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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102917412.

SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology

Kristine E. Zengeler, Daniel A. Shapiro, Katherine R. Bruch, Catherine R. Lammert, Hannah Ennerfelt, John R. Lukens

Brain Behav Immun. Author manuscript; available in PMC 2023 Jun 26.

Published in final edited form as: Brain Behav Immun. 2023 Feb; 108: 80–97. Published online 2022 Nov 4. doi: 10.1016/j.bbi.2022.10.024

PMCID:: PMC10291741

Abstract Article PDF–2.7M

Select item 83579573.

Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cells

Aydan Bulut-Karslioglu, Hu Jin, Yun-Kyo Kim, Brandon Cho, Marcela Guzman-Ayala, Andrew J. K. Williamson, Miroslav Hejna, Maximilian Stötzel, Anthony D. Whetton, Jun S. Song, Miguel Ramalho-Santos

Nat Commun. 2021; 12: 4859. Published online 2021 Aug 11. doi: 10.1038/s41467-021-25088-3

PMCID:: PMC8357957

Abstract Article PDF–4.1M

Select item 79689254.

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

Xiaochen Fan, V Pragathi Masamsetti, Jane QJ Sun, Kasper Engholm-Keller, Pierre Osteil, Joshua Studdert, Mark E Graham, Nicolas Fossat, Patrick PL Tam

eLife. 2021; 10: e62873. Published online 2021 Feb 8. doi: 10.7554/eLife.62873

PMCID:: PMC7968925

Abstract Article PDF–4.0M

Select item 74833065.

Chromatin Regulator, CHD1, Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

Di Zhao, Li Cai, Xin Lu, Xin Liang, Jiexi Li, Peiwen Chen, Michael Ittmann, Xiaoying Shang, Shan Jiang, Haoyan Li, Chenling Meng, Ivonne Flores, Jian H. Song, James W Horner, Zhengdao Lan, Chang-Jiun Wu, Jun Li, Qing Chang, Ko-Chien Chen, Guocan Wang, Pingna Deng, Denise J. Spring, Y. Alan Wang, Ronald A. DePinho

Cancer Discov. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Cancer Discov. 2020 Sep; 10(9): 1374–1387. Published online 2020 May 8. doi: 10.1158/2159-8290.CD-19-1352

PMCID:: PMC7483306

Abstract Article PDF–1.3M

Select item 70424896.

Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations

Joel J. Hughes, Ebba Alkhunaizi, Paul Kruszka, Louise C. Pyle, Dorothy K. Grange, Seth I. Berger, Katelyn K. Payne, Diane Masser-Frye, Tommy Hu, Michelle R. Christie, Nancy J. Clegg, Joshua L. Everson, Ariel F. Martinez, Laurence E. Walsh, Emma Bedoukian, Marilyn C. Jones, Catharine Jean Harris, Korbinian M. Riedhammer, Daniela Choukair, Patricia Y. Fechner, Meilan M. Rutter, Sophia B. Hufnagel, Maian Roifman, Gad B. Kletter, Emmanuele Delot, Eric Vilain, Robert J. Lipinski, Chad M. Vezina, Maximilian Muenke, David Chitayat

Am J Hum Genet. 2020 Jan 2; 106(1): 121–128. Published online 2019 Dec 26. doi: 10.1016/j.ajhg.2019.12.004

PMCID:: PMC7042489

Abstract Article PDF–1.1M

Select item 64677837.

CHD1 loss alters AR binding at lineage-specific enhancers and modulates distinct transcriptional programs to drive prostate tumorigenesis

Michael A. Augello, Deli Liu, Lesa D. Deonarine, Brian D. Robinson, Dennis Huang, Suzan Stelloo, Mirjam Blattner, Ashley S. Doane, Elissa W.P. Wong, Yu Chen, Mark A. Rubin, Himisha Beltran, Olivier Elemento, Andries M. Bergman, Wilbert Zwart, Andrea Sboner, Noah Dephoure, Christopher E. Barbieri

Cancer Cell. Author manuscript; available in PMC 2020 Apr 15.

Published in final edited form as: Cancer Cell. 2019 Apr 15; 35(4): 603–617.e8. Published online 2019 Mar 28. doi: 10.1016/j.ccell.2019.03.001

Correction in:: Cancer Cell. 2019 May 13; 35(5): 817–819.

PMCID:: PMC6467783

Abstract Article PDF–3.2M

Select item 63514818.

Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

Ines Schoberleitner, Anna Mutti, Anupam Sah, Alexandra Wille, Francisco Gimeno-Valiente, Paolo Piatti, Maria Kharitonova, Luis Torres, Gerardo López-Rodas, Jeffrey J. Liu, Nicolas Singewald, Christoph Schwarzer, Alexandra Lusser

Front Mol Neurosci. 2019; 12: 3. Published online 2019 Jan 23. doi: 10.3389/fnmol.2019.00003

PMCID:: PMC6351481

Abstract Article PDF–2.2M

Select item 58340749.

CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair

T. R. Shenoy, G. Boysen, M. Y. Wang, Q. Z. Xu, W. Guo, F. M. Koh, C. Wang, L. Z. Zhang, Y. Wang, V. Gil, S. Aziz, R. Christova, D. N. Rodrigues, M. Crespo, P. Rescigno, N. Tunariu, R. Riisnaes, Z. Zafeiriou, P. Flohr, W. Yuan, E. Knight, A. Swain, M. Ramalho-Santos, D. Y. Xu, J. de Bono, H. Wu

Ann Oncol. 2017 Jul; 28(7): 1495–1507. Published online 2017 Apr 5. doi: 10.1093/annonc/mdx165

PMCID:: PMC5834074

Abstract Article PDF–1.4M

Select item 529582110.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 439428411.

Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription

Fong Ming Koh, Carlos O. Lizama, Priscilla Wong, John S. Hawkins, Ann C. Zovein, Miguel Ramalho-Santos

Proc Natl Acad Sci U S A. 2015 Apr 7; 112(14): E1734–E1743. Published online 2015 Mar 23. doi: 10.1073/pnas.1424850112

PMCID:: PMC4394284

Abstract Article PDF–1.9M

Select item 430611212.

Embryonic stem cell differentiation requires full length Chd1

Paolo Piatti, Chin Yan Lim, Roxana Nat, Andreas Villunger, Stephan Geley, Yan Ting Shue, Claudia Soratroi, Markus Moser, Alexandra Lusser

Sci Rep. 2015; 5: 8007. Published online 2015 Jan 26. doi: 10.1038/srep08007

PMCID:: PMC4306112

Abstract Article PDF–2.3M

Select item 429915013.

Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast

Marcela Guzman-Ayala, Michael Sachs, Fong Ming Koh, Courtney Onodera, Aydan Bulut-Karslioglu, Chih-Jen Lin, Priscilla Wong, Rachel Nitta, Jun S. Song, Miguel Ramalho-Santos

Development. 2015 Jan 1; 142(1): 118–127. doi: 10.1242/dev.114843

PMCID:: PMC4299150

Abstract Article

Select item 410492114.

Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis

Jingwen Wu, Jianqiang Bao, Minkyung Kim, Shuiqiao Yuan, Chong Tang, Huili Zheng, Grant S. Mastick, Chen Xu, Wei Yan

Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28): E2851–E2857. Published online 2014 Jun 30. doi: 10.1073/pnas.1407777111

PMCID:: PMC4104921

Abstract Article PDF–1.8M

Select item 398390515.

The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1

Peter J Skene, Aaron E Hernandez, Mark Groudine, Steven Henikoff

eLife. 2014; 3: e02042. Published online 2014 Apr 15. doi: 10.7554/eLife.02042

PMCID:: PMC3983905

Abstract Article PDF–7.2M

Select item 389157616.

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

Alexandre Gaspar-Maia, Adi Alajem, Fanny Polesso, Rupa Sridharan, Michael Mason, Amy Heidersbach, João Ramalho-Santos, Michael T. McManus, Kathrin Plath, Eran Meshorer, Miguel Ramalho-Santos

Nature. Author manuscript; available in PMC 2014 Jan 14.

Published in final edited form as: Nature. 2009 Aug 13; 460(7257): 863–868. Published online 2009 Jul 8. doi: 10.1038/nature08212

PMCID:: PMC3891576

Abstract Article PDF–3.0M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 343226418.

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Dyna I. Shirasaki, Erin R. Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, X. William Yang

Neuron. Author manuscript; available in PMC 2013 Jul 12.

Published in final edited form as: Neuron. 2012 Jul 12; 75(1): 41–57. doi: 10.1016/j.neuron.2012.05.024

PMCID:: PMC3432264

Abstract Article PDF–4.9M

Select item 320558919.

Mediator coordinates PIC assembly with recruitment of CHD1

Justin J. Lin, Lynn W. Lehmann, Giancarlo Bonora, Rupa Sridharan, Ajay A. Vashisht, Nancy Tran, Kathrin Plath, James A. Wohlschlegel, Michael Carey

Genes Dev. 2011 Oct 15; 25(20): 2198–2209. doi: 10.1101/gad.17554711

PMCID:: PMC3205589

Abstract Article PDF–1.5M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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