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Select item 111159001.

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo

Christian Feißt, Carlo Pergola, Marija Rakonjac, Antonietta Rossi, Andreas Koeberle, Gabriele Dodt, Marika Hoffmann, Christina Hoernig, Lutz Fischer, Dieter Steinhilber, Lutz Franke, Gisbert Schneider, Olof Rådmark, Lidia Sautebin, Oliver Werz

Cell Mol Life Sci. 2009 Aug; 66(16): 2759–2771. Published online 2009 Jul 5. doi: 10.1007/s00018-009-0078-3

PMCID:: PMC11115900

Abstract Article PDF–414K

Select item 110656982.

The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions

Astrid S. Kahnt, Ann-Kathrin Häfner, Dieter Steinhilber

Oncogene. 2024; 43(18): 1319–1327. Published online 2024 Apr 4. doi: 10.1038/s41388-024-03016-1

PMCID:: PMC11065698

Abstract Article PDF–1.1M

Select item 109300703.

ALOX5可作为与免疫细胞浸润相关的非小细胞肺癌预后生物标志物

赵倩倩, 孙之, 潘月眉, 荆琪, 李伟, 王传玺

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Mar 28; 48(3): 311–322. Chinese. doi: 10.11817/j.issn.1672-7347.2023.220427

PMCID:: PMC10930070

Abstract Article PDF–9.7M

Select item 108845364.

Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression

Lulu Han, Yuxin Chen, Nan Huang, Xiaowan Zhou, Yanfang Lv, Huizhong Li, Dafei Chai, Junnian Zheng, Gang Wang

Cancer Biol Med. 2024 Feb 15; 21(2): 175–192. Published online 2024 Jan 2. doi: 10.20892/j.issn.2095-3941.2023.0248

PMCID:: PMC10884536

Abstract Article PDF–2.8M

Select item 106467545.

Oncogenic PIK3CA recruits myeloid‐derived suppressor cells to shape the immunosuppressive tumour microenvironment in luminal breast cancer through the 5‐lipoxygenase‐dependent arachidonic acid pathway

Xingchen Li, Guidong Chen, Fanchen Wang, Xiaojing Guo, Rui Zhang, Pengpeng Liu, Li Dong, Wenwen Yu, Huan Wang, Hailong Wang, Jinpu Yu

Clin Transl Med. 2023 Nov; 13(11): e1483. Published online 2023 Nov 15. doi: 10.1002/ctm2.1483

PMCID:: PMC10646754

Abstract Article PDF–16M

Select item 98425086.

Knock-out of 5-lipoxygenase in overexpressing tumor cells—consequences on gene expression and cellular function

Hannah Weisser, Tamara Göbel, G. Melissa Krishnathas, Marius Kreiß, Carlo Angioni, Duran Sürün, Dominique Thomas, Tobias Schmid, Ann-Kathrin Häfner, Astrid S. Kahnt

Cancer Gene Ther. 2023; 30(1): 108–123. Published online 2022 Sep 16. doi: 10.1038/s41417-022-00531-9

PMCID:: PMC9842508

Abstract Article PDF–3.5M

Select item 98198897.

Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation

Beatrice Dufrusine, Silvia Valentinuzzi, Sandra Bibbò, Verena Damiani, Paola Lanuti, Damiana Pieragostino, Piero Del Boccio, Ersilia D’Alessandro, Alberto Rabottini, Alessandro Berghella, Nerino Allocati, Katia Falasca, Claudio Ucciferri, Francesco Mucedola, Marco Di Perna, Laura Martino, Jacopo Vecchiet, Vincenzo De Laurenzi, Enrico Dainese

Int J Mol Sci. 2023 Jan; 24(1): 15. Published online 2022 Dec 20. doi: 10.3390/ijms24010015

PMCID:: PMC9819889

Abstract Article PDF–2.1M

Select item 96729608.

Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling

Saiyang Xie, Mengya Chen, Wenxi Fang, Shiqiang Liu, Qingqing Wu, Chen Liu, Yun Xing, Wenke Shi, Man Xu, Min Zhang, Si Chen, Xiaofeng Zeng, Shasha Wang, Wei Deng, Qizhu Tang

eBioMedicine. 2022 Dec; 86: 104359. Published online 2022 Nov 14. doi: 10.1016/j.ebiom.2022.104359

PMCID:: PMC9672960

Abstract Article PDF–7.2M

Select item 92626149.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 914644310.

Respiratory Syncytial Virus Nonstructural Protein 1 Promotes 5-Lipoxygenase via miR-19a-3p

Mei Zheng, Panpan Fan, Pu Yang, Junwen Zheng, Dongchi Zhao

J Immunol Res. 2022; 2022: 4086710. Published online 2022 May 20. doi: 10.1155/2022/4086710

PMCID:: PMC9146443

Abstract Article PDF–1.4M

Select item 889086711.

5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration

Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin

Oxid Med Cell Longev. 2022; 2022: 1792894. Published online 2022 Feb 23. doi: 10.1155/2022/1792894

PMCID:: PMC8890867

Abstract Article PDF–3.9M

Select item 857641612.

LTB₄-Driven Inflammation and Increased Expression of ALOX5/ACE2 During Severe COVID-19 in Individuals With Diabetes

Icaro Bonyek-Silva, Antônio Fernando Araújo Machado, Thiago Cerqueira-Silva, Sara Nunes, Márcio Rivison Silva Cruz, Jéssica Silva, Reinan Lima Santos, Aldina Barral, Pablo Rafael Silveira Oliveira, Ricardo Khouri, C. Henrique Serezani, Cláudia Brodskyn, Juliana Ribeiro Caldas, Manoel Barral-Netto, Viviane Boaventura, Natalia Machado Tavares

Diabetes. 2021 Sep; 70(9): 2120–2130. Published online 2021 Jun 15. doi: 10.2337/db20-1260

PMCID:: PMC8576416

Abstract Article PDF–1.8M

Select item 834846413.

Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review

Juan Antonio Giménez-Bastida, Antonio González-Sarrías, José Moisés Laparra-Llopis, Claus Schneider, Juan Carlos Espín

Int J Mol Sci. 2021 Aug; 22(15): 7937. Published online 2021 Jul 25. doi: 10.3390/ijms22157937

PMCID:: PMC8348464

Abstract Article PDF–2.0M

Select item 833581914.

ALOX5‐5‐HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation

Jianjun Tang, Chuang Zhang, Jingjing Lin, Peng Duan, Jian Long, Hongyan Zhu

Cancer Med. 2021 Aug; 10(15): 5246–5255. Published online 2021 Jun 13. doi: 10.1002/cam4.4066

PMCID:: PMC8335819

Abstract Article PDF–1.3M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011