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Items: 1 to 20 of 23

1.
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform
Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia
eLife. 2022; 11: e81398. Published online 2022 Sep 30. doi: 10.7554/eLife.81398
PMCID:
PMC9578707
AbstractArticlePDF–3.3M
2.
ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1
Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen
Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119
PMCID:
PMC9231623
AbstractArticlePDF–6.0M
3.
A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis
Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou
Cancer Res Treat. 2022 Apr; 54(2): 525–540. Published online 2021 Jun 29. doi: 10.4143/crt.2021.373
PMCID:
PMC9016320
AbstractArticlePDF–3.0M
4.
Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog
M. Seppala, B. Thivichon-Prince, G.M. Xavier, N. Shaffie, I. Sangani, A.A. Birjandi, J. Rooney, J.N.S. Lau, R. Dhaliwal, O. Rossi, M.A. Riaz, D. Stonehouse-Smith, Y. Wang, S.N. Papageorgiou, L. Viriot, M.T. Cobourne
J Dent Res. 2022 Apr; 101(4): 473–482. Published online 2021 Nov 19. doi: 10.1177/00220345211049403
PMCID:
PMC8935464
AbstractArticlePDF–4.4M
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
Microglia induces Gas1 expression in human brain tumor-initiating cells to reduce tumorigenecity
Susobhan Sarkar, Candice C. Poon, Reza Mirzaei, Khalil S. Rawji, Walter Hader, Pinaki Bose, John Kelly, Jeffrey F. Dunn, V. Wee Yong
Sci Rep. 2018; 8: 15286. Published online 2018 Oct 16. doi: 10.1038/s41598-018-33306-0
PMCID:
PMC6191418
AbstractArticlePDF–2.7M
7.
ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest
Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara
Biol Open. 2018 Mar 15; 7(3): bio031575. Published online 2018 Feb 15. doi: 10.1242/bio.031575
PMCID:
PMC5898266
AbstractArticlePDF–3.4M
8.
TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions
Charles A. S. Banks, Gina Boanca, Zachary T. Lee, Cassandra G. Eubanks, Gaye L. Hattem, Allison Peak, Lauren E. Weems, Juliana J. Conkright, Laurence Florens, Michael P. Washburn
Mol Cell Proteomics. 2016 Nov; 15(11): 3435–3449. Published online 2016 Sep 8. doi: 10.1074/mcp.M116.060509
PMCID:
PMC5098041
AbstractArticlePDF–2.1M
9.
Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1
Katja Rosti, Adrian Goldman, Tommi Kajander
BMC Biochem. 2015; 16: 8. Published online 2015 Feb 28. doi: 10.1186/s12858-015-0037-6
PMCID:
PMC4349606
AbstractArticlePDF–2.5M
10.
Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH
Daniel E. Pineda-Alvarez, Erich Roessler, Ping Hu, Kshitij Srivastava, Benjamin D. Solomon, C. Evan Siple, Chen-Ming Fan, Maximilian Muenke
Hum Genet. Author manuscript; available in PMC 2013 Jun 28.
Published in final edited form as: Hum Genet. 2012 Feb; 131(2): 301–310. Published online 2011 Aug 13. doi: 10.1007/s00439-011-1078-6
PMCID:
PMC3695622
AbstractArticlePDF–697K
11.
Gas1 Interferes with AβPP Trafficking by Facilitating the Accumulation of Immature AβPP in Endoplasmic Reticulum-Associated Raft Subdomains
Julien Chapuis, Valérie Vingtdeux, Hemachander Capiralla, Peter Davies, Philippe Marambaud
J Alzheimers Dis. Author manuscript; available in PMC 2013 Jan 1.
Published in final edited form as: J Alzheimers Dis. 2012 Jan; 28(1): 127–135. doi: 10.3233/JAD-2011-110434
PMCID:
PMC3309423
AbstractArticlePDF–1.6M
12.
Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-β precursor protein
Julien Chapuis, Valérie Vingtdeux, Fabien Campagne, Peter Davies, Philippe Marambaud
Hum Mol Genet. 2011 May 15; 20(10): 2026–2036. Published online 2011 Feb 28. doi: 10.1093/hmg/ddr085
PMCID:
PMC3279048
AbstractArticlePDF–465K
13.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
14.
Genome-Wide Detection of Allele Specific Copy Number Variation Associated with Insulin Resistance in African Americans from the HyperGEN Study
Marguerite R. Irvin, Nathan E. Wineinger, Treva K. Rice, Nicholas M. Pajewski, Edmond K. Kabagambe, Charles C. Gu, Jim Pankow, Kari E. North, Jemma B. Wilk, Barry I. Freedman, Nora Franceschini, Uli Broeckel, Hemant K. Tiwari, Donna K. Arnett
PLoS One. 2011; 6(8): e24052. Published online 2011 Aug 25. doi: 10.1371/journal.pone.0024052
PMCID:
PMC3162025
AbstractArticlePDF–119K
15.
Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility “Hot-Spot”
Sharon E. Johnatty, Jonathan Beesley, Xiaoqing Chen, Stuart Macgregor, David L. Duffy, Amanda B. Spurdle, Anna deFazio, Natalie Gava, Penelope M. Webb, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Mary Anne Rossing, Jennifer Anne Doherty, Marc T. Goodman, Galina Lurie, Pamela J. Thompson, Lynne R. Wilkens, Roberta B. Ness, Kirsten B. Moysich, Jenny Chang-Claude, Shan Wang-Gohrke, Daniel W. Cramer, Kathryn L. Terry, Susan E. Hankinson, Shelley S. Tworoger, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Stephen J. Chanock, Paul D. Pharoah, Honglin Song, Alice S. Whitemore, Celeste L. Pearce, Daniel O. Stram, Anna H. Wu, Malcolm C. Pike, Simon A. Gayther, Susan J. Ramus, Usha Menon, Aleksandra Gentry-Maharaj, Hoda Anton-Culver, Argyrios Ziogas, Estrid Hogdall, Susanne K. Kjaer, Claus Hogdall, Andrew Berchuck, Joellen M. Schildkraut, Edwin S. Iversen, Patricia G. Moorman, Catherine M. Phelan, Thomas A. Sellers, Julie M. Cunningham, Robert A. Vierkant, David N. Rider, Ellen L. Goode, Izhak Haviv, Georgia Chenevix-Trench, Ovarian Cancer Association Consortium
PLoS Genet. 2010 Jul; 6(7): e1001016. Published online 2010 Jul 8. doi: 10.1371/journal.pgen.1001016
PMCID:
PMC2900295
AbstractArticlePDF–587K
16.
Mig-6 controls EGFR trafficking and suppresses gliomagenesis
Haoqiang Ying, Hongwu Zheng, Kenneth Scott, Ruprecht Wiedemeyer, Haiyan Yan, Carol Lim, Joseph Huang, Sabin Dhakal, Elena Ivanova, Yonghong Xiao, Hailei Zhang, Jian Hu, Jayne M. Stommel, Michelle A. Lee, An-Jou Chen, Ji-Hye Paik, Oreste Segatto, Cameron Brennan, Lisa A. Elferink, Y. Alan Wang, Lynda Chin, Ronald A. DePinho
Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15): 6912–6917. Published online 2010 Mar 29. doi: 10.1073/pnas.0914930107
PMCID:
PMC2872443
AbstractArticlePDF–967K
17.
Identification of GAS1 as an Epirubicin Resistance-related Gene in Human Gastric Cancer Cells with a Partially Randomized Small Interfering RNA Library
Lina Zhao, Yanglin Pan, Yi Gang, Honghong Wang, Haifeng Jin, Jun Tie, Lin Xia, Yongguo Zhang, Lijie He, Liping Yao, Taidong Qiao, Tingting Li, Zhiguo Liu, Daiming Fan
J Biol Chem. 2009 Sep 25; 284(39): 26273–26285. Published online 2009 Jul 28. doi: 10.1074/jbc.M109.028068
PMCID:
PMC2785315
AbstractArticlePDF–2.3M
18.
Ubiquitin-mediated proteolysis of HuR by heat shock
Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe
EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67
PMCID:
PMC2683047
AbstractArticlePDF–1.4M
19.
A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene
Stephane Gobeil, Xiaochun Zhu, Charles J. Doillon, Michael R. Green
Genes Dev. 2008 Nov 1; 22(21): 2932–2940. doi: 10.1101/gad.1714608
PMCID:
PMC2577790
AbstractArticlePDF–629K
20.
HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
Yan Xu, Joseph Kulkosky, Edward Acheampong, Giuseppe Nunnari, Julie Sullivan, Roger J. Pomerantz
Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 7070–7075. Published online 2004 Apr 21. doi: 10.1073/pnas.0304859101
PMCID:
PMC406467
AbstractArticlePDF–362K

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