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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 92121702.

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1^rd8 mouse model

Sonia M. Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa Stone, Nattaya Damkham, Lillian F. Hyde, James G. Peterson, Wanda Hicks, Gregory W. Carter, Jürgen K. Naggert, Mark P. Krebs, Patsy M. Nishina

PLoS Genet. 2022 Jun; 18(6): e1009798. Published online 2022 Jun 8. doi: 10.1371/journal.pgen.1009798

PMCID:: PMC9212170

Abstract Article PDF–6.4M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 71097454.

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Yangyang Xie, Li Gao, Chunhui Xu, Liming Chu, Lei Gao, Ruichi Wu, Yu Liu, Ting Liu, Xiao-jian Sun, Ruibao Ren, Jingyan Tang, Yi Zheng, Yong Zhou, Shuhong Shen

Haematologica. 2020 Apr; 105(4): 925–936. Prepublished online 2019 Aug 29. doi: 10.3324/haematol.2018.210286

PMCID:: PMC7109745

Abstract Article PDF–2.7M

Select item 67779795.

Myogenic vasoconstriction requires G₁₂/G₁₃ and LARG to maintain local and systemic vascular resistance

Ramesh Chennupati, Angela Wirth, Julie Favre, Rui Li, Rémy Bonnavion, Young-June Jin, Astrid Wietelmann, Frank Schweda, Nina Wettschureck, Daniel Henrion, Stefan Offermanns

eLife. 2019; 8: e49374. Published online 2019 Sep 24. doi: 10.7554/eLife.49374

PMCID:: PMC6777979

Abstract Article PDF–4.6M

Select item 66927706.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 58627717.

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury

Nat Genet. Author manuscript; available in PMC 2018 Aug 19.

Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7

PMCID:: PMC5862771

Abstract Article PDF–2.5M

Select item 58457818.

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation

Siying Zou, Alexandra M. Teixeira, Mingzhu Yin, Yaozu Xiang, Juliana Xavier-Ferruccio, Ping-xia Zhang, John Hwa, Wang Min, Diane S. Krause

Thromb Haemost. Author manuscript; available in PMC 2018 Mar 12.

Published in final edited form as: Thromb Haemost. 2016 Aug 30; 116(3): 506–516. Published online 2016 Jun 23. doi: 10.1160/TH15-11-0848

PMCID:: PMC5845781

Abstract Article PDF–846K

Select item 57436109.

LARG GEF and ARHGAP18 Orchestrate RhoA Activity to Control Mesenchymal Stem Cell Lineage

William R. Thompson, Sherwin S. Yen, Gunes Uzer, Zhihui Xie, Buer Sen, Maya Styner, Keith Burridge, Janet Rubin

Bone. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Bone. 2018 Feb; 107: 172–180. Published online 2017 Dec 5. doi: 10.1016/j.bone.2017.12.001

PMCID:: PMC5743610

Abstract Article PDF–1.1M

Select item 564508210.

Spatio-temporal profile of postynaptic interactomes integrates components of complex brain disorders

Jing Li, Wangshu Zhang, Hui Yang, Daniel P. Howrigan, Brent Wilkinson, Tade Souaiaia, Oleg V. Evgrafov, Giulio Genovese, Veronica A. Clementel, Jennifer C. Tudor, Ted Abel, James A. Knowles, Benjamin M. Neale, Kai Wang, Fengzhu Sun, Marcelo P. Coba

Nat Neurosci. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Nat Neurosci. 2017 Aug; 20(8): 1150–1161. Published online 2017 Jun 26. doi: 10.1038/nn.4594

PMCID:: PMC5645082

Abstract Article PDF–2.3M

Select item 550370911.

Potentiation of receptor responses induced by prolonged binding of Gα₁₃ and leukemia-associated RhoGEF

Eva-Lisa Bodmann, Anna-Lena Krett, Moritz Bünemann

FASEB J. 2017 Aug; 31(8): 3663–3676. Published online 2017 May 2. doi: 10.1096/fj.201700026R

PMCID:: PMC5503709

Abstract Article

Select item 475516812.

Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice

C. M. Williams, M. T. Harper, R. Goggs, T. G. Walsh, S. Offermanns, A. W. Poole

J Thromb Haemost. 2015 Nov; 13(11): 2102–2107. Published online 2015 Oct 20. doi: 10.1111/jth.13129

PMCID:: PMC4755168

Abstract Article PDF–407K

Select item 439424113.

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

Constantinos M. Mikelis, May Simaan, Koji Ando, Shigetomo Fukuhara, Atsuko Sakurai, Panomwat Amornphimoltham, Andrius Masedunskas, Roberto Weigert, Triantafyllos Chavakis, Ralf Adams, Stefan Offermanns, Naoki Mochizuki, Yi Zheng, J. Silvio Gutkind

Nat Commun. Author manuscript; available in PMC 2015 Oct 10.

Published in final edited form as: Nat Commun. 2015; 6: 6725. Published online 2015 Apr 10. doi: 10.1038/ncomms7725

PMCID:: PMC4394241

Abstract Article PDF–2.6M

Select item 406000014.

Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation

Othman Al-Shboul, Ancy D. Nalli, Divya P. Kumar, Ruizhe Zhou, Sunila Mahavadi, John F. Kuemmerle, John R. Grider, Karnam S. Murthy

Am J Physiol Cell Physiol. 2014 Jun 15; 306(12): C1129–C1141. Published online 2014 Apr 16. doi: 10.1152/ajpcell.00021.2014

PMCID:: PMC4060000

Abstract Article

Select item 396495515.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 392605316.

Genetic dissection of plexin signaling in vivo

Thomas Worzfeld, Jakub M. Swiercz, Aycan Sentürk, Berit Genz, Alexander Korostylev, Suhua Deng, Jingjing Xia, Mikio Hoshino, Jonathan A. Epstein, Andrew M. Chan, Brigitte Vollmar, Amparo Acker-Palmer, Rohini Kuner, Stefan Offermanns

Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6): 2194–2199. Published online 2014 Jan 27. doi: 10.1073/pnas.1308418111

PMCID:: PMC3926053

Abstract Article PDF–1.3M

Select item 389611817.

The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

Qin Li, Sika Zheng, Areum Han, Chia-Ho Lin, Peter Stoilov, Xiang-Dong Fu, Douglas L Black

eLife. 2014; 3: e01201. Published online 2014 Jan 21. doi: 10.7554/eLife.01201

Correction in:: eLife. 2017; 6: e31550.

PMCID:: PMC3896118

Abstract Article PDF–12M

Select item 383714218.

Agonist-induced Ca²⁺ Sensitization in Smooth Muscle: REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY

Mykhaylo V. Artamonov, Ko Momotani, Andra Stevenson, David R. Trentham, Urszula Derewenda, Zygmunt S. Derewenda, Paul W. Read, J. Silvio Gutkind, Avril V. Somlyo

J Biol Chem. 2013 Nov 22; 288(47): 34030–34040. Published online 2013 Oct 8. doi: 10.1074/jbc.M113.514596

PMCID:: PMC3837142

Abstract Article PDF–1.8M

Select item 363690719.

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation

Constantinos M. Mikelis, Todd R. Palmby, May Simaan, Wenling Li, Roman Szabo, Ruth Lyons, Daniel Martin, Hiroshi Yagi, Shigetomo Fukuhara, Hiroki Chikumi, Rebeca Galisteo, Yoh-suke Mukouyama, Thomas H. Bugge, J. Silvio Gutkind

J Biol Chem. 2013 Apr 26; 288(17): 12232–12243. Published online 2013 Mar 6. doi: 10.1074/jbc.M112.428599

PMCID:: PMC3636907

Abstract Article PDF–3.7M

Select item 362035120.

RhoGEF12 controls cardiac remodeling by integrating G protein– and integrin-dependent signaling cascades

Mikito Takefuji, Marcus Krüger, Kishor K. Sivaraj, Kozo Kaibuchi, Stefan Offermanns, Nina Wettschureck

J Exp Med. 2013 Apr 8; 210(4): 665–673. doi: 10.1084/jem.20122126

PMCID:: PMC3620351

Abstract Article PDF–2.2M

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