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Select item 110313801.

CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa

Nicholas D. Nolan, Xuan Cui, Brian M. Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F. Hu, Laura A. Jenny, Chyuan-Sheng Lin, Daniel T. Hass, Jianhai Du, James B. Hurley, Stephen H. Tsang

Cell Rep Med. 2024 Apr 16; 5(4): 101459. Published online 2024 Mar 21. doi: 10.1016/j.xcrm.2024.101459

PMCID:: PMC11031380

Abstract Article PDF–6.3M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106170193.

Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei

Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4

PMCID:: PMC10617019

Abstract Article PDF–8.3M

Select item 103904924.

Three-dimensional molecular architecture of mouse organogenesis

Fangfang Qu, Wenjia Li, Jian Xu, Ruifang Zhang, Jincan Ke, Xiaodie Ren, Xiaogao Meng, Lexin Qin, Jingna Zhang, Fangru Lu, Xin Zhou, Xi Luo, Zhen Zhang, Minhan Wang, Guangming Wu, Duanqing Pei, Jiekai Chen, Guizhong Cui, Shengbao Suo, Guangdun Peng

Nat Commun. 2023; 14: 4599. Published online 2023 Jul 31. doi: 10.1038/s41467-023-40155-7

PMCID:: PMC10390492

Abstract Article PDF–13M

Select item 103770035.

Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development

Sophie Wulf, Luisa Mizko, Karl-Heinz Herrmann, Marta Sánchez-Carbonell, Anja Urbach, Cornelius Lemke, Alexander Berndt, Ivonne Loeffler, Gunter Wolf

Biomolecules. 2023 Jul; 13(7): 1037. Published online 2023 Jun 24. doi: 10.3390/biom13071037

PMCID:: PMC10377003

Abstract Article PDF–2.0M

Select item 102660326.

Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism

Yaqian Xue, Aoyuan Cui, Shuang Wei, Fengguang Ma, Zhengshuai Liu, Xia Fang, Shaofeng Huo, Xiaoyang Sun, Wenjing Li, Zhimin Hu, Yuxiao Liu, Genxiang Cai, Weitong Su, Jiuxiang Zhao, Xi Yan, Chenlin Gao, Jian Wen, Haibing Zhang, Hong Li, Yi Liu, Xu Lin, Yong Xu, Wenguang Fu, Jing Fang, Yu Li

Proc Natl Acad Sci U S A. 2023 Jun 6; 120(23): e2219419120. Published online 2023 May 30. doi: 10.1073/pnas.2219419120

PMCID:: PMC10266032

Abstract Article PDF–4.9M

Select item 97468077.

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss

JCI Insight. 2022 Nov 22; 7(22): e153337. Published online 2022 Nov 22. doi: 10.1172/jci.insight.153337

PMCID:: PMC9746807

Abstract Article PDF–4.9M

Select item 89880088.

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju

J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787

PMCID:: PMC8988008

Abstract Article PDF–6.1M

Select item 89332809.

Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth

Ying Jin, Yamu Pan, Shuang Zheng, Yao Liu, Jie Xu, Yazhi Peng, Zemei Zhang, Yadong Wang, Yulian Xiong, Lei Xu, Kaiyu Mu, Suwen Chen, Fei Zheng, Ye Yuan, Jian Fu

Oncogene. 2022; 41(12): 1752–1766. Published online 2022 Feb 5. doi: 10.1038/s41388-022-02203-2

PMCID:: PMC8933280

Abstract Article PDF–8.6M

Select item 888674510.

Adaptation of the Oxygen Sensing System during Lung Development

Karin M. Kirschner, Simon Kelterborn, Herrmann Stehr, Johanna L. T. Penzlin, Charlotte L. J. Jacobi, Stefanie Endesfelder, Miriam Sieg, Jochen Kruppa, Christof Dame, Lina K. Sciesielski

Oxid Med Cell Longev. 2022; 2022: 9714669. Published online 2022 Feb 18. doi: 10.1155/2022/9714669

PMCID:: PMC8886745

Abstract Article PDF–2.8M

Select item 865875411.

PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes

Aude Angelini, Pradip K. Saha, Antrix Jain, Sung Yun Jung, Randall L. Mynatt, Xinchun Pi, Liang Xie

Cell Rep. Author manuscript; available in PMC 2021 Dec 9.

Published in final edited form as: Cell Rep. 2021 Oct 5; 37(1): 109767. doi: 10.1016/j.celrep.2021.109767

PMCID:: PMC8658754

Abstract Article PDF–2.3M

Select item 864341712.

Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function

Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Joseph

Endocrinology. 2022 Jan; 163(1): bqab226. Published online 2021 Oct 28. doi: 10.1210/endocr/bqab226

PMCID:: PMC8643417

Abstract Article

Select item 847073413.

Prolyl Hydroxylase Domain-Containing Protein 3 Gene Expression in Chondrocytes Is Not Essential for Bone Development in Mice

Weirong Xing, Sheila Pourteymoor, Gustavo A. Gomez, Yian Chen, Subburaman Mohan

Cells. 2021 Sep; 10(9): 2200. Published online 2021 Aug 26. doi: 10.3390/cells10092200

PMCID:: PMC8470734

Abstract Article PDF–2.4M

Select item 840998214.

Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice

Daniela Nasteska, Federica Cuozzo, Katrina Viloria, Elspeth M. Johnson, Alpesh Thakker, Rula Bany Bakar, Rebecca L. Westbrook, Jonathan P. Barlow, Monica Hoang, Jamie W. Joseph, Gareth G. Lavery, Ildem Akerman, James Cantley, Leanne Hodson, Daniel A. Tennant, David J. Hodson

JCI Insight. 2021 Aug 23; 6(16): e140288. Published online 2021 Aug 23. doi: 10.1172/jci.insight.140288

PMCID:: PMC8409982

Abstract Article PDF–10M

Select item 819255715.

Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection

Bibo Zhu, Yue Wu, Su Huang, Ruixuan Zhang, Young Min Son, Chaofan Li, In Su Cheon, Xiaochen Gao, Min Wang, Yao Chen, Xian Zhou, Quynh Nguyen, Anthony T. Phan, Supriya Behl, M. Mark Taketo, Matthias Mack, Virginia S. Shapiro, Hu Zeng, Hideki Ebihara, John J. Mullon, Eric S. Edell, Janani S. Reisenauer, Nadir Demirel, Ryan M. Kern, Rana Chakraborty, Weiguo Cui, Mark H. Kaplan, Xiaobo Zhou, Ananda W. Goldrath, Jie Sun

Immunity. 2021 Jun 8; 54(6): 1200–1218.e9. Published online 2021 May 4. doi: 10.1016/j.immuni.2021.04.001

PMCID:: PMC8192557

Abstract Article PDF–7.4M

Select item 806525516.

PHD3 loss promotes exercise capacity and fat oxidation in skeletal muscle

Haejin Yoon, Jessica B. Spinelli, Elma Zaganjor, Samantha J. Wong, Natalie J. German, Elizabeth C. Randall, Afsah Dean, Allen Clermont, Joao A. Paulo, Daniel Garcia, Hao Li, Olivia Rombold, Nathalie Y. R. Agar, Laurie J. Goodyear, Reuben J. Shaw, Steven P. Gygi, Johan Auwerx, Marcia C. Haigis

Cell Metab. Author manuscript; available in PMC 2021 Apr 24.

Published in final edited form as: Cell Metab. 2020 Aug 4; 32(2): 215–228.e7. Published online 2020 Jul 13. doi: 10.1016/j.cmet.2020.06.017

PMCID:: PMC8065255

Abstract Article PDF–1.3M

Select item 803896317.

HIF1α is a direct regulator of steroidogenesis in the adrenal gland

Deepika Watts, Johanna Stein, Ana Meneses, Nicole Bechmann, Ales Neuwirth, Denise Kaden, Anja Krüger, Anupam Sinha, Vasileia Ismini Alexaki, Luis Gustavo Perez-Rivas, Stefan Kircher, Antoine Martinez, Marily Theodoropoulou, Graeme Eisenhofer, Mirko Peitzsch, Ali El-Armouche, Triantafyllos Chavakis, Ben Wielockx

Cell Mol Life Sci. 2021 Apr; 78(7): 3577–3590. Published online 2021 Jan 19. doi: 10.1007/s00018-020-03750-1

PMCID:: PMC8038963

Abstract Article PDF–1.5M

Select item 802118818.

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery

George Z. Wei, Sujata Saraswat Ohri, Nicolas K. Khattar, Adam W. Listerman, Catherine H. Doyle, Kariena R. Andres, Saravanan S. Karuppagounder, Rajiv R. Ratan, Scott R. Whittemore, Michal Hetman

PLoS One. 2021; 16(4): e0249591. Published online 2021 Apr 5. doi: 10.1371/journal.pone.0249591

PMCID:: PMC8021188

Abstract Article PDF–820K

Select item 790021919.

Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice

Ivan Menendez-Montes, Beatriz Escobar, Manuel J. Gomez, Teresa Albendea-Gomez, Beatriz Palacios, Elena Bonzon-Kulichenko, Jose Luis Izquierdo-Garcia, Ana Vanessa Alonso, Alessia Ferrarini, Luis Jesus Jimenez-Borreguero, Jesus Ruiz-Cabello, Jesus Vázquez, Silvia Martin-Puig

iScience. 2021 Feb 19; 24(2): 102124. Published online 2021 Feb 3. doi: 10.1016/j.isci.2021.102124

PMCID:: PMC7900219

Abstract Article PDF–6.0M

Select item 786388720.

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation

Steffi Heidenreich, Pamela Weber, Heike Stephanowitz, Konstantin M. Petricek, Till Schütte, Moritz Oster, Antti M. Salo, Miriam Knauer, Isabel Goehring, Na Yang, Nicole Witte, Anne Schumann, Manuela Sommerfeld, Matthias Muenzner, Johanna Myllyharju, Eberhard Krause, Michael Schupp

J Biol Chem. 2020 Dec 11; 295(50): 17158–17168. Published online 2020 Oct 6. doi: 10.1074/jbc.RA120.014402

PMCID:: PMC7863887

Abstract Article PDF–2.8M

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