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Select item 115650401.

Single-cell RNA transcriptomics in mice reveals embryonic origin of fibrosis due to maternal obesity

Md Nazmul Hossain, Yao Gao, Xinrui Li, Liang Zhao, Xiangdong Liu, Jeanene Marie de Avila, Mei-Jun Zhu, Min Du

eBioMedicine. 2024 Nov; 109: 105421. Published online 2024 Oct 30. doi: 10.1016/j.ebiom.2024.105421

PMCID:: PMC11565040

Abstract Article PDF–4.9M

Select item 113988662.

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

Jiansen Lu, Jiahuan Zhang, Huaji Jiang, Zhiqiang Hu, Yufen Zhang, Lian He, Jianwu Yang, Yingchao Xie, Dan Wu, Hongyu Li, Ke Zeng, Peng Tan, Qingyue Xiao, Zijing Song, Chenglong Pan, Xiaochun Bai, Xiao Yu

eLife. 2024; 12: RP87935. Published online 2024 Sep 13. doi: 10.7554/eLife.87935

PMCID:: PMC11398866

Abstract Article PDF–7.8M

Select item 113952673.

Rabies Virus Regulates Inflammatory Response in BV-2 Cells through Activation of Myd88 and NF-κB Signaling Pathways via TLR7

Yuan Xie, Yinglin Chi, Xiaoyan Tao, Pengcheng Yu, Qian Liu, Minghui Zhang, Nuo Yang, Shuqing Liu, Wuyang Zhu

Int J Mol Sci. 2024 Sep; 25(17): 9144. Published online 2024 Aug 23. doi: 10.3390/ijms25179144

PMCID:: PMC11395267

Abstract Article PDF–22M

Select item 113217614.

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

Jyotsna, Binayak Sarkar, Mohit Yadav, Alvina Deka, Manasvini Markandey, Priyadarshini Sanyal, Perumal Nagarajan, Nilesh Gaikward, Vineet Ahuja, Debasisa Mohanty, Soumen Basak, Rajesh S Gokhale

eLife. 2024; 12: RP93273. Published online 2024 Aug 13. doi: 10.7554/eLife.93273

PMCID:: PMC11321761

Abstract Article PDF–3.9M

Select item 113216375.

Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis

Wenxin Feng, Ningning Niu, Ping Lu, Zhuo Chen, Hanyu Rao, Wei Zhang, Chunxiao Ma, Changwei Liu, Yue Xu, Wei‐Qiang Gao, Jing Xue, Li Li

Adv Sci (Weinh) 2024 Aug; 11(30): 2309387. Published online 2024 Jun 18. doi: 10.1002/advs.202309387

PMCID:: PMC11321637

Abstract Article PDF–7.7M

Select item 111441946.

IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development

Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas

Nat Commun. 2024; 15: 4673. Published online 2024 Jun 1. doi: 10.1038/s41467-024-48854-5

PMCID:: PMC11144194

Abstract Article PDF–3.9M

Select item 110151627.

Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination

Shah Md Toufiqur Rahman, Apeksha Singh, Sarina Lowe, Mohammad Aqdas, Kevin Jiang, Haripriya Vaidehi Narayanan, Alexander Hoffmann, Myong-Hee Sung

Cell Rep. Author manuscript; available in PMC 2024 Apr 13.

Published in final edited form as: Cell Rep. 2024 Mar 26; 43(3): 113940. Published online 2024 Mar 13. doi: 10.1016/j.celrep.2024.113940

PMCID:: PMC11015162

Abstract Article PDF–2.0M

Select item 109909418.

Formation of memory assemblies through the DNA-sensing TLR9 pathway

Vladimir Jovasevic, Elizabeth M. Wood, Ana Cicvaric, Hui Zhang, Zorica Petrovic, Anna Carboncino, Kendra K. Parker, Thomas E. Bassett, Maria Moltesen, Naoki Yamawaki, Hande Login, Joanna Kalucka, Farahnaz Sananbenesi, Xusheng Zhang, Andre Fischer, Jelena Radulovic

Nature. 2024; 628(8006): 145–153. Published online 2024 Mar 27. doi: 10.1038/s41586-024-07220-7

PMCID:: PMC10990941

Abstract Article PDF–58M

Select item 109868159.

NF-κB subunits RelA and c-Rel selectively control CD4⁺ T cell function in multiple sclerosis and cancer

Guilhem Lalle, Raphaëlle Lautraite, Khaled Bouherrou, Maud Plaschka, Aurora Pignata, Allison Voisin, Julie Twardowski, Marlène Perrin-Niquet, Pierre Stéphan, Sarah Durget, Laurie Tonon, Maude Ardin, Cyril Degletagne, Alain Viari, Laurence Belgarbi Dutron, Nathalie Davoust, Thomas S. Postler, Jingyao Zhao, Christophe Caux, Julie Caramel, Stéphane Dalle, Philippe A. Cassier, Ulf Klein, Marc Schmidt-Supprian, Roland Liblau, Sankar Ghosh, Yenkel Grinberg-Bleyer

J Exp Med. 2024 Jun 3; 221(6): e20231348. Published online 2024 Apr 2. doi: 10.1084/jem.20231348

PMCID:: PMC10986815

Abstract Article PDF–7.9M

Select item 1094853110.

The NF-κB RelA transcription factor is not required for CD8+ T-cell function in acute viral infection and cancer

Allison Voisin, Maud Plaschka, Marlène Perrin-Niquet, Julie Twardowski, Insaf Boutemine, Baptiste Eluard, Guilhem Lalle, Pierre Stéphan, Khaled Bouherrou, Laurie Tonon, Roxane Pommier, Anthony Ferrari, Ulf Klein, Mélanie Wencker, Véronique Baud, Philippe A. Cassier, Yenkel Grinberg-Bleyer

Front Immunol. 2024; 15: 1379777. Published online 2024 Mar 5. doi: 10.3389/fimmu.2024.1379777

PMCID:: PMC10948531

Abstract Article PDF–5.7M

Select item 1090769111.

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen

Cell Death Dis. 2024 Mar; 15(3): 180. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06545-5

PMCID:: PMC10907691

Abstract Article PDF–9.3M

Select item 1075358812.

Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease

Tao Cheng, Chidera Agwu, Kyuhwan Shim, Baolin Wang, Sanjay Jain, Moe R. Mahjoub

Development. 2023 Dec 15; 150(24): dev201976. Published online 2023 Dec 21. doi: 10.1242/dev.201976

PMCID:: PMC10753588

Abstract Article

Select item 1064989113.

TCR-independent CD137 (4–1BB) signaling promotes CD8⁺-exhausted T cell proliferation and terminal differentiation

Andrea C. Pichler, Nadège Carrié, Marine Cuisinier, Samira Ghazali, Allison Voisin, Pierre-Paul Axisa, Marie Tosolini, Céline Mazzotti, Dominic P. Golec, Sabrina Maheo, Laura do Souto, Rüçhan Ekren, Eve Blanquart, Lea Lemaitre, Virginie Feliu, Marie-Véronique Joubert, Jennifer L. Cannons, Camille Guillerey, Hervé Avet-Loiseau, Tania H. Watts, Benoit L. Salomon, Olivier Joffre, Yenkel Grinberg-Bleyer, Pamela L. Schwartzberg, Liliana E. Lucca, Ludovic Martinet

Immunity. Author manuscript; available in PMC 2023 Nov 15.

Published in final edited form as: Immunity. 2023 Jul 11; 56(7): 1631–1648.e10. Published online 2023 Jun 30. doi: 10.1016/j.immuni.2023.06.007

PMCID:: PMC10649891

Abstract Article PDF–3.7M

Select item 1062146914.

Production of a p65^fl/fl/LysMCre mouse model with dysfunctional NF-κB signaling in bone marrow-derived macrophages

Ahmet K. Korkaya, Jeffrey Fischer, Anthony Peppers, Sean M. Crosson, Manira Rayamajhi, Edward A. Miao, Albert S. Baldwin, Jr, Jennifer W. Bradford

Innate Immun. 2023 Nov; 29(8): 171–185. Published online 2023 Oct 13. doi: 10.1177/17534259231205993

PMCID:: PMC10621469

Abstract Article PDF–2.3M

Select item 1036756815.

Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling

Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He

Int J Biol Sci. 2023; 19(11): 3428–3440. Published online 2023 Jul 3. doi: 10.7150/ijbs.84426

PMCID:: PMC10367568

Abstract Article PDF–7.2M

Select item 1032806616.

Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses

Stefanie Luecke, Adewunmi Adelaja, Xiaolu Guo, Supriya Sen, Roberto Spreafico, Apeksha Singh, Yi Liu, Brooks Taylor, Jessica Diaz, Quen Cheng, Alexander Hoffmann

EMBO Rep. 2023 Jul; 24(7): e55986. Published online 2023 May 22. doi: 10.15252/embr.202255986

PMCID:: PMC10328066

Abstract Article PDF–6.1M

Select item 1031789517.

RELA governs a network of islet-specific metabolic genes necessary for beta cell function

Nathan W. Zammit, Ying Ying Wong, Stacey N. Walters, Joanna Warren, Simon C. Barry, Shane T. Grey

Diabetologia. 2023; 66(8): 1516–1531. Published online 2023 Jun 14. doi: 10.1007/s00125-023-05931-6

PMCID:: PMC10317895

Abstract Article PDF–3.0M

Select item 1018570318.

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao

J Orthop Translat. 2023 May; 40: 13–26. Published online 2023 May 5. doi: 10.1016/j.jot.2023.04.003

PMCID:: PMC10185703

Abstract Article PDF–4.9M

Select item 1010744819.

Circadian disruption in lung fibroblasts enhances NF‐κB activity to exacerbate neutrophil recruitment

Shannon L. Cox, James R. O'Siorain, Yan He, Ronan Lordan, Amruta Naik, Soon Yew Tang, Shaon Sengupta, Garret A. FitzGerald, Richard G. Carroll, Annie M. Curtis

FASEB J. 2023 Feb; 37(2): e22753. Published online 2023 Jan 9. doi: 10.1096/fj.202201456R

PMCID:: PMC10107448

Abstract Article PDF–7.7M

Select item 1007046020.

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer

Lioba Koerner, Marcel Schmiel, Tsun-Po Yang, Martin Peifer, Reinhard Buettner, Manolis Pasparakis

Cell Death Differ. 2023 Apr; 30(4): 938–951. Published online 2023 Jan 18. doi: 10.1038/s41418-023-01112-5

PMCID:: PMC10070460

Abstract Article PDF–7.1M

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