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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108698003.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 105432714.

EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance

Bárbara de la Peña Avalos, Romain Tropée, Pascal H. G. Duijf, Eloïse Dray

Mol Cancer. 2023; 22: 158. Published online 2023 Sep 30. doi: 10.1186/s12943-023-01861-4

PMCID:: PMC10543271

Abstract Article PDF–9.5M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98918736.

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis

Yu Jia, Hui-Yan Li, Jue Wang, Xing Chen, Lu Lou, Yan-Yan Wei, Ying Wang, Shi-Jing Mo

J Cancer. 2023; 14(2): 200–218. Published online 2023 Jan 1. doi: 10.7150/jca.79905

PMCID:: PMC9891873

Abstract Article PDF–5.6M

Select item 98435107.

Aberrant DNA methylation and expression of EYA4 in gastric cardia intestinal metaplasia

Chenxi Li, Zhaohui Liu, Guohua Xu, Shibin Wu, Yunhui Peng, Ruinuan Wu, Shukun Zhao, Xiaoqi Liao, Runhua Lin

Saudi J Gastroenterol. 2022 Nov-Dec; 28(6): 456–465. Published online 2022 Nov 4. doi: 10.4103/sjg.sjg_228_22

PMCID:: PMC9843510

Abstract Article PDF–7.9M

Select item 91094018.

Identification of a novel CNV at the EYA4 gene in a Chinese family with autosomal dominant nonsyndromic hearing loss

Weixun Zhang, Jing Song, Busheng Tong, Mengye Ma, Luo Guo, Yasheng Yuan, Juanmei Yang

BMC Med Genomics. 2022; 15: 113. Published online 2022 May 16. doi: 10.1186/s12920-022-01269-x

PMCID:: PMC9109401

Abstract Article PDF–1.0M

Select item 88288959.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 851692210.

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53

Yafei Guo, Qin Li, Gang Zhao, Jie Zhang, Hang Yuan, Tianyu Feng, Deqiong Ou, Rui Gu, Siqi Li, Kai Li, Ping Lin

Cell Death Dis. 2021 Oct; 12(10): 945. Published online 2021 Oct 14. doi: 10.1038/s41419-021-04208-3

PMCID:: PMC8516922

Abstract Article PDF–8.2M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796343012.

Early truncation of the N‐terminal variable region of EYA4 gene causes dominant hearing loss without cardiac phenotype

Yanfang Mi, Danhua Liu, Beiping Zeng, Yongan Tian, Hui Zhang, Bei Chen, Juanli Zhang, Hong Xue, Wenxue Tang, Yulin Zhao, Hongen Xu

Mol Genet Genomic Med. 2021 Jan; 9(1): e1569. Published online 2020 Dec 10. doi: 10.1002/mgg3.1569

PMCID:: PMC7963430

Abstract Article PDF–997K

Select item 795953413.

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

Peng-bo Yang, Pei-pei Hou, Fu-yuan Liu, Wen-bin Hong, Hang-zi Chen, Xiao-yu Sun, Peng Li, Yi Zhang, Cui-yu Ju, Li-juan Luo, Sheng-fu Wu, Jia-xin Zhou, Zhi-jing Wang, Jian-ping He, Li Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin, Qiao Wu

Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44): 27412–27422. Published online 2020 Oct 21. doi: 10.1073/pnas.2002997117

PMCID:: PMC7959534

Abstract Article PDF–3.1M

Select item 787370114.

Global proteomics of Ubqln2-based murine models of ALS

Alexandra M. Whiteley, Miguel A. Prado, Stefanie A.H. de Poot, Joao A. Paulo, Marissa Ashton, Sara Dominguez, Martin Weber, Hai Ngu, John Szpyt, Mark P. Jedrychowski, Amy Easton, Steven P. Gygi, Thimo Kurz, Mervyn J. Monteiro, Eric J. Brown, Daniel Finley

J Biol Chem. 2021 Jan-Jun; 296: 100153. Published online 2020 Dec 10. doi: 10.1074/jbc.RA120.015960

PMCID:: PMC7873701

Abstract Article PDF–3.0M

Select item 719291015.

The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II

Yana van der Weegen, Hadar Golan-Berman, Tycho E. T. Mevissen, Katja Apelt, Román González-Prieto, Joachim Goedhart, Elisheva E. Heilbrun, Alfred C. O. Vertegaal, Diana van den Heuvel, Johannes C. Walter, Sheera Adar, Martijn S. Luijsterburg

Nat Commun. 2020; 11: 2104. Published online 2020 Apr 30. doi: 10.1038/s41467-020-15903-8

Correction in:: Nat Commun. 2020; 11: 5734.

PMCID:: PMC7192910

Abstract Article PDF–4.5M

Select item 714834416.

Insights into the pathophysiology of DFNA10 hearing loss associated with novel EYA4 variants

Matias Morín, Lucía Borreguero, Kevin T Booth, María Lachgar, Patrick Huygen, Manuela Villamar, Fernando Mayo, Luis Carlos Barrio, Luciana Santos Serrão de Castro, Carmelo Morales, Ignacio del Castillo, Beatriz Arellano, Dolores Tellería, Richard J. H. Smith, Hela Azaiez, M. A. Moreno Pelayo

Sci Rep. 2020; 10: 6213. Published online 2020 Apr 10. doi: 10.1038/s41598-020-63256-5

PMCID:: PMC7148344

Abstract Article PDF–2.6M

Select item 704665917.

Prevalence and clinical features of hearing loss caused by EYA4 variants

Jun Shinagawa, Hideaki Moteki, Shin-ya Nishio, Kenji Ohyama, Koshi Otsuki, Satoshi Iwasaki, Shin Masuda, Chie Oshikawa, Yumi Ohta, Yasuhiro Arai, Masahiro Takahashi, Naoko Sakuma, Satoko Abe, Yuika Sakurai, Hirofumi Sakaguchi, Takashi Ishino, Natsumi Uehara, Shin-ichi Usami

Sci Rep. 2020; 10: 3662. Published online 2020 Feb 27. doi: 10.1038/s41598-020-60259-0

PMCID:: PMC7046659

Abstract Article PDF–1.7M

Select item 677862218.

EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β‐catenin at Ser552

Xiao‐Xu Zhu, Jian‐Hui Li, Jian‐Peng Cai, Xun Hou, Chen‐Song Huang, Xi‐Tai Huang, Jie‐Qin Wang, Shi‐Jin Li, Qiong‐Cong Xu, Xiao‐Yu Yin

Cancer Sci. 2019 Oct; 110(10): 3110–3121. Published online 2019 Aug 28. doi: 10.1111/cas.14159

PMCID:: PMC6778622

Abstract Article PDF–1.8M

Select item 653351519.

EYA4 serves as a prognostic biomarker in hepatocellular carcinoma and suppresses tumour angiogenesis and metastasis

Fangming Gu, Shengxian Yuan, Lei Liu, Peng Zhu, Yuan Yang, Zeya Pan, Weiping Zhou

J Cell Mol Med. 2019 Jun; 23(6): 4208–4216. Published online 2019 Apr 7. doi: 10.1111/jcmm.14309

PMCID:: PMC6533515

Abstract Article PDF–1.8M

Select item 652424720.

Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis

Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin, Jian Huang

Mol Cancer. 2019; 18: 95. Published online 2019 May 17. doi: 10.1186/s12943-019-1025-z

PMCID:: PMC6524247

Abstract Article PDF–17M

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