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Select item 104735671.

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations

Jian Ren, Yazi Huang, Yeqing Ren, Tianqi Tu, Baoshan Qiu, Daosheng Ai, Zhanying Bi, Xue Bai, Fengzhi Li, Jun-Liszt Li, Xing-jun Chen, Ziyan Feng, Zongpei Guo, Jianfeng Lei, An Tian, Ziwei Cui, Volkhard Lindner, Ralf H Adams, Yibo Wang, Fei Zhao, Jakob Körbelin, Wenzhi Sun, Yilong Wang, Hongqi Zhang, Tao Hong, Woo-ping Ge

Brain. 2023 Sep; 146(9): 3634–3647. Published online 2023 Mar 30. doi: 10.1093/brain/awad104

PMCID:: PMC10473567

Abstract Article PDF–1.5M

Select item 104241502.

TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development

Erdyni N. Tsitsikov, Khanh P. Phan, Yufeng Liu, Alla V. Tsytsykova, Mike Kinter, Lauren Selland, Lori Garman, Courtney Griffin, Ian F. Dunn

iScience. 2023 Aug 18; 26(8): 107474. Published online 2023 Jul 25. doi: 10.1016/j.isci.2023.107474

PMCID:: PMC10424150

Abstract Article PDF–5.6M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 63472944.

MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis

Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D. Hoeck, Jingwen Yu, Liang Liu, Yvonne Y. C. Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C. H. Ng, Xiaoyin Niu, Bing Su, Axel Behrens, Zhiheng Xu

PLoS Biol. 2018 Dec; 16(12): e2006613. Published online 2018 Dec 19. doi: 10.1371/journal.pbio.2006613

PMCID:: PMC6347294

Abstract Article PDF–3.5M

Select item 60208105.

Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice

Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang, Bing Su, Junling Liu

Blood Adv. 2018 Jun 26; 2(12): 1439–1448. Published online 2018 Jun 25. doi: 10.1182/bloodadvances.2017015149

PMCID:: PMC6020810

Abstract Article PDF–3.7M

Select item 57670336.

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson’s disease

Longping Yao, Yongyi Ye, Hengxu Mao, Fengfei Lu, Xiaozheng He, Guohui Lu, Shizhong Zhang

J Neuroinflammation. 2018; 15: 13. Published online 2018 Jan 12. doi: 10.1186/s12974-018-1053-4

PMCID:: PMC5767033

Abstract Article PDF–3.8M

Select item 49813897.

Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Jaesung P. Choi, Matthew Foley, Zinan Zhou, Weng-Yew Wong, Naveena Gokoolparsadh, J. Simon C. Arthur, Dean Y. Li, Xiangjian Zheng

PLoS One. 2016; 11(8): e0160833. Published online 2016 Aug 11. doi: 10.1371/journal.pone.0160833

PMCID:: PMC4981389

Abstract Article PDF–6.3M

Select item 48640358.

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signaling

Zinan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai, Lauren M. Goddard, Robert Shenkar, Su Zhou, Jisheng Yang, Alexander C. Wright, Matthew Foley, J. Simon C. Arthur, Kevin J. Whitehead, Issam A. Awad, Dean Y. Li, Xiangjian Zheng, Mark L. Kahn

Nature. Author manuscript; available in PMC 2016 Sep 30.

Published in final edited form as: Nature. 2016 Apr 7; 532(7597): 122–126. Published online 2016 Mar 30. doi: 10.1038/nature17178

Correction in:: Nature. 2016 May 25; 536(7617): 488.

PMCID:: PMC4864035

Abstract Article PDF–3.0M

Select item 45898649.

The cerebral cavernous malformation pathway controls embryonic endocardial gene expression through regulation of MEKK3 signaling and KLF expression

Zinan Zhou, David Rawnsley, Lauren Goddard, Wei Pan, Xing-Jun Cao, Zoltan Jakus, Hui Zheng, Jisheng Yang, Simon Arthur, Kevin J. Whitehead, Dean Li, Bin Zhou, Benjamin A. Garcia, Xiangjian Zheng, Mark L. Kahn

Dev Cell. Author manuscript; available in PMC 2016 Jan 26.

Published in final edited form as: Dev Cell. 2015 Jan 26; 32(2): 168–180. doi: 10.1016/j.devcel.2014.12.009

PMCID:: PMC4589864

Abstract Article PDF–3.7M

Select item 452611410.

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

Oriana S. Fisher, Hanqiang Deng, Dou Liu, Ya Zhang, Rong Wei, Yong Deng, Fan Zhang, Angeliki Louvi, Benjamin E. Turk, Titus J. Boggon, Bing Su

Nat Commun. 2015; 6: 7937. Published online 2015 Aug 3. doi: 10.1038/ncomms8937

PMCID:: PMC4526114

Abstract Article PDF–2.2M

Select item 415653411.

A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose-tissue inflammation in obesity

Eloy D. Hernandez, Sang Jun Lee, Ji Young Kim, Angeles Duran, Juan F. Linares, Tomoko Yajima, Timo D. Müller, Matthias H. Tschöp, Steven R. Smith, Maria T. Diaz-Meco, Jorge Moscat

Cell Metab. Author manuscript; available in PMC 2015 Sep 2.

Published in final edited form as: Cell Metab. 2014 Sep 2; 20(3): 499–511. Published online 2014 Jul 17. doi: 10.1016/j.cmet.2014.06.008

PMCID:: PMC4156534

Abstract Article PDF–1.7M

Select item 383367412.

MEKK3 Regulates IFN-γ Production in T Cells through the Rac1/2-Dependent MAPK Cascades

Xiaofang Wang, Fan Zhang, Fanping Chen, Dou Liu, Yi Zheng, Yongliang Zhang, Chen Dong, Bing Su

J Immunol. Author manuscript; available in PMC 2013 Nov 19.

Published in final edited form as: J Immunol. 2011 May 15; 186(10): 10.4049/jimmunol.1002127. Published online 2011 Apr 6. doi: 10.4049/jimmunol.1002127

PMCID:: PMC3833674

Abstract Article PDF–1.5M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 307301414.

The kinases MEKK2 and MEKK3 regulate Transforming Growth Factor-β-mediated helper T cell differentiation

Xing Chang, Fang Liu, Xiaofang Wang, Aiping Lin, Hongyu Zhao, Bing Su

Immunity. Author manuscript; available in PMC 2012 Feb 25.

Published in final edited form as: Immunity. 2011 Feb 25; 34(2): 201–212. Published online 2011 Feb 17. doi: 10.1016/j.immuni.2011.01.017

PMCID:: PMC3073014

Abstract Article PDF–631K

Select item 292342815.

MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival

Xiaofang Wang, Xing Chang, Valeria Facchinetti, Yuan Zhuang, Bing Su

J Immunol. Author manuscript; available in PMC 2010 Aug 18.

Published in final edited form as: J Immunol. 2009 Mar 15; 182(6): 3597–3608. doi: 10.4049/jimmunol.0803738

PMCID:: PMC2923428

Abstract Article PDF–1.3M

Select item 287475016.

Vasculogenesis Driven by Bone Marrow-Derived Cells Is Essential for Growth of Ewing’s Sarcomas

Ling Yu, Bing Su, Mario Hollomon, Yong Deng, Valeria Facchinetti, Eugenie S. Kleinerman

Cancer Res. Author manuscript; available in PMC 2011 Feb 15.

Published in final edited form as: Cancer Res. 2010 Feb 15; 70(4): 1334–1343. Published online 2010 Feb 2. doi: 10.1158/0008-5472.CAN-09-2795

PMCID:: PMC2874750

Abstract Article PDF–1.7M

Select item 272822017.

MEKK3 initiates TGFβ2-dependent EMT during endocardial cushion morphogenesis

Mark V. Stevens, Derrick M. Broka, Patti Parker, Elisa Rogowitz, Richard R. Vaillancourt, Todd D. Camenisch

Circ Res. Author manuscript; available in PMC 2009 Dec 5.

Published in final edited form as: Circ Res. 2008 Dec 5; 103(12): 1430–1440. Published online 2008 Nov 13. doi: 10.1161/CIRCRESAHA.108.180752

PMCID:: PMC2728220

Abstract Article PDF–3.6M

Select item 271929918.

MEKK3 is required for lysophosphatidic acid-induced NF-κB activation

Wenjing Sun, Hongxiu Li, Yang Yu, Yihui Fan, Brian C. Grabiner, Renfang Mao, Ningling Ge, Hong Zhang, Songbin Fu, Xin Lin, Jianhua Yang

Cell Signal. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Cell Signal. 2009 Oct; 21(10): 1488–1494. Published online 2009 May 22. doi: 10.1016/j.cellsig.2009.05.007

PMCID:: PMC2719299

Abstract Article PDF–927K

Select item 266870219.

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

Kelsey N. Retting, Buer Song, Byeong S. Yoon, Karen M. Lyons

Development. 2009 Apr 1; 136(7): 1093–1104. Published online 2009 Feb 18. doi: 10.1242/dev.029926

PMCID:: PMC2668702

Abstract Article

Select item 255627020.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

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