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Select item 108531831.

CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease

Jonas Rybnicek, Yuxiao Chen, Milos Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David A. Bennett, Shreejoy Tripathy, Daniel Felsky, Evelyn K. Lambe

Transl Psychiatry. 2024; 14: 83. Published online 2024 Feb 8. doi: 10.1038/s41398-024-02785-3

PMCID:: PMC10853183

Abstract Article PDF–2.8M

Select item 102983442.

The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19

Daniela Valencia-Pérez Rea, Ramcés Falfán-Valencia, Ingrid Fricke-Galindo, Ivette Buendía-Roldán, Leslie Chávez-Galán, Karol J. Nava-Quiroz, Jesús Alanis-Ponce, Gloria Pérez-Rubio

Int J Mol Sci. 2023 Jun; 24(12): 9811. Published online 2023 Jun 6. doi: 10.3390/ijms24129811

PMCID:: PMC10298344

Abstract Article PDF–765K

Select item 95633973.

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients

Lynda Saber Cherif, Zania Diabasana, Jeanne-Marie Perotin, Julien Ancel, Laure M. G. Petit, Maëva A. Devilliers, Arnaud Bonnomet, Nathalie Lalun, Gonzague Delepine, Uwe Maskos, Philippe Gosset, Myriam Polette, Anaëlle Muggeo, Thomas Guillard, Gaëtan Deslée, Valérian Dormoy

Cells. 2022 Oct; 11(19): 2937. Published online 2022 Sep 20. doi: 10.3390/cells11192937

PMCID:: PMC9563397

Abstract Article PDF–5.3M

Select item 95177774.

Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine

Krzysztof Chmielowiec, Jolanta Chmielowiec, Aleksandra Strońska-Pluta, Grzegorz Trybek, Małgorzata Śmiarowska, Aleksandra Suchanecka, Grzegorz Woźniak, Aleksandra Jaroń, Anna Grzywacz

Int J Environ Res Public Health. 2022 Sep; 19(17): 10478. Published online 2022 Aug 23. doi: 10.3390/ijerph191710478

PMCID:: PMC9517777

Abstract Article PDF–756K

Select item 92316235.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91197366.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 82688437.

Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia

Zania Diabasana, Jeanne-Marie Perotin, Randa Belgacemi, Julien Ancel, Pauline Mulette, Claire Launois, Gonzague Delepine, Xavier Dubernard, Jean-Claude Mérol, Christophe Ruaux, Philippe Gosset, Uwe Maskos, Myriam Polette, Gaëtan Deslée, Valérian Dormoy

Int J Mol Sci. 2021 Jul; 22(13): 6657. Published online 2021 Jun 22. doi: 10.3390/ijms22136657

PMCID:: PMC8268843

Abstract Article PDF–2.3M

Select item 82360788.

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs

Katherine M. Almasy, Jonathan P. Davies, Lars Plate

Mol Cell Proteomics. 2021; 20: 100120. Published online 2021 Jun 27. doi: 10.1016/j.mcpro.2021.100120

PMCID:: PMC8236078

Abstract Article PDF–4.6M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 798628310.

Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases

Chen Yao, Roby Joehanes, Rory Wilson, Toshiko Tanaka, Luigi Ferrucci, Anja Kretschmer, Holger Prokisch, Katharina Schramm, Christian Gieger, Annette Peters, Melanie Waldenberger, Carola Marzi, Christian Herder, Daniel Levy

Clin Epigenetics. 2021; 13: 60. Published online 2021 Mar 22. doi: 10.1186/s13148-021-01041-5

PMCID:: PMC7986283

Abstract Article PDF–1.2M

Select item 795846311.

Linking the CHRNA5 SNP to drug abuse liability: from circuitry to cellular mechanisms

Julia K. Brynildsen, Julie A. Blendy

Neuropharmacology. Author manuscript; available in PMC 2022 Mar 15.

Published in final edited form as: Neuropharmacology. 2021 Mar 15; 186: 108480. Published online 2021 Feb 1. doi: 10.1016/j.neuropharm.2021.108480

PMCID:: PMC7958463

Abstract Article PDF–644K

Select item 788649312.

The relationship between CHRNA5/A3/B4 gene cluster polymorphisms and lung cancer risk: An updated meta-analysis and systematic review

Xingxu Yi, Wanzhen Li, Yiyuan Wang, Xueran Chen, Fang Ye, Gengyun Sun, Jingxian Chen

Medicine (Baltimore) 2021 Feb 12; 100(6): e24355. Published online 2021 Feb 12. doi: 10.1097/MD.0000000000024355

PMCID:: PMC7886493

Abstract Article PDF–1.3M

Select item 755538213.

Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung Adenocarcinoma Progression

Mong-Lien Wang, Yi-Fan Hsu, Chih-Hsuan Liu, Ya-Ling Kuo, Yi-Chen Chen, Yi-Chen Yeh, Hsiang-Ling Ho, Yu-Chung Wu, Teh-Ying Chou, Cheng-Wen Wu

Int J Mol Sci. 2020 Sep; 21(18): 6829. Published online 2020 Sep 17. doi: 10.3390/ijms21186829

PMCID:: PMC7555382

Abstract Article PDF–3.5M

Select item 731723814.

Identification of susceptibility variants to benign childhood epilepsy with centro-temporal spikes (BECTS) in Chinese Han population

Xiu-Yu Shi, Geng Wang, Ting Li, Zhixiu Li, Paul Leo, Zhisheng Liu, Gefei Wu, Hongmin Zhu, Yuqin Zhang, Dong Li, Li Gao, Liu Yang, Wei Wang, Jianxiang Liao, Jiwen Wang, Shuizhen Zhou, Hua Wang, Xiaojing Li, Jingyun Gao, Li Zhang, Xiaomei Shu, Dan Li, Yan Li, Chunhong Chen, Xiuju Zhang, Gabriel Cuellar Partida, Mischa Lundberg, David Reutens, Perry Bartlett, Matthew A Brown, Li-Ping Zou, Huji Xu

EBioMedicine. 2020 Jul; 57: 102840. Published online 2020 Jun 21. doi: 10.1016/j.ebiom.2020.102840

PMCID:: PMC7317238

Abstract Article PDF–1.5M

Select item 710959015.

Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria

Asma Mimouni, Etienne Rouleau, Patrick Saulnier, Amina Marouani, Med Lamine Abdelali, Taha Filali, Leila Beddar, Abdelhak Lakehal, Ahmed Hireche, Asma Boudersa, Mahmoud Aissaoui, Hacene Ramtani, Khalid Bouhedjar, Djamel Abdellouche, Messaouda Oudjehih, Ibtissem Boudokhane, Noureddine Abadi, Dalila Satta

Pulm Med. 2020; 2020: 7649038. Published online 2020 Mar 20. doi: 10.1155/2020/7649038

PMCID:: PMC7109590

Abstract Article PDF–426K

Select item 690893616.

Cholinergic α5 nicotinic receptor is involved in the proliferation and invasion of human prostate cancer cells

Jin-Chun Qi, Wen-Yong Xue, Yan-Ping Zhang, Chang-Bao Qu, Bao-Sai Lu, Yue-Wei Yin, Kai-Long Liu, Dong-Bin Wang, Wei Li, Zong-Mao Zhao

Oncol Rep. 2020 Jan; 43(1): 159–168. Published online 2019 Nov 20. doi: 10.3892/or.2019.7411

PMCID:: PMC6908936

Abstract Article PDF–1.0M

Select item 690037417.

Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population

Mariana R. Silva, Gilka J. F. Gattás, Juliana De Antonio, Isabela Firigato, Otávio A. Curioni, Fernanda de Toledo Gonçalves

Mol Genet Genomic Med. 2019 Dec; 7(12): e998. Published online 2019 Oct 9. doi: 10.1002/mgg3.998

PMCID:: PMC6900374

Abstract Article PDF–334K

Select item 673228418.

Impact of CHRNA5 polymorphisms on the risk of schizophrenia in the Chinese Han population

Dafei Zhan, Qiankun Yao, Shaojian Fu, Xianglai Liu, Jun Zhou, Daqiang Chen, Chuanlong Yu

Mol Genet Genomic Med. 2019 Sep; 7(9): e869. Published online 2019 Jul 24. doi: 10.1002/mgg3.869

PMCID:: PMC6732284

Abstract Article PDF–575K

Select item 670944819.

Low smoking-exposure, the adolescent brain, and the modulating role of CHRNA5 polymorphisms

Bader Chaarani, Kees-Jan Kan, Scott Mackey, Philip A. Spechler, Alexandra Potter, Catherine Orr, Nicholas D’Alberto, Kelsey E. Hudson, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos-Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Henrik Walter, Robert Whelan, Stephen T. Higgins, Gunter Schumann, Robert R. Althoff, Elliot A. Stein, Hugh Garavan, IMAGEN Consortium

Biol Psychiatry Cogn Neurosci Neuroimaging. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jul; 4(7): 672–679. Published online 2019 Mar 15. doi: 10.1016/j.bpsc.2019.02.006

PMCID:: PMC6709448

Abstract Article PDF–680K

Select item 666808020.

CHRNA5/CHRNA3 gene cluster is a risk factor for lumbar disc herniation: a case-control study

Xuejun Yang, Xiaodong Guo, Zhi Huang, Yifeng Da, Wenhua Xing, Feng Li, Manglai Li, Ke Sun, Haiyu Jia, Yong Zhu

J Orthop Surg Res. 2019; 14: 243. Published online 2019 Jul 30. doi: 10.1186/s13018-019-1254-2

PMCID:: PMC6668080

Abstract Article PDF–784K

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