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Select item 111478121.

Co-localization of the sodium-glucose co-transporter-2 channel (SGLT-2) with endothelin ET_A and ET_B receptors in human cardiorenal tissue

Thomas L. Williams, Rhoda E. Kuc, Anna L. Paterson, George R. Abraham, Anna L. Pullinger, Janet J. Maguire, Sanjay Sinha, Peter J. Greasley, Philip Ambery, Anthony P. Davenport

Biosci Rep. 2024 Jun 26; 44(6): BSR20240604. Published online 2024 May 31. doi: 10.1042/BSR20240604

PMCID:: PMC11147812

Abstract Article PDF–3.6M

Select item 109555202.

Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling (Review)

Bixian Chen, Jing Guo, Hongmei Ye, Xinyu Wang, Yufei Feng

Mol Med Rep. 2024 May; 29(5): 73. Published online 2024 Mar 11. doi: 10.3892/mmr.2024.13197

PMCID:: PMC10955520

Abstract Article PDF–2.1M

Select item 109016613.

Inhibition of Sodium-Glucose Cotransporter-2 during Serum Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO Signaling Pathway

Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Yu-Mi Lim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee

Endocrinol Metab (Seoul) 2024 Feb; 39(1): 98–108. Published online 2024 Jan 3. doi: 10.3803/EnM.2023.1786

PMCID:: PMC10901661

Abstract Article PDF–2.0M

Select item 108032894.

Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter

Masahiro Hiraizumi, Tomoya Akashi, Kouta Murasaki, Hiroyuki Kishida, Taichi Kumanomidou, Nao Torimoto, Osamu Nureki, Ikuko Miyaguchi

Nat Struct Mol Biol. 2024; 31(1): 159–169. Published online 2023 Dec 6. doi: 10.1038/s41594-023-01134-0

PMCID:: PMC10803289

Abstract Article PDF–11M

Select item 107074855.

A Transcriptome Array-Based Approach to Link SGLT-2 and Intrarenal Complement C5 Synthesis in Diabetic Nephropathy

Peter Korsten, Björn Tampe

Int J Mol Sci. 2023 Dec; 24(23): 17066. Published online 2023 Dec 2. doi: 10.3390/ijms242317066

PMCID:: PMC10707485

Abstract Article PDF–1.5M

Select item 101163386.

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility: an updated meta-analysis

Yuwei Wang, Lili Huo, Changqing Yang, Xiaofeng He

Biosci Rep. 2023 Apr 26; 43(4): BSR20222553. Published online 2023 Apr 19. doi: 10.1042/BSR20222553

PMCID:: PMC10116338

Abstract Article PDF–1.8M

Select item 97127537.

Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy

Hui Chen, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen

Front Endocrinol (Lausanne) 2022; 13: 1020252. Published online 2022 Nov 17. doi: 10.3389/fendo.2022.1020252

PMCID:: PMC9712753

Abstract Article PDF–5.6M

Select item 96060648.

Hepatic expression of sodium–glucose cotransporter 2 (SGLT2) in patients with chronic liver disease

Dan Nakano, Jun Akiba, Tsubasa Tsutsumi, Machiko Kawaguchi, Takafumi Yoshida, Hironori Koga, Takumi Kawaguchi

Med Mol Morphol. 2022; 55(4): 304–315. Published online 2022 Sep 21. doi: 10.1007/s00795-022-00334-9

PMCID:: PMC9606064

Abstract Article PDF–1.1M

Select item 91266789.

circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells

Sheng Chen

Dis Markers. 2022; 2022: 6103086. Published online 2022 May 16. doi: 10.1155/2022/6103086

PMCID:: PMC9126678

Abstract Article PDF–2.3M

Select item 898500610.

Effects of Sodium-Glucose Cotransporter 2 on Amputation Events: A Systematic Review and Meta-Analysis of Randomized-Controlled Trials

Ray Meng See, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Alicia Swee Yan Yip, Shariel Leong, Caitlin Fern Wee, Alex Jia Yang Cheong, Chi-Hang Lee, Mark Yan-Yee Chan, Tiong Cheng Yeo, Raymond C.C. Wong, Peter Chang, Choon Chiet Hong, Ping Chai, Ching-Hui Sia

Pharmacology. 2022 Mar; 107(3-4): 123–130. Published online 2021 Dec 23. doi: 10.1159/000520903

PMCID:: PMC8985006

Abstract Article

Select item 846690511.

Treatment Response to SGLT2 Inhibitors: From Clinical Characteristics to Genetic Variations

Jasna Klen, Vita Dolžan

Int J Mol Sci. 2021 Sep; 22(18): 9800. Published online 2021 Sep 10. doi: 10.3390/ijms22189800

PMCID:: PMC8466905

Abstract Article PDF–533K

Select item 844396412.

Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors' Target Prediction

Huanqiang Li, Ziling Mai, Sijia Yu, Bo Wang, Wenguang Lai, Guanzhong Chen, Chunyun Zhou, Jin Liu, Yongquan Yang, Shiqun Chen, Yong Liu, Jiyan Chen

Biomed Res Int. 2021; 2021: 4229194. Published online 2021 Sep 8. doi: 10.1155/2021/4229194

PMCID:: PMC8443964

Abstract Article PDF–1.1M

Select item 834769813.

Cardioprotection by SGLT2 Inhibitors—Does It All Come Down to Na⁺?

Maximilian Trum, Johannes Riechel, Stefan Wagner

Int J Mol Sci. 2021 Aug; 22(15): 7976. Published online 2021 Jul 26. doi: 10.3390/ijms22157976

PMCID:: PMC8347698

Abstract Article PDF–2.2M

Select item 831939314.

Effects of SGLT2 inhibitors on stroke and its subtypes in patients with type 2 diabetes: a systematic review and meta-analysis

Wen-Hsuan Tsai, Shih-Ming Chuang, Sung-Chen Liu, Chun-Chuan Lee, Ming-Nan Chien, Ching-Hsiang Leung, Shu-Jung Liu, Hong-Mou Shih

Sci Rep. 2021; 11: 15364. Published online 2021 Jul 28. doi: 10.1038/s41598-021-94945-4

PMCID:: PMC8319393

Abstract Article PDF–1.4M

Select item 819989315.

Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species

Xiaoling Li, Gregor Römer, Raphaela P. Kerindongo, Jeroen Hermanides, Martin Albrecht, Markus W. Hollmann, Coert J. Zuurbier, Benedikt Preckel, Nina C. Weber

Int J Mol Sci. 2021 Jun; 22(11): 6044. Published online 2021 Jun 3. doi: 10.3390/ijms22116044

PMCID:: PMC8199893

Abstract Article PDF–1.7M

Select item 819938316.

Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to Clinical Effects

Giuseppe Palmiero, Arturo Cesaro, Erica Vetrano, Pia Clara Pafundi, Raffaele Galiero, Alfredo Caturano, Elisabetta Moscarella, Felice Gragnano, Teresa Salvatore, Luca Rinaldi, Paolo Calabrò, Ferdinando Carlo Sasso

Int J Mol Sci. 2021 Jun; 22(11): 5863. Published online 2021 May 30. doi: 10.3390/ijms22115863

PMCID:: PMC8199383

Abstract Article PDF–1.7M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 758700118.

Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains

Yoichi Chiba, Yasunori Sugiyama, Nozomu Nishi, Wakako Nonaka, Ryuta Murakami, Masaki Ueno

Neuropathology. 2020 Oct; 40(5): 482–491. Published online 2020 Jun 2. doi: 10.1111/neup.12665

PMCID:: PMC7587001

Abstract Article PDF–17M

Select item 755465619.

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Nancy Antoine, Firas Khattab, Bao-Khanh Lai, Davide Brusa, Birgit Stierstorfer, Holger Klein, Bilal Singh, Lucie Ruiz, Michael Pieper, Michael Mark, Pedro L. Herrera, Fiona M. Gribble, Frank Reimann, Anne Wojtusciszyn, Christophe Broca, Nano Rita, Lorenzo Piemonti, Patrick Gilon

Mol Metab. 2020 Dec; 42: 101071. Published online 2020 Sep 5. doi: 10.1016/j.molmet.2020.101071

PMCID:: PMC7554656

Abstract Article PDF–5.0M

Select item 752826120.

Characterization of left ventricular myocardial sodium-glucose cotransporter 1 expression in patients with end-stage heart failure

Alex Ali Sayour, Attila Oláh, Mihály Ruppert, Bálint András Barta, Eszter Mária Horváth, Kálmán Benke, Miklós Pólos, István Hartyánszky, Béla Merkely, Tamás Radovits

Cardiovasc Diabetol. 2020; 19: 159. Published online 2020 Sep 30. doi: 10.1186/s12933-020-01141-1

PMCID:: PMC7528261

Abstract Article PDF–3.6M

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