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Select item 111940851.

EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells

Néstor García-Rodríguez, Iria Domínguez-García, María del Carmen Domínguez-Pérez, Pablo Huertas

Nucleic Acids Res. 2024 Jun 24; 52(11): 6376–6391. Published online 2024 May 9. doi: 10.1093/nar/gkae317

PMCID:: PMC11194085

Abstract Article PDF–2.4M

Select item 108119482.

EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression

Zefeng Wang, Zheng Chao, Qi Wang, Fan Zou, Tianbao Song, Lizhe Xu, Jinzhuo Ning, Fan Cheng

J Transl Med. 2024; 22: 104. Published online 2024 Jan 26. doi: 10.1186/s12967-023-04822-z

PMCID:: PMC10811948

Abstract Article PDF–20M

Select item 107497103.

Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-β1/Smad signaling feedback loop

Mengting Li, Fengxing Huang, Weining Zhu, Yanan Peng, Fei Xu, Wenjie Li, Qiu Zhao, Lan Liu

Hepatol Commun. 2024 Jan; 8(1): e0342. Published online 2023 Dec 22. doi: 10.1097/HC9.0000000000000342

PMCID:: PMC10749710

Abstract Article PDF–2.7M

Select item 102879164.

MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1

Jung-Min Oh, Yujin Kang, Jumi Park, Yubin Sung, Dayoung Kim, Yuri Seo, Eun A Lee, Jae Sun Ra, Enkhzul Amarsanaa, Young-Un Park, Seon Young Lee, Jung Me Hwang, Hongtae Kim, Orlando Schärer, Seung Woo Cho, Changwook Lee, Kei-ichi Takata, Ja Yil Lee, Kyungjae Myung

Nucleic Acids Res. 2023 Jun 23; 51(11): 5584–5602. Published online 2023 May 4. doi: 10.1093/nar/gkad308

PMCID:: PMC10287916

Abstract Article PDF–2.6M

Select item 102818785.

The FBXO32/ATR/ATM axis acts as a molecular switch to control the sensitivity of osteosarcoma cells to irradiation through its regulation of EXO1 expression: FBXO32/ATR/ATM/EXO1 axis induces OS cells to anti-radiotherapy

Yao Lu, Panpan Huang, Yanli Li, Wenyu Liu, Jing Li, Rui Zhao, Haihua Feng, Ce Shi, Gaolu Cao

Acta Biochim Biophys Sin (Shanghai) 2023 May; 55(5): 842–852. Published online 2023 May 24. doi: 10.3724/abbs.2023049

PMCID:: PMC10281878

Abstract Article PDF–1.9M

Select item 100856216.

Construction and validation of a hypoxia-related risk signature identified EXO1 as a prognostic biomarker based on 12 genes in lung adenocarcinoma

Qirui Chen, Shuo Chen, Jing Wang, Yan Zhao, Xin Ye, Yili Fu, Yi Liu

Aging (Albany NY) 2023 Mar 31; 15(6): 2293–2307. Published online 2023 Mar 25. doi: 10.18632/aging.204613

PMCID:: PMC10085621

Abstract Article PDF–1.6M

Select item 98736477.

A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene

Yuandi Gao, Laure Guitton-Sert, Julien Dessapt, Yan Coulombe, Amélie Rodrigue, Larissa Milano, Andréanne Blondeau, Nicolai Balle Larsen, Julien P. Duxin, Samer Hussein, Amélie Fradet-Turcotte, Jean-Yves Masson

Nat Commun. 2023; 14: 381. Published online 2023 Jan 24. doi: 10.1038/s41467-023-35802-y

PMCID:: PMC9873647

Abstract Article PDF–5.4M

Select item 95847018.

The Roles of EXO1 and RPA1 Polymorphisms in Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy

Jia He, Zhan Wang, Ying Wang, Ting Zou, Xiang-Ping Li, Juan Chen

Dis Markers. 2022; 2022: 3306189. Published online 2022 Oct 13. doi: 10.1155/2022/3306189

PMCID:: PMC9584701

Abstract Article PDF–785K

Select item 93434559.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 845831711.

ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1

Shuang Yan, Man Song, Jie Ping, Shu-ting Lai, Xiao-yu Cao, Chen-Jun Bai, Da-Fei Xie, Hua Guan, Shan-shan Gao, Ping-Kun Zhou

Cell Death Discov. 2021; 7: 260. Published online 2021 Sep 22. doi: 10.1038/s41420-021-00633-7

Correction in:: Cell Death Discov. 2022; 8: 460.

PMCID:: PMC8458317

Abstract Article PDF–7.6M

Select item 838406712.

FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair

Katja Kratz, Mariela Artola-Borán, Saho Kobayashi-Era, Gene Koh, Goncalo Oliveira, Shunsuke Kobayashi, Andreia Oliveira, Xueqing Zou, Julia Richter, Masataka Tsuda, Hiroyuki Sasanuma, Shunichi Takeda, Joanna I. Loizou, Alessandro A. Sartori, Serena Nik-Zainal, Josef Jiricny

Mol Cell Biol. 2021 Sep; 41(9): e00303-21. Prepublished online 2021 Jul 6. Published online 2021 Aug 24. doi: 10.1128/MCB.00303-21

PMCID:: PMC8384067

Abstract Article PDF–916K

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 791045914.

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams

Nat Commun. 2021; 12: 1302. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21478-9

PMCID:: PMC7910459

Abstract Article PDF–3.3M

Select item 757276615.

PCAF-mediated histone acetylation promotes replication fork degradation by MRE11 and EXO1 in BRCA-deficient cells

Jae Jin Kim, Seo Yun Lee, Ji-Hye Choi, Hyun Goo Woo, Blerta Xhemalce, Kyle M. Miller

Mol Cell. Author manuscript; available in PMC 2021 Oct 15.

Published in final edited form as: Mol Cell. 2020 Oct 15; 80(2): 327–344.e8. Published online 2020 Sep 22. doi: 10.1016/j.molcel.2020.08.018

PMCID:: PMC7572766

Abstract Article PDF–2.9M

Select item 726978916.

BAP1 maintains chromosome stability by stabilizing DIDO1 in renal cell carcinoma

Jiantao Xiao, Ruhan Zhang, Jingtao Peng, Zhonghua Yang

Am J Cancer Res. 2020; 10(5): 1455–1466. Published online 2020 May 1.

PMCID:: PMC7269789

Abstract Article PDF–1.4M

Select item 722983217.

EXO1 resection at G-quadruplex structures facilitates resolution and replication

Susanna Stroik, Kevin Kurtz, Kevin Lin, Sergey Karachenets, Chad L Myers, Anja-Katrin Bielinsky, Eric A Hendrickson

Nucleic Acids Res. 2020 May 21; 48(9): 4960–4975. Published online 2020 Mar 31. doi: 10.1093/nar/gkaa199

PMCID:: PMC7229832

Abstract Article PDF–5.3M

Select item 720589418.

RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase

Ying Xie, Yi-Ke Liu, Zong-Pei Guo, Hua Guan, Xiao-Dan Liu, Da-Fei Xie, Yi-Guo Jiang, Teng Ma, Ping-Kun Zhou

Cell Death Differ. 2020 Apr; 27(4): 1383–1397. Published online 2019 Sep 27. doi: 10.1038/s41418-019-0424-4

PMCID:: PMC7205894

Abstract Article PDF–5.2M

Select item 709265919.

Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer

Dongyun He, Tao Li, Minjia Sheng, Ben Yang

Med Sci Monit. 2020; 26: e918751-1–e918751-8. Prepublished online 2020 Jan 22. Published online 2020 Mar 13. doi: 10.12659/MSM.918751

PMCID:: PMC7092659

Abstract Article PDF–485K

Select item 698656320.

Pathway Analysis of Single-Nucleotide Polymorphisms Potentially Associated with Glioblastoma Multiforme Susceptibility Using Random Forests

Jeffrey S. Chang, Ru-Fang Yeh, John K. Wiencke, Joseph L. Wiemels, Ivan Smirnov, Alexander R. Pico, Tarik Tihan, Joe Patoka, Rei Miike, Jennette D. Sison, Terri Rice, Margaret R. Wrensch

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Jan 28.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 Jun; 17(6): 1368–1373. doi: 10.1158/1055-9965.EPI-07-2830

PMCID:: PMC6986563

Abstract Article PDF–327K

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