; 15(8): e0237847. Published online 2020 Aug 24. doi: 10.1371/journal.pone.0237847

PMCID:: PMC7446792

Abstract Article PDF–1.8M

Select item 742839913.

A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis

Shruthi Ravimohan, Pholo Maenetje, Sara C Auld, Itai Ncube, Mandla Mlotshwa, William Chase, Caroline T Tiemessen, Mboyo-Di-Tamba Vangu, Robert S Wallis, Gavin Churchyard, Drew Weissman, Hardy Kornfeld, Gregory P Bisson

Clin Infect Dis. 2020 Aug 15; 71(4): 924–932. Published online 2019 Nov 22. doi: 10.1093/cid/ciz898

PMCID:: PMC7428399

Abstract Article PDF–2.7M

Select item 742436514.

Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease

Xuerong Liu, Xiaogang Bai, Jing Zhao, Chaoqun Gao, Peng Du, Jin-an Zhang, Sheli Li

Biomed Res Int. 2020; 2020: 1378427. Published online 2020 Aug 4. doi: 10.1155/2020/1378427

PMCID:: PMC7424365

Abstract Article PDF–383K

Select item 724662215.

NLRC4, ASC and Caspase-1 Are Inflammasome Components That Are Mediated by P2Y₂R Activation in Breast Cancer Cells

Hana Jin, Hye Jung Kim

Int J Mol Sci. 2020 May; 21(9): 3337. Published online 2020 May 8. doi: 10.3390/ijms21093337

PMCID:: PMC7246622

Abstract Article PDF–2.5M

Select item 681514016.

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

Akhouri Kishore Raghawan, Rajashree Ramaswamy, Vegesna Radha, Ghanshyam Swarup

Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21694–21703. Published online 2019 Oct 9. doi: 10.1073/pnas.1905261116

PMCID:: PMC6815140

Abstract Article PDF–1.8M

Select item 679649217.

Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression

Shouhua Wang, Yongjie Zhang, Qiang Cai, Mingzhe Ma, Long Yang Jin, Mingzhe Weng, Di Zhou, Zhaohui Tang, Jian Dong Wang, Zhiwei Quan

Mol Cancer. 2019; 18: 145. Published online 2019 Oct 17. doi: 10.1186/s12943-019-1078-z

PMCID:: PMC6796492

Abstract Article PDF–4.1M

Select item 657991518.

Flagellin/NLRC4 Pathway Rescues NLRP3-Inflammasome Defect in Dendritic Cells From HIV-Infected Patients: Perspective for New Adjuvant in Immunocompromised Individuals

Edione Cristina dos Reis, Vinícius Nunes Cordeiro Leal, Jaíne Lima da Silva Soares, Fernanda Pereira Fernandes, Dhêmerson Souza de Lima, Bruna Cunha de Alencar, Alessandra Pontillo

Front Immunol. 2019; 10: 1291. Published online 2019 Jun 11. doi: 10.3389/fimmu.2019.01291

PMCID:: PMC6579915

Abstract Article PDF–3.0M

Select item 653651719.

Upregulation of the NLRC4 inflammasome contributes to poor prognosis in glioma patients

Jaejoon Lim, Min Jun Kim, YoungJoon Park, Ju Won Ahn, So Jung Hwang, Jong-Seok Moon, Kyung Gi Cho, KyuBum Kwack

Sci Rep. 2019; 9: 7895. Published online 2019 May 27. doi: 10.1038/s41598-019-44261-9

PMCID:: PMC6536517

Abstract Article PDF–3.8M

Select item 631151520.

Cryo-EM structure of the NLRC4^CARD filament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly

Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Brendan Antiochos, Edward H. Egelman, Jungsan Sohn

J Biol Chem. 2018 Dec 28; 293(52): 20240–20248. Published online 2018 Nov 1. doi: 10.1074/jbc.RA118.006050

PMCID:: PMC6311515

Abstract Article PDF–2.8M

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