PMC Links for GEO Profiles (Select 125131407) - PMC

Veronika Vaclavik, Aurelie Navarro, Alain Jacot-Guillarmod, Armand Bottani, Young Joo Sun, Joel A. Franco, Vinit B. Mahajan, Vasily Smirnov, Isabelle Bouvet-Drumare

Graefes Arch Clin Exp Ophthalmol. 2024; 262(6): 1737–1744. Published online 2024 Jan 11. doi: 10.1007/s00417-023-06345-1

PMCID:: PMC11105987

Abstract Article PDF–6.5M

Select item 109332674.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108452365.

Molecular insights of KMT2D and clinical aspects of Kabuki Syndrome Type 1

Carly S. Golden, Saylor Williams, Maria A. Serrano

Birth Defects Res. Author manuscript; available in PMC 2024 Feb 6.

Published in final edited form as: Birth Defects Res. 2023 Nov 15; 115(19): 1809–1824. Published online 2023 May 9. doi: 10.1002/bdr2.2183

PMCID:: PMC10845236

Abstract Article PDF–911K

Select item 108159136.

KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans

Allison J. Kalinousky, Teresa R. Luperchio, Katrina M. Schrode, Jacqueline R. Harris, Li Zhang, Valerie B. DeLeon, Jill A. Fahrner, Amanda M. Lauer, Hans T. Bjornsson

Genes (Basel) 2024 Jan; 15(1): 48. Published online 2023 Dec 28. doi: 10.3390/genes15010048

PMCID:: PMC10815913

Abstract Article PDF–1.9M

Select item 107870677.

EBF2 Links KMT2D‐Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN

Bing Yao, Mengying Xing, Shixin Meng, Shang Li, Jingwan Zhou, Ming Zhang, Chen Yang, Shuang Qu, Yucui Jin, Hongyan Yuan, Ke Zen, Changyan Ma

Adv Sci (Weinh) 2024 Jan; 11(2): 2302037. Published online 2023 Nov 28. doi: 10.1002/advs.202302037

PMCID:: PMC10787067

Abstract Article PDF–18M

Select item 107675988.

Hearing characteristics and otoradiological abnormalities in three patients with novel pathogenic variants of KMT2D‐related Kabuki syndrome

Zhoushu Zheng, Lu Ding, Meihong Wang, Yinghui Zhang, Yihui Yang, Ming Tang, Jun Xu, Liangjiong Wang, Junhua Wu, Haibo Li

Mol Genet Genomic Med. 2024 Jan; 12(1): e2306. Published online 2023 Nov 3. doi: 10.1002/mgg3.2306

PMCID:: PMC10767598

Abstract Article PDF–1.3M

Select item 106524649.

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder

Cell Commun Signal. 2023; 21: 328. Published online 2023 Nov 16. doi: 10.1186/s12964-023-01335-6

PMCID:: PMC10652464

Abstract Article PDF–8.0M

Select item 1056587610.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1038870611.

KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

Yuanwang Pan, Han Han, Hai Hu, Hua Wang, Yueqiang Song, Yuan Hao, Xinyuan Tong, Ayushi S Patel, Selim Misirlioglu, Sittinon Tang, Hsin-Yi Huang, Ke Geng, Ting Chen, Angeliki Karatza, Fiona Sherman, Kristen E Labbe, Fan Yang, Alison Chafitz, Chengwei Peng, Chenchen Guo, Andre L Moreira, Vamsidhar Velcheti, Sally CM Lau, Pengfei Sui, Haiquan Chen, J Alan Diehl, Anil K Rustgi, Adam J Bass, John T Poirier, Xiaoyang Zhang, Hongbin Ji, Hua Zhang, Kwok-Kin Wong

Cancer Cell. Author manuscript; available in PMC 2024 Jan 9.

Published in final edited form as: Cancer Cell. 2023 Jan 9; 41(1): 88–105.e8. Published online 2022 Dec 15. doi: 10.1016/j.ccell.2022.11.015

PMCID:: PMC10388706

Abstract Article PDF–3.8M

Select item 1037259012.

MLL4 Regulates the Progression of Non–Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang, Rongfang Qiu, Qiaoyou Weng, Ziwei Xu, Jingjing Song, Siyu Zhao, Miaomiao Meng, Dengke Zhang, Chunli Kong, Hailin Wang, Min Xu, Zhongwei Zhao, Jiansong Ji

Cancer Res Treat. 2023 Jul; 55(3): 778–803. Published online 2023 Jan 26. doi: 10.4143/crt.2022.1042

PMCID:: PMC10372590

Abstract Article PDF–4.8M

Select item 1033010013.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

Shuang Lu, Hong Sun Kim, Yubo Cao, Karan Bedi, Lili Zhao, Ishwarya Venkata Narayanan, Brian Magnuson, Yumei Gu, Jing Yang, Zhujun Yi, Sepideh Babaniamansour, Sargis Shameon, Chang Xu, Michelle T. Paulsen, Ping Qiu, Sivakumar Jeyarajan, Mats Ljungman, Dafydd Thomas, Yali Dou, Howard Crawford, Marina Pasca di Magliano, Kai Ge, Bo Yang, Jiaqi Shi

Int J Cancer. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Int J Cancer. 2023 Aug 1; 153(3): 552–570. Published online 2023 May 4. doi: 10.1002/ijc.34528

PMCID:: PMC10330100

Abstract Article PDF–1.5M

Select item 1032509614.

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression

Jin Wei, Mia Madel Alfajaro, Wesley L. Cai, Vincent R. Graziano, Madison S. Strine, Renata B. Filler, Scott B. Biering, Sylvia A. Sarnik, Sonam Patel, Bridget L. Menasche, Susan R. Compton, Silvana Konermann, Patrick D. Hsu, Robert C. Orchard, Qin Yan, Craig B. Wilen

PLoS Pathog. 2023 Jul; 19(7): e1011351. Published online 2023 Jul 6. doi: 10.1371/journal.ppat.1011351

PMCID:: PMC10325096

Abstract Article PDF–2.9M

Select item 1032362915.

KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition

Jing Xu, Ailing Zhong, Shan Zhang, Mei Chen, Lanxin Zhang, Xiaohang Hang, Jianan Zheng, Baohong Wu, Xintong Deng, Xiangyu Pan, Zhongwang Wang, Lu Qi, Kaidou Shi, Shujun Li, Yiyun Wang, Manli Wang, Xuelan Chen, Qi Zhang, Pengpeng Liu, Robert Peter Gale, Chong Chen, Yu Liu, Ting Niu

Adv Sci (Weinh) 2023 Jul; 10(19): 2206098. Published online 2023 May 4. doi: 10.1002/advs.202206098

PMCID:: PMC10323629

Abstract Article PDF–3.9M

Select item 1015161516.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 1008921417.

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells

Sofija Vlasevska, Laura Garcia-Ibanez, Romain Duval, Antony B. Holmes, Rahat Jahan, Bowen Cai, Andrew Kim, Tongwei Mo, Katia Basso, Rajesh K. Soni, Govind Bhagat, Riccardo Dalla-Favera, Laura Pasqualucci

Proc Natl Acad Sci U S A. 2023 Mar 14; 120(11): e2218330120. Published online 2023 Mar 9. doi: 10.1073/pnas.2218330120

PMCID:: PMC10089214

Abstract Article PDF–4.9M

Select item 1006742018.

Association of KMT2C/D loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer

Ruiqi Liu, Yanling Niu, Chao Liu, Xin Zhang, Jinku Zhang, Min Shi, Wenbo Zou, Binbin Gu, Honglin Zhu, Danhua Wang, Hongling Yuan, Wei Li, Dandan Zhao, Qiaosong Zheng, Rong Liu, Weiping Chen, Tonghui Ma, Yanqiao Zhang

Cancer Sci. 2023 Apr; 114(4): 1229–1239. Published online 2023 Jan 24. doi: 10.1111/cas.15716

PMCID:: PMC10067420

Abstract Article PDF–4.1M

Select item 986621019.

Mutational Landscape of Bladder Cancer in Mexican Patients: KMT2D Mutations and chr11q15.5 Amplifications Are Associated with Muscle Invasion

María D. Pérez-Montiel, Dennis Cerrato-Izaguirre, Yesennia Sánchez-Pérez, Jose Diaz-Chavez, Carlo César Cortés-González, Jairo A. Rubio, Miguel A. Jiménez-Ríos, Luis A. Herrera, Anna Scavuzzo, Abelardo Meneses-García, Ricardo Hernández-Martínez, Felipe Vaca-Paniagua, Andrea Ramírez, Alicia Orozco, David Cantú-de-León, Diddier Prada

Int J Mol Sci. 2023 Jan; 24(2): 1092. Published online 2023 Jan 6. doi: 10.3390/ijms24021092

PMCID:: PMC9866210

Abstract Article PDF–2.0M

Select item 981306220.

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers

Anna Maria Stroynowska-Czerwinska, Magdalena Klimczak, Michal Pastor, Asgar Abbas Kazrani, Katarzyna Misztal, Matthias Bochtler

Cell Mol Life Sci. 2023 Jan; 80(1): 23. Published online 2023 Jan 4. doi: 10.1007/s00018-022-04651-1

PMCID:: PMC9813062

Abstract Article PDF–8.1M

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