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Select item 112219721.

Upregulation of TCPTP in Macrophages Is Involved in IL-35 Mediated Attenuation of Experimental Colitis

Baoren Zhang, Chenglu Sun, Yanglin Zhu, Hong Qin, Dejun Kong, Jingyi Zhang, Bo Shao, Xiang Li, Shaohua Ren, Hongda Wang, Jingpeng Hao, Hao Wang

Mediators Inflamm. 2024; 2024: 3282679. Published online 2024 Jun 13. doi: 10.1155/2024/3282679

PMCID:: PMC11221972

Abstract Article PDF–4.7M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102131063.

PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice

Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz, Pritha Chatterjee, Alina N. Santos, Hillmin Lei, Sharon Jahng, Timothy Chu, Ali Shawki, Elaine Hanson, Lars Eckmann, André J. Ouellette, Declan F. McCole

Cell Mol Gastroenterol Hepatol. 2023; 16(1): 39–62. Published online 2023 Apr 7. doi: 10.1016/j.jcmgh.2023.03.009

PMCID:: PMC10213106

Abstract Article PDF–8.7M

Select item 99774974.

PTPN2 regulates bacterial clearance in a mouse model of enteropathogenic and enterohemorrhagic E. coli infection

Marianne R. Spalinger, Vinicius Canale, Anica Becerra, Ali Shawki, Meli’sa Crawford, Alina N. Santos, Pritha Chatterjee, Jiang Li, Meera G. Nair, Declan F. McCole

JCI Insight. 2023 Feb 22; 8(4): e156909. Published online 2023 Feb 22. doi: 10.1172/jci.insight.156909

PMCID:: PMC9977497

Abstract Article PDF–6.3M

Select item 98519775.

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

Xu Wang, Chao Yang, Xuejie Wang, Jinmin Miao, Weitao Chen, Yiren Zhou, Ying Xu, Yongyan An, Aifang Cheng, Wenkang Ye, Mengxian Chen, Dong Song, Xue Yuan, Jiguang Wang, Peiyuan Qian, Angela Ruohao Wu, Zhong-Yin Zhang, Kai Liu

Neuron. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Neuron. 2023 Jan 18; 111(2): 236–255.e7. Published online 2022 Nov 11. doi: 10.1016/j.neuron.2022.10.028

PMCID:: PMC9851977

Abstract Article PDF–3.6M

Select item 88658026.

PTPN2 elicits cell autonomous and non–cell autonomous effects on antitumor immunity in triple-negative breast cancer

Pei Kee Goh, Florian Wiede, Mara N. Zeissig, Kara L. Britt, Shuwei Liang, Tim Molloy, Nathan Goode, Rachel Xu, Sherene Loi, Mathias Muller, Patrick O. Humbert, Catriona McLean, Tony Tiganis

Sci Adv. 2022 Feb; 8(8): eabk3338. Published online 2022 Feb 23. doi: 10.1126/sciadv.abk3338

PMCID:: PMC8865802

Abstract Article PDF–5.2M

Select item 87322767.

Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation

Marianne R. Spalinger, Meli’sa Crawford, Sarah D. Bobardt, Jiang Li, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Pritha Chatterjee, Meera G. Nair, Declan F. McCole

Mucosal Immunol. 2022; 15(1): 74–83. Published online 2021 Aug 21. doi: 10.1038/s41385-021-00441-3

PMCID:: PMC8732276

Abstract Article PDF–1.8M

Select item 86668298.

Autoimmune susceptibility gene PTPN2 is required for clearance of adherent-invasive Escherichia coli by integrating bacterial uptake and lysosomal defence

Marianne Rebecca Spalinger, Ali Shawki, Pritha Chatterjee, Vinicius Canale, Alina Santos, Anica Sayoc-Becerra, Michael Scharl, Michel L Tremblay, James Borneman, Declan F McCole

Gut. 2022 Jan; 71(1): 89–99. Published online 2021 Feb 9. doi: 10.1136/gutjnl-2020-323636

PMCID:: PMC8666829

Abstract Article PDF–7.0M

Select item 84095879.

T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling

Ronald R. Marchelletta, Moorthy Krishnan, Marianne R. Spalinger, Taylaur W. Placone, Rocio Alvarez, Anica Sayoc-Becerra, Vinicius Canale, Ali Shawki, Young Su Park, Lucas H.P. Bernts, Stephen Myers, Michel L. Tremblay, Kim E. Barrett, Evan Krystofiak, Bechara Kachar, Dermot P.B. McGovern, Christopher R. Weber, Elaine M. Hanson, Lars Eckmann, Declan F. McCole

J Clin Invest. 2021 Sep 1; 131(17): e138230. Published online 2021 Sep 1. doi: 10.1172/JCI138230

PMCID:: PMC8409587

Abstract Article PDF–18M

Select item 826928410.

Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N₂ in Dendritic Cells to Protect from Elevated Colitis

Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Anna Niechcial, Julianne B. Riggs, Marcin Wawrzyniak, Kirstin Atrott, Marnix van de Sande, Silvia Lang, Burkhard Becher, Gerhard Rogler, Michael Scharl, Marianne R. Spalinger

Int J Mol Sci. 2021 Jul; 22(13): 6820. Published online 2021 Jun 25. doi: 10.3390/ijms22136820

PMCID:: PMC8269284

Abstract Article PDF–2.7M

Select item 826150111.

Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

Jin Yang, Zhike Li, Meiling Shen, Yan Wang, Li Wang, Jiamiao Li, Wen Yang, Jie Li, Haijun Li, Xinxin Wang, Qinjie Wu, Changyang Gong

Adv Sci (Weinh) 2021 Jul; 8(13): 2100292. Published online 2021 May 14. doi: 10.1002/advs.202100292

PMCID:: PMC8261501

Abstract Article PDF–5.9M

Select item 809113312.

Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8⁺ T cells in skin

Katharina Hochheiser, Florian Wiede, Teagan Wagner, David Freestone, Matthias H. Enders, Moshe Olshansky, Brendan Russ, Simone Nüssing, Emma Bawden, Asolina Braun, Annabell Bachem, Elise Gressier, Robyn McConville, Simone L. Park, Claerwen M. Jones, Gayle M. Davey, David E. Gyorki, David Tscharke, Ian A. Parish, Stephen Turner, Marco J. Herold, Tony Tiganis, Sammy Bedoui, Thomas Gebhardt

J Exp Med. 2021 Jun 7; 218(6): e20200940. Published online 2021 Apr 29. doi: 10.1084/jem.20200940

PMCID:: PMC8091133

Abstract Article PDF–5.0M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 790988014.

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Garron T. Dodd, Seung Jae Kim, Mathieu Méquinion, Chrysovalantou E. Xirouchaki, Jens C. Brüning, Zane B. Andrews, Tony Tiganis

Sci Adv. 2021 Feb; 7(9): eabf4100. Published online 2021 Feb 26. doi: 10.1126/sciadv.abf4100

PMCID:: PMC7909880

Abstract Article PDF–8.4M

Select item 788039515.

PTPN2 negatively regulates macrophage inflammation in atherosclerosis

Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan

Aging (Albany NY) 2021 Jan 31; 13(2): 2768–2779. Published online 2020 Dec 19. doi: 10.18632/aging.202326

PMCID:: PMC7880395

Abstract Article PDF–1.6M

Select item 782880716.

Titanium Dioxide Presents a Different Profile in Dextran Sodium Sulphate-Induced Experimental Colitis in Mice Lacking the IBD Risk Gene Ptpn2 in Myeloid Cells

Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Häfliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Bäbler, Kirstin Atrott, Silvia Lang, Michael Scharl

Int J Mol Sci. 2021 Jan; 22(2): 772. Published online 2021 Jan 14. doi: 10.3390/ijms22020772

PMCID:: PMC7828807

Abstract Article PDF–6.5M

Select item 777337517.

Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development

Egle Katkeviciute, Larissa Hering, Ana Montalban-Arques, Philipp Busenhart, Marlene Schwarzfischer, Roberto Manzini, Javier Conde, Kirstin Atrott, Silvia Lang, Gerhard Rogler, Elisabeth Naschberger, Vera S. Schellerer, Michael Stürzl, Andreas Rickenbacher, Matthias Turina, Achim Weber, Sebastian Leibl, Gabriel E. Leventhal, Mitchell Levesque, Onur Boyman, Michael Scharl, Marianne R. Spalinger

J Clin Invest. 2021 Jan 4; 131(1): e140281. Published online 2021 Jan 4. doi: 10.1172/JCI140281

PMCID:: PMC7773375

Abstract Article PDF–22M

Select item 774306618.

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

Marianne R. Spalinger, Rong Hai, Jiang Li, Alina N. Santos, Tara M. Nordgren, Michel L. Tremblay, Lars Eckmann, Elaine Hanson, Michael Scharl, Xiwei Wu, Brigid S. Boland, Declan F. McCole

Version 1. bioRxiv. Preprint. 2020 Dec 9. doi: 10.1101/2020.12.09.416586

PMCID:: PMC7743066

Abstract Article PDF–3.0M

Select item 768044319.

PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.

Marianne R. Spalinger, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Vinicius Canale, Moorthy Krishnan, Anna Niechcial, Nicole Obialo, Michael Scharl, Jiang Li, Meera G. Nair, Declan F. McCole

Gastroenterology. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Gastroenterology. 2020 Nov; 159(5): 1763–1777.e14. Published online 2020 Jul 9. doi: 10.1053/j.gastro.2020.07.004

PMCID:: PMC7680443

Abstract Article PDF–2.4M

Select item 761064620.

Activation of naïve CD4⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4⁺ T cells

Jason P. Twohig, Ana Cardus Figueras, Robert Andrews, Florian Wiede, Benjamin C. Cossins, Alicia Derrac Soria, Myles J. Lewis, Michael J. Townsend, David Millrine, Jasmine Li, David G. Hill, Javier Uceda Fernandez, Xiao Liu, Barbara Szomolay, Christopher J. Pepper, Philip R. Taylor, Costantino Pitzalis, Tony Tiganis, Nigel M. Williams, Gareth W. Jones, Simon A. Jones

Nat Immunol. Author manuscript; available in PMC 2021 Apr 20.

Published in final edited form as: Nat Immunol. 2019 Apr 1; 20(4): 458–470. Published online 2019 Mar 19. doi: 10.1038/s41590-019-0350-0

PMCID:: PMC7610646

Abstract Article PDF–3.0M

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