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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 100665622.

Reciprocal regulatory balance within the CLEC16A–RNF41 mitophagy complex depends on an intrinsically disordered protein region

Morgan A. Gingerich, Jie Zhu, Biaoxin Chai, Michael P. Vincent, Nuli Xie, Vaibhav Sidarala, Nicholas A. Kotov, Debashish Sahu, Daniel J. Klionsky, Santiago Schnell, Scott A. Soleimanpour

J Biol Chem. 2023 Apr; 299(4): 103057. Published online 2023 Feb 22. doi: 10.1016/j.jbc.2023.103057

PMCID:: PMC10066562

Abstract Article PDF–1.8M

Select item 92332983.

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion

Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez-Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A. Soleimanpour, Amelia K. Linnemann, Tristan A. Rodriguez, Guy A. Rutter

Diabetes. 2022 Jul; 71(7): 1472–1489. Published online 2022 Apr 26. doi: 10.2337/db21-0800

PMCID:: PMC9233298

Abstract Article PDF–82M

Select item 80849454.

Inducible knockout of Clec16a in mice results in sensory neurodegeneration

Heather S. Hain, Rahul Pandey, Marina Bakay, Bryan P. Strenkowski, Danielle Harrington, Micah Romer, William W. Motley, Jian Li, Eunjoo Lancaster, Lindsay Roth, Judith B. Grinspan, Steven S. Scherer, Hakon Hakonarson

Sci Rep. 2021; 11: 9319. Published online 2021 Apr 29. doi: 10.1038/s41598-021-88895-0

PMCID:: PMC8084945

Abstract Article PDF–2.3M

Select item 80168755.

JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

Rahul Pandey, Marina Bakay, Bryan P. Strenkowski, Heather S. Hain, Hakon Hakonarson

Sci Rep. 2021; 11: 7372. Published online 2021 Apr 1. doi: 10.1038/s41598-021-86493-8

PMCID:: PMC8016875

Abstract Article PDF–2.4M

Select item 78197516.

Mitophagy protects β cells from inflammatory damage in diabetes

Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, Benjamin Thompson, Lisa Christen, Morgan A. Gingerich, Jie Zhu, Tracy Stromer, Jianhua Ren, Emma C. Reck, Biaoxin Chai, John A. Corbett, Thomas Mandrup-Poulsen, Leslie S. Satin, Scott A. Soleimanpour

JCI Insight. 2020 Dec 17; 5(24): e141138. Published online 2020 Dec 17. doi: 10.1172/jci.insight.141138

PMCID:: PMC7819751

Abstract Article PDF–25M

Select item 74159917.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 64784138.

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury

Huachun Cui, Sami Banerjee, Sijia Guo, Na Xie, Jing Ge, Dingyuan Jiang, Martin Zörnig, Victor J. Thannickal, Gang Liu

JCI Insight. 2019 Feb 21; 4(4): e124522. Published online 2019 Feb 21. doi: 10.1172/jci.insight.124522

PMCID:: PMC6478413

Abstract Article PDF–6.2M

Select item 63679729.

The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice

Rahul Pandey, Marina Bakay, Heather S. Hain, Bryan Strenkowski, Anastasiya Yermakova, Jake A. Kushner, Jordan S. Orange, Hakon Hakonarson

Front Immunol. 2019; 10: 68. Published online 2019 Feb 1. doi: 10.3389/fimmu.2019.00068

PMCID:: PMC6367972

Abstract Article PDF–3.5M

Select item 614323110.

CLEC16A regulates splenocyte and NK cell function in part through MEK signaling

Rahul Pandey, Marina Bakay, Heather S. Hain, Bryan Strenkowski, Barakat Z. B. Elsaqa, Jeffrey D. Roizen, Jake A. Kushner, Jordan S. Orange, Hakon Hakonarson

PLoS One. 2018; 13(9): e0203952. Published online 2018 Sep 18. doi: 10.1371/journal.pone.0203952

PMCID:: PMC6143231

Abstract Article PDF–17M

Select item 578006011.

Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy

Gemma Pearson, Biaoxin Chai, Tracy Vozheiko, Xueying Liu, Malathi Kandarpa, Robert C. Piper, Scott A. Soleimanpour

Diabetes. 2018 Feb; 67(2): 265–277. Published online 2017 Nov 27. doi: 10.2337/db17-0321

PMCID:: PMC5780060

Abstract Article PDF–2.2M

Select item 479691012.

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Veronika Redmann, Christopher A. Lamb, Seungmin Hwang, Robert C. Orchard, Sungsu Kim, Minoo Razi, Ashley Milam, Sunmin Park, Christine C. Yokoyama, Amal Kambal, Darren Kreamalmeyer, Marie K. Bosch, Maolei Xiao, Karen Green, Jungsu Kim, Shondra M. Pruett-Miller, David M. Ornitz, Paul M. Allen, Wandy L. Beatty, Robert E. Schmidt, Aaron DiAntonio, Sharon A. Tooze, Herbert W. Virgin

Sci Rep. 2016; 6: 23326. Published online 2016 Mar 18. doi: 10.1038/srep23326

PMCID:: PMC4796910

Abstract Article PDF–3.2M

Select item 458763713.

Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells

Scott A. Soleimanpour, Alana M. Ferrari, Jeffrey C. Raum, David N. Groff, Juxiang Yang, Brett A. Kaufman, Doris A. Stoffers

Diabetes. 2015 Oct; 64(10): 3475–3484. Published online 2015 Jun 17. doi: 10.2337/db15-0376

PMCID:: PMC4587637

Abstract Article PDF–1.8M

Select item 451222714.

Tshz1 Regulates Pancreatic β-Cell Maturation

Jeffrey C. Raum, Scott A. Soleimanpour, David N. Groff, Nathalie Coré, Laurent Fasano, Alistair N. Garratt, Chunhua Dai, Alvin C. Powers, Doris A. Stoffers

Diabetes. 2015 Aug; 64(8): 2905–2914. Published online 2015 Apr 27. doi: 10.2337/db14-1443

PMCID:: PMC4512227

Abstract Article PDF–1.3M

Select item 448439215.

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

Heather Fairfield, Anuj Srivastava, Guruprasad Ananda, Rangjiao Liu, Martin Kircher, Anuradha Lakshminarayana, Belinda S. Harris, Son Yong Karst, Louise A. Dionne, Coleen C. Kane, Michelle Curtain, Melissa L. Berry, Patricia F. Ward-Bailey, Ian Greenstein, Candice Byers, Anne Czechanski, Jocelyn Sharp, Kristina Palmer, Polyxeni Gudis, Whitney Martin, Abby Tadenev, Laurent Bogdanik, C. Herbert Pratt, Bo Chang, David G. Schroeder, Gregory A. Cox, Paul Cliften, Jeffrey Milbrandt, Stephen Murray, Robert Burgess, David E. Bergstrom, Leah Rae Donahue, Hanan Hamamy, Amira Masri, Federico A. Santoni, Periklis Makrythanasis, Stylianos E. Antonarakis, Jay Shendure, Laura G. Reinholdt

Genome Res. 2015 Jul; 25(7): 948–957. doi: 10.1101/gr.186882.114

PMCID:: PMC4484392

Abstract Article PDF–604K

Select item 444404416.

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

Jin Li, Silje F. Jørgensen, S. Melkorka Maggadottir, Marina Bakay, Klaus Warnatz, Joseph Glessner, Rahul Pandey, Ulrich Salzer, Reinhold E. Schmidt, Elena Perez, Elena Resnick, Sigune Goldacker, Mary Buchta, Torsten Witte, Leonid Padyukov, Vibeke Videm, Trine Folseraas, Faranaz Atschekzei, James T. Elder, Rajan P. Nair, Juliane Winkelmann, Christian Gieger, Markus M Nöthen, Carsten Büning, Stephan Brand, Kathleen E. Sullivan, Jordan S. Orange, Børre Fevang, Stefan Schreiber, Wolfgang Lieb, Pål Aukrust, Helen Chapel, Charlotte Cunningham-Rundles, Andre Franke, Tom H. Karlsen, Bodo Grimbacher, Hakon Hakonarson, Lennart Hammarström, Eva Ellinghaus

Nat Commun. Author manuscript; available in PMC 2015 Oct 20.

Published in final edited form as: Nat Commun. 2015; 6: 6804. Published online 2015 Apr 20. doi: 10.1038/ncomms7804

PMCID:: PMC4444044

Abstract Article PDF–569K

Select item 443925717.

The autoimmunity-associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection

Cornelia Schuster, Kay D. Gerold, Kilian Schober, Lilli Probst, Kevin Boerner, Mi-Jeong Kim, Anna Ruckdeschel, Thomas Serwold, Stephan Kissler

Immunity. Author manuscript; available in PMC 2016 May 19.

Published in final edited form as: Immunity. 2015 May 19; 42(5): 942–952. Published online 2015 May 12. doi: 10.1016/j.immuni.2015.04.011

PMCID:: PMC4439257

Abstract Article PDF–556K

Select item 418427618.

The diabetes susceptibility gene Clec16a regulates mitophagy

Scott A. Soleimanpour, Aditi Gupta, Marina Bakay, Alana M. Ferrari, David N. Groff, João Fadista, Lynn A. Spruce, Jake A. Kushner, Leif Groop, Steven H. Seeholzer, Brett A. Kaufman, Hakon Hakonarson, Doris A. Stoffers

Cell. Author manuscript; available in PMC 2015 Jun 19.

Published in final edited form as: Cell. 2014 Jun 19; 157(7): 1577–1590. doi: 10.1016/j.cell.2014.05.016

PMCID:: PMC4184276

Abstract Article PDF–2.6M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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