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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 88100182.

ADAMTS-13-regulated nuclear factor E2-related factor 2 signaling inhibits ferroptosis to ameliorate cisplatin-induced acute kidney injuy: Running title: Role of ADAMTS-13 and ferroptosis in AKI.

Xiaoyan Meng, Wenjing Huang, Weiwei Mo, Tingting Shu, Haoqiang Yang, Haibo Ning

Bioengineered. 2021; 12(2): 11610–11621. Published online 2021 Dec 7. doi: 10.1080/21655979.2021.1994707

PMCID:: PMC8810018

Abstract Article PDF–3.4M

Select item 70940263.

Antibodies that conformationally activate ADAMTS13 allosterically enhance metalloprotease domain function

An-Sofie Schelpe, Anastasis Petri, Elien Roose, Inge Pareyn, Hans Deckmyn, Simon F. De Meyer, James T. B. Crawley, Karen Vanhoorelbeke

Blood Adv. 2020 Mar 24; 4(6): 1072–1080. Published online 2020 Mar 20. doi: 10.1182/bloodadvances.2019001375

PMCID:: PMC7094026

Abstract Article PDF–1.2M

Select item 67642664.

Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy

Liang Zheng, Di Zhang, Wenjing Cao, Wen-Chao Song, X. Long Zheng

Blood. 2019 Sep 26; 134(13): 1095–1105. Prepublished online 2019 Aug 13. doi: 10.1182/blood.2019001040

PMCID:: PMC6764266

Abstract Article

Select item 67099915.

Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura

Reheman Adili, Michael Holinstat

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Sep; 39(9): 1817–1830. Published online 2019 Jul 25. doi: 10.1161/ATVBAHA.119.312848

PMCID:: PMC6709991

Abstract Article PDF–2.9M

Select item 62146166.

Transfusion of platelets loaded with recombinant ADAMTS13 is efficacious for inhibiting arterial thrombosis in mice and in human

Mohammad S. Abdelgawwad, Wenjing Cao, Liang Zheng, Nicole K. Kocher, Lance A. Williams, X. Long Zheng

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Nov; 38(11): 2731–2743. doi: 10.1161/ATVBAHA.118.311407

PMCID:: PMC6214616

Abstract Article PDF–1.9M

Select item 61280827.

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

Yingang Wu, Wei Liu, Yuan Zhou, Tristan Hilton, Zilong Zhao, Wei Liu, Min Wang, Jason Yeon, Katie Houck, Perumal Thiagarajan, Fangyi Zhang, Fu-Dong Shi, Xiaoping Wu, Min Li, Jing-fei Dong, Jianning Zhang

Blood. 2018 Sep 6; 132(10): 1075–1084. Prepublished online 2018 Jun 25. doi: 10.1182/blood-2018-03-841932

PMCID:: PMC6128082

Abstract Article

Select item 60556128.

Role of von Willebrand factor and ADAMTS‐13 in early brain injury after experimental subarachnoid hemorrhage

H. Wan, Y. Wang, J. Ai, S. Brathwaite, H. Ni, R.L. Macdonald, E.M. Hol, J.C.M. Meijers, M.D.I. Vergouwen

J Thromb Haemost. 2018 Jul; 16(7): 1413–1422. Published online 2018 Jun 8. doi: 10.1111/jth.14136

PMCID:: PMC6055612

Abstract Article PDF–657K

Select item 58237699.

Endothelial cell-derived von Willebrand factor, but not platelet-derived, promotes atherosclerosis in Apoe-deficient mice

Prakash Doddapattar, Nirav Dhanesha, Mehul R. Chorawala, Chandler Tinsman, Manish Jain, Manasa K. Nayak, Janice M. Staber, Anil K. Chauhan

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Mar; 38(3): 520–528. Published online 2018 Jan 18. doi: 10.1161/ATVBAHA.117.309918

PMCID:: PMC5823769

Abstract Article PDF–1.9M

Select item 550128710.

ADAMTS13 retards progression of diabetic nephropathy by inhibiting intrarenal thrombosis in mice

Nirav Dhanesha, Prakash Doddapattar, Mehul R Chorawala, Manasa K. Nayak, Koichi Kokame, Janice M. Staber, Steven R. Lentz, Anil K. Chauhan

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2018 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 Jul; 37(7): 1332–1338. Published online 2017 May 11. doi: 10.1161/ATVBAHA.117.309539

PMCID:: PMC5501287

Abstract Article PDF–661K

Select item 550114711.

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery

Haochen Xu, Yongliang Cao, Xing Yang, Ping Cai, Lijing Kang, Ximin Zhu, Haiyu Luo, Lu Lu, Lixiang Wei, Xiaofei Bai, Yuanbo Zhu, Bing-Qiao Zhao, Wenying Fan

Blood. 2017 Jul 6; 130(1): 11–22. Prepublished online 2017 Apr 20. doi: 10.1182/blood-2016-10-747089

PMCID:: PMC5501147

Abstract Article

Select item 535657112.

Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis

Lukas Goertz, Stefan Werner Schneider, Anna Desch, Frank Thomas Mayer, Julian Koett, Kai Nowak, Ioannis Karampinis, Michael K. Bohlmann, Viktor Umansky, Alexander Thomas Bauer

Oncotarget. 2016 Oct 18; 7(42): 68527–68545. Published online 2016 Sep 2. doi: 10.18632/oncotarget.11832

PMCID:: PMC5356571

Abstract Article PDF–15M

Select item 529582113.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 500189514.

Endothelial cell-derived VWF is the major determinant that mediates VWF-dependent acute ischemic stroke by promoting post-ischemic thrombo-inflammation

Nirav Dhanesha, Prem Prakash, Prakash Doddapattar, Ira Khanna, Molly J Pollpeter, Manasa K. Nayak, Janice M. Staber, Anil K. Chauhan

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9): 1829–1837. Published online 2016 Jul 21. doi: 10.1161/ATVBAHA.116.307660

PMCID:: PMC5001895

Abstract Article PDF–2.7M

Select item 496883015.

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

Louis Deforche, Claudia Tersteeg, Elien Roose, Aline Vandenbulcke, Nele Vandeputte, Inge Pareyn, Elien De Cock, Hanspeter Rottensteiner, Hans Deckmyn, Simon F. De Meyer, Karen Vanhoorelbeke

PLoS One. 2016; 11(8): e0160388. Published online 2016 Aug 1. doi: 10.1371/journal.pone.0160388

PMCID:: PMC4968830

Abstract Article PDF–2.6M

Select item 444088416.

Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models

Brandy Pickens, Yingying Mao, Dengju Li, Don L. Siegel, Mortimer Poncz, Douglas B. Cines, X. Long Zheng

Blood. 2015 May 21; 125(21): 3326–3334. Prepublished online 2015 Mar 23. doi: 10.1182/blood-2014-07-587139

PMCID:: PMC4440884

Abstract Article

Select item 443201017.

von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans

Alexander T. Bauer, Jan Suckau, Kathrin Frank, Anna Desch, Lukas Goertz, Andreas H. Wagner, Markus Hecker, Tobias Goerge, Ludmila Umansky, Philipp Beckhove, Jochen Utikal, Christian Gorzelanny, Nancy Diaz-Valdes, Viktor Umansky, Stefan W. Schneider

Blood. 2015 May 14; 125(20): 3153–3163. Prepublished online 2015 Feb 24. doi: 10.1182/blood-2014-08-595686

PMCID:: PMC4432010

Abstract Article

Select item 438838118.

Probing ADAMTS13 Substrate Specificity using Phage Display

Karl C. Desch, Colin Kretz, Andrew Yee, Robert Gildersleeve, Kristin Metzger, Nidhi Agrawal, Jane Cheng, David Ginsburg

PLoS One. 2015; 10(4): e0122931. Published online 2015 Apr 7. doi: 10.1371/journal.pone.0122931

PMCID:: PMC4388381

Abstract Article PDF–828K

Select item 438355319.

Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects

Dorothy Concepcion, Kevin D. Ross, Kasey R. Hutt, Gene W. Yeo, Bruce A. Hamilton

PLoS Genet. 2015 Apr; 11(4): e1005123. Published online 2015 Apr 2. doi: 10.1371/journal.pgen.1005123

PMCID:: PMC4383553

Abstract Article PDF–1.3M

Select item 401328720.

Carboxyl-terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large VWF string formation under flow in a free thiol-dependent manner

Jialing Bao, Juan Xiao, Yingying Mao, X. Long Zheng

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Feb; 34(2): 397–407. Published online 2013 Dec 19. doi: 10.1161/ATVBAHA.113.302547

PMCID:: PMC4013287

Abstract Article PDF–1.4M

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