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Items: 1 to 20 of 46

1.
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family
Anabel Cámara-Checa, Francesca Perin, Marcos Rubio-Alarcón, María Dago, Teresa Crespo-García, Josu Rapún, María Marín, Jorge Cebrián, Ricardo Gómez, Francisco Bermúdez-Jiménez, Lorenzo Monserrat, Juan Tamargo, Ricardo Caballero, Juan Jiménez-Jáimez, Eva Delpón
Proc Natl Acad Sci U S A. 2023 Dec 5; 120(49): e2305135120. Published online 2023 Nov 30. doi: 10.1073/pnas.2305135120
PMCID:
PMC10710060
AbstractArticlePDF–2.4M
2.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage
iScience. 2023 May 19; 26(5): 106701. Published online 2023 Apr 18. doi: 10.1016/j.isci.2023.106701
PMCID:
PMC10189495
AbstractArticlePDF–5.3M
3.
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation
Hongrui Wang, Tong Wu, Zhuo Huang, Jinghan Huang, Ze Geng, Bing Cui, Yupeng Yan, Yu Zhang, Yibo Wang
J Biol Chem. 2022 Nov; 298(11): 102599. Published online 2022 Oct 14. doi: 10.1016/j.jbc.2022.102599
PMCID:
PMC9663530
AbstractArticlePDF–4.4M
4.
Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system
Stefan Peischard, Melina Möller, Paul Disse, Huyen Tran Ho, Arie O. Verkerk, Nathalie Strutz-Seebohm, Thomas Budde, Sven G. Meuth, Patrick A. Schweizer, Silke Morris, Lena Mücher, Verónica Eisner, Dierk Thomas, Karin Klingel, Karin Busch, Guiscard Seebohm
Cell Mol Life Sci. 2022 Aug; 79(8): 440. Published online 2022 Jul 21. doi: 10.1007/s00018-022-04435-7
PMCID:
PMC9304080
AbstractArticlePDF–2.6M
5.
Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel
Leo C.T. Ng, Yue Xian Li, Filip Van Petegem, Eric A. Accili
Biophys J. 2022 Apr 5; 121(7): 1166–1183. Published online 2022 Feb 24. doi: 10.1016/j.bpj.2022.02.035
PMCID:
PMC9034293
AbstractArticlePDF–1.4M
6.
Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Satoshi Akagi, Toru Miyoshi, Hiroshi Morita, Hiroshi Ito
Stem Cell Res Ther. 2022; 13: 141. Published online 2022 Apr 1. doi: 10.1186/s13287-022-02818-y
PMCID:
PMC8973792
AbstractArticlePDF–3.9M
7.
Clinical Presentation of Left Ventricular Noncompaction Cardiomyopathy and Bradycardia in Three Families Carrying HCN4 Pathogenic Variants
Agata Paszkowska, Dorota Piekutowska-Abramczuk, Elżbieta Ciara, Alicja Mirecka-Rola, Monika Brzezinska, Dorota Wicher, Grażyna Kostrzewa, Jędrzej Sarnecki, Lidia Ziółkowska
Genes (Basel) 2022 Mar; 13(3): 477. Published online 2022 Mar 8. doi: 10.3390/genes13030477
PMCID:
PMC8949387
AbstractArticlePDF–2.2M
8.
Gating movements and ion permeation in HCN4 pacemaker channels
Andrea Saponaro, Daniel Bauer, M. Hunter Giese, Paolo Swuec, Alessandro Porro, Federica Gasparri, Atiyeh Sadat Sharifzadeh, Antonio Chaves-Sanjuan, Laura Alberio, Giacomo Parisi, Gabriele Cerutti, Oliver B. Clarke, Kay Hamacher, Henry M. Colecraft, Filippo Mancia, Wayne A. Hendrickson, Steven A. Siegelbaum, Dario DiFrancesco, Martino Bolognesi, Gerhard Thiel, Bina Santoro, Anna Moroni
Mol Cell. 2021 Jul 15; 81(14): 2929–2943.e6. doi: 10.1016/j.molcel.2021.05.033
PMCID:
PMC8294335
AbstractArticle
9.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
10.
Genetic Analysis of Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Cation Channels in Sudden Unexpected Death in Epilepsy Cases
Emily Tu, Louise Waterhouse, Johan Duflou, Richard D. Bagnall, Christopher Semsarian
Brain Pathol. 2011 Nov; 21(6): 692–698. Published online 2011 Aug 16. doi: 10.1111/j.1750-3639.2011.00500.x
PMCID:
PMC8094053
AbstractArticlePDF–332K
11.
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking
Nadine Erlenhardt, Olaf Kletke, Franziska Wohlfarth, Marlene A. Komadowski, Lukas Clasen, Hisaki Makimoto, Susanne Rinné, Malte Kelm, Christiane Jungen, Niels Decher, Christian Meyer, Nikolaj Klöcker
Pflugers Arch. 2020; 472(12): 1733–1742. Published online 2020 Oct 23. doi: 10.1007/s00424-020-02481-3
PMCID:
PMC7691308
AbstractArticlePDF–1.3M
12.
GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation
Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
EBioMedicine. 2019 Jan; 39: 377–387. Published online 2018 Nov 28. doi: 10.1016/j.ebiom.2018.11.040
PMCID:
PMC6355642
AbstractArticlePDF–2.0M
13.
Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
Anna M. D. Végh, A. Dénise den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A. B. van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. de Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan, Gerard J. J. Boink
Molecules. 2019 Jan; 24(1): 181. Published online 2019 Jan 5. doi: 10.3390/molecules24010181
PMCID:
PMC6337610
AbstractArticlePDF–3.1M
14.
Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia
Alicia D’Souza, Charles M. Pearman, Yanwen Wang, Shu Nakao, Sunil Jit R.J. Logantha, Charlotte Cox, Hayley Bennett, Yu Zhang, Anne Berit Johnsen, Nora Linscheid, Pi Camilla Poulsen, Jonathan Elliott, Jessica Coulson, Jamie McPhee, Abigail Robertson, Paula A. da Costa Martins, Ashraf Kitmitto, Ulrik Wisløff, Elizabeth J. Cartwright, Oliver Monfredi, Alicia Lundby, Halina Dobrzynski, Delvac Oceandy, Gwilym M. Morris, Mark R. Boyett
Circ Res. 2017 Oct 13; 121(9): 1058–1068. Published online 2017 Oct 12. doi: 10.1161/CIRCRESAHA.117.311607
PMCID:
PMC5636198
AbstractArticlePDF–2.6M
15.
Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia
Stephen Boulton, Madoka Akimoto, Sam Akbarizadeh, Giuseppe Melacini
J Biol Chem. 2017 Apr 14; 292(15): 6414–6428. Published online 2017 Feb 7. doi: 10.1074/jbc.M116.773697
PMCID:
PMC5391768
AbstractArticlePDF–4.4M
16.
Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation
YAO-DONG LI, YI-FAN HONG, YUEERGULI YUSUFUAJI, BAO-PENG TANG, XIAN-HUI ZHOU, GUO-JUN XU, JIN-XIN LI, LIN SUN, JIANG-HUA ZHANG, QIANG XIN, JIAN XIONG, YU-TONG JI, YU ZHANG
Mol Med Rep. 2015 Sep; 12(3): 3243–3248. Published online 2015 May 25. doi: 10.3892/mmr.2015.3831
PMCID:
PMC4526032
AbstractArticlePDF–587K
17.
Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels
Bryan VanSchouwen, Madoka Akimoto, Maryam Sayadi, Federico Fogolari, Giuseppe Melacini
J Biol Chem. 2015 Jul 17; 290(29): 17642–17654. Published online 2015 May 4. doi: 10.1074/jbc.M115.651877
PMCID:
PMC4505013
AbstractArticlePDF–2.9M
18.
Cardiac arrhythmia induced by genetic silencing of “funny” (f) channels is rescued by GIRK4 inactivation
Pietro Mesirca, Jacqueline Alig, Angelo G. Torrente, Jana Christina Müller, Laurine Marger, Anne Rollin, Claire Marquilly, Anne Vincent, Stefan Dubel, Isabelle Bidaud, Anne Fernandez, Anika Seniuk, Birgit Engeland, Jasmin Singh, Lucile Miquerol, Heimo Ehmke, Thomas Eschenhagen, Joel Nargeot, Kevin Wickman, Dirk Isbrandt, Matteo E. Mangoni
Nat Commun. Author manuscript; available in PMC 2015 Feb 21.
Published in final edited form as: Nat Commun. 2014; 5: 4664. Published online 2014 Aug 21. doi: 10.1038/ncomms5664
PMCID:
PMC4207211
AbstractArticlePDF–3.4M
19.
A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP
Madoka Akimoto, Zaiyong Zhang, Stephen Boulton, Rajeevan Selvaratnam, Bryan VanSchouwen, Melanie Gloyd, Eric A. Accili, Oliver F. Lange, Giuseppe Melacini
J Biol Chem. 2014 Aug 8; 289(32): 22205–22220. Published online 2014 May 30. doi: 10.1074/jbc.M114.572164
PMCID:
PMC4139233
AbstractArticlePDF–4.4M
20.
A Novel Trafficking-defective HCN4 Mutation is Associated with Early-Onset Atrial Fibrillation
Vincenzo Macri, Saagar N. Mahida, Michael L. Zhang, Moritz F. Sinner, Elena V. Dolmatova, Nathan R. Tucker, Micheal McLellan, Marisa A. Shea, David J. Milan, Kathryn L. Lunetta, Emelia J. Benjamin, Patrick T. Ellinor
Heart Rhythm. Author manuscript; available in PMC 2015 Jun 1.
Published in final edited form as: Heart Rhythm. 2014 Jun; 11(6): 1055–1062. Published online 2014 Mar 4. doi: 10.1016/j.hrthm.2014.03.002
PMCID:
PMC4130372
AbstractArticlePDF–741K

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