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Select item 101123621.

Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells

Yihe Yan, Leting Zheng, Qiang Du, Bing Yan, David A. Geller

Cancer Immunol Immunother. 2020 Sep; 69(9): 1891–1903. Published online 2020 May 6. doi: 10.1007/s00262-020-02586-9

PMCID:: PMC10112362

Abstract Article PDF–1.5M

Select item 97625502.

IRF2 is required for development and functional maturation of human NK cells

Eva Persyn, Sigrid Wahlen, Laura Kiekens, Wouter Van Loocke, Hannah Siwe, Els Van Ammel, Zenzi De Vos, Filip Van Nieuwerburgh, Patrick Matthys, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq

Front Immunol. 2022; 13: 1038821. Published online 2022 Dec 5. doi: 10.3389/fimmu.2022.1038821

PMCID:: PMC9762550

Abstract Article PDF–8.1M

Select item 89389893.

CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors

Yijie Ma, Michael Walsh, Katharina Bernhardt, Camille W Ashbaugh, Stephen J Trudeau, Isabelle Ashbaugh, Sizun Jiang, Chang Jiang, Bo Zhao, David Root, John Doench, Benjamin E. Gewurz

Cell Host Microbe. Author manuscript; available in PMC 2022 Mar 22.

Published in final edited form as: Cell Host Microbe. 2017 May 10; 21(5): 580–591.e7. doi: 10.1016/j.chom.2017.04.005

PMCID:: PMC8938989

Abstract Article PDF–2.0M

Select item 88122344.

IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer

Yan-Jie Chen, Shu-Neng Luo, Hao Wu, Ning-Ping Zhang, Ling Dong, Tao-Tao Liu, Li Liang, Xi-Zhong Shen

J Transl Med. 2022; 20: 68. Published online 2022 Feb 3. doi: 10.1186/s12967-022-03275-0

PMCID:: PMC8812234

Abstract Article PDF–10M

Select item 86910905.

IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3

Kai Ren, Ya Zhu, Honggang Sun, Shilin Li, Xiaoqiong Duan, Shuang Li, Yujia Li, Bin Li, Limin Chen

Virol J. 2021; 18: 256. Published online 2021 Dec 20. doi: 10.1186/s12985-021-01724-8

PMCID:: PMC8691090

Abstract Article PDF–1.2M

Select item 82148566.

IRF2‐mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells by acting as a competing endogenous RNA

Guiwen Ye, Peng Wang, Zhongyu Xie, Jinteng Li, Guan Zheng, Wenjie Liu, Qian Cao, Ming Li, Shuizhong Cen, Zhaofeng Li, Wenhui Yu, Yanfeng Wu, Huiyong Shen

Clin Transl Med. 2021 Jun; 11(6): e429. Published online 2021 Jun 20. doi: 10.1002/ctm2.429

PMCID:: PMC8214856

Abstract Article PDF–6.4M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80090488.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 75668819.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 749056010.

A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation

Jonathan Poh, Amy H. Ponsford, James Boyd, Jonathan Woodsmith, Ulrich Stelzl, Erich Wanker, Nicholas Harper, David MacEwan, Christopher M. Sanderson

Redox Biol. 2020 Oct; 37: 101686. Published online 2020 Aug 20. doi: 10.1016/j.redox.2020.101686

PMCID:: PMC7490560

Abstract Article PDF–8.6M

Select item 676103511.

Frequent loss of IRF2 in cancers leads to immune evasion through decreased MHC-I antigen presentation and increased PD-L1 expression

Barry A. Kriegsman, Pranitha Vangala, Benjamin J. Chen, Paul Meraner, Abraham L. Brass, Manuel Garber, Kenneth L. Rock

J Immunol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: J Immunol. 2019 Oct 1; 203(7): 1999–2010. Published online 2019 Aug 30. doi: 10.4049/jimmunol.1900475

PMCID:: PMC6761035

Abstract Article PDF–2.1M

Select item 672702712.

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

Sacha Benaoudia, Amandine Martin, Marta Puig Gamez, Gabrielle Gay, Brice Lagrange, Maxence Cornut, Kyrylo Krasnykov, Jean‐Baptiste Claude, Cyril F Bourgeois, Sandrine Hughes, Benjamin Gillet, Omran Allatif, Antoine Corbin, Romeo Ricci, Thomas Henry

EMBO Rep. 2019 Sep; 20(9): e48235. Published online 2019 Jul 29. doi: 10.15252/embr.201948235

PMCID:: PMC6727027

Abstract Article PDF–2.0M

Select item 666837413.

TRIM14 expression is regulated by IRF‐1 and IRF‐2

Jingang Cui, Xiao Xu, Yutong Li, Xiaomei Hu, Yingpeng Xie, Juan Tan, Wentao Qiao

FEBS Open Bio. 2019 Aug; 9(8): 1413–1420. Published online 2019 Jul 1. doi: 10.1002/2211-5463.12682

PMCID:: PMC6668374

Abstract Article PDF–749K

Select item 658775514.

Silencing H19 regulated proliferation, invasion, and autophagy in the placenta by targeting miR‐18a‐5p

Lei Zhang, Xinru Deng, Xian Shi, Xiaojing Dong

J Cell Biochem. 2019 Jun; 120(6): 9006–9015. Published online 2018 Dec 9. doi: 10.1002/jcb.28172

PMCID:: PMC6587755

Abstract Article PDF–936K

Select item 654822115.

UBE3A regulates the transcription of IRF, an antiviral immunity

Ryohei Furumai, Kota Tamada, Xiaoxi Liu, Toru Takumi

Hum Mol Genet. 2019 Jun 15; 28(12): 1947–1958. Published online 2019 Jan 26. doi: 10.1093/hmg/ddz019

PMCID:: PMC6548221

Abstract Article PDF–11M

Select item 642409816.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz

iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026

PMCID:: PMC6424098

Abstract Article PDF–11M

Select item 593843117.

Interferon regulatory factor 1 inactivation in human cancer

Khaldoon Alsamman, Omar S. El-Masry

Biosci Rep. 2018 Jun 29; 38(3): BSR20171672. Prepublished online 2018 Mar 29. Published online 2018 May 8. doi: 10.1042/BSR20171672

PMCID:: PMC5938431

Abstract Article PDF–796K

Select item 556474818.

miR-302b inhibits cancer-related inflammation by targeting ERBB4, IRF2 and CXCR4 in esophageal cancer

Mingxin Zhang, Lingmin Zhang, Manli Cui, Wenguang Ye, Pengjiang Zhang, Suna Zhou, Jingjie Wang

Oncotarget. 2017 Jul 25; 8(30): 49053–49063. Published online 2017 Apr 11. doi: 10.18632/oncotarget.17041

PMCID:: PMC5564748

Abstract Article PDF–4.7M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 552069220.

MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer

Chen Liang, Xing Zhang, Hui-Min Wang, Xiao-Min Liu, Xin-ju Zhang, Bo Zheng, Guang-Ren Qian, Zhong-Liang Ma

Cell Death Dis. 2017 May; 8(5): e2764. Published online 2017 May 4. doi: 10.1038/cddis.2017.145

PMCID:: PMC5520692

Abstract Article PDF–3.1M

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