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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 101652552.

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui

iScience. 2023 May 19; 26(5): 106670. Published online 2023 Apr 14. doi: 10.1016/j.isci.2023.106670

PMCID:: PMC10165255

Abstract Article PDF–8.2M

Select item 93760863.

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Daniel T. Meier, Leila Rachid, Sophia J. Wiedemann, Shuyang Traub, Kelly Trimigliozzi, Marc Stawiski, Loïc Sauteur, Denise V. Winter, Christelle Le Foll, Catherine Brégère, Raphael Guzman, Alex Odermatt, Marianne Böni-Schnetzler, Marc Y. Donath

Nat Commun. 2022; 13: 4761. Published online 2022 Aug 13. doi: 10.1038/s41467-022-32509-4

PMCID:: PMC9376086

Abstract Article PDF–3.6M

Select item 90441774.

The G209R Mutant Mouse as a Model for Human PCSK1 Polyendocrinopathy

Manita Shakya, Surbhi, Nicolle K Martin, Anoop Arunagiri, Martin G Martin, Peter Arvan, Malcolm J Low, Iris Lindberg

Endocrinology. 2022 May; 163(5): bqac024. Published online 2022 Mar 4. doi: 10.1210/endocr/bqac024

PMCID:: PMC9044177

Abstract Article

Select item 82913795.

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria C. De Rosa, Valentina Klaus, Rick Rausch, Vidhu V. Thaker, Elisabeth Graf, Tim M. Strom, Anne-Laure Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen C. Woods, Gert O. Pflugfelder, Rubén Nogueiras, Lori Zeltser, Ilona C. Grunwald Kadow, Anne Moon, Cristina García-Cáceres, Matthias Mann, Mathias Treier, Claudia A. Doege, Matthias H. Tschöp

Nat Metab. Author manuscript; available in PMC 2021 Jul 20.

Published in final edited form as: Nat Metab. 2019 Feb; 1(2): 222–235. Published online 2019 Jan 28. doi: 10.1038/s42255-018-0028-1

PMCID:: PMC8291379

Abstract Article PDF–2.4M

Select item 82532306.

Mice Lacking PC1/3 Expression in POMC-expressing Cells Do Not Develop Obesity

Manita Shakya, Surbhi, Anne White, C Bruce Verchere, Malcolm J Low, Iris Lindberg

Endocrinology. 2021 Jun; 162(6): bqab055. Published online 2021 Mar 10. doi: 10.1210/endocr/bqab055

PMCID:: PMC8253230

Abstract Article

Select item 81705037.

A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing

Georgina K.C. Dowsett, Brian Y.H. Lam, John A. Tadross, Irene Cimino, Debra Rimmington, Anthony P. Coll, Joseph Polex-Wolf, Lotte Bjerre Knudsen, Charles Pyke, Giles S.H. Yeo

Mol Metab. 2021 Nov; 53: 101240. Published online 2021 May 4. doi: 10.1016/j.molmet.2021.101240

PMCID:: PMC8170503

Abstract Article PDF–4.1M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 70601569.

A novel mutation in the mouse Pcsk1 gene showing obesity and diabetes

Nor I. A. Muhsin, Liz Bentley, Ying Bai, Michelle Goldsworthy, Roger D. Cox

Mamm Genome. 2020; 31(1): 17–29. Published online 2020 Jan 23. doi: 10.1007/s00335-020-09826-4

PMCID:: PMC7060156

Abstract Article PDF–5.5M

Select item 692045410.

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Mariam Lofty Khaled, Yelena Bykhovskaya, Chunfang Gu, Alice Liu, Michelle D. Drewry, Zhong Chen, Barbara A. Mysona, Emily Parker, Ryan P. McNabb, Hongfang Yu, Xiaowen Lu, Jing Wang, Xiaohui Li, Abdulrahman Al-Muammar, Jerome I. Rotter, Louise F. Porter, Amy Estes, Mitchell A. Watsky, Sylvia B. Smith, Hongyan Xu, Khaled K. Abu-Amero, Anthony Kuo, Stephen B. Shears, Yaron S. Rabinowitz, Yutao Liu

Sci Rep. 2019; 9: 19406. Published online 2019 Dec 18. doi: 10.1038/s41598-019-55866-5

PMCID:: PMC6920454

Abstract Article PDF–4.3M

Select item 689242411.

Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D

Timothy S Jarvela, Surbhi, Manita Shakya, Tomas Bachor, Anne White, Malcolm J Low, Iris Lindberg

Endocrinology. 2019 Nov; 160(11): 2630–2645. Published online 2019 Sep 2. doi: 10.1210/en.2019-00418

PMCID:: PMC6892424

Abstract Article

Select item 553686512.

Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets

Katie L. Sinagoga, William J. Stone, Jacqueline V. Schiesser, Jamie I. Schweitzer, Leesa Sampson, Yi Zheng, James M. Wells

Development. 2017 Jul 1; 144(13): 2402–2414. doi: 10.1242/dev.146316

PMCID:: PMC5536865

Abstract Article

Select item 538488013.

Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter

Alfredo Oliveros, Phillip Starski, Daniel Lindberg, Sun Choi, Carrie J. Heppelmann, Surendra Dasari, Doo-Sup Choi

J Proteome Res. Author manuscript; available in PMC 2017 Apr 7.

Published in final edited form as: J Proteome Res. 2017 Apr 7; 16(4): 1445–1459. Published online 2017 Feb 27. doi: 10.1021/acs.jproteome.6b00830

PMCID:: PMC5384880

Abstract Article PDF–3.4M

Select item 529582114.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 519971015.

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome

Lisa C. Burnett, Charles A. LeDuc, Carlos R. Sulsona, Daniel Paull, Richard Rausch, Sanaa Eddiry, Jayne F. Martin Carli, Michael V. Morabito, Alicja A. Skowronski, Gabriela Hubner, Matthew Zimmer, Liheng Wang, Robert Day, Brynn Levy, Ilene Fennoy, Beatrice Dubern, Christine Poitou, Karine Clement, Merlin G. Butler, Michael Rosenbaum, Jean Pierre Salles, Maithe Tauber, Daniel J. Driscoll, Dieter Egli, Rudolph L. Leibel

J Clin Invest. 2017 Jan 3; 127(1): 293–305. Published online 2016 Dec 12. doi: 10.1172/JCI88648

PMCID:: PMC5199710

Abstract Article PDF–1.3M

Select item 499213816.

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown

Nat Commun. 2016; 7: 12444. Published online 2016 Aug 18. doi: 10.1038/ncomms12444

PMCID:: PMC4992138

Abstract Article PDF–2.2M

Select item 476311117.

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development

Ahmed M. Abdellatif, Hisashi Oishi, Takahiro Itagaki, Yunshin Jung, Hossam H. Shawki, Yukari Okita, Yoshikazu Hasegawa, Hiroyuki Suzuki, Salah E. El-Morsy, Mesbah A. El-Sayed, Mahmoud B. Shoaib, Fumihiro Sugiyama, Satoru Takahashi

PLoS One. 2016; 11(2): e0150010. Published online 2016 Feb 22. doi: 10.1371/journal.pone.0150010

PMCID:: PMC4763111

Abstract Article PDF–14M

Select item 472597718.

The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways

M. Duhamel, F. Rodet, A. N. Murgoci, R. Desjardins, H. Gagnon, M. Wisztorski, I. Fournier, R. Day, M. Salzet

Sci Rep. 2016; 6: 19360. Published online 2016 Jan 18. doi: 10.1038/srep19360

PMCID:: PMC4725977

Abstract Article PDF–1.9M

Select item 451223019.

Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function

Shivatra Chutima Talchai, Domenico Accili

Diabetes. 2015 Aug; 64(8): 2868–2879. Published online 2015 Mar 17. doi: 10.2337/db14-1696

PMCID:: PMC4512230

Abstract Article PDF–2.7M

Select item 442219820.

Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry

Atira Hardiman, Theodore C Friedman, William C Grunwald, Jr, Machi Furuta, Ziaorong Zhu, Donald F Steiner, David R Cool

J Mol Endocrinol. Author manuscript; available in PMC 2015 May 6.

Published in final edited form as: J Mol Endocrinol. 2005 Jun; 34(3): 739–751. doi: 10.1677/jme.1.01812

PMCID:: PMC4422198

Abstract Article PDF–935K

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