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Items: 1 to 20 of 30

1.
A Novel GUCA1A Variant Associated with Cone Dystrophy Alters cGMP Signaling in Photoreceptors by Strongly Interacting with and Hyperactivating Retinal Guanylate Cyclase
Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Antonio Mattia Modarelli, Matteo Bertelli, Leonardo Colombo, Daniele Dell’Orco
Int J Mol Sci. 2021 Oct; 22(19): 10809. Published online 2021 Oct 6. doi: 10.3390/ijms221910809
PMCID:
PMC8509414
AbstractArticlePDF–5.2M
2.
Impaired Ca2+ Sensitivity of a Novel GCAP1 Variant Causes Cone Dystrophy and Leads to Abnormal Synaptic Transmission Between Photoreceptors and Bipolar Cells
Valerio Marino, Giuditta Dal Cortivo, Paolo Enrico Maltese, Giorgio Placidi, Elisa De Siena, Benedetto Falsini, Matteo Bertelli, Daniele Dell’Orco
Int J Mol Sci. 2021 Apr; 22(8): 4030. Published online 2021 Apr 14. doi: 10.3390/ijms22084030
PMCID:
PMC8070792
AbstractArticlePDF–4.5M
3.
Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca2+ or Mg2+: Hints to Understand Protein Activity
Francesco Bonì, Valerio Marino, Carlo Bidoia, Eloise Mastrangelo, Alberto Barbiroli, Daniele Dell’Orco, Mario Milani
Biomolecules. 2020 Oct; 10(10): 1408. Published online 2020 Oct 5. doi: 10.3390/biom10101408
PMCID:
PMC7600425
AbstractArticlePDF–2.8M
4.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
5.
Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to “Locking” Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition
Seher Abbas, Valerio Marino, Laura Bielefeld, Karl-Wilhelm Koch, Daniele Dell’Orco
Int J Mol Sci. 2020 Feb; 21(3): 752. Published online 2020 Jan 23. doi: 10.3390/ijms21030752
PMCID:
PMC7037459
AbstractArticlePDF–5.2M
6.
Functional characterization of a novel GUCA1A missense mutation (D144G) in autosomal dominant cone dystrophy: A novel pathogenic GUCA1A variant in COD
Suzhen Tang, Yujun Xia, Yunhai Dai, Yaning Liu, Jingshuo Li, Xiaojing Pan, Peng Chen
Mol Vis. 2019; 25: 921–xxx. Published online 2019 Dec 31.
PMCID:
PMC6982429
AbstractArticlePDF–4.8M
7.
Normal GCAPs partly compensate for altered cGMP signaling in retinal dystrophies associated with mutations in GUCA1A
Daniele Dell’Orco, Giuditta Dal Cortivo
Sci Rep. 2019; 9: 20105. Published online 2019 Dec 27. doi: 10.1038/s41598-019-56606-5
PMCID:
PMC6934868
AbstractArticlePDF–2.4M
8.
Characterization of GUCA1A-associated dominant cone/cone-rod dystrophy: low prevalence among Japanese patients with inherited retinal dystrophies
Kei Mizobuchi, Takaaki Hayashi, Satoshi Katagiri, Kazutoshi Yoshitake, Kaoru Fujinami, Lizhu Yang, Kazuki Kuniyoshi, Kei Shinoda, Shigeki Machida, Mineo Kondo, Shinji Ueno, Hiroko Terasaki, Tomokazu Matsuura, Kazushige Tsunoda, Takeshi Iwata, Tadashi Nakano
Sci Rep. 2019; 9: 16851. Published online 2019 Nov 14. doi: 10.1038/s41598-019-52660-1
PMCID:
PMC6856191
AbstractArticlePDF–3.0M
9.
A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration
Igor V. Peshenko, Artur V. Cideciyan, Alexander Sumaroka, Elena V. Olshevskaya, Alexander Scholten, Seher Abbas, Karl-Wilhelm Koch, Samuel G. Jacobson, Alexander M. Dizhoor
J Biol Chem. 2019 Mar 8; 294(10): 3476–3488. Published online 2019 Jan 8. doi: 10.1074/jbc.RA118.006180
PMCID:
PMC6416442
AbstractArticlePDF–3.0M
10.
GUCA1A mutation causes maculopathy in a five-generation family with a wide spectrum of severity
Xue Chen, Xunlun Sheng, Wenjuan Zhuang, Xiantao Sun, Guohua Liu, Xun Shi, Guofu Huang, Yan Mei, Yingjie Li, Xinyuan Pan, Yani Liu, Zili Li, Qingshun Zhao, Biao Yan, Chen Zhao
Genet Med. 2017 Aug; 19(8): 945–954. Published online 2017 Jan 26. doi: 10.1038/gim.2016.217
PMCID:
PMC5548935
AbstractArticlePDF–1.6M
11.
Cone dystrophy or macular dystrophy associated with novel autosomal dominant GUCA1A mutations
Gaël Manes, Sonia Mamouni, Emilie Hérald, Anne-Claire Richard, Audrey Sénéchal, Karim Aouad, Béatrice Bocquet, Isabelle Meunier, Christian P. Hamel
Mol Vis. 2017; 23: 198–209. Published online 2017 Apr 3.
PMCID:
PMC5389339
AbstractArticlePDF–2.7M
12.
Label-free quantification of calcium-sensor targeting to photoreceptor guanylate cyclase and rhodopsin kinase by backscattering interferometry
Stefan Sulmann, Amanda Kussrow, Darryl J. Bornhop, Karl-Wilhelm Koch
Sci Rep. 2017; 7: 45515. Published online 2017 Mar 31. doi: 10.1038/srep45515
PMCID:
PMC5374524
AbstractArticlePDF–777K
13.
Allosteric communication pathways routed by Ca2+/Mg2+ exchange in GCAP1 selectively switch target regulation modes
Valerio Marino, Daniele Dell’Orco
Sci Rep. 2016; 6: 34277. Published online 2016 Oct 14. doi: 10.1038/srep34277
PMCID:
PMC5064319
AbstractArticlePDF–2.3M
14.
Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface
Igor V. Peshenko, Elena V. Olshevskaya, Alexander M. Dizhoor
J Biol Chem. 2015 Aug 7; 290(32): 19584–19596. Published online 2015 Jun 22. doi: 10.1074/jbc.M115.661371
PMCID:
PMC4528125
AbstractArticlePDF–3.8M
15.
Evaluating the Role of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Domains in Binding Guanylyl Cyclase-activating Proteins (GCAPs)
Igor V. Peshenko, Elena V. Olshevskaya, Alexander M. Dizhoor
J Biol Chem. 2015 Mar 13; 290(11): 6913–6924. Published online 2015 Jan 23. doi: 10.1074/jbc.M114.629642
PMCID:
PMC4358116
AbstractArticlePDF–2.7M
16.
The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets
Maria Katsogiannou, Claudia Andrieu, Virginie Baylot, Anaïs Baudot, Nelson J. Dusetti, Odile Gayet, Pascal Finetti, Carmen Garrido, Daniel Birnbaum, François Bertucci, Christine Brun, Palma Rocchi
Mol Cell Proteomics. 2014 Dec; 13(12): 3585–3601. Published online 2014 Oct 1. doi: 10.1074/mcp.M114.041228
PMCID:
PMC4256507
AbstractArticlePDF–3.9M
17.
Identification of Target Binding Site in Photoreceptor Guanylyl Cyclase-activating Protein 1 (GCAP1)
Igor V. Peshenko, Elena V. Olshevskaya, Sunghyuk Lim, James B. Ames, Alexander M. Dizhoor
J Biol Chem. 2014 Apr 4; 289(14): 10140–10154. Published online 2014 Feb 24. doi: 10.1074/jbc.M113.540716
PMCID:
PMC3974984
AbstractArticlePDF–4.6M
18.
Disease Progression in Autosomal Dominant Cone-Rod Dystrophy Caused by a Novel Mutation (D100G) in the GUCA1A Gene
Eva Nong, Winston Lee, Joanna E. Merriam, Rando Allikmets, Stephen H. Tsang
Doc Ophthalmol. Author manuscript; available in PMC 2015 Feb 1.
Published in final edited form as: Doc Ophthalmol. 2014 Feb; 128(1): 59–67. Published online 2013 Dec 19. doi: 10.1007/s10633-013-9420-z
PMCID:
PMC3974164
AbstractArticlePDF–1.8M
19.
Novel GUCA1A Mutations Suggesting Possible Mechanisms of Pathogenesis in Cone, Cone-Rod, and Macular Dystrophy Patients
Kunka Kamenarova, Marta Corton, Blanca García-Sandoval, Patricia Fernández-San Jose, Valentin Panchev, Almudena Ávila-Fernández, Maria Isabel López-Molina, Christina Chakarova, Carmen Ayuso, Shomi S. Bhattacharya
Biomed Res Int. 2013; 2013: 517570. Published online 2013 Aug 14. doi: 10.1155/2013/517570
PMCID:
PMC3759255
AbstractArticlePDF–4.7M
20.
Retinal Degeneration 3 (RD3) Protein Inhibits Catalytic Activity of Retinal Membrane Guanylyl Cyclase (RetGC) and Its Stimulation by Activating Proteins
Igor V. Peshenko, Elena V. Olshevskaya, Seifollah Azadi, Laurie L. Molday, Robert S. Molday, Alexander M. Dizhoor
Biochemistry. Author manuscript; available in PMC 2012 Nov 8.
Published in final edited form as: Biochemistry. 2011 Nov 8; 50(44): 9511–9519. Published online 2011 Oct 11. doi: 10.1021/bi201342b
PMCID:
PMC3206180
AbstractArticlePDF–2.2M

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